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When rural is no longer rural: Demand for subspecialty trained surgeons increases with increasing population of a non-metropolitan area.

Cook MR, Hughes D, Deal SB, Sarap MD, Hughes TG, Deveney KE, Brasel KJ, Alseidi AA.

Am J Surg. 2019 Jun 12. pii: S0002-9610(19)30504-5. doi: 10.1016/j.amjsurg.2019.06.004. [Epub ahead of print]


Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study.

Avenali M, Toffoli M, Mullin S, McNeil A, Hughes DA, Mehta A, Blandini F, Schapira AHV.

J Neurol Neurosurg Psychiatry. 2019 Jun 20. pii: jnnp-2019-320394. doi: 10.1136/jnnp-2019-320394. [Epub ahead of print]


Increasing Use, Geographic Variation, and Disparities in Emergency Department CT for Suspected Urolithiasis.

Balthazar P, Sadigh G, Hughes D, Rosenkrantz AB, Hanna T, Duszak R Jr.

J Am Coll Radiol. 2019 Jun 17. pii: S1546-1440(19)30630-1. doi: 10.1016/j.jacr.2019.05.033. [Epub ahead of print]


Comorbidity burden in axial spondyloarthritis: a cluster analysis.

Zhao SS, Radner H, Siebert S, Duffield SJ, Thong D, Hughes DM, Moots RJ, Solomon DH, Goodson NJ.

Rheumatology (Oxford). 2019 Apr 9. pii: kez119. doi: 10.1093/rheumatology/kez119. [Epub ahead of print]


Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy.

Li-Gao R, Hughes DA, le Cessie S, de Mutsert R, den Heijer M, Rosendaal FR, Willems van Dijk K, Timpson NJ, Mook-Kanamori DO.

PLoS One. 2019 Jun 20;14(6):e0218549. doi: 10.1371/journal.pone.0218549. eCollection 2019.


Constructing 'exceptionality': a neglected aspect of NHS rationing.

Hughes D, Doheny S.

Sociol Health Illn. 2019 Jun 20. doi: 10.1111/1467-9566.12976. [Epub ahead of print]


Rapidly rotating Rayleigh-Bénard convection with a tilted axis.

Novi L, von Hardenberg J, Hughes DW, Provenzale A, Spiegel EA.

Phys Rev E. 2019 May;99(5-1):053116. doi: 10.1103/PhysRevE.99.053116.


Inpatient Cross-Cover Consensus Recommendations for Medical and Surgical Residents: A Delphi Analysis.

Heidemann LA, Fitzgerald JT, Hughes DT, Hartley S.

J Grad Med Educ. 2019 Jun;11(3):277-283. doi: 10.4300/JGME-D-18-00707.1.


Response: To statistical significance and beyond.

Zhao SS, Hughes DM.

Clin Rheumatol. 2019 Jun 15. doi: 10.1007/s10067-019-04630-1. [Epub ahead of print] No abstract available.


Analysis of paramyxovirus transcription and replication by high-throughput sequencing.

Wignall-Fleming EB, Hughes DJ, Vattipally S, Modha S, Goodbourn S, Davison AJ, Randall RE.

J Virol. 2019 Jun 12. pii: JVI.00571-19. doi: 10.1128/JVI.00571-19. [Epub ahead of print]


Determining the Patient Complexity of Head CT Examinations: Implications for Proper Valuation of a Critical Imaging Service.

Chen MM, Hirsch JA, Lee RK, Hughes DR, Nicola GN, Rosenkrantz AB.

Curr Probl Diagn Radiol. 2019 May 10. pii: S0363-0188(19)30084-2. doi: 10.1067/j.cpradiol.2019.05.007. [Epub ahead of print]


Dynamic and game theory of infectious disease stigmas.

Reluga TC, Smith RA, Hughes DP.

J Theor Biol. 2019 Sep 7;476:95-107. doi: 10.1016/j.jtbi.2019.05.020. Epub 2019 May 30.


A randomised controlled trial evaluating arrhythmia burden, risk of sudden cardiac death and stroke in patients with Fabry disease: the role of implantable loop recorders (RaILRoAD) compared with current standard practice.

Vijapurapu R, Kozor R, Hughes DA, Woolfson P, Jovanovic A, Deegan P, Rusk R, Figtree GA, Tchan M, Whalley D, Kotecha D, Leyva F, Moon J, Geberhiwot T, Steeds RP.

Trials. 2019 May 31;20(1):314. doi: 10.1186/s13063-019-3425-1.


Expansion of Dental Care for Low-Income Children Through a Mobile Services Program.

Spetz J, Pourat N, Chen X, Lee C, Martinez A, Xin K, Hughes D.

J Sch Health. 2019 May 29. doi: 10.1111/josh.12789. [Epub ahead of print]


Rapid Scotch Whisky Analysis and Authentication using Desorption Atmospheric Pressure Chemical Ionisation Mass Spectrometry.

Smith BL, Hughes DM, Badu-Tawiah AK, Eccles R, Goodall I, Maher S.

Sci Rep. 2019 May 29;9(1):7994. doi: 10.1038/s41598-019-44456-0.


Transcatheter Dialysis Conduit Procedures: Changing National and State-Level Medicare Use Patterns over 15 Years.

Chiarello MA, Duszak R Jr, Hemingway J, Hughes DR, Patel A, Rosenkrantz AB.

J Vasc Interv Radiol. 2019 May 24. pii: S1051-0443(19)30366-5. doi: 10.1016/j.jvir.2019.03.019. [Epub ahead of print]


Operon concatenation is an ancient feature that restricts the potential to rearrange bacterial chromosomes.

Brandis G, Cao S, Hughes D.

Mol Biol Evol. 2019 May 27. pii: msz129. doi: 10.1093/molbev/msz129. [Epub ahead of print]


UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy.

Seaborne RA, Hughes DC, Turner DC, Owens DJ, Baehr LM, Gorski P, Semenova EA, Borisov OV, Larin AK, Popov DV, Generozov EV, Sutherland H, Ahmetov II, Jarvis JC, Bodine SC, Sharples AP.

J Physiol. 2019 May 15. doi: 10.1113/JP278073. [Epub ahead of print]


International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O'Keefe SJ, Gaskins HR, Teare J, Yu J, Hughes DJ, Verstraelen H, Burton J, O'Toole PW, Rosenberg DW, Marchesi JR, Kinross JM.

Gut. 2019 May 15. pii: gutjnl-2019-318556. doi: 10.1136/gutjnl-2019-318556. [Epub ahead of print]


What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK.

Ring A, Jacoby A, Baker G, Holmes E, Hughes D, Kierans C, Marson A.

Epilepsy Behav. 2019 Jun;95:181-191. doi: 10.1016/j.yebeh.2019.03.033. Epub 2019 May 6.


Management of Staple Line Leaks Following Sleeve Gastrectomy-a Systematic Review.

Hughes D, Hughes I, Khanna A.

Obes Surg. 2019 May 6. doi: 10.1007/s11695-019-03896-3. [Epub ahead of print]


Ant colonies maintain social homeostasis in the face of decreased density.

Modlmeier AP, Colman E, Hanks EM, Bringenberg R, Bansal S, Hughes DP.

Elife. 2019 May 2;8. pii: e38473. doi: 10.7554/eLife.38473.


Nationwide Trends in Use of Catheter-Directed Therapy for Treatment of Pulmonary Embolism in Medicare Beneficiaries from 2004 to 2016.

Gayou EL, Makary MS, Hughes DR, Hemingway J, Elliott ED, Spain JW, Prevedello LM.

J Vasc Interv Radiol. 2019 Jun;30(6):801-806. doi: 10.1016/j.jvir.2019.02.024. Epub 2019 Apr 27.


Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT.

Ramanan AV, Dick AD, Jones AP, Hughes DA, McKay A, Rosala-Hallas A, Williamson PR, Hardwick B, Hickey H, Rainford N, Hickey G, Kolamunnage-Dona R, Culeddu G, Plumpton C, Wood E, Compeyrot-Lacassagne S, Woo P, Edelsten C, Beresford MW.

Health Technol Assess. 2019 Apr;23(15):1-140. doi: 10.3310/hta23150.


Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.

Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, Siddiq A, Hybsier S, Overvad K, Tjønneland A, Omichessan H, Perduca V, Boutron-Ruault MC, Kühn T, Katzke V, Aleksandrova K, Trichopoulou A, Karakatsani A, Kotanidou A, Tumino R, Panico S, Masala G, Agnoli C, Naccarati A, Bueno-de-Mesquita B, Vermeulen RCH, Weiderpass E, Skeie G, Nøst TH, Lujan-Barroso L, Quirós JR, Huerta JM, Rodríguez-Barranco M, Barricarte A, Gylling B, Harlid S, Bradbury KE, Wareham N, Khaw KT, Gunter M, Murphy N, Freisling H, Tsilidis K, Aune D, Riboli E, Hesketh JE, Hughes DJ.

Nutrients. 2019 Apr 25;11(4). pii: E935. doi: 10.3390/nu11040935.


There's a frog in my salad! A review of online media coverage for wild vertebrates found in prepackaged produce in the United States.

Hughes DF, Green ML, Warner JK, Davidson PC.

Sci Total Environ. 2019 Jul 20;675:1-12. doi: 10.1016/j.scitotenv.2019.03.254. Epub 2019 Mar 19. Review.


Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus.

Crudgington H, Rogers M, Bray L, Carter B, Currier J, Dunkley C, Gibbon FM, Hughes D, Lyle S, Roberts D, Tudur Smith C, Gringras P, Pal DK, Morris C.

Epilepsia. 2019 May;60(5):857-871. doi: 10.1111/epi.14735. Epub 2019 Apr 25.


Smoking does not protect patients with axial spondyloarthritis from attacks of uveitis.

Zhao SS, Macfarlane GJ, Jones GT, Gaffney K, Hughes DM, Moots RJ, Goodson NJ.

Ann Rheum Dis. 2019 Apr 20. pii: annrheumdis-2019-215348. doi: 10.1136/annrheumdis-2019-215348. [Epub ahead of print] No abstract available.


Vitamin D Trends in the Pediatric Orthopaedic Population: A Survey.

Williams K, Hughes D, Horan M.

J Pediatr Orthop. 2019 Apr 16. doi: 10.1097/BPO.0000000000001394. [Epub ahead of print]


Evolutionary history of burrowing asps (Lamprophiidae: Atractaspidinae) with emphasis on fang evolution and prey selection.

Portillo F, Stanley EL, Branch WR, Conradie W, Rödel MO, Penner J, Barej MF, Kusamba C, Muninga WM, Aristote MM, Bauer AM, Trape JF, Nagy ZT, Carlino P, Pauwels OSG, Menegon M, Ineich I, Burger M, Zassi-Boulou AG, Mazuch T, Jackson K, Hughes DF, Behangana M, Greenbaum E.

PLoS One. 2019 Apr 17;14(4):e0214889. doi: 10.1371/journal.pone.0214889. eCollection 2019. Erratum in: PLoS One. 2019 May 13;14(5):e0217035.


Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout.

Hill-McManus D, Marshall S, Soto E, Hughes DA.

Clin Pharmacol Ther. 2019 Apr 16. doi: 10.1002/cpt.1454. [Epub ahead of print]


Intraoperative parathyroid hormone levels ≤40 pg/mL are associated with the lowest persistence rates after parathyroidectomy for primary hyperparathyroidism.

Claflin J, Dhir A, Espinosa NM, Antunez AG, Cohen MS, Gauger PG, Miller BS, Hughes DT.

Surgery. 2019 Jul;166(1):50-54. doi: 10.1016/j.surg.2019.01.024. Epub 2019 Apr 8.


Improving Medication Adherence Research Reporting: European Society for Patient Adherence, Compliance and Persistence Medication Adherence Reporting Guideline.

De Geest S, Zullig LL, Dunbar-Jacob J, Hughes D, Wilson IB, Vrijens B.

J Cardiovasc Nurs. 2019 May/Jun;34(3):199-200. doi: 10.1097/JCN.0000000000000572. No abstract available.


A profile of health, lifestyle and training habits of 4720 Australian recreational runners-The case for promoting running for health benefits.

Kozlovskaia M, Vlahovich N, Rathbone E, Manzanero S, Keogh J, Hughes DC.

Health Promot J Austr. 2019 Apr;30(2):172-179. doi: 10.1002/hpja.30. Epub 2018 Jan 31.


Seasonal variations of Google searches for joint swelling: implications for patient-reported outcomes.

Zhao S, Duffield SJ, Hughes DM.

Clin Rheumatol. 2019 Jun;38(6):1791-1792. doi: 10.1007/s10067-019-04534-0. Epub 2019 Apr 11. No abstract available.


Basic LEUCINE ZIPPER TRANSCRIPTION FACTOR67 Transactivates DELAY OF GERMINATION1 to Establish Primary Seed Dormancy in Arabidopsis.

Bryant FM, Hughes D, Hassani-Pak K, Eastmond PJ.

Plant Cell. 2019 Jun;31(6):1276-1288. doi: 10.1105/tpc.18.00892. Epub 2019 Apr 8.


A Mobile-Based Deep Learning Model for Cassava Disease Diagnosis.

Ramcharan A, McCloskey P, Baranowski K, Mbilinyi N, Mrisho L, Ndalahwa M, Legg J, Hughes DP.

Front Plant Sci. 2019 Mar 20;10:272. doi: 10.3389/fpls.2019.00272. eCollection 2019.


Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.

Blair JC, McKay A, Ridyard C, Thornborough K, Bedson E, Peak M, Didi M, Annan F, Gregory JW, Hughes DA, Gamble C; SCIPI investigators.

BMJ. 2019 Apr 3;365:l1226. doi: 10.1136/bmj.l1226.


Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome.

Panfilio KA, Vargas Jentzsch IM, Benoit JB, Erezyilmaz D, Suzuki Y, Colella S, Robertson HM, Poelchau MF, Waterhouse RM, Ioannidis P, Weirauch MT, Hughes DST, Murali SC, Werren JH, Jacobs CGC, Duncan EJ, Armisén D, Vreede BMI, Baa-Puyoulet P, Berger CS, Chang CC, Chao H, Chen MM, Chen YT, Childers CP, Chipman AD, Cridge AG, Crumière AJJ, Dearden PK, Didion EM, Dinh H, Doddapaneni HV, Dolan A, Dugan S, Extavour CG, Febvay G, Friedrich M, Ginzburg N, Han Y, Heger P, Holmes CJ, Horn T, Hsiao YM, Jennings EC, Johnston JS, Jones TE, Jones JW, Khila A, Koelzer S, Kovacova V, Leask M, Lee SL, Lee CY, Lovegrove MR, Lu HL, Lu Y, Moore PJ, Munoz-Torres MC, Muzny DM, Palli SR, Parisot N, Pick L, Porter ML, Qu J, Refki PN, Richter R, Rivera-Pomar R, Rosendale AJ, Roth S, Sachs L, Santos ME, Seibert J, Sghaier E, Shukla JN, Stancliffe RJ, Tidswell O, Traverso L, van der Zee M, Viala S, Worley KC, Zdobnov EM, Gibbs RA, Richards S.

Genome Biol. 2019 Apr 2;20(1):64. doi: 10.1186/s13059-019-1660-0.


State-Level Variation in Inferior Vena Cava Filter Utilization Across Medicare and Commercially Insured Populations.

Kishore D, Horný M, Rosenkrantz AB, Hemingway J, Hughes DR, Duszak R Jr.

AJR Am J Roentgenol. 2019 Apr 1:1-8. doi: 10.2214/AJR.18.20673. [Epub ahead of print]


Safety of switching to Migalastat from enzyme replacement therapy in Fabry disease: Experience from the Phase 3 ATTRACT study.

Hughes DA, Nicholls K, Sunder-Plassmann G, Jovanovic A, Feldt-Rasmussen U, Schiffmann R, Giugliani R, Jain V, Viereck C, Castelli JP, Skuban N, Barth JA, Bichet DG.

Am J Med Genet A. 2019 Jun;179(6):1069-1073. doi: 10.1002/ajmg.a.61105. Epub 2019 Mar 28. No abstract available.


Is There a Difference in Sonographic Estimation of Amniotic Fluid Volume When Measuring With the Probe Perpendicular to the Floor Compared With Perpendicular to the Uterine Contour?

Hughes DS, Whittington JR, Kim H, Gunderman B, Ounpraseuth S, Magann EF.

J Obstet Gynaecol Can. 2019 Mar 22. pii: S1701-2163(19)30033-7. doi: 10.1016/j.jogc.2019.01.017. [Epub ahead of print]


Identifying patients who will not reachieve remission after breakthrough seizures.

Hughes DM, Bonnett LJ, Marson AG, García-Fiñana M.

Epilepsia. 2019 Apr;60(4):774-782. doi: 10.1111/epi.14697. Epub 2019 Mar 22.


Corrigendum: Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium.

Vestö K, Huseby DL, Snygg I, Wang H, Hughes D, Rhen M.

Front Microbiol. 2019 Mar 5;10:386. doi: 10.3389/fmicb.2019.00386. eCollection 2019.


Management of Unruptured Intracranial Aneurysms in Older Adults: A Cost-effectiveness Analysis.

Malhotra A, Wu X, Forman HP, Matouk CC, Hughes DR, Gandhi D, Sanelli P.

Radiology. 2019 May;291(2):411-417. doi: 10.1148/radiol.2019182353. Epub 2019 Mar 19.


De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes.

Vadgama N, Pittman A, Simpson M, Nirmalananthan N, Murray R, Yoshikawa T, De Rijk P, Rees E, Kirov G, Hughes D, Fitzgerald T, Kristiansen M, Pearce K, Cerveira E, Zhu Q, Zhang C, Lee C, Hardy J, Nasir J.

Eur J Hum Genet. 2019 Jul;27(7):1121-1133. doi: 10.1038/s41431-019-0376-7. Epub 2019 Mar 18.


The Role of Vitamin D in Pediatric Orthopedics.

Horan MP, Williams K, Hughes D.

Orthop Clin North Am. 2019 Apr;50(2):181-191. doi: 10.1016/j.ocl.2018.10.002. Review.


Pegunigalsidase alfa, a novel PEGylated enzyme replacement therapy for Fabry disease, provides sustained plasma concentrations and favorable pharmacodynamics: A 1-year Phase 1/2 clinical trial.

Schiffmann R, Goker-Alpan O, Holida M, Giraldo P, Barisoni L, Colvin RB, Jennette CJ, Maegawa G, Boyadjiev SA, Gonzalez D, Nicholls K, Tuffaha A, Atta MG, Rup B, Charney MR, Paz A, Szlaifer M, Alon S, Brill-Almon E, Chertkoff R, Hughes D.

J Inherit Metab Dis. 2019 May;42(3):534-544. doi: 10.1002/jimd.12080. Epub 2019 Apr 8.


Systematic review: outcomes and adverse events from randomised trials in Crohn's disease.

Catt H, Hughes D, Kirkham JJ, Bodger K.

Aliment Pharmacol Ther. 2019 Apr;49(8):978-996. doi: 10.1111/apt.15174. Epub 2019 Mar 3. Review.



Hughes DA, Culeddu G, Plumpton C, Wood E, Dick AD, Beresford MW, Ramanan AV.

Ophthalmology. 2019 Mar;126(3):e24-e25. doi: 10.1016/j.ophtha.2018.12.005. No abstract available.


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