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Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness in L. lactis SK11.

Dijkstra AR, Starrenburg MJC, Todt T, van Hijum SAFT, Hugenholtz J, Bron PA.

Front Microbiol. 2018 Oct 15;9:2418. doi: 10.3389/fmicb.2018.02418. eCollection 2018.


Strain-Dependent Transcriptome Signatures for Robustness in Lactococcus lactis.

Dijkstra AR, Alkema W, Starrenburg MJ, Hugenholtz J, van Hijum SA, Bron PA.

PLoS One. 2016 Dec 14;11(12):e0167944. doi: 10.1371/journal.pone.0167944. eCollection 2016.


Genome-scale reconstruction of the Streptococcus pyogenes M49 metabolic network reveals growth requirements and indicates potential drug targets.

Levering J, Fiedler T, Sieg A, van Grinsven KW, Hering S, Veith N, Olivier BG, Klett L, Hugenholtz J, Teusink B, Kreikemeyer B, Kummer U.

J Biotechnol. 2016 Aug 20;232:25-37. doi: 10.1016/j.jbiotec.2016.01.035. Epub 2016 Mar 10.


Polyol production during heterofermentative growth of the plant isolate Lactobacillus florum 2F.

Tyler CA, Kopit L, Doyle C, Yu AO, Hugenholtz J, Marco ML.

J Appl Microbiol. 2016 May;120(5):1336-45. doi: 10.1111/jam.13108. Epub 2016 Apr 4.


Using a genome-scale metabolic model of Enterococcus faecalis V583 to assess amino acid uptake and its impact on central metabolism.

Veith N, Solheim M, van Grinsven KW, Olivier BG, Levering J, Grosseholz R, Hugenholtz J, Holo H, Nes I, Teusink B, Kummer U.

Appl Environ Microbiol. 2015 Mar;81(5):1622-33. doi: 10.1128/AEM.03279-14. Epub 2014 Dec 19.


Use of non-growing Lactococcus lactis cell suspensions for production of volatile metabolites with direct relevance for flavour formation during dairy fermentations.

van de Bunt B, Bron PA, Sijtsma L, de Vos WM, Hugenholtz J.

Microb Cell Fact. 2014 Dec 10;13:176. doi: 10.1186/s12934-014-0176-2.


Fermentation-induced variation in heat and oxidative stress phenotypes of Lactococcus lactis MG1363 reveals transcriptome signatures for robustness.

Dijkstra AR, Alkema W, Starrenburg MJ, Hugenholtz J, van Hijum SA, Bron PA.

Microb Cell Fact. 2014 Nov 4;13:148. doi: 10.1186/s12934-014-0148-6.


Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress.

Dijkstra AR, Setyawati MC, Bayjanov JR, Alkema W, van Hijum SA, Bron PA, Hugenholtz J.

Appl Environ Microbiol. 2014 Jan;80(2):603-11. doi: 10.1128/AEM.03434-13. Epub 2013 Nov 8.


Food biotechnology.

Vaughan EE, Hugenholtz J.

Curr Opin Biotechnol. 2013 Apr;24(2):121-3. doi: 10.1016/j.copbio.2013.01.010. Epub 2013 Feb 14. No abstract available.


Traditional biotechnology for new foods and beverages.

Hugenholtz J.

Curr Opin Biotechnol. 2013 Apr;24(2):155-9. doi: 10.1016/j.copbio.2013.01.001. Epub 2013 Feb 8. Review.


Role of phosphate in the central metabolism of two lactic acid bacteria--a comparative systems biology approach.

Levering J, Musters MW, Bekker M, Bellomo D, Fiedler T, de Vos WM, Hugenholtz J, Kreikemeyer B, Kummer U, Teusink B.

FEBS J. 2012 Apr;279(7):1274-90. doi: 10.1111/j.1742-4658.2012.08523.x. Epub 2012 Mar 12.


Functional identification in Lactobacillus reuteri of a PocR-like transcription factor regulating glycerol utilization and vitamin B12 synthesis.

Santos F, Spinler JK, Saulnier DM, Molenaar D, Teusink B, de Vos WM, Versalovic J, Hugenholtz J.

Microb Cell Fact. 2011 Jul 21;10:55. doi: 10.1186/1475-2859-10-55.


Characterization of three lactic acid bacteria and their isogenic ldh deletion mutants shows optimization for YATP (cell mass produced per mole of ATP) at their physiological pHs.

Fiedler T, Bekker M, Jonsson M, Mehmeti I, Pritzschke A, Siemens N, Nes I, Hugenholtz J, Kreikemeyer B.

Appl Environ Microbiol. 2011 Jan;77(2):612-7. doi: 10.1128/AEM.01838-10. Epub 2010 Nov 19.


Understanding the physiology of Lactobacillus plantarum at zero growth.

Goffin P, van de Bunt B, Giovane M, Leveau JH, Höppener-Ogawa S, Teusink B, Hugenholtz J.

Mol Syst Biol. 2010 Sep 21;6:413. doi: 10.1038/msb.2010.67.


Risk assessment of genetically modified lactic acid bacteria using the concept of substantial equivalence.

LeBlanc JG, Van Sinderen D, Hugenholtz J, Piard JC, Sesma F, de Giori GS.

Curr Microbiol. 2010 Dec;61(6):590-5. doi: 10.1007/s00284-010-9657-7. Epub 2010 May 7.


High-level expression of Lactobacillus beta-galactosidases in Lactococcus lactis using the food-grade, nisin-controlled expression system NICE.

Maischberger T, Mierau I, Peterbauer CK, Hugenholtz J, Haltrich D.

J Agric Food Chem. 2010 Feb 24;58(4):2279-87. doi: 10.1021/jf902895g.


Functional genomics for food fermentation processes.

Smid EJ, Hugenholtz J.

Annu Rev Food Sci Technol. 2010;1:497-519. doi: 10.1146/ Review.


Supplementation with engineered Lactococcus lactis improves the folate status in deficient rats.

LeBlanc JG, Sybesma W, Starrenburg M, Sesma F, de Vos WM, de Giori GS, Hugenholtz J.

Nutrition. 2010 Jul-Aug;26(7-8):835-41. doi: 10.1016/j.nut.2009.06.023.


The evidence that pseudovitamin B(12) is biologically active in mammals is still lacking - a comment on Molina et al.'s (2009) experimental design.

Santos F, Teusink B, de Vos WM, Hugenholtz J.

J Appl Microbiol. 2009 Nov;107(5):1763; author reply 1764. doi: 10.1111/j.1365-2672.2009.04468.x. Epub 2009 Jul 13. No abstract available.


Heme and menaquinone induced electron transport in lactic acid bacteria.

Brooijmans R, Smit B, Santos F, van Riel J, de Vos WM, Hugenholtz J.

Microb Cell Fact. 2009 May 29;8:28. doi: 10.1186/1475-2859-8-28.


Effect of amino acid availability on vitamin B12 production in Lactobacillus reuteri.

Santos F, Teusink B, Molenaar D, van Heck M, Wels M, Sieuwerts S, de Vos WM, Hugenholtz J.

Appl Environ Microbiol. 2009 Jun;75(12):3930-6. doi: 10.1128/AEM.02487-08. Epub 2009 Apr 17.


Genome-scale model of Streptococcus thermophilus LMG18311 for metabolic comparison of lactic acid bacteria.

Pastink MI, Teusink B, Hols P, Visser S, de Vos WM, Hugenholtz J.

Appl Environ Microbiol. 2009 Jun;75(11):3627-33. doi: 10.1128/AEM.00138-09. Epub 2009 Apr 3.


Lactobacillus plantarum WCFS1 electron transport chains.

Brooijmans RJ, de Vos WM, Hugenholtz J.

Appl Environ Microbiol. 2009 Jun;75(11):3580-5. doi: 10.1128/AEM.00147-09. Epub 2009 Apr 3.


Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyle.

Brooijmans R, de Vos WM, Hugenholtz J.

F1000 Biol Rep. 2009 Apr 29;1:34. doi: 10.3410/B1-34.


9th International Symposium on Lactic Acid Bacteria.

Kuipers OP, Poolman B, Hugenholtz J.

Appl Environ Microbiol. 2008 Aug;74(15):4589. doi: 10.1128/AEM.01384-08. Epub 2008 Jun 27. No abstract available.


Unraveling microbial interactions in food fermentations: from classical to genomics approaches.

Sieuwerts S, de Bok FA, Hugenholtz J, van Hylckama Vlieg JE.

Appl Environ Microbiol. 2008 Aug;74(16):4997-5007. doi: 10.1128/AEM.00113-08. Epub 2008 Jun 20. Review. No abstract available.


High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112.

Santos F, Wegkamp A, de Vos WM, Smid EJ, Hugenholtz J.

Appl Environ Microbiol. 2008 May;74(10):3291-4. doi: 10.1128/AEM.02719-07. Epub 2008 Mar 14.


The complete coenzyme B12 biosynthesis gene cluster of Lactobacillus reuteri CRL1098.

Santos F, Vera JL, van der Heijden R, Valdez G, de Vos WM, Sesma F, Hugenholtz J.

Microbiology. 2008 Jan;154(Pt 1):81-93. doi: 10.1099/mic.0.2007/011569-0.


Folate biofortification in food plants.

Bekaert S, Storozhenko S, Mehrshahi P, Bennett MJ, Lambert W, Gregory JF 3rd, Schubert K, Hugenholtz J, Van Der Straeten D, Hanson AD.

Trends Plant Sci. 2008 Jan;13(1):28-35. Epub 2007 Dec 20. Review.


Diversity analysis of dairy and nondairy Lactococcus lactis isolates, using a novel multilocus sequence analysis scheme and (GTG)5-PCR fingerprinting.

Rademaker JL, Herbet H, Starrenburg MJ, Naser SM, Gevers D, Kelly WJ, Hugenholtz J, Swings J, van Hylckama Vlieg JE.

Appl Environ Microbiol. 2007 Nov;73(22):7128-37. Epub 2007 Sep 21.


Pseudovitamin B(12) is the corrinoid produced by Lactobacillus reuteri CRL1098 under anaerobic conditions.

Santos F, Vera JL, Lamosa P, de Valdez GF, de Vos WM, Santos H, Sesma F, Hugenholtz J.

FEBS Lett. 2007 Oct 16;581(25):4865-70. Epub 2007 Sep 17.


Glutathione protects Lactococcus lactis against acid stress.

Zhang J, Fu RY, Hugenholtz J, Li Y, Chen J.

Appl Environ Microbiol. 2007 Aug;73(16):5268-75. Epub 2007 Jun 29.


Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.

Brooijmans RJ, Poolman B, Schuurman-Wolters GK, de Vos WM, Hugenholtz J.

J Bacteriol. 2007 Jul;189(14):5203-9. Epub 2007 May 11.


High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering.

Ladero V, Ramos A, Wiersma A, Goffin P, Schanck A, Kleerebezem M, Hugenholtz J, Smid EJ, Hols P.

Appl Environ Microbiol. 2007 Mar;73(6):1864-72. Epub 2007 Jan 19.


Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host.

Fu RY, Bongers RS, van Swam II, Chen J, Molenaar D, Kleerebezem M, Hugenholtz J, Li Y.

Metab Eng. 2006 Nov;8(6):662-71. Epub 2006 Aug 4.


Metabolic models for rational improvement of lactic acid bacteria as cell factories.

Smid EJ, van Enckevort FJ, Wegkamp A, Boekhorst J, Molenaar D, Hugenholtz J, Siezen RJ, Teusink B.

J Appl Microbiol. 2005;98(6):1326-31. Review. No abstract available.


Functional ingredient production: application of global metabolic models.

Smid EJ, Molenaar D, Hugenholtz J, de Vos WM, Teusink B.

Curr Opin Biotechnol. 2005 Apr;16(2):190-7. Review.


Overproduction of heterologous mannitol 1-phosphatase: a key factor for engineering mannitol production by Lactococcus lactis.

Wisselink HW, Moers AP, Mars AE, Hoefnagel MH, de Vos WM, Hugenholtz J.

Appl Environ Microbiol. 2005 Mar;71(3):1507-14.


A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants.

Klaus SM, Wegkamp A, Sybesma W, Hugenholtz J, Gregory JF 3rd, Hanson AD.

J Biol Chem. 2005 Feb 18;280(7):5274-80. Epub 2004 Dec 16.


Using Lactococcus lactis for glutathione overproduction.

Li Y, Hugenholtz J, Sybesma W, Abee T, Molenaar D.

Appl Microbiol Biotechnol. 2005 Apr;67(1):83-90. Epub 2004 Oct 13.


Riboflavin production in Lactococcus lactis: potential for in situ production of vitamin-enriched foods.

Burgess C, O'connell-Motherway M, Sybesma W, Hugenholtz J, van Sinderen D.

Appl Environ Microbiol. 2004 Oct;70(10):5769-77.


Expression of Sulfolobus solfataricus alpha-glucosidase in Lactococcus lactis.

Giuliano M, Schiraldi C, Marotta MR, Hugenholtz J, De Rosa M.

Appl Microbiol Biotechnol. 2004 Jun;64(6):829-32. Epub 2004 Feb 20.


Transformation of folate-consuming Lactobacillus gasseri into a folate producer.

Wegkamp A, Starrenburg M, de Vos WM, Hugenholtz J, Sybesma W.

Appl Environ Microbiol. 2004 May;70(5):3146-8.


Multivitamin production in Lactococcus lactis using metabolic engineering.

Sybesma W, Burgess C, Starrenburg M, van Sinderen D, Hugenholtz J.

Metab Eng. 2004 Apr;6(2):109-15.


Enhancement of trehalose production in dairy propionibacteria through manipulation of environmental conditions.

Cardoso FS, Gaspar P, Hugenholtz J, Ramos A, Santos H.

Int J Food Microbiol. 2004 Mar 1;91(2):195-204.


Engineering metabolic highways in Lactococci and other lactic acid bacteria.

de Vos WM, Hugenholtz J.

Trends Biotechnol. 2004 Feb;22(2):72-9. Review.


Controlled modulation of folate polyglutamyl tail length by metabolic engineering of Lactococcus lactis.

Sybesma W, Van Den Born E, Starrenburg M, Mierau I, Kleerebezem M, De Vos WM, Hugenholtz J.

Appl Environ Microbiol. 2003 Dec;69(12):7101-7.


Glutathione protects Lactococcus lactis against oxidative stress.

Li Y, Hugenholtz J, Abee T, Molenaar D.

Appl Environ Microbiol. 2003 Oct;69(10):5739-45.

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