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Items: 1 to 50 of 188

1.

Structural studies suggest aggregation as one of the modes of action for teixobactin.

Öster C, Walkowiak GP, Hughes DE, Spoering AL, Peoples AJ, Catherwood AC, Tod JA, Lloyd AJ, Herrmann T, Lewis K, Dowson CG, Lewandowski JR.

Chem Sci. 2018 Sep 20;9(47):8850-8859. doi: 10.1039/c8sc03655a. eCollection 2018 Dec 21.

2.

Erratum: A new antibiotic kills pathogens without detectable resistance.

Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K.

Nature. 2015 Apr 16;520(7547):388. doi: 10.1038/nature14303. Epub 2015 Feb 25. No abstract available.

PMID:
25731174
3.

A new antibiotic kills pathogens without detectable resistance.

Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K.

Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Erratum in: Nature. 2015 Apr 16;520(7547):388.

PMID:
25561178
4.

The real paradox: the case of the missing hat.

Hughes DE.

Mil Med. 2012 Dec;177(12):vii-viii. No abstract available.

PMID:
23397683
5.

Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors.

Austin C, Pettit SN, Magnolo SK, Sanvoisin J, Chen W, Wood SP, Freeman LD, Pengelly RJ, Hughes DE.

J Biomol Screen. 2012 Aug;17(7):868-76. doi: 10.1177/1087057112445785. Epub 2012 May 9.

PMID:
22573733
6.

The importance of magnetic resonance imaging in a symptomatic "bipartite" os peroneum: a case report.

Chadwick C, Highland AM, Hughes DE, Davies MB.

J Foot Ankle Surg. 2011 Jan-Feb;50(1):82-6. doi: 10.1053/j.jfas.2010.08.008. Epub 2010 Sep 27.

PMID:
20870425
7.

FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.

Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Kalinichenko VV, Costa RH, Raychaudhuri P, Tyner AL, Lau LF.

J Biol Chem. 2008 Jul 25;283(30):20770-8. doi: 10.1074/jbc.M709892200. Epub 2008 Jun 4.

8.

Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.

Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS.

Hypertension. 2007 Mar;49(3):467-72. Epub 2007 Jan 22.

PMID:
17242304
9.

Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.

Radhakrishnan SK, Bhat UG, Hughes DE, Wang IC, Costa RH, Gartel AL.

Cancer Res. 2006 Oct 1;66(19):9731-5.

10.

An innovative education program: the peer competency validator model.

Ringerman E, Flint LL, Hughes DE.

J Nurses Staff Dev. 2006 May-Jun;22(3):114-21; quiz 122-3.

PMID:
16760770
11.
12.

C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells.

Yoshida Y, Hughes DE, Rausa FM 3rd, Kim IM, Tan Y, Darlington GJ, Costa RH.

Hepatology. 2006 Feb;43(2):276-86.

13.

Mixed reality in education, entertainment, and training.

Hughes CE, Stapleton CB, Hughes DE, Smith EM.

IEEE Comput Graph Appl. 2005 Nov-Dec;25(6):24-30. No abstract available.

PMID:
16315474
14.

Exploiting new approaches for natural product drug discovery in the biotechnology industry.

Gullo VP, Hughes DE.

Drug Discov Today Technol. 2005 Autumn;2(3):281-6. doi: 10.1016/j.ddtec.2005.08.002.

PMID:
24981948
15.

Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.

Kim IM, Zhou Y, Ramakrishna S, Hughes DE, Solway J, Costa RH, Kalinichenko VV.

J Biol Chem. 2005 Nov 11;280(45):37908-16. Epub 2005 Sep 6.

16.

ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.

Datta A, Sen J, Hagen J, Korgaonkar CK, Caffrey M, Quelle DE, Hughes DE, Ackerson TJ, Costa RH, Raychaudhuri P.

Mol Cell Biol. 2005 Sep;25(18):8024-36.

18.
19.

Intramedullary and extramedullary fat globules on magnetic resonance imaging as a diagnostic sign for osteomyelitis.

Davies AM, Hughes DE, Grimer RJ.

Eur Radiol. 2005 Oct;15(10):2194-9. Epub 2005 Apr 29.

PMID:
15864595
20.

A phthalide with in vitro growth inhibitory activity from an oidiodendron strain.

Mullady EL, Millett WP, Yoo HD, Weiskopf AS, Chen J, Ditullio D, Knight-Connoni V, Hughes DE, Pierceall WE.

J Nat Prod. 2004 Dec;67(12):2086-9.

PMID:
15620258
21.

Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator.

Rausa FM 3rd, Hughes DE, Costa RH.

J Biol Chem. 2004 Oct 8;279(41):43070-6. Epub 2004 Aug 9.

22.

Affinity capillary electrophoresis for the screening of novel antimicrobial targets.

Lewis LM, Engle LJ, Pierceall WE, Hughes DE, Shaw KJ.

J Biomol Screen. 2004 Jun;9(4):303-8.

PMID:
15191647
23.

Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery.

Pierceall WE, Zhang L, Hughes DE.

Methods Mol Biol. 2004;261:187-98. Review.

PMID:
15064459
24.

Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.

Hughes DE, Stolz DB, Yu S, Tan Y, Reddy JK, Watkins SC, Diehl AM, Costa RH.

Hepatology. 2003 Jun;37(6):1414-24.

PMID:
12774021
25.

Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo.

Banks KE, Anderson AL, Tang H, Hughes DE, Costa RH, McLachlan A.

J Virol. 2002 Dec;76(24):12974-80.

26.

Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.

Yu S, Cao WQ, Kashireddy P, Meyer K, Jia Y, Hughes DE, Tan Y, Feng J, Yeldandi AV, Rao MS, Costa RH, Gonzalez FJ, Reddy JK.

J Biol Chem. 2001 Nov 9;276(45):42485-91. Epub 2001 Sep 10.

27.
28.
29.
30.

Implications for improved high-dose methotrexate therapeutic effects in cultured human breast cancer and bone marrow cells.

Bowen D, Southerland WM, Johnson DH, Hawkins M Jr, Hughes DE.

Cancer Detect Prev. 2000;24(5):452-8. Erratum in: Cancer Detect Prev 2001;25(2):222.

PMID:
11129987
31.

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma.

Shipman CM, Vanderkerken K, Rogers MJ, Lippitt JM, Asosingh K, Hughes DE, Van Camp B, Russell RG, Croucher PI.

Br J Haematol. 2000 Oct;111(1):283-6.

PMID:
11091214
32.

Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.

Nicklin MJ, Hughes DE, Barton JL, Ure JM, Duff GW.

J Exp Med. 2000 Jan 17;191(2):303-12.

33.

Selectivity in human breast cancer and human bone marrow using trimetrexate in combination with 5-fluorouracil.

Bowen D, Johnson DH, Southerland WM, Hughes DE, Hawkins M Jr.

Anticancer Res. 1999 Sep-Oct;19(5B):3837-40.

PMID:
10628320
34.
35.

Recent advances in bone biology provide insight into the pathogenesis of bone diseases.

Boyce BF, Hughes DE, Wright KR, Xing L, Dai A.

Lab Invest. 1999 Feb;79(2):83-94. Review.

PMID:
10068197
36.

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro.

Fisher JE, Rogers MJ, Halasy JM, Luckman SP, Hughes DE, Masarachia PJ, Wesolowski G, Russell RG, Rodan GA, Reszka AA.

Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8.

37.

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ.

J Bone Miner Res. 1998 Apr;13(4):581-9.

38.

Interaction of swainsonine with lymphoid and highly perfused tissues: a pharmacokinetics explanation for sustained immunomodulation.

Bowen D, Southerland WM, Bowen CD, Hughes DE.

Anticancer Res. 1997 Nov-Dec;17(6D):4345-6.

PMID:
9494531
39.

Map positions of 47 Arabidopsis sequences with sequence similarity to disease resistance genes.

Botella MA, Coleman MJ, Hughes DE, Nishimura MT, Jones JD, Somerville SC.

Plant J. 1997 Nov;12(5):1197-211.

40.

Automated microanalysis using magnetic beads with commercial capillary electrophoretic instrumentation.

Rashkovetsky LG, Lyubarskaya YV, Foret F, Hughes DE, Karger BL.

J Chromatogr A. 1997 Sep 26;781(1-2):197-204.

PMID:
9368386
41.

Apoptosis in bone physiology and disease.

Hughes DE, Boyce BF.

Mol Pathol. 1997 Jun;50(3):132-7. Review. No abstract available.

42.
43.

Analysis and significance of anti-nuclear antibodies in dogs.

Bell SC, Hughes DE, Bennett D, Bari AS, Kelly DF, Carter SD.

Res Vet Sci. 1997 Jan-Feb;62(1):83-4.

PMID:
9160432
44.
45.

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.

Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF.

Nat Med. 1996 Oct;2(10):1132-6.

PMID:
8837613
46.

Analysis of human articular chondrocyte CD44 isoform expression and function in health and disease.

Salter DM, Godolphin JL, Gourlay MS, Lawson MF, Hughes DE, Dunne E.

J Pathol. 1996 Aug;179(4):396-402.

PMID:
8869287
47.
48.

A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates.

Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF.

J Bone Miner Res. 1996 Feb;11(2):150-9. Review. No abstract available.

PMID:
8822338
50.

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.

Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF.

J Bone Miner Res. 1995 Oct;10(10):1478-87.

PMID:
8686503

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