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Items: 26

1.

Perfusion Controls Muscle Glucose Uptake by Altering the Rate of Glucose Dispersion In Vivo.

McClatchey PM, Williams IM, Xu Z, Mignemi NA, Hughey CC, McGuinness OP, Beckman JA, Wasserman DH.

Am J Physiol Endocrinol Metab. 2019 Sep 17. doi: 10.1152/ajpendo.00260.2019. [Epub ahead of print]

PMID:
31526289
2.

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword.

Hughey CC, Crawford PA.

Cell Metab. 2019 Jun 4;29(6):1236-1238. doi: 10.1016/j.cmet.2019.05.013.

PMID:
31167118
3.

Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2).

Gregory JM, Smith TJ, Slaughter JC, Mason HR, Hughey CC, Smith MS, Kandasamy B, Greeley SAW, Philipson LH, Naylor RN, Letourneau LR, Abumrad NN, Cherrington AD, Moore DJ.

Diabetes. 2019 Aug;68(8):1565-1576. doi: 10.2337/db19-0324. Epub 2019 May 15.

PMID:
31092478
4.

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH.

Mol Metab. 2019 May;23:1-13. doi: 10.1016/j.molmet.2019.02.006. Epub 2019 Feb 25.

5.

Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.

Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1118-E1135. doi: 10.1152/ajpendo.00496.2018. Epub 2019 Mar 5.

PMID:
30835508
6.

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.

Lantier L, Williams AS, Hughey CC, Bracy DP, James FD, Ansari MA, Gius D, Wasserman DH.

PLoS One. 2018 Dec 11;13(12):e0208634. doi: 10.1371/journal.pone.0208634. eCollection 2018.

7.

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K.

Nat Med. 2018 Sep;24(9):1395-1406. doi: 10.1038/s41591-018-0159-7. Epub 2018 Aug 27.

8.

Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates.

Hughey CC, Trefts E, Bracy DP, James FD, Donahue EP, Wasserman DH.

J Biol Chem. 2018 Jul 27;293(30):11944-11954. doi: 10.1074/jbc.RA118.002568. Epub 2018 Jun 11.

9.

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Hughey CC, James FD, Bracy DP, Donahue EP, Young JD, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2017 Dec 8;292(49):20125-20140. doi: 10.1074/jbc.M117.811547. Epub 2017 Oct 16.

10.

Correction: Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Wall ML, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Aug 16;12(8):e0183601. doi: 10.1371/journal.pone.0183601. eCollection 2017.

11.

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation.

Hasenour CM, Ridley DE, James FD, Hughey CC, Donahue EP, Viollet B, Foretz M, Young JD, Wasserman DH.

PLoS One. 2017 Jan 20;12(1):e0170382. doi: 10.1371/journal.pone.0170382. eCollection 2017. Erratum in: PLoS One. 2017 Aug 16;12 (8):e0183601.

12.

Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo.

Hasenour CM, Wall ML, Ridley DE, Hughey CC, James FD, Wasserman DH, Young JD.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E191-203. doi: 10.1152/ajpendo.00003.2015. Epub 2015 May 19.

13.

O-GlcNAc modification is associated with insulin sensitivity in the whole blood of healthy young adult males.

Myslicki JP, Shearer J, Hittel DS, Hughey CC, Belke DD.

Diabetol Metab Syndr. 2014 Sep 9;6(1):96. doi: 10.1186/1758-5996-6-96. eCollection 2014.

14.

Approach to assessing determinants of glucose homeostasis in the conscious mouse.

Hughey CC, Wasserman DH, Lee-Young RS, Lantier L.

Mamm Genome. 2014 Oct;25(9-10):522-38. doi: 10.1007/s00335-014-9533-z. Epub 2014 Jul 30. Review.

15.

Myostatin inhibits proliferation and insulin-stimulated glucose uptake in mouse liver cells.

Watts R, Ghozlan M, Hughey CC, Johnsen VL, Shearer J, Hittel DS.

Biochem Cell Biol. 2014 Jun;92(3):226-34. doi: 10.1139/bcb-2014-0004. Epub 2014 Apr 24.

PMID:
24882465
16.

5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo.

Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH.

J Biol Chem. 2014 Feb 28;289(9):5950-9. doi: 10.1074/jbc.M113.528232. Epub 2014 Jan 8.

17.

Diminishing impairments in glucose uptake, mitochondrial content, and ADP-stimulated oxygen flux by mesenchymal stem cell therapy in the infarcted heart.

Hughey CC, James FD, Ma L, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Shearer J.

Am J Physiol Cell Physiol. 2014 Jan 1;306(1):C19-27. doi: 10.1152/ajpcell.00156.2013. Epub 2013 Nov 6.

18.

Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart.

Hughey CC, Ma L, James FD, Bracy DP, Wang Z, Wasserman DH, Rottman JN, Hittel DS, Shearer J.

Cardiovasc Diabetol. 2013 Sep 4;12:128. doi: 10.1186/1475-2840-12-128.

19.

Enhanced stem cell engraftment and modulation of hepatic reactive oxygen species production in diet-induced obesity.

Nyamandi VZ, Johnsen VL, Hughey CC, Hittel DS, Khan A, Newell C, Shearer J.

Obesity (Silver Spring). 2014 Mar;22(3):721-9. doi: 10.1002/oby.20580. Epub 2013 Sep 23.

20.

Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.

Johnsen VL, Belke DD, Hughey CC, Hittel DS, Hepple RT, Koch LG, Britton SL, Shearer J.

Physiol Genomics. 2013 Jan 7;45(1):17-25. doi: 10.1152/physiolgenomics.00111.2012. Epub 2012 Nov 6.

21.

Increased oxygen consumption and OXPHOS potential in superhealer mesenchymal stem cells.

Hughey CC, Alfaro MP, Belke DD, Rottman JN, Young PP, Wasserman DH, Shearer J.

Cell Regen (Lond). 2012 Jun 28;1(1):3. doi: 10.1186/2045-9769-1-3. eCollection 2012.

22.

Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism.

Hughey CC, Johnsen VL, Ma L, James FD, Young PP, Wasserman DH, Rottman JN, Hittel DS, Shearer J.

Am J Physiol Endocrinol Metab. 2012 Jan 15;302(2):E163-72. doi: 10.1152/ajpendo.00443.2011. Epub 2011 Oct 4.

23.

Differentiating short- and long-term effects of diet in the obese mouse using (1) H-nuclear magnetic resonance metabolomics.

Duggan GE, Hittel DS, Hughey CC, Weljie A, Vogel HJ, Shearer J.

Diabetes Obes Metab. 2011 Sep;13(9):859-62. doi: 10.1111/j.1463-1326.2011.01410.x.

PMID:
21486381
24.

Respirometric oxidative phosphorylation assessment in saponin-permeabilized cardiac fibers.

Hughey CC, Hittel DS, Johnsen VL, Shearer J.

J Vis Exp. 2011 Feb 28;(48). pii: 2431. doi: 10.3791/2431.

25.

Exercise training does not correct abnormal cardiac glycogen accumulation in the db/db mouse model of type 2 diabetes.

Shearer J, Ross KD, Hughey CC, Johnsen VL, Hittel DS, Severson DL.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E31-9. doi: 10.1152/ajpendo.00525.2010. Epub 2011 Mar 8.

26.

Hyperinsulinemic-euglycemic clamp in the conscious rat.

Hughey CC, Hittel DS, Johnsen VL, Shearer J.

J Vis Exp. 2011 Feb 7;(48). pii: 2432. doi: 10.3791/2432.

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