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Items: 1 to 50 of 171

1.

Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor.

Uchida N, Leonard A, Stroncek D, Panch SR, West K, Molloy E, Hughes TE, Hauffe S, Taylor T, Fitzhugh C, Hankins JS, Wilson M, Sharma A, Tsai SQ, Weiss MJ, Hsieh M, Tisdale JF.

Haematologica. 2020 Feb 13. pii: haematol.2019.236182. doi: 10.3324/haematol.2019.236182. [Epub ahead of print] No abstract available.

2.

A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework.

Hoare SRJ, Tewson PH, Quinn AM, Hughes TE.

Sci Rep. 2020 Feb 4;10(1):1766. doi: 10.1038/s41598-020-58421-9.

3.

MetAP2 Inhibitor Treatment of High-Fat and -Fructose Fed Dogs: Impact on the Response to Oral Glucose Ingestion and a Hyperinsulinemic Hyperglycemic Clamp.

Moore MC, Coate KC, Scott M, Kraft G, Vath JE, Hughes TE, Farmer B, Cherrington AD.

Am J Physiol Endocrinol Metab. 2020 Jan 28. doi: 10.1152/ajpendo.00451.2019. [Epub ahead of print]

PMID:
31990576
4.

A prospective evaluation on the interaction of fluconazole and voriconazole on serum concentrations of budesonide in patients treated for gastrointestinal GVHD.

Hughes TE, Stansfield L, Kumar P, Worthy T, Tian X, Childs RW.

Bone Marrow Transplant. 2020 Jan 17. doi: 10.1038/s41409-020-0786-8. [Epub ahead of print]

PMID:
31953533
5.

Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43.

Harlen KM, Roush EC, Clayton JE, Martinka S, Hughes TE.

Front Cell Neurosci. 2019 Dec 18;13:535. doi: 10.3389/fncel.2019.00535. eCollection 2019.

6.

Correction to: A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.

Shen Y, Dana H, Abdelfattah AS, Patel R, Shea J, Molina RS, Rawal B, Rancic V, Chang YF, Wu L, Chen Y, Qian Y, Wiens MD, Hambleton N, Ballanyi K, Hughes TE, Drobizhev M, Kim DS, Koyama M, Schreiter ER, Campbell RE.

BMC Biol. 2019 Oct 30;17(1):85. doi: 10.1186/s12915-019-0707-8.

7.

Structure-based characterization of novel TRPV5 inhibitors.

Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC 3rd, Filizola M, Rohacs T, Moiseenkova-Bell VY.

Elife. 2019 Oct 25;8. pii: e49572. doi: 10.7554/eLife.49572.

8.

Think before you prescribe: how dentistry contributes to antibiotic resistance.

Sukumar S, Martin FE, Hughes TE, Adler CJ.

Aust Dent J. 2019 Oct 15. doi: 10.1111/adj.12727. [Epub ahead of print] Review.

PMID:
31613388
9.

Molecular mechanism of TRPV2 channel modulation by cannabidiol.

Pumroy RA, Samanta A, Liu Y, Hughes TE, Zhao S, Yudin Y, Rohacs T, Han S, Moiseenkova-Bell VY.

Elife. 2019 Sep 30;8. pii: e48792. doi: 10.7554/eLife.48792.

10.

Prospective Study of a Novel, Radiation-Free, Reduced-Intensity Bone Marrow Transplantation Platform for Primary Immunodeficiency Diseases.

Dimitrova D, Gea-Banacloche J, Steinberg SM, Sadler JL, Hicks SN, Carroll E, Wilder JS, Parta M, Skeffington L, Hughes TE, Blau JE, Broadney MM, Rose JJ, Hsu AP, Fletcher R, Nunes NS, Yan XY, Telford WG, Kapoor V, Cohen JI, Freeman AF, Garabedian E, Holland SM, Lisco A, Malech HL, Notarangelo LD, Sereti I, Shah NN, Uzel G, Zerbe CS, Fowler DH, Gress RE, Kanakry CG, Kanakry JA.

Biol Blood Marrow Transplant. 2020 Jan;26(1):94-106. doi: 10.1016/j.bbmt.2019.08.018. Epub 2019 Sep 4.

PMID:
31493539
11.

Redundant SCARECROW genes pattern distinct cell layers in roots and leaves of maize.

Hughes TE, Sedelnikova OV, Wu H, Becraft PW, Langdale JA.

Development. 2019 Jul 19;146(14). pii: dev177543. doi: 10.1242/dev.177543.

12.

Understanding the Fluorescence Change in Red Genetically Encoded Calcium Ion Indicators.

Molina RS, Qian Y, Wu J, Shen Y, Campbell RE, Drobizhev M, Hughes TE.

Biophys J. 2019 May 21;116(10):1873-1886. doi: 10.1016/j.bpj.2019.04.007. Epub 2019 Apr 13.

13.

Cryo Electron Microscopy of TRP Channels.

Samanta A, Hughes TET, Moiseenkova-Bell VY.

Methods Mol Biol. 2019;1987:39-50. doi: 10.1007/978-1-4939-9446-5_3.

PMID:
31028672
14.

A genetically encoded near-infrared fluorescent calcium ion indicator.

Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, Shoham S, Razansky D, Boyden ES, Campbell RE.

Nat Methods. 2019 Feb;16(2):171-174. doi: 10.1038/s41592-018-0294-6. Epub 2019 Jan 21.

15.

Structural insights on TRPV5 gating by endogenous modulators.

Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY.

Nat Commun. 2018 Oct 10;9(1):4198. doi: 10.1038/s41467-018-06753-6.

16.

Understanding the Genetic Basis of C4 Kranz Anatomy with a View to Engineering C3 Crops.

Sedelnikova OV, Hughes TE, Langdale JA.

Annu Rev Genet. 2018 Nov 23;52:249-270. doi: 10.1146/annurev-genet-120417-031217. Epub 2018 Sep 12. Review.

PMID:
30208293
17.

Physiological mechanisms of sustained fumagillin-induced weight loss.

An J, Wang L, Patnode ML, Ridaura VK, Haldeman JM, Stevens RD, Ilkayeva O, Bain JR, Muehlbauer MJ, Glynn EL, Thomas S, Muoio D, Summers SA, Vath JE, Hughes TE, Gordon JI, Newgard CB.

JCI Insight. 2018 Mar 8;3(5). pii: 99453. doi: 10.1172/jci.insight.99453.

18.

Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.

Burkey BF, Hoglen NC, Inskeep P, Wyman M, Hughes TE, Vath JE.

J Pharmacol Exp Ther. 2018 May;365(2):301-313. doi: 10.1124/jpet.117.246272. Epub 2018 Feb 28.

PMID:
29491038
19.

Depth and durability of response to ibrutinib in CLL: 5-year follow-up of a phase 2 study.

Ahn IE, Farooqui MZH, Tian X, Valdez J, Sun C, Soto S, Lotter J, Housel S, Stetler-Stevenson M, Yuan CM, Maric I, Calvo KR, Nierman P, Hughes TE, Saba NS, Marti GE, Pittaluga S, Herman SEM, Niemann CU, Pedersen LB, Geisler CH, Childs R, Aue G, Wiestner A.

Blood. 2018 May 24;131(21):2357-2366. doi: 10.1182/blood-2017-12-820910. Epub 2018 Feb 26.

20.

Transient Receptor Potential (TRP) Channels.

Samanta A, Hughes TET, Moiseenkova-Bell VY.

Subcell Biochem. 2018;87:141-165. doi: 10.1007/978-981-10-7757-9_6. Review.

21.

A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.

Shen Y, Dana H, Abdelfattah AS, Patel R, Shea J, Molina RS, Rawal B, Rancic V, Chang YF, Wu L, Chen Y, Qian Y, Wiens MD, Hambleton N, Ballanyi K, Hughes TE, Drobizhev M, Kim DS, Koyama M, Schreiter ER, Campbell RE.

BMC Biol. 2018 Jan 16;16(1):9. doi: 10.1186/s12915-018-0480-0. Erratum in: BMC Biol. 2019 Oct 30;17(1):85.

22.

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.

Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY.

Nat Struct Mol Biol. 2018 Jan;25(1):53-60. doi: 10.1038/s41594-017-0009-1. Epub 2018 Jan 1.

23.

Near-Infrared Fluorescent Proteins Engineered from Bacterial Phytochromes in Neuroimaging.

Piatkevich KD, Suk HJ, Kodandaramaiah SB, Yoshida F, DeGennaro EM, Drobizhev M, Hughes TE, Desimone R, Boyden ES, Verkhusha VV.

Biophys J. 2017 Nov 21;113(10):2299-2309. doi: 10.1016/j.bpj.2017.09.007. Epub 2017 Oct 7.

24.

Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.

McCandless SE, Yanovski JA, Miller J, Fu C, Bird LM, Salehi P, Chan CL, Stafford D, Abuzzahab MJ, Viskochil D, Barlow SE, Angulo M, Myers SE, Whitman BY, Styne D, Roof E, Dykens EM, Scheimann AO, Malloy J, Zhuang D, Taylor K, Hughes TE, Kim DD, Butler MG.

Diabetes Obes Metab. 2017 Dec;19(12):1751-1761. doi: 10.1111/dom.13021. Epub 2017 Jul 13.

25.

Blue-Shifted Green Fluorescent Protein Homologues Are Brighter than Enhanced Green Fluorescent Protein under Two-Photon Excitation.

Molina RS, Tran TM, Campbell RE, Lambert GG, Salih A, Shaner NC, Hughes TE, Drobizhev M.

J Phys Chem Lett. 2017 Jun 15;8(12):2548-2554. doi: 10.1021/acs.jpclett.7b00960. Epub 2017 May 25.

26.

Haploidentical Related Donor Hematopoietic Stem Cell Transplantation for Dedicator-of-Cytokinesis 8 Deficiency Using Post-Transplantation Cyclophosphamide.

Shah NN, Freeman AF, Su H, Cole K, Parta M, Moutsopoulos NM, Baris S, Karakoc-Aydiner E, Hughes TE, Kong HH, Holland SM, Hickstein DD.

Biol Blood Marrow Transplant. 2017 Jun;23(6):980-990. doi: 10.1016/j.bbmt.2017.03.016. Epub 2017 Mar 10. Erratum in: Biol Blood Marrow Transplant. 2019 Feb;25(2):e65-e67.

27.

US immigration order strikes against biotech.

Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS.

Nat Biotechnol. 2017 Mar 7;35(3):204-206. doi: 10.1038/nbt.3824. No abstract available.

PMID:
28267733
28.

Deciphering the molecular mechanism responsible for GCaMP6m's Ca2+-dependent change in fluorescence.

Barnett LM, Hughes TE, Drobizhev M.

PLoS One. 2017 Feb 9;12(2):e0170934. doi: 10.1371/journal.pone.0170934. eCollection 2017.

29.

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood.

Herndon TM, Chen SS, Saba NS, Valdez J, Emson C, Gatmaitan M, Tian X, Hughes TE, Sun C, Arthur DC, Stetler-Stevenson M, Yuan CM, Niemann CU, Marti GE, Aue G, Soto S, Farooqui MZH, Herman SEM, Chiorazzi N, Wiestner A.

Leukemia. 2017 Jun;31(6):1340-1347. doi: 10.1038/leu.2017.11. Epub 2017 Jan 11.

30.

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.

Moore BS, Stepanchick AN, Tewson PH, Hartle CM, Zhang J, Quinn AM, Hughes TE, Mirshahi T.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13069-13074. Epub 2016 Oct 31.

31.

Haploidentical related donor hematopoietic stem cell transplantation with post-transplantation cyclophosphamide for DOCK8 deficiency.

Freeman AF, Shah NN, Parta M, Su HC, Brofferio A, Gradus-Pizlo I, Butty S, Hughes TE, Kleiner DE, Avila D, Heller T, Kong HH, Holland SM, Hickstein DD.

J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1239-1242.e1. doi: 10.1016/j.jaip.2016.06.028. Epub 2016 Sep 15. No abstract available.

32.

New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories.

Tewson PH, Martinka S, Shaner NC, Hughes TE, Quinn AM.

J Biomol Screen. 2016 Mar;21(3):298-305. doi: 10.1177/1087057115618608. Epub 2015 Dec 11.

33.

C4 Photosynthesis in the Rice Paddy: Insights from the Noxious Weed Echinochloa glabrescens.

Covshoff S, Szecowka M, Hughes TE, Smith-Unna R, Kelly S, Bailey KJ, Sage TL, Pachebat JA, Leegood R, Hibberd JM.

Plant Physiol. 2016 Jan;170(1):57-73. doi: 10.1104/pp.15.00889. Epub 2015 Nov 2.

34.

Long- and Short-Range Electrostatic Fields in GFP Mutants: Implications for Spectral Tuning.

Drobizhev M, Callis PR, Nifosì R, Wicks G, Stoltzfus C, Barnett L, Hughes TE, Sullivan P, Rebane A.

Sci Rep. 2015 Aug 19;5:13223. doi: 10.1038/srep13223.

35.

Green fluorescent protein with anionic tryptophan-based chromophore and long fluorescence lifetime.

Sarkisyan KS, Goryashchenko AS, Lidsky PV, Gorbachev DA, Bozhanova NG, Gorokhovatsky AY, Pereverzeva AR, Ryumina AP, Zherdeva VV, Savitsky AP, Solntsev KM, Bommarius AS, Sharonov GV, Lindquist JR, Drobizhev M, Hughes TE, Rebane A, Lukyanov KA, Mishin AS.

Biophys J. 2015 Jul 21;109(2):380-9. doi: 10.1016/j.bpj.2015.06.018.

36.

Two-photon directed evolution of green fluorescent proteins.

Stoltzfus CR, Barnett LM, Drobizhev M, Wicks G, Mikhaylov A, Hughes TE, Rebane A.

Sci Rep. 2015 Jul 6;5:11968. doi: 10.1038/srep11968.

37.

Live-cell multiphoton fluorescence correlation spectroscopy with an improved large Stokes shift fluorescent protein.

Guan Y, Meurer M, Raghavan S, Rebane A, Lindquist JR, Santos S, Kats I, Davidson MW, Mazitschek R, Hughes TE, Drobizhev M, Knop M, Shah JV.

Mol Biol Cell. 2015 Jun 1;26(11):2054-66. doi: 10.1091/mbc.E14-10-1473. Epub 2015 Apr 15.

38.

Efficacy and safety of beloranib for weight loss in obese adults: a randomized controlled trial.

Kim DD, Krishnarajah J, Lillioja S, de Looze F, Marjason J, Proietto J, Shakib S, Stuckey BGA, Vath JE, Hughes TE.

Diabetes Obes Metab. 2015 Jun;17(6):566-572. doi: 10.1111/dom.12457. Epub 2015 Mar 31.

PMID:
25732625
39.

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange.

Ding Y, Li J, Enterina JR, Shen Y, Zhang I, Tewson PH, Mo GC, Zhang J, Quinn AM, Hughes TE, Maysinger D, Alford SC, Zhang Y, Campbell RE.

Nat Methods. 2015 Mar;12(3):195-8. doi: 10.1038/nmeth.3261. Epub 2015 Jan 26.

40.

Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial.

Farooqui MZ, Valdez J, Martyr S, Aue G, Saba N, Niemann CU, Herman SE, Tian X, Marti G, Soto S, Hughes TE, Jones J, Lipsky A, Pittaluga S, Stetler-Stevenson M, Yuan C, Lee YS, Pedersen LB, Geisler CH, Calvo KR, Arthur DC, Maric I, Childs R, Young NS, Wiestner A.

Lancet Oncol. 2015 Feb;16(2):169-76. doi: 10.1016/S1470-2045(14)71182-9. Epub 2014 Dec 31.

41.

Multiphoton photochemistry of red fluorescent proteins in solution and live cells.

Drobizhev M, Stoltzfus C, Topol I, Collins J, Wicks G, Mikhaylov A, Barnett L, Hughes TE, Rebane A.

J Phys Chem B. 2014 Aug 7;118(31):9167-79. doi: 10.1021/jp502477c. Epub 2014 Jul 23.

42.

The impact of widespread regulatory neofunctionalization on homeolog gene evolution following whole-genome duplication in maize.

Hughes TE, Langdale JA, Kelly S.

Genome Res. 2014 Aug;24(8):1348-55. doi: 10.1101/gr.172684.114. Epub 2014 Apr 30.

43.

PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity.

Chen X, Egly C, Riley AM, Li W, Tewson P, Hughes TE, Quinn AM, Obukhov AG.

Cells. 2014 Apr 4;3(2):247-57. doi: 10.3390/cells3020247.

44.

Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.

Ito S, Bollard CM, Carlsten M, Melenhorst JJ, Biancotto A, Wang E, Chen J, Kotliarov Y, Cheung F, Xie Z, Marincola F, Tanimoto K, Battiwalla M, Olnes MJ, Perl S, Schum P, Hughes TE, Keyvanfar K, Hensel N, Muranski P, Young NS, Barrett AJ.

Mol Ther. 2014 Jul;22(7):1388-1395. doi: 10.1038/mt.2014.50. Epub 2014 Apr 1.

45.

The dentition: the outcomes of morphogenesis leading to variations of tooth number, size and shape.

Brook AH, Jernvall J, Smith RN, Hughes TE, Townsend GC.

Aust Dent J. 2014 Jun;59 Suppl 1:131-42. doi: 10.1111/adj.12160. Epub 2014 Mar 20. Review.

46.

General and craniofacial development are complex adaptive processes influenced by diversity.

Brook AH, O'Donnell MB, Hone A, Hart E, Hughes TE, Smith RN, Townsend GC.

Aust Dent J. 2014 Jun;59 Suppl 1:13-22. doi: 10.1111/adj.12158. Epub 2014 Mar 12.

47.

Dental phenomics: advancing genotype to phenotype correlations in craniofacial research.

Yong R, Ranjitkar S, Townsend GC, Smith RN, Evans AR, Hughes TE, Lekkas D, Brook AH.

Aust Dent J. 2014 Jun;59 Suppl 1:34-47. doi: 10.1111/adj.12156. Epub 2014 Feb 24. Review.

48.

Epigenetics: a new frontier in dentistry.

Williams SD, Hughes TE, Adler CJ, Brook AH, Townsend GC.

Aust Dent J. 2014 Jun;59 Suppl 1:23-33. doi: 10.1111/adj.12155. Epub 2014 Feb 24. Review.

49.

Bosutinib: a second-generation tyrosine kinase inhibitor for chronic myelogenous leukemia.

Stansfield L, Hughes TE, Walsh-Chocolaad TL.

Ann Pharmacother. 2013 Dec;47(12):1703-11. doi: 10.1177/1060028013503124. Review.

PMID:
24396109
50.

The teeth and faces of twins: providing insights into dentofacial development and oral health for practising oral health professionals.

Hughes TE, Townsend GC, Pinkerton SK, Bockmann MR, Seow WK, Brook AH, Richards LC, Mihailidis S, Ranjitkar S, Lekkas D.

Aust Dent J. 2014 Jun;59 Suppl 1:101-16. doi: 10.1111/adj.12101. Epub 2013 Oct 2. Review.

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