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REMEMBRANCE: Robert W. Simons.

Hughes KT, Maloy S.

Mol Microbiol. 2019 Aug;112(2):333-334. doi: 10.1111/mmi.14333. Epub 2019 Aug 9. No abstract available.


Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene.

Wozniak CE, Lin Z, Schmidt EW, Hughes KT, Liou TG.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00463-18. doi: 10.1128/AAC.00463-18. Print 2018 Sep.


Communication across the bacterial cell envelope depends on the size of the periplasm.

Asmar AT, Ferreira JL, Cohen EJ, Cho SH, Beeby M, Hughes KT, Collet JF.

PLoS Biol. 2017 Dec 19;15(12):e2004303. doi: 10.1371/journal.pbio.2004303. eCollection 2017 Dec.


"Lost in translation: Seeing the forest by focusing on the trees".

Hughes KT, Chevance FFV.

RNA Biol. 2018 Feb 1;15(2):182-185. doi: 10.1080/15476286.2017.1403717. Epub 2017 Dec 15.


Type-III secretion pore formed by flagellar protein FliP.

Ward E, Renault TT, Kim EA, Erhardt M, Hughes KT, Blair DF.

Mol Microbiol. 2018 Jan;107(1):94-103. doi: 10.1111/mmi.13870. Epub 2017 Nov 28.


The bacterium has landed.

Hughes KT, Berg HC.

Science. 2017 Oct 27;358(6362):446-447. doi: 10.1126/science.aaq0143. No abstract available.


Flagellum Length Control: How Long Is Long Enough?

Hughes KT.

Curr Biol. 2017 Jun 5;27(11):R413-R415. doi: 10.1016/j.cub.2017.04.008.


Dual host specificity of phage SP6 is facilitated by tailspike rotation.

Tu J, Park T, Morado DR, Hughes KT, Molineux IJ, Liu J.

Virology. 2017 Jul;507:206-215. doi: 10.1016/j.virol.2017.04.017. Epub 2017 Apr 26.


Variability in bacterial flagella re-growth patterns after breakage.

Paradis G, Chevance FFV, Liou W, Renault TT, Hughes KT, Rainville S, Erhardt M.

Sci Rep. 2017 Apr 28;7(1):1282. doi: 10.1038/s41598-017-01302-5.


Case for the genetic code as a triplet of triplets.

Chevance FFV, Hughes KT.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4745-4750. doi: 10.1073/pnas.1614896114. Epub 2017 Apr 17.


Nanoscale-length control of the flagellar driveshaft requires hitting the tethered outer membrane.

Cohen EJ, Ferreira JL, Ladinsky MS, Beeby M, Hughes KT.

Science. 2017 Apr 14;356(6334):197-200. doi: 10.1126/science.aam6512.


Coupling of Flagellar Gene Expression with Assembly in Salmonella enterica.

Chevance FF, Hughes KT.

Methods Mol Biol. 2017;1593:47-71. doi: 10.1007/978-1-4939-6927-2_4.


Identical folds used for distinct mechanical functions of the bacterial flagellar rod and hook.

Fujii T, Kato T, Hiraoka KD, Miyata T, Minamino T, Chevance FF, Hughes KT, Namba K.

Nat Commun. 2017 Jan 25;8:14276. doi: 10.1038/ncomms14276.


Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical charged-residue cluster.

Erhardt M, Wheatley P, Kim EA, Hirano T, Zhang Y, Sarkar MK, Hughes KT, Blair DF.

Mol Microbiol. 2017 Apr;104(2):234-249. doi: 10.1111/mmi.13623. Epub 2017 Feb 28.


Mg2+-dependent translational speed bump acts to regulate gene transcription.

Hughes KT.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14881-14883. doi: 10.1073/pnas.1618222114. Epub 2016 Dec 19. No abstract available.


Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage.

Hughes KT, Beasley MB.

Arch Pathol Lab Med. 2017 Jul;141(7):916-922. doi: 10.5858/arpa.2016-0342-RA. Epub 2016 Sep 21. Review.


Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli.

Hengge R, Galperin MY, Ghigo JM, Gomelsky M, Green J, Hughes KT, Jenal U, Landini P.

J Bacteriol. 2015 Jul 6;198(1):7-11. doi: 10.1128/JB.00424-15. Print 2016 Jan 1.


Molecular ruler determines needle length for the Salmonella Spi-1 injectisome.

Wee DH, Hughes KT.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4098-103. doi: 10.1073/pnas.1423492112. Epub 2015 Mar 16.


Genome Sequence of Salmonella Phage χ.

Hendrix RW, Ko CC, Jacobs-Sera D, Hatfull GF, Erhardt M, Hughes KT, Casjens SR.

Genome Announc. 2015 Feb 26;3(1). pii: e01229-14. doi: 10.1128/genomeA.01229-14.


ATPase-independent type-III protein secretion in Salmonella enterica.

Erhardt M, Mertens ME, Fabiani FD, Hughes KT.

PLoS Genet. 2014 Nov 13;10(11):e1004800. doi: 10.1371/journal.pgen.1004800. eCollection 2014 Nov.


FliT selectively enhances proteolysis of FlhC subunit in FlhD4C2 complex by an ATP-dependent protease, ClpXP.

Sato Y, Takaya A, Mouslim C, Hughes KT, Yamamoto T.

J Biol Chem. 2014 Nov 21;289(47):33001-11. doi: 10.1074/jbc.M114.593749. Epub 2014 Oct 2.


Comparative analysis of the secretion capability of early and late flagellar type III secretion substrates.

Singer HM, Erhardt M, Hughes KT.

Mol Microbiol. 2014 Aug;93(3):505-20. doi: 10.1111/mmi.12675. Epub 2014 Jul 6.


The effects of codon context on in vivo translation speed.

Chevance FF, Le Guyon S, Hughes KT.

PLoS Genet. 2014 Jun 5;10(6):e1004392. doi: 10.1371/journal.pgen.1004392. eCollection 2014 Jun.


Rod-to-hook transition for extracellular flagellum assembly is catalyzed by the L-ring-dependent rod scaffold removal.

Cohen EJ, Hughes KT.

J Bacteriol. 2014 Jul;196(13):2387-95. doi: 10.1128/JB.01580-14. Epub 2014 Apr 18.


Analysis of factors that affect FlgM-dependent type III secretion for protein purification with Salmonella enterica serovar Typhimurium.

Guo S, Alshamy I, Hughes KT, Chevance FF.

J Bacteriol. 2014 Jul;196(13):2333-47. doi: 10.1128/JB.01572-14. Epub 2014 Apr 4.


High-resolution mapping defines the cooperative architecture of Polycomb response elements.

Orsi GA, Kasinathan S, Hughes KT, Saminadin-Peter S, Henikoff S, Ahmad K.

Genome Res. 2014 May;24(5):809-20. doi: 10.1101/gr.163642.113. Epub 2014 Mar 25.


Differential transmembrane domain GXXXG motif pairing impacts major histocompatibility complex (MHC) class II structure.

Dixon AM, Drake L, Hughes KT, Sargent E, Hunt D, Harton JA, Drake JR.

J Biol Chem. 2014 Apr 25;289(17):11695-703. doi: 10.1074/jbc.M113.516997. Epub 2014 Mar 11.


The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression.

Mouslim C, Hughes KT.

PLoS Pathog. 2014 Mar 6;10(3):e1003987. doi: 10.1371/journal.ppat.1003987. eCollection 2014 Mar.


The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.

Singer HM, Kühne C, Deditius JA, Hughes KT, Erhardt M.

J Bacteriol. 2014 Apr;196(7):1448-57. doi: 10.1128/JB.01438-13. Epub 2014 Jan 31.


Bacterial flagellin-specific chaperone FliS interacts with anti-sigma factor FlgM.

Galeva A, Moroz N, Yoon YH, Hughes KT, Samatey FA, Kostyukova AS.

J Bacteriol. 2014 Mar;196(6):1215-21. doi: 10.1128/JB.01278-13. Epub 2014 Jan 10.


Common and distinct structural features of Salmonella injectisome and flagellar basal body.

Kawamoto A, Morimoto YV, Miyata T, Minamino T, Hughes KT, Kato T, Namba K.

Sci Rep. 2013 Nov 28;3:3369. doi: 10.1038/srep03369.


RflM functions as a transcriptional repressor in the autogenous control of the Salmonella Flagellar master operon flhDC.

Singer HM, Erhardt M, Hughes KT.

J Bacteriol. 2013 Sep;195(18):4274-82. doi: 10.1128/JB.00728-13. Epub 2013 Jul 19.


Nucleosome-depleted chromatin gaps recruit assembly factors for the H3.3 histone variant.

Schneiderman JI, Orsi GA, Hughes KT, Loppin B, Ahmad K.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19721-6. doi: 10.1073/pnas.1206629109. Epub 2012 Nov 12.


The locus of enterocyte effacement type III secretion specificity switch: the devil's in the data for a common mechanism.

Hughes KT.

J Bacteriol. 2012 Nov;194(22):6019-22. doi: 10.1128/JB.01520-12. Epub 2012 Aug 24. No abstract available.


Flagellar hook length is controlled by a secreted molecular ruler.

Hughes KT.

J Bacteriol. 2012 Sep;194(18):4793-6. doi: 10.1128/JB.00343-12. Epub 2012 Jul 13. No abstract available.


Rebuttal: Mystery of FliK in Length Control of the Flagellar Hook.

Hughes KT.

J Bacteriol. 2012 Sep;194(18):4801. doi: 10.1128/JB.06454-11. Epub 2012 Jul 13. No abstract available.


Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system.

Singer HM, Erhardt M, Steiner AM, Zhang MM, Yoshikami D, Bulaj G, Olivera BM, Hughes KT.

MBio. 2012 May 29;3(3). pii: e00115-12. doi: 10.1128/mBio.00115-12. Print 2012.


YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex.

Takaya A, Erhardt M, Karata K, Winterberg K, Yamamoto T, Hughes KT.

Mol Microbiol. 2012 Mar;83(6):1268-84. doi: 10.1111/j.1365-2958.2012.08007.x. Epub 2012 Mar 2.


Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins.

Briegel A, Li X, Bilwes AM, Hughes KT, Jensen GJ, Crane BR.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3766-71. doi: 10.1073/pnas.1115719109. Epub 2012 Feb 21.


An infrequent molecular ruler controls flagellar hook length in Salmonella enterica.

Erhardt M, Singer HM, Wee DH, Keener JP, Hughes KT.

EMBO J. 2011 Jun 7;30(14):2948-61. doi: 10.1038/emboj.2011.185.


Inactivation of Ascaris suum by short-chain fatty acids.

Butkus MA, Hughes KT, Bowman DD, Liotta JL, Jenkins MB, Labare MP.

Appl Environ Microbiol. 2011 Jan;77(1):363-6. doi: 10.1128/AEM.01675-10. Epub 2010 Nov 5.


Bacterial nanomachines: the flagellum and type III injectisome.

Erhardt M, Namba K, Hughes KT.

Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a000299. doi: 10.1101/cshperspect.a000299. Epub 2010 Oct 6. Review.


Multiple promoters contribute to swarming and the coordination of transcription with flagellar assembly in Salmonella.

Wozniak CE, Chevance FF, Hughes KT.

J Bacteriol. 2010 Sep;192(18):4752-62. doi: 10.1128/JB.00093-10. Epub 2010 Jul 16.


The role of the FliK molecular ruler in hook-length control in Salmonella enterica.

Erhardt M, Hirano T, Su Y, Paul K, Wee DH, Mizuno S, Aizawa S, Hughes KT.

Mol Microbiol. 2010 Mar;75(5):1272-84. doi: 10.1111/j.1365-2958.2010.07050.x. Epub 2010 Feb 1.


C-ring requirement in flagellar type III secretion is bypassed by FlhDC upregulation.

Erhardt M, Hughes KT.

Mol Microbiol. 2010 Jan;75(2):376-93. doi: 10.1111/j.1365-2958.2009.06973.x. Epub 2009 Nov 17.


Benchmarking yeast two-hybrid systems using the interactions of bacterial motility proteins.

Rajagopala SV, Hughes KT, Uetz P.

Proteomics. 2009 Dec;9(23):5296-302. doi: 10.1002/pmic.200900282.


Interaction of FliK with the bacterial flagellar hook is required for efficient export specificity switching.

Minamino T, Moriya N, Hirano T, Hughes KT, Namba K.

Mol Microbiol. 2009 Oct;74(1):239-251. doi: 10.1111/j.1365-2958.2009.06871.x. Epub 2009 Sep 2.


Autonomous and FliK-dependent length control of the flagellar rod in Salmonella enterica.

Takahashi N, Mizuno S, Hirano T, Chevance FF, Hughes KT, Aizawa S.

J Bacteriol. 2009 Oct;191(20):6469-72. doi: 10.1128/JB.00509-09. Epub 2009 Aug 7.


The Helicobacter pylori anti-sigma factor FlgM is predominantly cytoplasmic and cooperates with the flagellar basal body protein FlhA.

Rust M, Borchert S, Niehus E, Kuehne SA, Gripp E, Bajceta A, McMurry JL, Suerbaum S, Hughes KT, Josenhans C.

J Bacteriol. 2009 Aug;191(15):4824-34. doi: 10.1128/JB.00018-09. Epub 2009 May 22.


Mutations in flk, flgG, flhA, and flhE that affect the flagellar type III secretion specificity switch in Salmonella enterica.

Hirano T, Mizuno S, Aizawa S, Hughes KT.

J Bacteriol. 2009 Jun;191(12):3938-49. doi: 10.1128/JB.01811-08. Epub 2009 Apr 17.

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