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Items: 26

1.

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors.

Spender LC, Ferguson GJ, Hughes GD, Davies BR, Goldberg FW, Herrera B, Taylor RG, Strathearn LS, Sansom OJ, Barry ST, Inman GJ.

Mol Pharmacol. 2019 Feb;95(2):222-234. doi: 10.1124/mol.118.112946. Epub 2018 Nov 20.

PMID:
30459156
2.

pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.

Jones GN, Rooney C, Griffin N, Roudier M, Young LA, Garcia-Trinidad A, Hughes GD, Whiteaker JR, Wilson Z, Odedra R, Zhao L, Ivey RG, Howat WJ, Harrington EA, Barrett JC, Ramos-Montoya A, Lau A, Paulovich AG, Cadogan EB, Pierce AJ.

Br J Cancer. 2018 Nov;119(10):1233-1243. doi: 10.1038/s41416-018-0286-4. Epub 2018 Nov 2.

PMID:
30385821
3.

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.

Barlaam B, Cadogan E, Campbell A, Colclough N, Dishington A, Durant S, Goldberg K, Hassall LA, Hughes GD, MacFaul PA, McGuire TM, Pass M, Patel A, Pearson S, Petersen J, Pike KG, Robb G, Stratton N, Xin G, Zhai B.

ACS Med Chem Lett. 2018 Jul 13;9(8):809-814. doi: 10.1021/acsmedchemlett.8b00200. eCollection 2018 Aug 9.

PMID:
30128072
4.

Nursing students' knowledge, attitude and practices of infection prevention and control guidelines at a tertiary institution in the Western Cape: A cross sectional study.

Rahiman F, Chikte U, Hughes GD.

Nurse Educ Today. 2018 Oct;69:20-25. doi: 10.1016/j.nedt.2018.06.021. Epub 2018 Jun 30.

PMID:
30007142
5.

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).

Pike KG, Barlaam B, Cadogan E, Campbell A, Chen Y, Colclough N, Davies NL, de-Almeida C, Degorce SL, Didelot M, Dishington A, Ducray R, Durant ST, Hassall LA, Holmes J, Hughes GD, MacFaul PA, Mulholland KR, McGuire TM, Ouvry G, Pass M, Robb G, Stratton N, Wang Z, Wilson J, Zhai B, Zhao K, Al-Huniti N.

J Med Chem. 2018 May 10;61(9):3823-3841. doi: 10.1021/acs.jmedchem.7b01896. Epub 2018 May 2.

PMID:
29683659
6.

The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy.

Greene J, Nguyen A, Bagby SM, Jones GN, Tai WM, Quackenbush KS, Schreiber A, Messersmith WA, Devaraj KM, Blatchford P, Eckhardt SG, Cadogan EB, Hughes GD, Smith A, Pitts TM, Arcaroli JJ.

Oncotarget. 2017 Dec 5;8(67):110904-110913. doi: 10.18632/oncotarget.22920. eCollection 2017 Dec 19.

7.

Health-seeking behaviours of older black women living with non-communicable diseases in an urban township in South Africa.

Aboyade OM, Beauclair R, Mbamalu ON, Puoane TR, Hughes GD.

BMC Complement Altern Med. 2016 Oct 24;16(1):410.

8.

Characterizing Herbal Medicine Use for Noncommunicable Diseases in Urban South Africa.

Hughes GD, Aboyade OM, Beauclair R, Mbamalu ON, Puoane TR.

Evid Based Complement Alternat Med. 2015;2015:736074. doi: 10.1155/2015/736074. Epub 2015 Oct 18.

9.

Central line complications.

Kornbau C, Lee KC, Hughes GD, Firstenberg MS.

Int J Crit Illn Inj Sci. 2015 Jul-Sep;5(3):170-8. doi: 10.4103/2229-5151.164940.

10.

The prevalence of traditional herbal medicine use among hypertensives living in South African communities.

Hughes GD, Aboyade OM, Clark BL, Puoane TR.

BMC Complement Altern Med. 2013 Feb 18;13:38. doi: 10.1186/1472-6882-13-38.

11.
12.

Prevalence and predictors of traditional medicine utilization among persons living with AIDS (PLWA) on antiretroviral (ARV) and prophylaxis treatment in both rural and urban areas in South Africa.

Hughes GD, Puoane TR, Clark BL, Wondwossen TL, Johnson Q, Folk W.

Afr J Tradit Complement Altern Med. 2012 Jul 1;9(4):470-84. eCollection 2012.

13.

Demographics and outcomes at American Society for Metabolic and Bariatric Surgery Centers of Excellence.

Pratt GM, Learn CA, Hughes GD, Clark BL, Warthen M, Pories W.

Surg Endosc. 2009 Apr;23(4):795-9. doi: 10.1007/s00464-008-0077-8. Epub 2009 Jan 30.

PMID:
19184200
14.

Prostate cancer community collaboration and partnership: education, awareness, recruitment, and outreach to southern African-American males.

Hughes GD, Sellers DB, Fraser L Jr, Teague R, Knight B.

J Cult Divers. 2007 Summer;14(2):68-73.

PMID:
19175246
15.

Fear of sexually transmitted infections among women with male migrant partners -- relationship to oscillatory migration pattern and risk-avoidance behaviour.

Hughes GD, Hoyo C, Puoane TR.

S Afr Med J. 2006 May;96(5):434-8. Erratum in: S Afr Med J. 2006 Jul;96(7):575-6.

16.

Impact of the HIV/AIDS pandemic on non-communicable disease prevention.

Puoane T, Hughes GD.

S Afr Med J. 2005 Apr;95(4):228, 230. Review. No abstract available.

17.

Public health education: a report from Mosul and a plan for change.

Hughes GD, Mack A, Golden KS.

BMC Public Health. 2005 Mar 31;5:29.

18.

Obesity and the African-American adolescent in mississippi: an overview.

Hughes GD, Areghan GA, Knight BN.

South Med J. 2005 Jan;98(1):72-8. Review.

PMID:
15678639
19.

Barriers and strategies for sustained participation of African-American men in cohort studies.

Hughes GD, Sellers DB, Fraser LB Jr, Knight B, Areghan GA.

Ethn Dis. 2003 Fall;13(4):534-6. No abstract available.

PMID:
14632274
20.

ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.

Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF.

Cancer Res. 2002 Aug 15;62(16):4645-55.

21.

Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models.

Blakey DC, Westwood FR, Walker M, Hughes GD, Davis PD, Ashton SE, Ryan AJ.

Clin Cancer Res. 2002 Jun;8(6):1974-83.

22.

Cardiovascular disease among women residing in rural America: epidemiology, explanations, and challenges.

Taylor HA, Hughes GD, Garrison RJ.

Am J Public Health. 2002 Apr;92(4):548-51.

23.

Localization properties of fractons in percolating structures.

Lambert CJ, Hughes GD.

Phys Rev Lett. 1991 Feb 25;66(8):1074-1077. No abstract available.

PMID:
10043989
24.

Can marketing help recruit and retain nurses?

Hughes GD.

Health Care Manage Rev. 1979 Summer;4(3):61-6.

PMID:
10243074
25.

Serum antinuclear antibodies in rheumatoid arthritis.

Hughes GD, Rothfield NF.

Conn Med. 1970 Mar;34(3):171-6. No abstract available.

PMID:
4906729
26.

The influence of risk-taking propensity on bargaining behavior.

Harnett DL, Cummings LL, Hughes GD.

Behav Sci. 1968 Mar;13(2):91-101. No abstract available.

PMID:
5641352

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