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Items: 1 to 50 of 62

1.

Opposing Temperature Dependence of the Stretching Response of Single PEG and PNiPAM Polymers.

Kolberg A, Wenzel C, Hackenstrass K, Schwarzl R, Rüttiger C, Hugel T, Gallei M, Netz RR, Balzer BN.

J Am Chem Soc. 2019 Jul 24;141(29):11603-11613. doi: 10.1021/jacs.9b04383. Epub 2019 Jul 15.

PMID:
31240903
2.

AFM Imaging Suggests Receptor-Free Penetration of Lipid Bilayers by Toxins.

Brander S, Jank T, Hugel T.

Langmuir. 2019 Jan 15;35(2):365-371. doi: 10.1021/acs.langmuir.8b03146. Epub 2019 Jan 2.

PMID:
30565941
3.

Kinetics of Transient Protein Complexes Determined via Diffusion-Independent Microfluidic Mixing and Fluorescence Stoichiometry.

Hellenkamp B, Thurn J, Stadlmeier M, Hugel T.

J Phys Chem B. 2018 Dec 13;122(49):11554-11560. doi: 10.1021/acs.jpcb.8b07437. Epub 2018 Oct 24.

4.

Publisher Correction: Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study.

Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Adariani SR, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T.

Nat Methods. 2018 Nov;15(11):984. doi: 10.1038/s41592-018-0193-x.

PMID:
30327572
5.

Conformational Dynamics of a Single Protein Monitored for 24 h at Video Rate.

Ye W, Götz M, Celiksoy S, Tüting L, Ratzke C, Prasad J, Ricken J, Wegner SV, Ahijado-Guzmán R, Hugel T, Sönnichsen C.

Nano Lett. 2018 Oct 10;18(10):6633-6637. doi: 10.1021/acs.nanolett.8b03342. Epub 2018 Sep 25.

6.

Nucleotide-Dependent Dimer Association and Dissociation of the Chaperone Hsp90.

Tych KM, Jahn M, Gegenfurtner F, Hechtl VK, Buchner J, Hugel T, Rief M.

J Phys Chem B. 2018 Dec 13;122(49):11373-11380. doi: 10.1021/acs.jpcb.8b07301. Epub 2018 Sep 13.

PMID:
30179494
7.

Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study.

Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Rezaei Adariani S, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T.

Nat Methods. 2018 Sep;15(9):669-676. doi: 10.1038/s41592-018-0085-0. Epub 2018 Aug 31. Erratum in: Nat Methods. 2018 Nov;15(11):984.

8.

Effects of Inhibitors on Hsp90's Conformational Dynamics, Cochaperone and Client Interactions.

Schmid S, Götz M, Hugel T.

Chemphyschem. 2018 Jul 17;19(14):1716-1721. doi: 10.1002/cphc.201800342. Epub 2018 May 25.

9.

Efficient use of single molecule time traces to resolve kinetic rates, models and uncertainties.

Schmid S, Hugel T.

J Chem Phys. 2018 Mar 28;148(12):123312. doi: 10.1063/1.5006604.

10.

Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions.

Götz M, Wortmann P, Schmid S, Hugel T.

J Vis Exp. 2018 Jan 30;(131). doi: 10.3791/56896.

PMID:
29443086
11.

Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy.

Jahn M, Tych K, Girstmair H, Steinmaßl M, Hugel T, Buchner J, Rief M.

Structure. 2018 Jan 2;26(1):96-105.e4. doi: 10.1016/j.str.2017.11.023. Epub 2017 Dec 21.

12.

Does similarity in call structure or foraging ecology explain interspecific information transfer in wild Myotis bats?

Hügel T, van Meir V, Muñoz-Meneses A, Clarin BM, Siemers BM, Goerlitz HR.

Behav Ecol Sociobiol. 2017;71(11):168. doi: 10.1007/s00265-017-2398-x. Epub 2017 Oct 29.

13.

Cooperative Nucleotide Binding in Hsp90 and Its Regulation by Aha1.

Wortmann P, Götz M, Hugel T.

Biophys J. 2017 Oct 17;113(8):1711-1718. doi: 10.1016/j.bpj.2017.08.032.

14.

Hydration Effects Turn a Highly Stretched Polymer from an Entropic into an Energetic Spring.

Liese S, Gensler M, Krysiak S, Schwarzl R, Achazi A, Paulus B, Hugel T, Rabe JP, Netz RR.

ACS Nano. 2017 Jan 24;11(1):702-712. doi: 10.1021/acsnano.6b07071. Epub 2016 Dec 21.

PMID:
27977927
15.

Multidomain structure and correlated dynamics determined by self-consistent FRET networks.

Hellenkamp B, Wortmann P, Kandzia F, Zacharias M, Hugel T.

Nat Methods. 2017 Feb;14(2):174-180. doi: 10.1038/nmeth.4081. Epub 2016 Dec 5.

16.

A Multicolor Single-Molecule FRET Approach to Study Protein Dynamics and Interactions Simultaneously.

Götz M, Wortmann P, Schmid S, Hugel T.

Methods Enzymol. 2016;581:487-516. doi: 10.1016/bs.mie.2016.08.024. Epub 2016 Oct 10.

PMID:
27793290
17.

Single-Molecule Analysis beyond Dwell Times: Demonstration and Assessment in and out of Equilibrium.

Schmid S, Götz M, Hugel T.

Biophys J. 2016 Oct 4;111(7):1375-1384. doi: 10.1016/j.bpj.2016.08.023.

18.

Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments.

Jahn M, Buchner J, Hugel T, Rief M.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1232-7. doi: 10.1073/pnas.1518827113. Epub 2016 Jan 19.

19.

Mechanism of Reversible Peptide-Bilayer Attachment: Combined Simulation and Experimental Single-Molecule Study.

Schwierz N, Krysiak S, Hugel T, Zacharias M.

Langmuir. 2016 Jan 26;32(3):810-21. doi: 10.1021/acs.langmuir.5b03435. Epub 2016 Jan 12.

PMID:
26717083
20.

The structure and mechanical properties of articular cartilage are highly resilient towards transient dehydration.

Boettcher K, Kienle S, Nachtsheim J, Burgkart R, Hugel T, Lieleg O.

Acta Biomater. 2016 Jan;29:180-187. doi: 10.1016/j.actbio.2015.09.034. Epub 2015 Sep 30.

PMID:
26432435
21.

Comparison of friction and wear of articular cartilage on different length scales.

Kienle S, Boettcher K, Wiegleb L, Urban J, Burgkart R, Lieleg O, Hugel T.

J Biomech. 2015 Sep 18;48(12):3052-8. doi: 10.1016/j.jbiomech.2015.07.027. Epub 2015 Aug 7.

PMID:
26294356
22.

Adsorption mechanism and valency of catechol-functionalized hyperbranched polyglycerols.

Krysiak S, Wei Q, Rischka K, Hartwig A, Haag R, Hugel T.

Beilstein J Org Chem. 2015 May 18;11:828-36. doi: 10.3762/bjoc.11.92. eCollection 2015.

23.

Investigating single molecule adhesion by atomic force spectroscopy.

Stetter FW, Kienle S, Krysiak S, Hugel T.

J Vis Exp. 2015 Feb 27;(96):e52456. doi: 10.3791/52456.

24.

The Hsp90 ensemble: coordinated Hsp90-cochaperone complexes regulate diverse cellular processes.

Schwenkert S, Hugel T, Cox MB.

Nat Struct Mol Biol. 2014 Dec;21(12):1017-21. doi: 10.1038/nsmb.2927. No abstract available.

PMID:
25469839
25.

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function.

Jahn M, Rehn A, Pelz B, Hellenkamp B, Richter K, Rief M, Buchner J, Hugel T.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17881-6. doi: 10.1073/pnas.1414073111. Epub 2014 Dec 2.

26.

Multivalent anchored and crosslinked hyperbranched polyglycerol monolayers as antifouling coating for titanium oxide surfaces.

Wei Q, Krysiak S, Achazi K, Becherer T, Noeske PM, Paulus F, Liebe H, Grunwald I, Dernedde J, Hartwig A, Hugel T, Haag R.

Colloids Surf B Biointerfaces. 2014 Oct 1;122:684-692. doi: 10.1016/j.colsurfb.2014.08.001. Epub 2014 Aug 10.

PMID:
25189471
27.

Single lipid extraction: the anchoring strength of cholesterol in liquid-ordered and liquid-disordered phases.

Stetter FWS, Cwiklik L, Jungwirth P, Hugel T.

Biophys J. 2014 Sep 2;107(5):1167-1175. doi: 10.1016/j.bpj.2014.07.018.

28.

Highly hydrated deformable polyethylene glycol-tethered lipid bilayers.

Hertrich S, Stetter F, Rühm A, Hugel T, Nickel B.

Langmuir. 2014 Aug 12;30(31):9442-7. doi: 10.1021/la4045804. Epub 2014 Jul 30.

PMID:
25046694
29.

Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery.

Ratzke C, Hellenkamp B, Hugel T.

Nat Commun. 2014 Jun 20;5:4192. doi: 10.1038/ncomms5192.

PMID:
24947016
30.

Effect of molecular architecture on single polymer adhesion.

Kienle S, Gallei M, Yu H, Zhang B, Krysiak S, Balzer BN, Rehahn M, Schlüter AD, Hugel T.

Langmuir. 2014 Apr 22;30(15):4351-7. doi: 10.1021/la500783n. Epub 2014 Apr 8.

PMID:
24679005
31.

Nucleotides and substrates trigger the dynamics of the Toc34 GTPase homodimer involved in chloroplast preprotein translocation.

Lumme C, Altan-Martin H, Dastvan R, Sommer MS, Oreb M, Schuetz D, Hellenkamp B, Mirus O, Kretschmer J, Lyubenova S, Kügel W, Medelnik JP, Dehmer M, Michaelis J, Prisner TF, Hugel T, Schleiff E.

Structure. 2014 Apr 8;22(4):526-38. doi: 10.1016/j.str.2014.02.004. Epub 2014 Mar 13.

32.

Peptide desorption kinetics from single molecule force spectroscopy studies.

Krysiak S, Liese S, Netz RR, Hugel T.

J Am Chem Soc. 2014 Jan 15;136(2):688-97. doi: 10.1021/ja410278r. Epub 2014 Jan 3.

PMID:
24328353
33.

Measuring the interaction between ions, biopolymers and interfaces--one polymer at a time.

Kienle S, Pirzer T, Krysiak S, Geisler M, Hugel T.

Faraday Discuss. 2013;160:329-40; discussion 389-403.

PMID:
23795508
34.

Adhesion property profiles of supported thin polymer films.

Balzer BN, Micciulla S, Dodoo S, Zerball M, Gallei M, Rehahn M, V Klitzing R, Hugel T.

ACS Appl Mater Interfaces. 2013 Jul 10;5(13):6300-6. doi: 10.1021/am4013424. Epub 2013 Jun 20.

PMID:
23738613
35.

Nanoscale friction mechanisms at solid-liquid interfaces.

Balzer BN, Gallei M, Hauf MV, Stallhofer M, Wiegleb L, Holleitner A, Rehahn M, Hugel T.

Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6541-4. doi: 10.1002/anie.201301255. Epub 2013 May 10. No abstract available.

PMID:
23666899
36.

The nanomechanical properties of lipid membranes are significantly influenced by the presence of ethanol.

Stetter FW, Hugel T.

Biophys J. 2013 Mar 5;104(5):1049-55. doi: 10.1016/j.bpj.2013.01.021.

37.

On the relationship between peptide adsorption resistance and surface contact angle: a combined experimental and simulation single-molecule study.

Schwierz N, Horinek D, Liese S, Pirzer T, Balzer BN, Hugel T, Netz RR.

J Am Chem Soc. 2012 Dec 5;134(48):19628-38. doi: 10.1021/ja304462u. Epub 2012 Nov 19.

PMID:
23101566
38.

From a ratchet mechanism to random fluctuations evolution of Hsp90's mechanochemical cycle.

Ratzke C, Nguyen MN, Mayer MP, Hugel T.

J Mol Biol. 2012 Oct 26;423(3):462-71. doi: 10.1016/j.jmb.2012.07.026. Epub 2012 Aug 6.

PMID:
22878379
39.

The effect of temperature on single-polypeptide adsorption.

Kienle S, Liese S, Schwierz N, Netz RR, Hugel T.

Chemphyschem. 2012 Mar;13(4):982-9. doi: 10.1002/cphc.201100776. Epub 2012 Jan 31.

PMID:
22290722
40.

Heat shock protein 90's mechanochemical cycle is dominated by thermal fluctuations.

Ratzke C, Berkemeier F, Hugel T.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):161-6. doi: 10.1073/pnas.1107930108. Epub 2011 Dec 19.

41.

[Effect of a synthetic GnRF vaccine (Improvac®) on daily weight gain and carcass quality of boars. A field trial in Bavaria].

Hügel T, Zöls S, Palzer A, Kaufmann S, Langhoff R, Ritzmann M, Heinritzi K.

Tierarztl Prax Ausg G Grosstiere Nutztiere. 2011;39(6):353-7. German.

PMID:
22167079
42.

Regulatory posttranslational modifications in hsp90 can be compensated by cochaperone aha1.

Schmid S, Hugel T.

Mol Cell. 2011 Mar 18;41(6):619-20. doi: 10.1016/j.molcel.2011.02.028.

43.

Controlling the structure of proteins at surfaces.

Geisler M, Xiao S, Puchner EM, Gräter F, Hugel T.

J Am Chem Soc. 2010 Dec 8;132(48):17277-81. doi: 10.1021/ja107212z. Epub 2010 Nov 16.

PMID:
21080669
44.

Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle.

Ratzke C, Mickler M, Hellenkamp B, Buchner J, Hugel T.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16101-6. doi: 10.1073/pnas.1000916107. Epub 2010 Aug 24.

45.

Bio-inspired novel design principles for artificial molecular motors.

Hugel T, Lumme C.

Curr Opin Biotechnol. 2010 Oct;21(5):683-9. doi: 10.1016/j.copbio.2010.06.003. Epub 2010 Jul 16. Review.

PMID:
20637594
46.

Polymer carpets.

Amin I, Steenackers M, Zhang N, Beyer A, Zhang X, Pirzer T, Hugel T, Jordan R, Gölzhäuser A.

Small. 2010 Aug 2;6(15):1623-30. doi: 10.1002/smll.201000448.

PMID:
20635346
47.

Pulling a single polymer molecule off a substrate reveals the binding thermodynamics of cosolutes.

Geisler M, Netz RR, Hugel T.

Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4730-3. doi: 10.1002/anie.200907098. No abstract available.

PMID:
20514652
48.

Aging of hydrogenated and oxidized diamond.

Geisler M, Hugel T.

Adv Mater. 2010 Jan 19;22(3):398-402. doi: 10.1002/adma.200902198. No abstract available.

PMID:
20217727
49.

Polymer adhesion at the solid-liquid interface probed by a single-molecule force sensor.

Geisler M, Balzer BN, Hugel T.

Small. 2009 Dec;5(24):2864-9. doi: 10.1002/smll.200901237.

PMID:
19882687
50.

Adsorption mechanism of polypeptides and their location at hydrophobic interfaces.

Pirzer T, Hugel T.

Chemphyschem. 2009 Nov 9;10(16):2795-9. doi: 10.1002/cphc.200900574.

PMID:
19830772

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