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Items: 1 to 50 of 95

1.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.

Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS.

Proc Natl Acad Sci U S A. 2020 Feb 3. pii: 201917914. doi: 10.1073/pnas.1917914117. [Epub ahead of print]

PMID:
32015135
2.

Systemic AAV9 gene therapy using the synapsin I promoter rescues a mouse model of neuronopathic Gaucher disease but with limited cross-correction potential to astrocytes.

Massaro G, Hughes MP, Whaler SM, Wallom KL, Priestman DA, Platt FM, Waddington SN, Rahim AA.

Hum Mol Genet. 2020 Jan 10. pii: ddz317. doi: 10.1093/hmg/ddz317. [Epub ahead of print]

PMID:
31919491
3.

Ten-Second Electrophysiology: Evaluation of the 3DEP Platform for high-speed, high-accuracy cell analysis.

Hoettges KF, Henslee EA, Torcal Serrano RM, Jabr RI, Abdallat RG, Beale AD, Waheed A, Camelliti P, Fry CH, van der Veen DR, Labeed FH, Hughes MP.

Sci Rep. 2019 Dec 16;9(1):19153. doi: 10.1038/s41598-019-55579-9.

4.

DNA Facilitates Oligomerization and Prevents Aggregation via DNA Networks.

Litberg TJ, Docter B, Hughes MP, Bourne J, Horowitz S.

Biophys J. 2020 Jan 7;118(1):162-171. doi: 10.1016/j.bpj.2019.11.022. Epub 2019 Nov 23.

PMID:
31839258
5.

Neonatal brain-directed gene therapy rescues a mouse model of neurodegenerative CLN6 Batten disease.

Kleine Holthaus SM, Herranz-Martin S, Massaro G, Aristorena M, Hoke J, Hughes MP, Maswood R, Semenyuk O, Basche M, Shah AZ, Klaska IP, Smith AJ, Mole SE, Rahim AA, Ali RR.

Hum Mol Genet. 2019 Dec 1;28(23):3867-3879. doi: 10.1093/hmg/ddz210.

PMID:
31807779
6.

Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2019 Oct;26(10):988. doi: 10.1038/s41594-019-0316-9.

PMID:
31530939
7.

Epilepsy Gene Therapy Using an Engineered Potassium Channel.

Snowball A, Chabrol E, Wykes RC, Shekh-Ahmad T, Cornford JH, Lieb A, Hughes MP, Massaro G, Rahim AA, Hashemi KS, Kullmann DM, Walker MC, Schorge S.

J Neurosci. 2019 Apr 17;39(16):3159-3169. doi: 10.1523/JNEUROSCI.1143-18.2019. Epub 2019 Feb 12.

8.

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R.

Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31.

9.

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.

Baruteau J, Perocheau DP, Hanley J, Lorvellec M, Rocha-Ferreira E, Karda R, Ng J, Suff N, Diaz JA, Rahim AA, Hughes MP, Banushi B, Prunty H, Hristova M, Ridout DA, Virasami A, Heales S, Howe SJ, Buckley SMK, Mills PB, Gissen P, Waddington SN.

Nat Commun. 2018 Aug 29;9(1):3505. doi: 10.1038/s41467-018-05972-1.

10.

AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease.

Hughes MP, Smith DA, Morris L, Fletcher C, Colaco A, Huebecker M, Tordo J, Palomar N, Massaro G, Henckaerts E, Waddington SN, Platt FM, Rahim AA.

Hum Mol Genet. 2018 Sep 1;27(17):3079-3098. doi: 10.1093/hmg/ddy212.

11.

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS.

Nat Struct Mol Biol. 2018 Jun;25(6):463-471. doi: 10.1038/s41594-018-0064-2. Epub 2018 May 21. Erratum in: Nat Struct Mol Biol. 2019 Oct;26(10):988.

12.

Barefoot plantar pressure measurement in Chronic Exertional Compartment Syndrome.

Roscoe D, Roberts AJ, Hulse D, Shaheen A, Hughes MP, Bennett A.

Gait Posture. 2018 Jun;63:10-16. doi: 10.1016/j.gaitpost.2018.04.009. Epub 2018 Apr 9.

PMID:
29702369
13.

Effects of anterior compartment fasciotomy on intramuscular compartment pressure in patients with chronic exertional compartment syndrome.

Roscoe D, Roberts AJ, Hulse D, Shaheen AF, Hughes MP, Bennet AN.

J R Army Med Corps. 2018 Sep;164(5):338-342. doi: 10.1136/jramc-2017-000895. Epub 2018 Apr 24.

PMID:
29691307
14.

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations.

Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS.

Protein Sci. 2018 Jul;27(7):1231-1242. doi: 10.1002/pro.3391. Epub 2018 Mar 10.

15.

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.

Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS.

Science. 2018 Feb 9;359(6376):698-701. doi: 10.1126/science.aan6398.

16.

Dielectrophoretic analysis of treated cancer cells for rapid assessment of treatment efficacy.

Mahabadi S, Labeed FH, Hughes MP.

Electrophoresis. 2018 Apr;39(8):1104-1110. doi: 10.1002/elps.201700488. Epub 2018 Feb 23.

PMID:
29405335
17.

High-throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-activated cell enrichment.

Faraghat SA, Hoettges KF, Steinbach MK, van der Veen DR, Brackenbury WJ, Henslee EA, Labeed FH, Hughes MP.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4591-4596. doi: 10.1073/pnas.1700773114. Epub 2017 Apr 13.

18.

Accuracy of two optical chlorophyll meters in predicting chemical composition and in vitro ruminal organic matter degradability of Brachiaria hybrid, Megathyrsus maximus, and Paspalum atratum.

Hughes MP, Mlambo V, Lallo CHO, Basha NAD, Nsahlai IV, Jennings PGA.

Anim Nutr. 2017 Mar;3(1):67-76. doi: 10.1016/j.aninu.2016.10.002. Epub 2016 Oct 28.

19.

Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach.

Henslee EA, Torcal Serrano RM, Labeed FH, Jabr RI, Fry CH, Hughes MP, Hoettges KF.

Analyst. 2016 Nov 14;141(23):6408-6415.

PMID:
27774532
20.

Purse-String-Assisted Full-Thickness Skin Graft: An Underutilized Technique to Reduce Graft Size and Improve Outcomes.

Hughes MP, Kalajian AH, Brown TS.

J Cutan Med Surg. 2016 Nov;20(6):607-609. Epub 2016 Jul 28. No abstract available.

PMID:
27469894
21.

Fifty years of dielectrophoretic cell separation technology.

Hughes MP.

Biomicrofluidics. 2016 Jun 30;10(3):032801. doi: 10.1063/1.4954841. eCollection 2016 May.

22.

Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model.

Rocha-Ferreira E, Rudge B, Hughes MP, Rahim AA, Hristova M, Robertson NJ.

Oxid Med Cell Longev. 2016;2016:5763743. doi: 10.1155/2016/5763743. Epub 2016 Jun 9.

23.

The Utility of Household Bleach in Dermatologic Surgery.

Hughes MP, Brown TS.

Dermatol Surg. 2016 Oct;42(10):1222-3. doi: 10.1097/DSS.0000000000000794. No abstract available.

PMID:
27347632
24.

Simultaneous Tunable Selection and Self-Assembly of Si Nanowires from Heterogeneous Feedstock.

Constantinou M, Rigas GP, Castro FA, Stolojan V, Hoettges KF, Hughes MP, Adkins E, Korgel BA, Shkunov M.

ACS Nano. 2016 Apr 26;10(4):4384-94. doi: 10.1021/acsnano.6b00005. Epub 2016 Mar 28.

PMID:
27002685
25.

A Case of Cutaneous Rosai-Dorfman Disease with underlying calvarial involvement and absence of BRAFV600E mutation.

Kaskas NM, Kern M, Johnson A, Hughes MP, Hardee M, Day J, Gokden M, Shalin SC, Gao L.

JAAD Case Rep. 2015 Nov 1;1(6):408-411. No abstract available.

26.

Apoptosis progression studied using parallel dielectrophoresis electrophysiological analysis and flow cytometry.

Mulhall HJ, Cardnell A, Hoettges KF, Labeed FH, Hughes MP.

Integr Biol (Camb). 2015 Nov;7(11):1396-401. doi: 10.1039/c5ib00109a.

PMID:
26235126
27.

A dielectrophoretic method of discrimination between normal oral epithelium, and oral and oropharyngeal cancer in a clinical setting.

Graham KA, Mulhall HJ, Labeed FH, Lewis MP, Hoettges KF, Kalavrezos N, McCaul J, Liew C, Porter S, Fedele S, Hughes MP.

Analyst. 2015 Aug 7;140(15):5198-204. doi: 10.1039/c5an00796h.

PMID:
26086875
28.

Effects of cell detachment methods on the dielectric properties of adherent and suspension cells.

Mahabadi S, Labeed FH, Hughes MP.

Electrophoresis. 2015 Jul;36(13):1493-8. doi: 10.1002/elps.201500022.

PMID:
25884244
29.

Perinatal systemic gene delivery using adeno-associated viral vectors.

Karda R, Buckley SM, Mattar CN, Ng J, Massaro G, Hughes MP, Kurian MA, Baruteau J, Gissen P, Chan JK, Bacchelli C, Waddington SN, Rahim AA.

Front Mol Neurosci. 2014 Nov 14;7:89. doi: 10.3389/fnmol.2014.00089. eCollection 2014. Review.

30.

Dielectrophoretic sample preparation for environmental monitoring of microorganisms: Soil particle removal.

Fatoyinbo HO, McDonnell MC, Hughes MP.

Biomicrofluidics. 2014 Aug 7;8(4):044115. doi: 10.1063/1.4892036. eCollection 2014 Jul.

31.

Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-Poly(dT) in solution.

Mohamad AS, Jeynes JC, Hughes MP.

IEEE Trans Nanobioscience. 2014 Mar;13(1):51-4. doi: 10.1109/TNB.2014.2299215.

PMID:
24594514
32.

Merkel Cell Carcinoma: Epidemiology, Target, and Therapy.

Hughes MP, Hardee ME, Cornelius LA, Hutchins LF, Becker JC, Gao L.

Curr Dermatol Rep. 2014 Jan 22;3:46-53. eCollection 2014. Review.

33.

Efficient dielectrophoretic cell enrichment using a dielectrophoresis-well based system.

Abdul Razak MA, Hoettges KF, Fatoyinbo HO, Labeed FH, Hughes MP.

Biomicrofluidics. 2013 Dec 4;7(6):64110. doi: 10.1063/1.4842395. eCollection 2013.

34.

Continuous flow nanoparticle concentration using alternating current-electroosmotic flow.

Hoettges KF, McDonnell MB, Hughes MP.

Electrophoresis. 2014 Feb;35(4):467-73. doi: 10.1002/elps.201300287. Epub 2013 Dec 5.

PMID:
24166772
35.

Factors affecting particle collection by electro-osmosis in microfluidic systems.

Mohtar MN, Hoettges KF, Hughes MP.

Electrophoresis. 2014 Feb;35(2-3):345-51. doi: 10.1002/elps.201300420. Epub 2013 Dec 2.

PMID:
24132700
36.

Solution processable multi-channel ZnO nanowire field-effect transistors with organic gate dielectric.

Opoku C, Hoettges KF, Hughes MP, Stolojan V, Silva SR, Shkunov M.

Nanotechnology. 2013 Oct 11;24(40):405203. doi: 10.1088/0957-4484/24/40/405203. Epub 2013 Sep 12.

PMID:
24029562
37.

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.

Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS.

Elife. 2013 Jul 16;2:e00857. doi: 10.7554/eLife.00857. Erratum in: Elife. 2013;2:e01252.

38.

Epithelial cancer cells exhibit different electrical properties when cultured in 2D and 3D environments.

Mulhall HJ, Hughes MP, Kazmi B, Lewis MP, Labeed FH.

Biochim Biophys Acta. 2013 Nov;1830(11):5136-41. doi: 10.1016/j.bbagen.2013.07.008. Epub 2013 Jul 18.

PMID:
23872353
39.

Process development for cell aggregate arrays encapsulated in a synthetic hydrogel using negative dielectrophoresis.

Abdallat RG, Ahmad Tajuddin AS, Gould DH, Hughes MP, Fatoyinbo HO, Labeed FH.

Electrophoresis. 2013 Apr;34(7):1059-67. doi: 10.1002/elps.201200459. Epub 2013 Mar 11.

PMID:
23436271
40.

Cytoplasm resistivity of mammalian atrial myocardium determined by dielectrophoresis and impedance methods.

Fry CH, Salvage SC, Manazza A, Dupont E, Labeed FH, Hughes MP, Jabr RI.

Biophys J. 2012 Dec 5;103(11):2287-94. doi: 10.1016/j.bpj.2012.10.023.

41.

Finite element analysis of thermal and acoustic processes during laser tattoo removal.

Humphries A, Lister TS, Wright PA, Hughes MP.

Lasers Surg Med. 2013 Feb;45(2):108-15. doi: 10.1002/lsm.22107. Epub 2012 Dec 31.

PMID:
23280416
42.

Characterization of human skeletal stem and bone cell populations using dielectrophoresis.

Ismail A, Hughes MP, Mulhall HJ, Oreffo RO, Labeed FH.

J Tissue Eng Regen Med. 2015 Feb;9(2):162-8. doi: 10.1002/term.1629. Epub 2012 Dec 6.

PMID:
23225773
43.

Determination of the thermal and physical properties of black tattoo ink using compound analysis.

Humphries A, Lister TS, Wright PA, Hughes MP.

Lasers Med Sci. 2013 Jul;28(4):1107-12. doi: 10.1007/s10103-012-1198-9. Epub 2012 Sep 15.

PMID:
22983425
44.

Characterization of putative iron responsive genes as species-specific indicators of iron stress in thalassiosiroid diatoms.

Whitney LP, Lins JJ, Hughes MP, Wells ML, Chappell PD, Jenkins BD.

Front Microbiol. 2011 Nov 25;2:234. doi: 10.3389/fmicb.2011.00234. eCollection 2011.

45.

Biophysical characteristics reveal neural stem cell differentiation potential.

Labeed FH, Lu J, Mulhall HJ, Marchenko SA, Hoettges KF, Estrada LC, Lee AP, Hughes MP, Flanagan LA.

PLoS One. 2011;6(9):e25458. doi: 10.1371/journal.pone.0025458. Epub 2011 Sep 30.

46.

Cancer, pre-cancer and normal oral cells distinguished by dielectrophoresis.

Mulhall HJ, Labeed FH, Kazmi B, Costea DE, Hughes MP, Lewis MP.

Anal Bioanal Chem. 2011 Nov;401(8):2455-63. doi: 10.1007/s00216-011-5337-0. Epub 2011 Aug 30.

PMID:
21877186
47.

Rapid, automated measurement of dielectrophoretic forces using DEP-activated microwells.

Broche LM, Hoettges KF, Ogin SL, Kass GE, Hughes MP.

Electrophoresis. 2011 Sep;32(17):2393-9. doi: 10.1002/elps.201100063. Epub 2011 Jul 29.

PMID:
21800330
48.

The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients.

Leblanc KG Jr, Hughes MP, Sheehan DJ.

Dermatol Surg. 2011 Jun;37(6):744-9. doi: 10.1111/j.1524-4725.2011.01973..x. Review.

PMID:
21605234
49.

5-year-old child with dermal lesion on buttock.

LeBlanc KG Jr, Hughes MP, Anderson JH, Davis LS.

Pediatr Dermatol. 2011 Mar-Apr;28(2):189-90. doi: 10.1111/j.1525-1470.2011.01395.x. No abstract available.

PMID:
21504450
50.

The predictive value of incidental PET/CT findings suspicious for breast cancer in women with non-breast malignancies.

Beatty JS, Williams HT, Gucwa AL, Hughes MP, Vasudeva VS, Aldridge BA, Fields DM, David GS, Lind DS, Kruse EJ, McLoughlin JM.

Am J Surg. 2009 Oct;198(4):495-9. doi: 10.1016/j.amjsurg.2009.06.009.

PMID:
19800454

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