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Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems.

Greenwood EC, van Dissel J, Rayner J, Hughes PE, van Wettere WHEJ.

Animals (Basel). 2019 Sep 5;9(9). pii: E658. doi: 10.3390/ani9090658.


Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping.

Greenwood EC, van Wettere WHEJ, Rayner J, Hughes PE, Plush KL.

Animals (Basel). 2018 Dec 22;9(1). pii: E8. doi: 10.3390/ani9010008.


Magnetic perturbation diagnostics in the high-temperature lithiated environment of LTX-β.

Hughes PE, Majeski R, Kaita R, Kozub T, Hansen C, Boyle DP.

Rev Sci Instrum. 2018 Oct;89(10):10J104. doi: 10.1063/1.5035359.


AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980.


Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer.

Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Sarosiek KA, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN.

Cancer Discov. 2018 Dec;8(12):1598-1613. doi: 10.1158/2159-8290.CD-18-0277. Epub 2018 Sep 25.


Controlling lactation oestrus: The final frontier for breeding herd management.

van Wettere WHEJ, Weaver AC, Greenwood EC, Terry R, Hughes PE, Kind KL.

Mol Reprod Dev. 2017 Sep;84(9):883-896. doi: 10.1002/mrd.22838. Epub 2017 Jun 19. Review.


MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor.

Caenepeel S, Cooke K, Wadsworth S, Huang G, Robert L, Moreno BH, Parisi G, Cajulis E, Kendall R, Beltran P, Ribas A, Coxon A, Hughes PE.

Oncotarget. 2017 Mar 14;8(11):17795-17809. doi: 10.18632/oncotarget.14855.


Dietary ractopamine supplementation during the first lactation affects milk composition, piglet growth and sow reproductive performance.

van Wettere WH, Pain SJ, Hughes PE.

Anim Reprod Sci. 2016 Nov;174:87-92. doi: 10.1016/j.anireprosci.2016.09.009. Epub 2016 Sep 13.


Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer.

Hughes PE, Caenepeel S, Wu LC.

Trends Immunol. 2016 Jul;37(7):462-476. doi: 10.1016/ Epub 2016 May 20. Review.


In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.

Hughes PE, Rex K, Caenepeel S, Yang Y, Zhang Y, Broome MA, Kha HT, Burgess TL, Amore B, Kaplan-Lefko PJ, Moriguchi J, Werner J, Damore MA, Baker D, Choquette DM, Harmange JC, Radinsky R, Kendall R, Dussault I, Coxon A.

Mol Cancer Ther. 2016 Jul;15(7):1568-79. doi: 10.1158/1535-7163.MCT-15-0871. Epub 2016 Apr 19.


Group and individual sow behavior is altered in early gestation by space allowance in the days immediately following grouping.

Greenwood EC, Plush KJ, van Wettere WH, Hughes PE.

J Anim Sci. 2016 Jan;94(1):385-93. doi: 10.2527/jas.2015-9427.


Design and installation of a ferromagnetic wall in tokamak geometry.

Hughes PE, Levesque JP, Rivera N, Mauel ME, Navratil GA.

Rev Sci Instrum. 2015 Oct;86(10):103504. doi: 10.1063/1.4932312.


The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors.

Stec MM, Andrews KL, Bo Y, Caenepeel S, Liao H, McCarter J, Mullady EL, San Miguel T, Subramanian R, Tamayo N, Whittington DA, Wang L, Wu T, Zalameda LP, Zhang N, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4136-42. doi: 10.1016/j.bmcl.2015.08.016. Epub 2015 Aug 8.


Melatonin implants do not alter estrogen feedback or advance puberty in gilts.

Kennaway DJ, Hughes PE, van Wettere WH.

Anim Reprod Sci. 2015 May;156:13-22. doi: 10.1016/j.anireprosci.2014.12.016. Epub 2015 Jan 3.


Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.

Lanman BA, Reed AB, Cee VJ, Hong FT, Pettus LH, Wurz RP, Andrews KL, Jiang J, McCarter JD, Mullady EL, San Miguel T, Subramanian R, Wang L, Whittington DA, Wu T, Zalameda L, Zhang N, Tasker AS, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5630-5634. doi: 10.1016/j.bmcl.2014.10.085. Epub 2014 Nov 1.


Human and bovine viruses in the Milwaukee River watershed: hydrologically relevant representation and relations with environmental variables.

Corsi SR, Borchardt MA, Spencer SK, Hughes PE, Baldwin AK.

Sci Total Environ. 2014 Aug 15;490:849-60. doi: 10.1016/j.scitotenv.2014.05.072. Epub 2014 Jun 6.


MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways.

Saiki AY, Caenepeel S, Yu D, Lofgren JA, Osgood T, Robertson R, Canon J, Su C, Jones A, Zhao X, Deshpande C, Payton M, Ledell J, Hughes PE, Oliner JD.

Oncotarget. 2014 Apr 30;5(8):2030-43.


Lactation estrus induction in multi- and primiparous sows in an Australian commercial pork production system.

Terry R, Kind KL, Lines DS, Kennett TE, Hughes PE, van Wettere WH.

J Anim Sci. 2014 May;92(5):2265-74. doi: 10.2527/jas.2013-7475. Epub 2014 Mar 18.


Split weaning increases the incidence of lactation oestrus in boar-exposed sows.

Terry R, Kind KL, Hughes PE, Kennaway DJ, Herde PJ, van Wettere WH.

Anim Reprod Sci. 2013 Nov 1;142(1-2):48-55. doi: 10.1016/j.anireprosci.2013.08.010. Epub 2013 Aug 28.


Wetland management reduces sediment and nutrient loading to the upper Mississippi river.

Kreiling RM, Schubauer-Berigan JP, Richardson WB, Bartsch LA, Hughes PE, Cavanaugh JC, Strauss EA.

J Environ Qual. 2013 Mar-Apr;42(2):573-83. doi: 10.2134/jeq2012.0248.


Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.

Norman MH, Andrews KL, Bo YY, Booker SK, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich BJ, Hong FT, Jackson CL, Jiang J, Lanman BA, Liu L, McCarter JD, Mullady EL, Nishimura N, Pettus LH, Reed AB, Miguel TS, Smith AL, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu X, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes PE.

J Med Chem. 2012 Sep 13;55(17):7796-816. doi: 10.1021/jm300846z. Epub 2012 Aug 30. Erratum in: J Med Chem. 2012 Oct 25;55(20):8975.


Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

Wurz RP, Liu L, Yang K, Nishimura N, Bo Y, Pettus LH, Caenepeel S, Freeman DJ, McCarter JD, Mullady EL, Miguel TS, Wang L, Zhang N, Andrews KL, Whittington DA, Jiang J, Subramanian R, Hughes PE, Norman MH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5714-20. doi: 10.1016/j.bmcl.2012.06.078. Epub 2012 Jul 3.


Supplementing sow gestation diets with betaine during summer increases litter size of sows with greater numbers of parities.

van Wettere WH, Herde P, Hughes PE.

Anim Reprod Sci. 2012 May;132(1-2):44-9. doi: 10.1016/j.anireprosci.2012.04.007. Epub 2012 Apr 28.


Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.

Smith AL, D'Angelo ND, Bo YY, Booker SK, Cee VJ, Herberich B, Hong FT, Jackson CL, Lanman BA, Liu L, Nishimura N, Pettus LH, Reed AB, Tadesse S, Tamayo NA, Wurz RP, Yang K, Andrews KL, Whittington DA, McCarter JD, Miguel TS, Zalameda L, Jiang J, Subramanian R, Mullady EL, Caenepeel S, Freeman DJ, Wang L, Zhang N, Wu T, Hughes PE, Norman MH.

J Med Chem. 2012 Jun 14;55(11):5188-219. doi: 10.1021/jm300184s. Epub 2012 May 23.


Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.

Stec MM, Andrews KL, Booker SK, Caenepeel S, Freeman DJ, Jiang J, Liao H, McCarter J, Mullady EL, San Miguel T, Subramanian R, Tamayo N, Wang L, Yang K, Zalameda LP, Zhang N, Hughes PE, Norman MH.

J Med Chem. 2011 Jul 28;54(14):5174-84. doi: 10.1021/jm2004442. Epub 2011 Jun 29.


Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.

Nishimura N, Siegmund A, Liu L, Yang K, Bryan MC, Andrews KL, Bo Y, Booker SK, Caenepeel S, Freeman D, Liao H, McCarter J, Mullady EL, San Miguel T, Subramanian R, Tamayo N, Wang L, Whittington DA, Zalameda L, Zhang N, Hughes PE, Norman MH.

J Med Chem. 2011 Jul 14;54(13):4735-51. doi: 10.1021/jm200386s. Epub 2011 Jun 20.


Nutritional restriction of pre-pubertal liveweight gain impairs ovarian follicle growth and oocyte developmental competence of replacement gilts.

van Wettere WH, Mitchell M, Revell DK, Hughes PE.

Theriogenology. 2011 Apr 15;75(7):1301-10. doi: 10.1016/j.theriogenology.2010.12.001. Epub 2011 Feb 4.


Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors.

Caenepeel S, Renshaw-Gegg L, Baher A, Bush TL, Baron W, Juan T, Manoukian R, Tasker AS, Polverino A, Hughes PE.

J Exp Clin Cancer Res. 2010 Jul 15;29:96. doi: 10.1186/1756-9966-29-96.


Ractopamine hydrochloride improves growth performance and carcass composition in immunocastrated boars, intact boars, and gilts.

Rikard-Bell C, Curtis MA, van Barneveld RJ, Mullan BP, Edwards AC, Gannon NJ, Henman DJ, Hughes PE, Dunshea FR.

J Anim Sci. 2009 Nov;87(11):3536-43. doi: 10.2527/jas.2009-2002. Epub 2009 Jul 31.


The effects of PG600 and boar exposure on oestrus detection and potential litter size following mating at either the induced (pubertal) or second oestrus.

Bartlett A, Pain SJ, Hughes PE, Stott P, van Wettere WH.

Anim Reprod Sci. 2009 Aug;114(1-3):219-27. doi: 10.1016/j.anireprosci.2008.08.020. Epub 2008 Aug 26.


Mixing gilts in early pregnancy does not affect embryo survival.

van Wettere WH, Pain SJ, Stott PG, Hughes PE.

Anim Reprod Sci. 2008 Mar 3;104(2-4):382-8. Epub 2007 Jul 19.


Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors.

Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Caenepeel S, Cee VJ, Chaffee SC, Emery M, Fretland J, Gallant P, Gu Y, Johnson RE, Kim JL, Long AM, Morrison M, Olivieri PR, Patel VF, Polverino A, Rose P, Wang L, Zhao H.

Bioorg Med Chem Lett. 2007 May 15;17(10):2886-9. Epub 2007 Feb 25.


Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Bready J, Caenepeel S, Cee VJ, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hoffman D, Johnson RE, Kendall R, Kim JL, Long AM, Morrison M, Olivieri PR, Patel VF, Polverino A, Rose P, Tempest P, Wang L, Whittington DA, Zhao H.

J Med Chem. 2007 Feb 22;50(4):611-26. Epub 2007 Jan 25.


Increasing the age of gilts at first boar contact improves the timing and synchrony of the pubertal response but does not affect potential litter size.

van Wettere WH, Revell DK, Mitchell M, Hughes PE.

Anim Reprod Sci. 2006 Sep;95(1-2):97-106. Epub 2005 Oct 25.


C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution.

Hansen M, Prior IA, Hughes PE, Oertli B, Chou FL, Willumsen BM, Hancock JF, Ginsberg MH.

Biochem Biophys Res Commun. 2003 Nov 28;311(4):829-38.


Ontogenetic and regional morphologic variations in the turkey ulna diaphysis: implications for functional adaptation of cortical bone.

Skedros JG, Hunt KJ, Hughes PE, Winet H.

Anat Rec A Discov Mol Cell Evol Biol. 2003 Jul;273(1):609-29.


Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase.

Hughes PE, Oertli B, Hansen M, Chou FL, Willumsen BM, Ginsberg MH.

Mol Biol Cell. 2002 Jul;13(7):2256-65.


R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras.

Hansen M, Rusyn EV, Hughes PE, Ginsberg MH, Cox AD, Willumsen BM.

Oncogene. 2002 Jun 27;21(28):4448-61.


R-Ras regulation of integrin function.

Hughes PE, Oertli B, Han J, Ginsberg MH.

Methods Enzymol. 2001;333:163-71. No abstract available.


Integrin activation controls metastasis in human breast cancer.

Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A, Mueller BM.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1853-8.


The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function.

Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE.

Oncogene. 2000 Oct 12;19(43):4961-9.


Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism.

Ramos JW, Hughes PE, Renshaw MW, Schwartz MA, Formstecher E, Chneiweiss H, Ginsberg MH.

Mol Biol Cell. 2000 Sep;11(9):2863-72.


Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases.

Alexi T, Borlongan CV, Faull RL, Williams CE, Clark RG, Gluckman PD, Hughes PE.

Prog Neurobiol. 2000 Apr;60(5):409-70. Review.


The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.

Alexi T, Hughes PE, van Roon-Mom WM, Faull RL, Williams CE, Clark RG, Gluckman PD.

Exp Neurol. 1999 Sep;159(1):84-97.


Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat.

Wu DD, Lai M, Hughes PE, Sirimanne E, Gluckman PD, Williams CE.

Brain Res. 1999 Jul 24;835(2):369-78.


Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets.

Law DA, Nannizzi-Alaimo L, Ministri K, Hughes PE, Forsyth J, Turner M, Shattil SJ, Ginsberg MH, Tybulewicz VL, Phillips DR.

Blood. 1999 Apr 15;93(8):2645-52.


Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system.

Hughes PE, Alexi T, Walton M, Williams CE, Dragunow M, Clark RG, Gluckman PD.

Prog Neurobiol. 1999 Feb;57(4):421-50. Review.


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