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Items: 1 to 50 of 139

1.

Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells.

Hutchinson SA, Lianto P, Moore JB, Hughes TA, Thorne JL.

Int J Mol Sci. 2019 Jul 2;20(13). pii: E3241. doi: 10.3390/ijms20133241.

2.

Training in neurology: lessons learnt.

Shribman S, Alexander SK, Zarkali A, Warner TT, Pereira AC, Hughes TAT, Mummery CJ.

Pract Neurol. 2019 May 13. pii: practneurol-2018-002129. doi: 10.1136/practneurol-2018-002129. [Epub ahead of print]

PMID:
31085719
3.

My year off: Rediscovering life after a stroke.

Farnworth E, Hughes TAT.

Pract Neurol. 2019 Jun;19(3):274. doi: 10.1136/practneurol-2018-002190. Epub 2019 Mar 5. No abstract available.

PMID:
30837302
4.

MiR-19b non-canonical binding is directed by HuR and confers chemosensitivity through regulation of P-glycoprotein in breast cancer.

Thorne JL, Battaglia S, Baxter DE, Hayes JL, Hutchinson SA, Jana S, Millican-Slater RA, Smith L, Teske MC, Wastall LM, Hughes TA.

Biochim Biophys Acta Gene Regul Mech. 2018 Nov;1861(11):996-1006. doi: 10.1016/j.bbagrm.2018.08.005. Epub 2018 Aug 31.

PMID:
30343695
5.

Neoadjuvant Endocrine Therapy in Breast Cancer Upregulates the Cytotoxic Drug Pump ABCG2/BCRP, and May Lead to Resistance to Subsequent Chemotherapy.

Baxter DE, Kim B, Hanby AM, Verghese ET, Sims AH, Hughes TA.

Clin Breast Cancer. 2018 Dec;18(6):481-488. doi: 10.1016/j.clbc.2018.07.002. Epub 2018 Jul 6.

6.

Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer.

Khot MI, Perry SL, Maisey T, Armstrong G, Andrew H, Hughes TA, Kapur N, Jayne DG.

Photodiagnosis Photodyn Ther. 2018 Sep;23:221-229. doi: 10.1016/j.pdpdt.2018.06.027. Epub 2018 Jun 30.

7.

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities.

Pollard J, Burns PA, Hughes TA, Ho-Yen C, Jones JL, Mukherjee G, Omoniyi-Esan GO, Titloye NA, Speirs V, Shaaban AM.

Pathobiology. 2018;85(4):220-226. doi: 10.1159/000488456. Epub 2018 May 23.

8.

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer.

Baldacchino S, Wastall LM, Saliba C, Hughes TA, Scerri C, Berwick A, Speirs V, Hanby AM, Grech G.

Tumour Biol. 2017 Oct;39(10):1010428317722064. doi: 10.1177/1010428317722064.

9.

On the road again: assessing driving ability in patients with neurological conditions.

Handley JD, Thomas RH, McKenna P, Hughes TAT.

Pract Neurol. 2017 Jun;17(3):203-206. doi: 10.1136/practneurol-2017-001601. Epub 2017 May 4. Review.

PMID:
28473607
10.

A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex.

Frej C, Mendez AJ, Ruiz M, Castillo M, Hughes TA, Dahlbäck B, Goldberg RB.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1194-1205. doi: 10.1161/ATVBAHA.117.309275. Epub 2017 Apr 6.

PMID:
28385702
11.

Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer.

Millican-Slater RA, Sayers CD, Hanby AM, Hughes TA.

Br J Cancer. 2016 Jul 26;115(3):339-45. doi: 10.1038/bjc.2016.178. Epub 2016 Jun 9.

12.

Human traces.

McLauchlan DJ, Hughes TA.

Pract Neurol. 2016 Jun;16(3):253. doi: 10.1136/practneurol-2016-001431. No abstract available.

PMID:
27179070
13.

Lipoprotein composition in patients with type 1 diabetes mellitus: Impact of lipases and adipokines.

Hughes TA, Calderon RM, Diaz S, Mendez AJ, Goldberg RB.

J Diabetes Complications. 2016 May-Jun;30(4):657-68. doi: 10.1016/j.jdiacomp.2016.01.018. Epub 2016 Jan 26.

PMID:
26997169
14.

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer.

Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Smalle N, Hughes TA, Carter CR.

Breast Cancer Res. 2016 Jan 26;18(1):10. doi: 10.1186/s13058-015-0669-x.

15.

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis.

Smith L, Baxter EW, Chambers PA, Green CA, Hanby AM, Hughes TA, Nash CE, Millican-Slater RA, Stead LF, Verghese ET, Speirs V.

PLoS One. 2015 Oct 5;10(10):e0139698. doi: 10.1371/journal.pone.0139698. eCollection 2015.

16.

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy.

Kim B, Stephen SL, Hanby AM, Horgan K, Perry SL, Richardson J, Roundhill EA, Valleley EM, Verghese ET, Williams BJ, Thorne JL, Hughes TA.

BMC Cancer. 2015 Sep 11;15:634. doi: 10.1186/s12885-015-1625-y.

17.

Elevated Lipoprotein Lipase Activity Does Not Account for the Association Between Adiponectin and HDL in Type 1 Diabetes.

Calderon RM, Diaz S, Szeto A, Llinas JA, Hughes TA, Mendez AJ, Goldberg RB.

J Clin Endocrinol Metab. 2015 Jul;100(7):2581-8. doi: 10.1210/jc.2015-1357. Epub 2015 May 5.

PMID:
25942477
18.

Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

Hayes J, Thygesen H, Droop A, Hughes TA, Westhead D, Lawler SE, Wurdak H, Short SC.

Oncoscience. 2014 Dec 26;2(3):252-62. eCollection 2015.

19.

CEA-targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models.

Tiernan JP, Ingram N, Marston G, Perry SL, Rushworth JV, Coletta PL, Millner PA, Jayne DG, Hughes TA.

Nanomedicine (Lond). 2015;10(8):1223-31. doi: 10.2217/nnm.14.202. Epub 2015 Feb 19.

20.

Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature.

Hayes J, Thygesen H, Tumilson C, Droop A, Boissinot M, Hughes TA, Westhead D, Alder JE, Shaw L, Short SC, Lawler SE.

Mol Oncol. 2015 Mar;9(3):704-14. doi: 10.1016/j.molonc.2014.11.004. Epub 2014 Nov 28.

21.

PSMD9 expression predicts radiotherapy response in breast cancer.

Langlands FE, Dodwell D, Hanby AM, Horgan K, Millican-Slater RA, Speirs V, Verghese ET, Smith L, Hughes TA.

Mol Cancer. 2014 Mar 28;13:73. doi: 10.1186/1476-4598-13-73.

22.

Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region.

Al-Nakhle H, Smith L, Bell SM, Burns PA, Cummings M, Hanby AM, Lane S, Parker MD, Hughes TA, Speirs V.

Int J Oncol. 2013 Dec;43(6):2039-45. doi: 10.3892/ijo.2013.2112. Epub 2013 Sep 25.

PMID:
24068253
23.

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion.

Verghese ET, Drury R, Green CA, Holliday DL, Lu X, Nash C, Speirs V, Thorne JL, Thygesen HH, Zougman A, Hull MA, Hanby AM, Hughes TA.

J Pathol. 2013 Nov;231(3):388-99. doi: 10.1002/path.4248.

24.

Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer.

Kim B, Fatayer H, Hanby AM, Horgan K, Perry SL, Valleley EM, Verghese ET, Williams BJ, Thorne JL, Hughes TA.

PLoS One. 2013 May 2;8(5):e62766. doi: 10.1371/journal.pone.0062766. Print 2013.

25.

Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting.

Tiernan JP, Perry SL, Verghese ET, West NP, Yeluri S, Jayne DG, Hughes TA.

Br J Cancer. 2013 Feb 19;108(3):662-7. doi: 10.1038/bjc.2012.605. Epub 2013 Jan 15.

26.

Co-treatment of acid mine drainage with municipal wastewater: performance evaluation.

Hughes TA, Gray NF.

Environ Sci Pollut Res Int. 2013 Nov;20(11):7863-77. doi: 10.1007/s11356-012-1303-4. Epub 2012 Nov 17.

PMID:
23161500
27.

Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours.

Cookson VJ, Bentley MA, Hogan BV, Horgan K, Hayward BE, Hazelwood LD, Hughes TA.

Cell Oncol (Dordr). 2012 Aug;35(4):301-8. doi: 10.1007/s13402-012-0089-1. Epub 2012 Jul 21.

PMID:
22821209
28.

Bacterial diversity in dried colostrum and whey sold as nutraceutical products.

Hayes MM, Hughes TA, Greene AK.

J Food Sci. 2012 Jul;77(7):M359-63. doi: 10.1111/j.1750-3841.2012.02771.x. Epub 2012 Jun 18.

PMID:
22708784
29.

Intra-operative tumour detection and staging in colorectal cancer surgery.

Tiernan JP, Ansari I, Hirst NA, Millner PA, Hughes TA, Jayne DG.

Colorectal Dis. 2012 Sep;14(9):e510-20. doi: 10.1111/j.1463-1318.2012.03078.x. Review.

PMID:
22564278
30.

The roles of microRNAs in sarcomas.

Drury R, Verghese ET, Hughes TA.

J Pathol. 2012 Aug;227(4):385-91. doi: 10.1002/path.4037. Epub 2012 May 23. Review.

PMID:
22488672
31.

Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin in carcinoma-associated fibroblasts.

Verghese ET, Shenoy H, Cookson VJ, Green CA, Howarth J, Partanen RH, Pollock S, Waterworth A, Speirs V, Hughes TA, Hanby AM.

Histopathology. 2011 Oct;59(4):609-18. doi: 10.1111/j.1365-2559.2011.03917.x.

PMID:
22014042
32.

South Wales joint neuroscience meeting, Bridgend, 29 April 2010: a 66-year-old man who suddenly couldn't drive.

O'Sullivan MJ, Neal JW, Walters RJ, Smith EE, Hughes TA.

Pract Neurol. 2011 Jun;11(3):153-9. doi: 10.1136/practneurol-2011-000020. No abstract available.

PMID:
21551109
33.

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer.

Satheesha S, Cookson VJ, Coleman LJ, Ingram N, Madhok B, Hanby AM, Suleman CA, Sabine VS, Macaskill EJ, Bartlett JM, Dixon JM, McElwaine JN, Hughes TA.

Mol Cancer. 2011 Feb 14;10:19. doi: 10.1186/1476-4598-10-19.

34.

Surgery induced immunosuppression.

Hogan BV, Peter MB, Shenoy HG, Horgan K, Hughes TA.

Surgeon. 2011 Feb;9(1):38-43. doi: 10.1016/j.surge.2010.07.011. Epub 2010 Sep 16. Review.

PMID:
21195330
35.

Perioperative reductions in circulating lymphocyte levels predict wound complications after excisional breast cancer surgery.

Hogan BV, Peter MB, Achuthan R, Beaumont AJ, Langlands FE, Shakes S, Wood PM, Shenoy HG, Orsi NM, Horgan K, Carter CR, Hughes TA.

Ann Surg. 2011 Feb;253(2):360-4. doi: 10.1097/SLA.0b013e318207c139.

PMID:
21169805
36.

Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer.

Smith L, Brannan RA, Hanby AM, Shaaban AM, Verghese ET, Peter MB, Pollock S, Satheesha S, Szynkiewicz M, Speirs V, Hughes TA.

J Cell Mol Med. 2010 Aug;14(8):2172-84. doi: 10.1111/j.1582-4934.2009.00867.x. Epub 2010 Jan 1.

37.

Targeting glucose metabolism: an emerging concept for anticancer therapy.

Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG.

Am J Clin Oncol. 2011 Dec;34(6):628-35. doi: 10.1097/COC.0b013e3181e84dec. Review.

PMID:
20805739
38.

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.

Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG.

Br J Cancer. 2010 Jun 8;102(12):1746-52. doi: 10.1038/sj.bjc.6605701. Epub 2010 May 18.

39.

Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer.

Al-Nakhle H, Burns PA, Cummings M, Hanby AM, Hughes TA, Satheesha S, Shaaban AM, Smith L, Speirs V.

Cancer Res. 2010 Jun 1;70(11):4778-84. doi: 10.1158/0008-5472.CAN-09-4104. Epub 2010 May 18.

40.

Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms.

Smith L, Coleman LJ, Cummings M, Satheesha S, Shaw SO, Speirs V, Hughes TA.

Biochem J. 2010 Jul 15;429(2):283-90. doi: 10.1042/BJ20100373.

PMID:
20462399
41.

Estrogen receptor regulation: don't forget translation.

Smith L, Speirs V, Hughes TA.

Breast Cancer Res Treat. 2010 May;121(1):251-2. doi: 10.1007/s10549-009-0641-5. No abstract available.

PMID:
19924527
42.

Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.

Elam MB, Yellaturu C, Howell GE, Deng X, Cowan GS, Kumar P, Park EA, Hiler ML, Wilcox HG, Hughes TA, Cook GA, Raghow R.

Metabolism. 2010 Apr;59(4):587-98. doi: 10.1016/j.metabol.2009.09.001. Epub 2009 Nov 14.

43.

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.

Coleman LJ, Peter MB, Teall TJ, Brannan RA, Hanby AM, Honarpisheh H, Shaaban AM, Smith L, Speirs V, Verghese ET, McElwaine JN, Hughes TA.

Br J Cancer. 2009 May 5;100(9):1393-9. doi: 10.1038/sj.bjc.6605044. Epub 2009 Apr 14.

44.

"Can I drive, doctor?" LEAN thinking may help us answer the question.

Thomas RH, Hughes TA.

Pract Neurol. 2009 Apr;9(2):71-8; discussion 78-9. doi: 10.1136/jnnp.2008.171157. Review.

PMID:
19289556
45.

Hepatic gene expression in morbidly obese women: implications for disease susceptibility.

Elam MB, Cowan GS Jr, Rooney RJ, Hiler ML, Yellaturu CR, Deng X, Howell GE, Park EA, Gerling IC, Patel D, Corton JC, Cagen LM, Wilcox HG, Gandhi M, Bahr MH, Allan MC, Wodi LA, Cook GA, Hughes TA, Raghow R.

Obesity (Silver Spring). 2009 Aug;17(8):1563-73. doi: 10.1038/oby.2009.49. Epub 2009 Mar 5.

46.

Clinical importance of estrogen receptor beta isoforms in breast cancer.

Speirs V, Green AR, Hughes TA, Ellis IO, Saunders PT, Shaaban AM.

J Clin Oncol. 2008 Dec 10;26(35):5825; author reply 5825-6. doi: 10.1200/JCO.2008.19.5909. Epub 2008 Nov 10. No abstract available.

PMID:
19001343
47.

Circulating tumour cells in breast cancer: Prognostic indicators, metastatic intermediates, or irrelevant bystanders? (Review).

Hogan BV, Peter MB, Shenoy H, Horgan K, Hughes TA.

Mol Med Rep. 2008 Nov-Dec;1(6):775-9. doi: 10.3892/mmr_00000027.

PMID:
21479484
48.

Dot-to-dot.

Thomas RH, Hughes TA.

Pract Neurol. 2008 Oct;8(5):325-9. doi: 10.1136/jnnp.2008.159525. No abstract available.

PMID:
18796589
49.

Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients.

Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PT, Groome NP, Speirs V.

Clin Cancer Res. 2008 Aug 15;14(16):5228-35. doi: 10.1158/1078-0432.CCR-07-4528.

50.

25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation.

Carbone LD, Rosenberg EW, Tolley EA, Holick MF, Hughes TA, Watsky MA, Barrow KD, Chen TC, Wilkin NK, Bhattacharya SK, Dowdy JC, Sayre RM, Weber KT.

Metabolism. 2008 Jun;57(6):741-8. doi: 10.1016/j.metabol.2008.01.011.

PMID:
18502255

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