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C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ.

Brain. 2019 Dec 1;142(12):3771-3790. doi: 10.1093/brain/awz302.


Imaging of morphological and biochemical hallmarks of apoptosis with optimized optogenetic tools.

Godwin WC, Hoffmann GF, Gray TJ, Hughes RM.

J Biol Chem. 2019 Nov 8;294(45):16918-16929. doi: 10.1074/jbc.RA119.009141. Epub 2019 Oct 3.


Challenges to saving China's freshwater biodiversity: Fishery exploitation and landscape pressures.

Chen Y, Qu X, Xiong F, Lu Y, Wang L, Hughes RM.

Ambio. 2019 Sep 10. doi: 10.1007/s13280-019-01246-2. [Epub ahead of print]


Abdominal Pain in the Elderly: An Unusual Case of Chronic Mesenteric Ischemia in the Emergency Department.

Lacey JI, Hughes RM, Noble V.

Clin Pract Cases Emerg Med. 2019 Jul 1;3(3):275-277. doi: 10.5811/cpcem.2019.5.41886. eCollection 2019 Aug.


Incorporating functional traits to enhance multimetric index performance and assess land use gradients.

Chen K, Rajper AR, Hughes RM, Olson JR, Wei H, Wang B.

Sci Total Environ. 2019 Nov 15;691:1005-1015. doi: 10.1016/j.scitotenv.2019.07.047. Epub 2019 Jul 4.


Optogenetic perturbation of the biochemical pathways that control cell behavior.

Haar LL, Lawrence DS, Hughes RM.

Methods Enzymol. 2019;622:309-328. doi: 10.1016/bs.mie.2019.02.020. Epub 2019 Mar 12.


Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer.

Torquato S, Pallavajjala A, Goldstein A, Toro PV, Silberstein JL, Lee J, Nakazawa M, Waters I, Chu D, Shinn D, Groginski T, Hughes RM, Simons BW, Khan H, Feng Z, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Eisenberger MA, Antonarakis ES, Trock BJ, Park BH, Hurley PJ.

JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00227. Epub 2019 Apr 3.


Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ.

Cancer Res. 2019 Jul 15;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23.


Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers.

Dasari AKR, Hughes RM, Wi S, Hung I, Gan Z, Kelly JW, Lim KH.

Sci Rep. 2019 Jan 10;9(1):33. doi: 10.1038/s41598-018-37230-1.


Student monitoring of the ecological quality of neotropical urban streams.

França JS, Solar R, Hughes RM, Callisto M.

Ambio. 2019 Aug;48(8):867-878. doi: 10.1007/s13280-018-1122-z. Epub 2018 Nov 17.


Assessment of disturbance at three spatial scales in two large tropical reservoirs.

de Morais L, de Oliveira Sanches B, Santos GB, Kaufmann PR, Hughes RM, Molozzi J, Callisto M.

J Limnol. 2017 Jul 1;76(2):240-252. doi: 10.4081/jlimnol.2016.1547.


A compendium of chemical and genetic approaches to light-regulated gene transcription.

Hughes RM.

Crit Rev Biochem Mol Biol. 2018 Oct;53(5):453-474. doi: 10.1080/10409238.2018.1487382. Epub 2018 Jul 24. Review.


protaTETHER - a method for the incorporation of variable linkers in protein fusions reveals impacts of linker flexibility in a PKAc-GFP fusion protein.

Norris JL, Hughes RM.

FEBS Open Bio. 2018 Apr 25;8(6):1029-1042. doi: 10.1002/2211-5463.12414. eCollection 2018 Jun.


Disentangling the pathways of land use impacts on the functional structure of fish assemblages in Amazon streams.

Leitão RP, Zuanon J, Mouillot D, Leal CG, Hughes RM, Kaufmann PR, Villéger S, Pompeu PS, Kasper D, de Paula FR, Ferraz SFB, Gardner TA.

Ecography (Cop.). 2018 Jan 1;41(1):219-232. doi: 10.1111/ecog.02845.


Development and validation of an environmental fragility index (EFI) for the neotropical savannah biome.

Macedo DR, Hughes RM, Kaufmann PR, Callisto M.

Sci Total Environ. 2018 Sep 1;635:1267-1279. doi: 10.1016/j.scitotenv.2018.04.216. Epub 2018 Apr 24.


Assessing the extent and relative risk of aquatic stressors on stream macroinvertebrate assemblages in the neotropical savanna.

Silva DRO, Herlihy AT, Hughes RM, Macedo DR, Callisto M.

Sci Total Environ. 2018 Aug 15;633:179-188. doi: 10.1016/j.scitotenv.2018.03.127. Epub 2018 Mar 21. No abstract available.


Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer.

Benzon B, Glavaris SA, Simons BW, Hughes RM, Ghabili K, Mullane P, Miller R, Nugent K, Shinder B, Tosoian J, Fuchs EJ, Tran PT, Hurley PJ, Vuica-Ross M, Schaeffer EM, Drake CG, Ross AE.

Prostate Cancer Prostatic Dis. 2018 Apr;21(1):126-136. doi: 10.1038/s41391-018-0035-z. Epub 2018 Mar 20.


Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy.

Ross AE, Hughes RM, Glavaris S, Ghabili K, He P, Anders NM, Harb R, Tosoian JJ, Marchionni L, Schaeffer EM, Partin AW, Allaf ME, Bivalacqua TJ, Chapman C, O'Neal T, DeMarzo AM, Hurley PJ, Rudek MA, Antonarakis ES.

Oncotarget. 2017 Oct 26;8(61):104182-104192. doi: 10.18632/oncotarget.22115. eCollection 2017 Nov 28.


A Murine Orthotopic Allograft to Model Prostate Cancer Growth and Metastasis.

Hughes RM, Simons BW, Hurley PJ.

Bio Protoc. 2017 Feb 20;7(4). pii: e2137. doi: 10.21769/BioProtoc.2137.


Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase.

O'Banion CP, Priestman MA, Hughes RM, Herring LE, Capuzzi SJ, Lawrence DS.

Cell Chem Biol. 2018 Jan 18;25(1):100-109.e8. doi: 10.1016/j.chembiol.2017.09.011. Epub 2017 Nov 5.


How Misapplication of the Hydrologic Unit Framework Diminishes the Meaning of Watersheds.

Omernik JM, Griffith GE, Hughes RM, Glover JB, Weber MH.

Environ Manage. 2017 Jul;60(1):1-11. doi: 10.1007/s00267-017-0854-z. Epub 2017 Apr 4.


Detection fidelity of AR mutations in plasma derived cell-free DNA.

Goldstein A, Toro PV, Lee J, Silberstein JL, Nakazawa M, Waters I, Cravero K, Chu D, Cochran RL, Kim M, Shinn D, Torquato S, Hughes RM, Pallavajjala A, Carducci MA, Paller CJ, Denmeade SR, Kressel B, Trock BJ, Eisenberger MA, Antonarakis ES, Park BH, Hurley PJ.

Oncotarget. 2017 Feb 28;8(9):15651-15662. doi: 10.18632/oncotarget.14926.


Environment: China deploys big data to clear smog.

Zhang B, Hughes RM.

Nature. 2017 Feb 1;542(7639):31. doi: 10.1038/542031a. No abstract available.


Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents.

Hughes RM, Marvin CM, Rodgers ZL, Ding S, Oien NP, Smith WJ, Lawrence DS.

Angew Chem Int Ed Engl. 2016 Dec 23;55(52):16080-16083. doi: 10.1002/anie.201609731. Epub 2016 Nov 22.


China's new environmental protection regulatory regime: Effects and gaps.

Zhang B, Cao C, Hughes RM, Davis WS.

J Environ Manage. 2017 Feb 1;187:464-469. doi: 10.1016/j.jenvman.2016.11.009. Epub 2016 Nov 11. Review. No abstract available.


CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.

Fertig EJ, Ozawa H, Thakar M, Howard JD, Kagohara LT, Krigsfeld G, Ranaweera RS, Hughes RM, Perez J, Jones S, Favorov AV, Carey J, Stein-O'Brien G, Gaykalova DA, Ochs MF, Chung CH.

Oncotarget. 2016 Nov 8;7(45):73845-73864. doi: 10.18632/oncotarget.12075.


The role of physical habitat and sampling effort on estimates of benthic macroinvertebrate taxonomic richness at basin and site scales.

Silva DR, Ligeiro R, Hughes RM, Callisto M.

Environ Monit Assess. 2016 Jun;188(6):340. doi: 10.1007/s10661-016-5326-z. Epub 2016 May 10.


Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.

Taslimi A, Zoltowski B, Miranda JG, Pathak GP, Hughes RM, Tucker CL.

Nat Chem Biol. 2016 Jun;12(6):425-30. doi: 10.1038/nchembio.2063. Epub 2016 Apr 11.


Spatial variations in fish assemblage structure in a southeastern Brazilian reservoir.

Sanches BO, Hughes RM, Macedo DR, Callisto M, Santos GB.

Braz J Biol. 2016 Feb;76(1):185-93. doi: 10.1590/1519-6984.16614. Epub 2016 Jan 22.


Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer.

Hurley PJ, Sundi D, Shinder B, Simons BW, Hughes RM, Miller RM, Benzon B, Faraj SF, Netto GJ, Vergara IA, Erho N, Davicioni E, Karnes RJ, Yan G, Ewing C, Isaacs SD, Berman DM, Rider JR, Jordahl KM, Mucci LA, Huang J, An SS, Park BH, Isaacs WB, Marchionni L, Ross AE, Schaeffer EM.

Clin Cancer Res. 2016 Jan 15;22(2):448-58. doi: 10.1158/1078-0432.CCR-15-0256. Epub 2015 Oct 7.


Optogenetic apoptosis: light-triggered cell death.

Hughes RM, Freeman DJ, Lamb KN, Pollet RM, Smith WJ, Lawrence DS.

Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12064-8. doi: 10.1002/anie.201506346. Epub 2015 Aug 25.


Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression.

Hurley PJ, Hughes RM, Simons BW, Huang J, Miller RM, Shinder B, Haffner MC, Esopi D, Kimura Y, Jabbari J, Ross AE, Erho N, Vergara IA, Faraj SF, Davicioni E, Netto GJ, Yegnasubramanian S, An SS, Schaeffer EM.

Cancer Res. 2015 Oct 15;75(20):4322-34. doi: 10.1158/0008-5472.CAN-15-0024. Epub 2015 Aug 20.


Fish stomach contents in benthic macroinvertebrate assemblage assessments.

Tupinambás TH, Pompeu PS, Gandini CV, Hughes RM, Callisto M.

Braz J Biol. 2015 Jan-Mar;75(1):157-64. doi: 10.1590/1519-6984.09913.


Combining and aggregating environmental data for status and trend assessments: challenges and approaches.

Maas-Hebner KG, Harte MJ, Molina N, Hughes RM, Schreck C, Yeakley JA.

Environ Monit Assess. 2015 May;187(5):278. doi: 10.1007/s10661-015-4504-8. Epub 2015 Apr 21.


B(12)-mediated, long wavelength photopolymerization of hydrogels.

Rodgers ZL, Hughes RM, Doherty LM, Shell JR, Molesky BP, Brugh AM, Forbes MD, Moran AM, Lawrence DS.

J Am Chem Soc. 2015 Mar 11;137(9):3372-8. doi: 10.1021/jacs.5b00182. Epub 2015 Feb 27.


Stream biomonitoring using macroinvertebrates around the globe: a comparison of large-scale programs.

Buss DF, Carlisle DM, Chon TS, Culp J, Harding JS, Keizer-Vlek HE, Robinson WA, Strachan S, Thirion C, Hughes RM.

Environ Monit Assess. 2015 Jan;187(1):4132. doi: 10.1007/s10661-014-4132-8. Epub 2014 Dec 9.


Optogenetic engineering: light-directed cell motility.

Hughes RM, Lawrence DS.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10904-7. doi: 10.1002/anie.201404198. Epub 2014 Aug 25.


Cell-mediated assembly of phototherapeutics.

Smith WJ, Oien NP, Hughes RM, Marvin CM, Rodgers ZL, Lee J, Lawrence DS.

Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10945-8. doi: 10.1002/anie.201406216. Epub 2014 Aug 22.


Quantitative tolerance values for common stream benthic macroinvertebrates in the Yangtze River Delta, Eastern China.

Qin CY, Zhou J, Cao Y, Zhang Y, Hughes RM, Wang BX.

Environ Monit Assess. 2014 Sep;186(9):5883-95. doi: 10.1007/s10661-014-3826-2. Epub 2014 May 28.


Visually determined stream mesohabitats influence benthic macroinvertebrate assessments in headwater streams.

Silva DR, Ligeiro R, Hughes RM, Callisto M.

Environ Monit Assess. 2014 Sep;186(9):5479-88. doi: 10.1007/s10661-014-3797-3. Epub 2014 May 10.


Impact of psychological distress on cardiovagal reactivation after a speech task.

Koutnik AP, Sanchez-Gonzalez MA, May RW, Hughes RM, Fincham FD.

J Hum Hypertens. 2014 Jun;28(6):399-401. doi: 10.1038/jhh.2013.127. Epub 2013 Dec 12.


Towards a protocol for stream macroinvertebrate sampling in China.

Li L, Liu L, Hughes RM, Cao Y, Wang X.

Environ Monit Assess. 2014 Jan;186(1):469-79. doi: 10.1007/s10661-013-3391-0. Epub 2013 Aug 31.


A social and ecological assessment of tropical land uses at multiple scales: the Sustainable Amazon Network.

Gardner TA, Ferreira J, Barlow J, Lees AC, Parry L, Vieira IC, Berenguer E, Abramovay R, Aleixo A, Andretti C, Aragão LE, Araújo I, de Ávila WS, Bardgett RD, Batistella M, Begotti RA, Beldini T, de Blas DE, Braga RF, Braga Dde L, de Brito JG, de Camargo PB, Campos dos Santos F, de Oliveira VC, Cordeiro AC, Cardoso TM, de Carvalho DR, Castelani SA, Chaul JC, Cerri CE, Costa Fde A, da Costa CD, Coudel E, Coutinho AC, Cunha D, D'Antona Á, Dezincourt J, Dias-Silva K, Durigan M, Esquerdo JC, Feres J, Ferraz SF, Ferreira AE, Fiorini AC, da Silva LV, Frazão FS, Garrett R, Gomes Ados S, Gonçalves Kda S, Guerrero JB, Hamada N, Hughes RM, Igliori DC, Jesus Eda C, Juen L, Junior M, de Oliveira Junior JM, de Oliveira Junior RC, Souza Junior C, Kaufmann P, Korasaki V, Leal CG, Leitão R, Lima N, Almeida Mde F, Lourival R, Louzada J, Mac Nally R, Marchand S, Maués MM, Moreira FM, Morsello C, Moura N, Nessimian J, Nunes S, Oliveira VH, Pardini R, Pereira HC, Pompeu PS, Ribas CR, Rossetti F, Schmidt FA, da Silva R, da Silva RC, da Silva TF, Silveira J, Siqueira JV, de Carvalho TS, Solar RR, Tancredi NS, Thomson JR, Torres PC, Vaz-de-Mello FZ, Veiga RC, Venturieri A, Viana C, Weinhold D, Zanetti R, Zuanon J.

Philos Trans R Soc Lond B Biol Sci. 2013 Apr 22;368(1619):20120166. doi: 10.1098/rstb.2012.0166. Print 2013 Jun 5. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2013 Aug 19;368(1624):20130307.


Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.

Hasumi H, Baba M, Hasumi Y, Huang Y, Oh H, Hughes RM, Klein ME, Takikita S, Nagashima K, Schmidt LS, Linehan WM.

J Natl Cancer Inst. 2012 Nov 21;104(22):1750-64. doi: 10.1093/jnci/djs418. Epub 2012 Nov 12.


The problem of using fixed-area subsampling methods to estimate macroinvertebrate richness: a case study with Neotropical stream data.

Ligeiro R, Ferreira W, Hughes RM, Callisto M.

Environ Monit Assess. 2013 May;185(5):4077-85. doi: 10.1007/s10661-012-2850-3. Epub 2012 Aug 29.


Rapid profiling of disease alleles using a tunable reporter of protein misfolding.

Pittman AM, Lage MD, Poltoratsky V, Vrana JD, Paiardini A, Roncador A, Cellini B, Hughes RM, Tucker CL.

Genetics. 2012 Nov;192(3):831-42. doi: 10.1534/genetics.112.143750. Epub 2012 Aug 24.


Light-mediated control of DNA transcription in yeast.

Hughes RM, Bolger S, Tapadia H, Tucker CL.

Methods. 2012 Dec;58(4):385-91. doi: 10.1016/j.ymeth.2012.08.004. Epub 2012 Aug 15.


The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.

Baba M, Keller JR, Sun HW, Resch W, Kuchen S, Suh HC, Hasumi H, Hasumi Y, Kieffer-Kwon KR, Gonzalez CG, Hughes RM, Klein ME, Oh HF, Bible P, Southon E, Tessarollo L, Schmidt LS, Linehan WM, Casellas R.

Blood. 2012 Aug 9;120(6):1254-61. doi: 10.1182/blood-2012-02-410407. Epub 2012 Jun 18.


Light-dependent, dark-promoted interaction between Arabidopsis cryptochrome 1 and phytochrome B proteins.

Hughes RM, Vrana JD, Song J, Tucker CL.

J Biol Chem. 2012 Jun 22;287(26):22165-72. doi: 10.1074/jbc.M112.360545. Epub 2012 May 10.

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