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Pervasive Linked Selection and Intermediate-Frequency Alleles Are Implicated in an Evolve-and-Resequencing Experiment of Drosophila simulans.

Kelly JK, Hughes KA.

Genetics. 2018 Dec 28. pii: genetics.301824.2018. doi: 10.1534/genetics.118.301824. [Epub ahead of print]


Human-mediated dispersal of terrestrial species between Antarctic biogeographic regions: A preliminary risk assessment.

Hughes KA, Convey P, Pertierra LR, Vega GC, Aragón P, Olalla-Tárraga MÁ.

J Environ Manage. 2019 Feb 15;232:73-89. doi: 10.1016/j.jenvman.2018.10.095. Epub 2018 Nov 21. Review.


'CPR for Feet' care bundle to improve foot assessment in inpatient diabetes.

O'Regan R, MacDonald R, Boyle JG, Hughes KA, McKenzie J.

BMJ Open Qual. 2018 Sep 4;7(3):e000196. doi: 10.1136/bmjoq-2017-000196. eCollection 2018.


Microplastics in marine sediments near Rothera Research Station, Antarctica.

Reed S, Clark M, Thompson R, Hughes KA.

Mar Pollut Bull. 2018 Aug;133:460-463. doi: 10.1016/j.marpolbul.2018.05.068. Epub 2018 Jun 19.


Why does the magnitude of genotype-by-environment interaction vary?

Saltz JB, Bell AM, Flint J, Gomulkiewicz R, Hughes KA, Keagy J.

Ecol Evol. 2018 May 8;8(12):6342-6353. doi: 10.1002/ece3.4128. eCollection 2018 Jun. Review.


GxG epistasis in growth and condition and the maintenance of genetic polymorphism in Gambusia holbrooki.

Culumber ZW, Kraft B, Lemakos V, Hoffner E, Travis J, Hughes KA.

Evolution. 2018 May;72(5):1146-1154. doi: 10.1111/evo.13474. Epub 2018 Apr 29.


Erratum: Non-adaptive plasticity potentiates rapid adaptive evolution of gene expression in nature.

Ghalambor CK, Hoke KL, Ruell EW, Fischer EK, Reznick DN, Hughes KA.

Nature. 2018 Mar 28;555(7698):688. doi: 10.1038/nature25499.


Ghalambor et al. reply.

Ghalambor CK, Hoke KL, Ruell EW, Fischer EK, Reznick DN, Hughes KA.

Nature. 2018 Mar 28;555(7698):E23. doi: 10.1038/nature25497. No abstract available.


Advancing behavioural genomics by considering timescale.

Rittschof CC, Hughes KA.

Nat Commun. 2018 Feb 12;9(1):489. doi: 10.1038/s41467-018-02971-0. Review.


Best Practices for Surgeons' Social Media Use: Statement of the Resident and Associate Society of the American College of Surgeons.

Logghe HJ, Boeck MA, Gusani NJ, Hardaway JC, Hughes KA, Mouawad NJ, Kulaylat AN, Hoffman RL, Turner P, Jones C, Leichtle SW.

J Am Coll Surg. 2018 Mar;226(3):317-327. doi: 10.1016/j.jamcollsurg.2017.11.022. Epub 2017 Dec 7. No abstract available.


Evaluating trace element bioavailability and potential transfer into marine food chains using immobilised diatom model species Phaeodactylum tricornutum, on King George Island, Antarctica.

Cabrita MT, Padeiro A, Amaro E, Dos Santos MC, Leppe M, Verkulich S, Hughes KA, Peter HU, Canário J.

Mar Pollut Bull. 2017 Aug 15;121(1-2):192-200. doi: 10.1016/j.marpolbul.2017.05.059. Epub 2017 Jun 7.


Microplastics in the Antarctic marine system: An emerging area of research.

Waller CL, Griffiths HJ, Waluda CM, Thorpe SE, Loaiza I, Moreno B, Pacherres CO, Hughes KA.

Sci Total Environ. 2017 Nov 15;598:220-227. doi: 10.1016/j.scitotenv.2017.03.283. Epub 2017 Apr 22. Review.


Correction: High Resolution Spatial Mapping of Human Footprint across Antarctica and Its Implications for the Strategic Conservation of Avifauna.

Pertierra LR, Hughes KA, Vega GC, Olalla-Tárraga MÁ.

PLoS One. 2017 Mar 3;12(3):e0173649. doi: 10.1371/journal.pone.0173649. eCollection 2017.


Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of dicloromezotiaz as a lepidoptera insecticide acting on nicotinic acetylcholine receptors1,2.

Zhang W, Holyoke CW Jr, Barry J, Cordova D, Leighty RM, Tong MT, Hughes KA, Lahm GP, Pahutski TF, Xu M, Briddell TA, McCann SF, Henry YT, Chen Y.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):911-917. doi: 10.1016/j.bmcl.2017.01.002. Epub 2017 Jan 5.


High Resolution Spatial Mapping of Human Footprint across Antarctica and Its Implications for the Strategic Conservation of Avifauna.

Pertierra LR, Hughes KA, Vega GC, Olalla-Tárraga MÁ.

PLoS One. 2017 Jan 13;12(1):e0168280. doi: 10.1371/journal.pone.0168280. eCollection 2017. Erratum in: PLoS One. 2017 Mar 3;12 (3):e0173649.


Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses.

Hughes KA, Leips J.

Ann N Y Acad Sci. 2017 Feb;1389(1):76-91. doi: 10.1111/nyas.13256. Epub 2016 Dec 9. Review.


Mesoionic insecticides: a novel class of insecticides that modulate nicotinic acetylcholine receptors.

Holyoke CW Jr, Cordova D, Zhang W, Barry JD, Leighty RM, Dietrich RF, Rauh JJ, Pahutski TF Jr, Lahm GP, Tong MT, Benner EA, Andreassi JL, Smith RM, Vincent DR, Christianson LA, Teixeira LA, Singh V, Hughes KA.

Pest Manag Sci. 2017 Apr;73(4):796-806. doi: 10.1002/ps.4496. Epub 2017 Feb 1.


Mesoionic pyrido[1,2-a]pyrimidinones: Discovery of triflumezopyrim as a potent hopper insecticide1.

Zhang W, Holyoke CW Jr, Pahutski TF, Lahm GP, Barry JD, Cordova D, Leighty RM, Singh V, Vicent DR, Tong MT, Hughes KA, McCann SF, Henry YT, Xu M, Briddell TA.

Bioorg Med Chem Lett. 2017 Jan 1;27(1):16-20. doi: 10.1016/j.bmcl.2016.11.042. Epub 2016 Nov 16.


Mesoionic pyrido[1,2-a]pyrimidinones: A novel class of insecticides inhibiting nicotinic acetylcholine receptors.

Zhang W, Holyoke CW Jr, Barry J, Leighty RM, Cordova D, Vincent DR, Hughes KA, Tong MT, McCann SF, Xu M, Briddell TA, Pahutski TF, Lahm GP.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5444-5449. doi: 10.1016/j.bmcl.2016.10.031. Epub 2016 Oct 13.


Environmental hazard assessment of contaminated soils in Antarctica: Using a structured tier 1 approach to inform decision-making.

Pereira JL, Pereira P, Padeiro A, Gonçalves F, Amaro E, Leppe M, Verkulich S, Hughes KA, Peter HU, Canário J.

Sci Total Environ. 2017 Jan 1;574:443-454. doi: 10.1016/j.scitotenv.2016.09.091. Epub 2016 Oct 14.


Trace element contamination and availability in the Fildes Peninsula, King George Island, Antarctica.

Padeiro A, Amaro E, Dos Santos MM, Araújo MF, Gomes SS, Leppe M, Verkulich S, Hughes KA, Peter HU, Canário J.

Environ Sci Process Impacts. 2016 Jun 15;18(6):648-57. doi: 10.1039/c6em00052e. Epub 2016 May 25.


Aerobiology Over Antarctica - A New Initiative for Atmospheric Ecology.

Pearce DA, Alekhina IA, Terauds A, Wilmotte A, Quesada A, Edwards A, Dommergue A, Sattler B, Adams BJ, Magalhães C, Chu WL, Lau MC, Cary C, Smith DJ, Wall DH, Eguren G, Matcher G, Bradley JA, de Vera JP, Elster J, Hughes KA, Cuthbertson L, Benning LG, Gunde-Cimerman N, Convey P, Hong SG, Pointing SB, Pellizari VH, Vincent WF.

Front Microbiol. 2016 Feb 16;7:16. doi: 10.3389/fmicb.2016.00016. eCollection 2016.


#ILookLikeASurgeon goes viral: How it happened.

Hughes KA.

Bull Am Coll Surg. 2015 Nov;100(11):10-6. No abstract available.


Stimulation of the Drosophila immune system alters genome-wide nucleosome occupancy.

Ren Y, Vera DL, Hughes KA, Dennis JH.

Genom Data. 2015 Jan 9;3:146-7. doi: 10.1016/j.gdata.2015.01.001. eCollection 2015 Mar.


Non-adaptive plasticity potentiates rapid adaptive evolution of gene expression in nature.

Ghalambor CK, Hoke KL, Ruell EW, Fischer EK, Reznick DN, Hughes KA.

Nature. 2015 Sep 17;525(7569):372-5. doi: 10.1038/nature15256. Epub 2015 Sep 2. Erratum in: Nature. 2018 Mar 28;555(7698):688.


Why are you here? To lead, to advocate, and to connect.

Hughes KA.

Bull Am Coll Surg. 2015 Jul;100(7):80-2. No abstract available.


Assessing the effectiveness of specially protected areas for conservation of Antarctica's botanical diversity.

Hughes KA, Ireland LC, Convey P, Fleming AH.

Conserv Biol. 2016 Feb;30(1):113-20. doi: 10.1111/cobi.12592. Epub 2015 Nov 2.


Challenging government health rhetoric.

Hughes KA.

Nurs N Z. 2015 Jun;21(5):2. No abstract available.


Assessing trace element contamination in Fildes Peninsula (King George Island) and Ardley Island, Antarctic.

Amaro E, Padeiro A, Mão de Ferro A, Mota AM, Leppe M, Verkulich S, Hughes KA, Peter HU, Canário J.

Mar Pollut Bull. 2015 Aug 15;97(1-2):523-527. doi: 10.1016/j.marpolbul.2015.05.018. Epub 2015 May 14.


Structural positioning of nurse leaders and empowerment.

Hughes KA, Carryer JB, White J.

J Clin Nurs. 2015 Aug;24(15-16):2125-32. doi: 10.1111/jocn.12839. Epub 2015 May 10.


Protection of Antarctic microbial communities - 'out of sight, out of mind'.

Hughes KA, Cowan DA, Wilmotte A.

Front Microbiol. 2015 Feb 25;6:151. doi: 10.3389/fmicb.2015.00151. eCollection 2015.


Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.

Upreti R, Naredo G, Faqehi AM, Hughes KA, Stewart LH, Walker BR, Homer NZ, Andrew R.

Talanta. 2015 Jan;131:728-35. doi: 10.1016/j.talanta.2014.07.087. Epub 2014 Aug 14.


Stress hyperglycaemia in hospitalised patients and their 3-year risk of diabetes: a Scottish retrospective cohort study.

McAllister DA, Hughes KA, Lone N, Mills NL, Sattar N, McKnight J, Wild SH.

PLoS Med. 2014 Aug 19;11(8):e1001708. doi: 10.1371/journal.pmed.1001708. eCollection 2014 Aug.


Vitellogenin family gene expression does not increase Drosophila lifespan or fecundity.

Ren Y, Hughes KA.

F1000Res. 2014 Jun 10;3:125. doi: 10.12688/f1000research.3975.1. eCollection 2014.


Investigating the insecticidal potential of Geomyces (Myxotrichaceae: Helotiales) and Mortierella (Mortierellacea: Mortierellales) isolated from Antarctica.

Edgington S, Thompson E, Moore D, Hughes KA, Bridge P.

Springerplus. 2014 Jun 9;3:289. doi: 10.1186/2193-1801-3-289. eCollection 2014.


Relative adrenal insufficiency in mice deficient in 5α-reductase 1.

Livingstone DE, Di Rollo EM, Yang C, Codrington LE, Mathews JA, Kara M, Hughes KA, Kenyon CJ, Walker BR, Andrew R.

J Endocrinol. 2014 Aug;222(2):257-66. doi: 10.1530/JOE-13-0563. Epub 2014 May 28.


5α-reductase type 1 modulates insulin sensitivity in men.

Upreti R, Hughes KA, Livingstone DE, Gray CD, Minns FC, Macfarlane DP, Marshall I, Stewart LH, Walker BR, Andrew R.

J Clin Endocrinol Metab. 2014 Aug;99(8):E1397-406. doi: 10.1210/jc.2014-1395. Epub 2014 May 13.


Discovery, synthesis, and evaluation of N-substituted amino-2(5H)-oxazolones as novel insecticides activating nicotinic acetylcholine receptors.

Zhang W, Barry JD, Cordova D, McCann SF, Benner EA, Hughes KA.

Bioorg Med Chem Lett. 2014 May 1;24(9):2188-92. doi: 10.1016/j.bmcl.2014.03.037. Epub 2014 Mar 21.


Phenotypic and genomic plasticity of alternative male reproductive tactics in sailfin mollies.

Fraser BA, Janowitz I, Thairu M, Travis J, Hughes KA.

Proc Biol Sci. 2014 Feb 26;281(1781):20132310. doi: 10.1098/rspb.2013.2310. Print 2014 Apr 22.


Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist.

Iqbal J, Andrew R, Cruden NL, Kenyon CJ, Hughes KA, Newby DE, Hadoke PW, Walker BR.

J Clin Endocrinol Metab. 2014 Mar;99(3):915-22. doi: 10.1210/jc.2013-2049. Epub 2013 Jan 1.


Mating advantage for rare males in wild guppy populations.

Hughes KA, Houde AE, Price AC, Rodd FH.

Nature. 2013 Nov 7;503(7474):108-10. doi: 10.1038/nature12717. Epub 2013 Oct 30.


Discovery of cyantraniliprole, a potent and selective anthranilic diamide ryanodine receptor activator with cross-spectrum insecticidal activity.

Selby TP, Lahm GP, Stevenson TM, Hughes KA, Cordova D, Annan IB, Barry JD, Benner EA, Currie MJ, Pahutski TF.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6341-5. doi: 10.1016/j.bmcl.2013.09.076. Epub 2013 Oct 1.


The role of learning by a predator, Rivulus hartii, in the rare-morph survival advantage in guppies.

Fraser BA, Hughes KA, Tosh DN, Rodd FH.

J Evol Biol. 2013 Dec;26(12):2597-605. doi: 10.1111/jeb.12251. Epub 2013 Oct 7.


Bacterial contamination of unused, disposable non-sterile gloves on a hospital orthopaedic ward.

Hughes KA, Cornwall J, Theis JC, Brooks HJ.

Australas Med J. 2013 Jun 30;6(6):331-8. doi: 10.4066/AMJ.2013.1675. Print 2013.


Measurement of tamsulosin in human serum by liquid chromatography-tandem mass spectrometry.

Upreti R, Homer NZ, Naredo G, Cobice DF, Hughes KA, Stewart LH, Walker BR, Andrew R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 1;930:121-8. doi: 10.1016/j.jchromb.2013.04.020. Epub 2013 Apr 19.


Genomic basis of aging and life-history evolution in Drosophila melanogaster.

Remolina SC, Chang PL, Leips J, Nuzhdin SV, Hughes KA.

Evolution. 2012 Nov;66(11):3390-403. doi: 10.1111/j.1558-5646.2012.01710.x. Epub 2012 Jun 27.


Conservation. Challenges to the future conservation of the Antarctic.

Chown SL, Lee JE, Hughes KA, Barnes J, Barrett PJ, Bergstrom DM, Convey P, Cowan DA, Crosbie K, Dyer G, Frenot Y, Grant SM, Herr D, Kennicutt MC 2nd, Lamers M, Murray A, Possingham HP, Reid K, Riddle MJ, Ryan PG, Sanson L, Shaw JD, Sparrow MD, Summerhayes C, Terauds A, Wall DH.

Science. 2012 Jul 13;337(6091):158-9. doi: 10.1126/science.1222821. No abstract available.


Age-specific variation in immune response in Drosophila melanogaster has a genetic basis.

Felix TM, Hughes KA, Stone EA, Drnevich JM, Leips J.

Genetics. 2012 Jul;191(3):989-1002. doi: 10.1534/genetics.112.140640. Epub 2012 May 2.


Recycling between cortisol and cortisone in human splanchnic, subcutaneous adipose, and skeletal muscle tissues in vivo.

Hughes KA, Manolopoulos KN, Iqbal J, Cruden NL, Stimson RH, Reynolds RM, Newby DE, Andrew R, Karpe F, Walker BR.

Diabetes. 2012 Jun;61(6):1357-64. doi: 10.2337/db11-1345. Epub 2012 Apr 17.


Continent-wide risk assessment for the establishment of nonindigenous species in Antarctica.

Chown SL, Huiskes AH, Gremmen NJ, Lee JE, Terauds A, Crosbie K, Frenot Y, Hughes KA, Imura S, Kiefer K, Lebouvier M, Raymond B, Tsujimoto M, Ware C, Van de Vijver B, Bergstrom DM.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4938-43. doi: 10.1073/pnas.1119787109. Epub 2012 Mar 5.

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