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Targeting MCL-1 in hematologic malignancies: Rationale and progress.

Wei AH, Roberts AW, Spencer A, Rosenberg AS, Siegel D, Walter RB, Caenepeel S, Hughes P, McIver Z, Mezzi K, Morrow PK, Stein A.

Blood Rev. 2020 Feb 21:100672. doi: 10.1016/j.blre.2020.100672. [Epub ahead of print] Review.


Retirement, GDPR, and word clouds.

Hughes P.

Br J Gen Pract. 2020 Feb 27;70(692):127. doi: 10.3399/bjgp20X708593. Print 2020 Mar. No abstract available.


Impact of elective on students' perceptions of treating patients with a substance use disorder.

Jarvi A, Hughes P, Shepherd JG, Hedgepeth Kennedy ML, Wilson CG.

J Am Pharm Assoc (2003). 2020 Feb 24. pii: S1544-3191(20)30034-0. doi: 10.1016/j.japh.2020.01.021. [Epub ahead of print]


Applying Educational Theory and Best Practices to Solve Common Challenges of Simulation-based Procedural Training in Emergency Medicine.

Cassara M, Schertzer K, Falk MJ, Wong AH, Hock SM, Bentley S, Paetow G, Conlon LW, Hughes PG, McKenna RT, Hrdy M, Lei C, Kulkarni M, Smith CM, Young A, Romo E, Smith MD, Hernandez J, Strother CG, Frallicciardi A, Nadir NA.

AEM Educ Train. 2019 Dec 27;4(Suppl 1):S22-S39. doi: 10.1002/aet2.10418. eCollection 2020 Feb.


Insights from Adopting a Data Commons Approach for Large-Scale Observational Cohort Studies: The California Teachers Study.

Lacey JV, Chung NT, Hughes P, Benbow JL, Duffy C, Savage KE, Spielfogel ES, Wang SS, Martinez ME, Chandra S.

Cancer Epidemiol Biomarkers Prev. 2020 Feb 12. pii: cebp.0842.2019. doi: 10.1158/1055-9965.EPI-19-0842. [Epub ahead of print]


A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.

Scarneo SA, Hughes PF, Yang KW, Carlson DA, Gurbani D, Westover KD, Haystead TAJ.

J Biol Chem. 2020 Feb 7;295(6):1565-1574. doi: 10.1074/jbc.RA119.011857. Epub 2019 Dec 30.


Making science accessible.

Tuosto K, Johnston JT, Connolly C, Lo C, Sanganyado E, Winter KA, Roembke T, Richter WE, Isaacson KJ, Raitor M, Kosanic A, Bessone L, Heim AB, Srivastava P, Hughes PW, Aamodt CM.

Science. 2020 Jan 3;367(6473):34-35. doi: 10.1126/science.aba6129. No abstract available.


Persistence of arctic-alpine flora during 24,000 years of environmental change in the Polar Urals.

Clarke CL, Edwards ME, Gielly L, Ehrich D, Hughes PDM, Morozova LM, Haflidason H, Mangerud J, Svendsen JI, Alsos IG.

Sci Rep. 2019 Dec 23;9(1):19613. doi: 10.1038/s41598-019-55989-9.


Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.

Scarneo SA, Eibschutz LS, Bendele PJ, Yang KW, Totzke J, Hughes P, Fox DA, Haystead TAJ.

Arthritis Res Ther. 2019 Dec 17;21(1):292. doi: 10.1186/s13075-019-2073-x.


The Leeds hand transplant programme: Review of the laboratory management of the first six cases.

Clark B, Carter C, Wilks DJ, Lobb M, Hughes P, Baker R, Kay SPJ.

Int J Immunogenet. 2020 Feb;47(1):28-33. doi: 10.1111/iji.12466. Epub 2019 Dec 15.


Dyslipidemias and cardiovascular risk scores in urban and rural populations in north-western Tanzania and southern Uganda.

Kavishe B, Vanobberghen F, Katende D, Kapiga S, Munderi P, Baisley K, Biraro S, Mosha N, Mutungi G, Mghamba J, Hughes P, Smeeth L, Grosskurth H, Peck R.

PLoS One. 2019 Dec 6;14(12):e0223189. doi: 10.1371/journal.pone.0223189. eCollection 2019.


Misinterpreting carbon accumulation rates in records from near-surface peat.

Young DM, Baird AJ, Charman DJ, Evans CD, Gallego-Sala AV, Gill PJ, Hughes PDM, Morris PJ, Swindles GT.

Sci Rep. 2019 Nov 29;9(1):17939. doi: 10.1038/s41598-019-53879-8.


Examining the Increased Rates of Deceased Donor Kidney Nonutilization in Australia: What Has Changed?

Sypek MP, Ullah S, Hughes PD, Clayton PA, McDonald SP.

Transplantation. 2019 Dec;103(12):2582-2590. doi: 10.1097/TP.0000000000002761.


Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.

Rescourio G, Gonzalez AZ, Jabri S, Belmontes B, Moody G, Whittington D, Huang X, Caenepeel S, Cardozo M, Cheng AC, Chow D, Dou H, Jones A, Kelly RC, Li Y, Lizarzaburu M, Lo MC, Mallari R, Meleza C, Rew Y, Simonovich S, Sun D, Turcotte S, Yan X, Wong SG, Yanez E, Zancanella M, Houze J, Medina JC, Hughes PE, Brown SP.

J Med Chem. 2019 Nov 27;62(22):10258-10271. doi: 10.1021/acs.jmedchem.9b01310. Epub 2019 Nov 18.


Hughes's Reverspectives: Radical Uses of Linear Perspective on Non-Coplanar Surfaces.

Papathomas TV, Hughes P.

Vision (Basel). 2019 Nov 18;3(4). pii: E63. doi: 10.3390/vision3040063.


Perceptions of Fear, Likelihood of Victimization, and Confidence About Dangerous Situations Among University Women in Poland.

Lickiewicz J, Hughes PP, Sałapa K, Tychmanowicz A, Makara-Studzińska M.

J Interpers Violence. 2019 Nov 13:886260519888190. doi: 10.1177/0886260519888190. [Epub ahead of print]


Insights into the labeling effect of Kidney Donor Performance Index reporting: The Australian experience.

Sypek MP, Hughes P, Holdsworth R, Kanellis J, McDonald S, Clayton PD.

Am J Transplant. 2020 Mar;20(3):870-878. doi: 10.1111/ajt.15656. Epub 2019 Nov 16.


Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems.

Greenwood EC, van Dissel J, Rayner J, Hughes PE, van Wettere WHEJ.

Animals (Basel). 2019 Sep 5;9(9). pii: E658. doi: 10.3390/ani9090658.


Briefing Prior to Simulation Activity .

Hughes PG, Hughes KE.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Aug 10.


From Ripple to Mavericks.

Lee JS, Bass BL, Hughes PJ, Davis-Blake A.

J Oral Maxillofac Surg. 2019 Aug;77(8):1532-1533. doi: 10.1016/j.joms.2019.02.026. No abstract available.


Medical Simulation Fellowships .

Hughes KE, Hughes PG.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Jul 6.


Double Defibrillation.

Ramzy M, Hughes PG.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
2019 Jun 28.


Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Other Populations and Newer Agents.

Sasadeusz J, Grigg A, Hughes PD, Lee Lim S, Lucas M, McColl G, McLachlan SA, Peters MG, Shackel N, Slavin M, Sundararajan V, Thompson A, Doyle J, Rickard J, De Cruz P, Gish RG, Visvanathan K.

Clin Liver Dis. 2019 Aug;23(3):521-534. doi: 10.1016/j.cld.2019.04.012. Epub 2019 Jun 5. Review.


Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Patients with Hematological and Solid Tumor Malignancies.

Sasadeusz J, Grigg A, Hughes PD, Lim SL, Lucas M, McColl G, McLachlan SA, Peters MG, Shackel N, Slavin M, Sundararajan V, Thompson A, Doyle J, Rickard J, De Cruz P, Gish RG, Visvanathan K.

Clin Liver Dis. 2019 Aug;23(3):511-519. doi: 10.1016/j.cld.2019.04.011. Epub 2019 Jun 6. Review.


Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients.

Sasadeusz J, Grigg A, Hughes PD, Lee Lim S, Lucas M, McColl G, McLachlan SA, Peters MG, Shackel N, Slavin M, Sundararajan V, Thompson A, Doyle J, Rickard J, De Cruz P, Gish RG, Visvanathan K.

Clin Liver Dis. 2019 Aug;23(3):493-509. doi: 10.1016/j.cld.2019.04.010. Epub 2019 Jun 6. Review.


Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Introduction and Immunology.

Sasadeusz J, Grigg A, Hughes PD, Lee Lim S, Lucas M, McColl G, McLachlan SA, Peters MG, Shackel N, Slavin M, Sundararajan V, Thompson A, Doyle J, Rickard J, De Cruz P, Gish RG, Visvanathan K.

Clin Liver Dis. 2019 Aug;23(3):487-492. doi: 10.1016/j.cld.2019.04.009. Epub 2019 Jun 6. Review.


Efficacy of Different Hair and Skin Decontamination Strategies with Identification of Associated Hazards to First Responders.

Larner J, Durrant A, Hughes P, Mahalingam D, Rivers S, Matar H, Thomas E, Barrett M, Pinhal A, Amer N, Hall C, Jackson T, Catalani V, Chilcott RP.

Prehosp Emerg Care. 2019 Jul 19:1-14. doi: 10.1080/10903127.2019.1636912. [Epub ahead of print]


Decontamination and management of contaminated hair following a CBRN incident.

Matar H, Pinhal A, Amer N, Barrett M, Thomas E, Hughes P, Larner J, Chilcott RP.

Toxicol Sci. 2019 Jun 26. pii: kfz145. doi: 10.1093/toxsci/kfz145. [Epub ahead of print]


MRI imaging of soft tissue tumours of the foot and ankle.

Hughes P, Miranda R, Doyle AJ.

Insights Imaging. 2019 Jun 3;10(1):60. doi: 10.1186/s13244-019-0749-z. Review.


External validation of the US and UK kidney donor risk indices for deceased donor kidney transplant survival in the Australian and New Zealand population.

Clayton PA, Dansie K, Sypek MP, White S, Chadban S, Kanellis J, Hughes P, Gulyani A, McDonald S.

Nephrol Dial Transplant. 2019 Dec 1;34(12):2127-2131. doi: 10.1093/ndt/gfz090.


Traverses, delays and fatalities at railway level crossings in Great Britain.

Evans AW, Hughes P.

Accid Anal Prev. 2019 Aug;129:66-75. doi: 10.1016/j.aap.2019.05.006. Epub 2019 May 22.


An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors.

O'Reilly A, Hughes P, Mann J, Lai Z, Teh JJ, Mclean E, Edmonds K, Lingard K, Chauhan D, Lynch J, Au L, Ludlow A, Pattison N, Wiseman T, Turajlic S, Gore M, Larkin J, Husson O.

Support Care Cancer. 2020 Feb;28(2):561-570. doi: 10.1007/s00520-019-04818-w. Epub 2019 May 14.


Frequency and outcomes of kidney donation from intensive care patients with acute renal failure requiring renal replacement therapy.

Sanders JM, Opdam HI, Furniss H, Hughes PD, Kanellis J, Jones D.

Nephrology (Carlton). 2019 Dec;24(12):1296-1303. doi: 10.1111/nep.13601. Epub 2019 Jun 10.


Iatrogenic Critical Care Procedure Complication Boot Camp: A Simulation-based Pilot Study.

Riefkohl-Ortiz E, Frey JA, Yee J, David Gothard M, Hughes PG, Ballas DA, Ahmed RA.

AEM Educ Train. 2019 Feb 19;3(2):188-192. doi: 10.1002/aet2.10317. eCollection 2019 Apr.


Effect of high-intensity versus low-intensity praziquantel treatment on HIV disease progression in HIV and Schistosoma mansoni co-infected patients: a randomised controlled trial.

Abaasa A, Asiki G, Obuku Ekii A, Wanyenze J, Pala P, J van Dam G, Corstjens PLAM, Hughes P, Ding S, Pantaleo G, Kaleebu P, Elliott AM, Kamali A.

Version 2. Wellcome Open Res. 2019 Apr 3 [revised 2019 Jan 1];3:81. doi: 10.12688/wellcomeopenres.14683.2. eCollection 2018.


Setup and Execution Of the Blindfolded Code Training Exercise.

Hughes PG, Hughes KE, Ahmed RA.

J Vis Exp. 2019 Mar 29;(145). doi: 10.3791/59248.


Why do not all living kidney donor candidates proceed to donation?

Cash E, Graver A, Kuo S, Kirkland G, Hughes P, Robertson A, Jose MD.

Intern Med J. 2019 Mar;49(3):384-387. doi: 10.1111/imj.14223.


Carbon monoxide poisoning at a Florida Hospital following Hurricane Irma.

Klein JG, Alter SM, Paley RJ, Hughes PG, Clayton LM, Benda W, Shih RD, Solano JJ.

Am J Emerg Med. 2019 Sep;37(9):1800-1801. doi: 10.1016/j.ajem.2019.03.009. Epub 2019 Mar 8. No abstract available.


Ossifying chronic subperiosteal haematoma of the iliac bone.

Hughes P, Dow D, Boyer L, Morganti V.

J Med Imaging Radiat Oncol. 2019 Aug;63(4):479-480. doi: 10.1111/1754-9485.12869. Epub 2019 Mar 14.


Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer.

Crouch BT, Gallagher J, Wang R, Duer J, Hall A, Soo MS, Hughes P, Haystead T, Ramanujam N.

Sci Rep. 2019 Mar 5;9(1):3461. doi: 10.1038/s41598-019-40252-y.


Single breath-held acquisition of coregistered 3D 129 Xe lung ventilation and anatomical proton images of the human lung with compressed sensing.

Collier GJ, Hughes PJC, Horn FC, Chan HF, Tahir B, Norquay G, Stewart NJ, Wild JM.

Magn Reson Med. 2019 Jul;82(1):342-347. doi: 10.1002/mrm.27713. Epub 2019 Feb 28.


How well do we manage the odontogenic keratocyst? A multicenter study.

Kinard B, Hansen G, Newman M, Dennis P, Haeffs T, Perez S, Hamao-Sakamoto A, Steed M, Hughes P, August M, Abramowicz S.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Apr;127(4):282-288. doi: 10.1016/j.oooo.2018.12.001. Epub 2018 Dec 14.


Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.

Wardill HR, Choo JM, Dmochowska N, Mavrangelos C, Campaniello MA, Bowen JM, Rogers GB, Hughes PA.

Inflamm Bowel Dis. 2019 Jun 18;25(7):1196-1207. doi: 10.1093/ibd/izz011.


Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost.

Lee SS, Almazan A, Decker S, Zhong Y, Ghebremeskel AN, Hughes P, Robinson MR, Burke JA, Weinreb RN.

Transl Vis Sci Technol. 2019 Jan 30;8(1):15. doi: 10.1167/tvst.8.1.15. eCollection 2019 Jan.


Seed traits are pleiotropically regulated by the flowering time gene PERPETUAL FLOWERING 1 (PEP1) in the perennial Arabis alpina.

Hughes PW, Soppe WJJ, Albani MC.

Mol Ecol. 2019 Mar;28(5):1183-1201. doi: 10.1111/mec.15034. Epub 2019 Mar 15.


Observations on the Natural History of Camurati-Engelmann Disease.

Hughes P, Hassan I, Que L, Mead P, Lee JH, Love DR, Prosser DO, Cundy T.

J Bone Miner Res. 2019 May;34(5):875-882. doi: 10.1002/jbmr.3670. Epub 2019 Feb 19.


Comparison of CT ventilation imaging and hyperpolarised gas MRI: effects of breathing manoeuvre.

Tahir BA, Marshall H, Hughes PJC, Brightling CE, Collier G, Ireland RH, Wild JM.

Phys Med Biol. 2019 Mar 7;64(5):055013. doi: 10.1088/1361-6560/ab0145.


Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis: A Randomized Clinical Trial.

Costello SP, Hughes PA, Waters O, Bryant RV, Vincent AD, Blatchford P, Katsikeros R, Makanyanga J, Campaniello MA, Mavrangelos C, Rosewarne CP, Bickley C, Peters C, Schoeman MN, Conlon MA, Roberts-Thomson IC, Andrews JM.

JAMA. 2019 Jan 15;321(2):156-164. doi: 10.1001/jama.2018.20046.


Application of immobilized ATP to the study of NLRP inflammasomes.

Liao KC, Sandall CF, Carlson DA, Ulke-Lemée A, Platnich JM, Hughes PF, Muruve DA, Haystead TAJ, MacDonald JA.

Arch Biochem Biophys. 2019 Jul 30;670:104-115. doi: 10.1016/ Epub 2019 Jan 11.


Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.

Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, Crane GM, Morrison SJ.

Elife. 2019 Jan 11;8. pii: e42274. doi: 10.7554/eLife.42274.

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