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Items: 1 to 50 of 338

1.

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M.

Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.

PMID:
31171447
2.

The AMPA Receptor Code of Synaptic Plasticity.

Diering GH, Huganir RL.

Neuron. 2018 Oct 24;100(2):314-329. doi: 10.1016/j.neuron.2018.10.018. Review.

PMID:
30359599
3.

Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities.

Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J.

Nat Cell Biol. 2018 Oct;20(10):1215-1225. doi: 10.1038/s41556-018-0200-6. Epub 2018 Sep 24.

4.

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.

Lin EYS, Silvian LF, Marcotte DJ, Banos CC, Jow F, Chan TR, Arduini RM, Qian F, Baker DP, Bergeron C, Hession CA, Huganir RL, Borenstein CF, Enyedy I, Zou J, Rohde E, Wittmann M, Kumaravel G, Rhodes KJ, Scannevin RH, Dunah AW, Guckian KM.

Sci Rep. 2018 Sep 7;8(1):13438. doi: 10.1038/s41598-018-31680-3.

5.

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.

Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Kato T, Araki Y, Huganir RL, Dawson TM, Yanagawa T, Okamoto K, Iijima M, Sesaki H.

Cell Metab. 2018 Oct 2;28(4):588-604.e5. doi: 10.1016/j.cmet.2018.06.014. Epub 2018 Jul 12.

PMID:
30017357
6.

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.

Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, Zhang M, Xiao J, Crespo P, Hell JW, Lin L, Huganir RL, Zhu JJ.

Neuron. 2018 May 16;98(4):783-800.e4. doi: 10.1016/j.neuron.2018.03.049. Epub 2018 Apr 26.

7.

Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover.

Heo S, Diering GH, Na CH, Nirujogi RS, Bachman JL, Pandey A, Huganir RL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3827-E3836. doi: 10.1073/pnas.1720956115. Epub 2018 Apr 2.

8.

BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation.

Kim DI, Cutler JA, Na CH, Reckel S, Renuse S, Madugundu AK, Tahir R, Goldschmidt HL, Reddy KL, Huganir RL, Wu X, Zachara NE, Hantschel O, Pandey A.

J Proteome Res. 2018 Feb 2;17(2):759-769. doi: 10.1021/acs.jproteome.7b00775. Epub 2017 Dec 28.

9.

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons.

Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL.

Neuron. 2017 Dec 6;96(5):1084-1098.e7. doi: 10.1016/j.neuron.2017.10.029. Epub 2017 Nov 16.

10.

Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.

Burgdorf CE, Schierberl KC, Lee AS, Fischer DK, Van Kempen TA, Mudragel V, Huganir RL, Milner TA, Glass MJ, Rajadhyaksha AM.

J Neurosci. 2017 Dec 6;37(49):11894-11911. doi: 10.1523/JNEUROSCI.2397-17.2017. Epub 2017 Oct 31.

11.

Phosphatidic acid-producing enzymes regulating the synaptic vesicle cycle: Role for PLD?

Barber CN, Huganir RL, Raben DM.

Adv Biol Regul. 2018 Jan;67:141-147. doi: 10.1016/j.jbior.2017.09.009. Epub 2017 Sep 28. Review.

12.

Selective Phosphorylation of AMPA Receptor Contributes to the Network of Long-Term Potentiation in the Anterior Cingulate Cortex.

Song Q, Zheng HW, Li XH, Huganir RL, Kuner T, Zhuo M, Chen T.

J Neurosci. 2017 Aug 30;37(35):8534-8548. doi: 10.1523/JNEUROSCI.0925-17.2017. Epub 2017 Aug 1.

13.

Erratum: BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ.

Genes Dev. 2017 Apr 15;31(8):846. doi: 10.1101/gad.300863.117. No abstract available.

14.

Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.

Wigerblad G, Huie JR, Yin HZ, Leinders M, Pritchard RA, Koehrn FJ, Xiao WH, Bennett GJ, Huganir RL, Ferguson AR, Weiss JH, Svensson CI, Sorkin LS.

Exp Neurol. 2017 Jul;293:144-158. doi: 10.1016/j.expneurol.2017.04.004. Epub 2017 Apr 12.

15.

Dynamic imaging of AMPA receptor trafficking in vitro and in vivo.

Roth RH, Zhang Y, Huganir RL.

Curr Opin Neurobiol. 2017 Aug;45:51-58. doi: 10.1016/j.conb.2017.03.008. Epub 2017 Apr 12. Review.

16.

BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Lim CS, Kang X, Mirabella V, Zhang H, Bu Q, Araki Y, Hoang ET, Wang S, Shen Y, Choi S, Kaang BK, Chang Q, Pang ZP, Huganir RL, Zhu JJ.

Genes Dev. 2017 Mar 15;31(6):537-552. doi: 10.1101/gad.294413.116. Erratum in: Genes Dev. 2017 Apr 15;31(8):846.

17.

GluA1 subunit ubiquitination mediates amyloid-β-induced loss of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

Guntupalli S, Jang SE, Zhu T, Huganir RL, Widagdo J, Anggono V.

J Biol Chem. 2017 May 19;292(20):8186-8194. doi: 10.1074/jbc.M116.774554. Epub 2017 Apr 4.

18.

GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors.

Chiu SL, Diering GH, Ye B, Takamiya K, Chen CM, Jiang Y, Niranjan T, Schwartz CE, Wang T, Huganir RL.

Neuron. 2017 Mar 22;93(6):1405-1419.e8. doi: 10.1016/j.neuron.2017.02.031. Epub 2017 Mar 9.

19.

Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM.

Mol Psychiatry. 2017 Dec;22(12):1735-1745. doi: 10.1038/mp.2017.9. Epub 2017 Feb 14.

20.

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.

Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL.

Science. 2017 Feb 3;355(6324):511-515. doi: 10.1126/science.aai8355. Epub 2017 Feb 2.

21.

O-GlcNAc transferase regulates excitatory synapse maturity.

Lagerlöf O, Hart GW, Huganir RL.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1684-1689. doi: 10.1073/pnas.1621367114. Epub 2017 Jan 31.

22.

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.

Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E619-E628. doi: 10.1073/pnas.1615792114. Epub 2017 Jan 9.

23.

Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine.

Zhang K, Xu T, Yuan Z, Wei Z, Yamaki VN, Huang M, Huganir RL, Cai X.

Sci Signal. 2016 Dec 13;9(458):ra123.

24.

Identification of the SNARE complex mediating the exocytosis of NMDA receptors.

Gu Y, Huganir RL.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12280-12285. Epub 2016 Oct 6.

25.

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.

Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M.

Cell. 2016 Aug 25;166(5):1163-1175.e12. doi: 10.1016/j.cell.2016.07.008.

26.

Extensive phosphorylation of AMPA receptors in neurons.

Diering GH, Heo S, Hussain NK, Liu B, Huganir RL.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4920-7. doi: 10.1073/pnas.1610631113. Epub 2016 Aug 1.

27.

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

Na Y, Park S, Lee C, Kim DK, Park JM, Sockanathan S, Huganir RL, Worley PF.

Neuron. 2016 Aug 3;91(3):561-73. doi: 10.1016/j.neuron.2016.06.017. Epub 2016 Jul 7.

28.

Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.

Noseda R, Guerrero-Valero M, Alberizzi V, Previtali SC, Sherman DL, Palmisano M, Huganir RL, Nave KA, Cuenda A, Feltri ML, Brophy PJ, Bolino A.

PLoS Biol. 2016 Apr 12;14(4):e1002440. doi: 10.1371/journal.pbio.1002440. eCollection 2016 Apr.

29.

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.

Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L.

Neuron. 2016 Apr 20;90(2):245-60. doi: 10.1016/j.neuron.2016.03.005. Epub 2016 Mar 31.

30.

The nutrient sensor OGT in PVN neurons regulates feeding.

Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW, Huganir RL.

Science. 2016 Mar 18;351(6279):1293-6. doi: 10.1126/science.aad5494.

31.

Differential vesicular sorting of AMPA and GABAA receptors.

Gu Y, Chiu SL, Liu B, Wu PH, Delannoy M, Lin DT, Wirtz D, Huganir RL.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.1073/pnas.1525726113. Epub 2016 Feb 2.

32.

DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses.

Goldschmidt HL, Tu-Sekine B, Volk L, Anggono V, Huganir RL, Raben DM.

Cell Rep. 2016 Jan 12;14(2):200-7. doi: 10.1016/j.celrep.2015.12.022. Epub 2015 Dec 31.

33.

Mapping homeostatic synaptic plasticity using cable properties of dendrites.

Queenan BN, Lee KJ, Tan H, Huganir RL, Vicini S, Pak DT.

Neuroscience. 2016 Feb 19;315:206-16. doi: 10.1016/j.neuroscience.2015.12.017. Epub 2015 Dec 14.

34.

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation.

Hussain NK, Thomas GM, Luo J, Huganir RL.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5883-90. doi: 10.1073/pnas.1518382112. Epub 2015 Oct 12.

35.

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD.

Nature. 2015 Sep 3;525(7567):56-61. doi: 10.1038/nature14973. Epub 2015 Aug 26.

36.

GRIP1 is required for homeostatic regulation of AMPAR trafficking.

Tan HL, Queenan BN, Huganir RL.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10026-31. doi: 10.1073/pnas.1512786112. Epub 2015 Jul 27.

37.

Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain.

Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M.

Neuron. 2015 May 20;86(4):1109. doi: 10.1016/j.neuron.2015.05.016. Epub 2015 May 20. No abstract available.

38.

Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.

Toda AM, Huganir RL.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6712-7. doi: 10.1073/pnas.1507229112. Epub 2015 May 11.

39.

Glutamate synapses in human cognitive disorders.

Volk L, Chiu SL, Sharma K, Huganir RL.

Annu Rev Neurosci. 2015 Jul 8;38:127-49. doi: 10.1146/annurev-neuro-071714-033821. Epub 2015 Apr 9. Review.

PMID:
25897873
40.

Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons.

Smafield T, Pasupuleti V, Sharma K, Huganir RL, Ye B, Zhou J.

Neuroinformatics. 2015 Oct;13(4):443-58. doi: 10.1007/s12021-015-9267-4.

41.

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation.

Widagdo J, Chai YJ, Ridder MC, Chau YQ, Johnson RC, Sah P, Huganir RL, Anggono V.

Cell Rep. 2015 Feb 10;10(5):783-795. doi: 10.1016/j.celrep.2015.01.015. Epub 2015 Feb 7.

42.

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.

Meye FJ, Valentinova K, Lecca S, Marion-Poll L, Maroteaux MJ, Musardo S, Moutkine I, Gardoni F, Huganir RL, Georges F, Mameli M.

Nat Neurosci. 2015 Mar;18(3):376-8. doi: 10.1038/nn.3923. Epub 2015 Feb 2.

43.

Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo.

Zhang Y, Cudmore RH, Lin DT, Linden DJ, Huganir RL.

Nat Neurosci. 2015 Mar;18(3):402-7. doi: 10.1038/nn.3936. Epub 2015 Feb 2.

44.

Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.

Araki Y, Zeng M, Zhang M, Huganir RL.

Neuron. 2015 Jan 7;85(1):173-189. doi: 10.1016/j.neuron.2014.12.023.

45.

Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain.

Koga K, Descalzi G, Chen T, Ko HG, Lu J, Li S, Son J, Kim T, Kwak C, Huganir RL, Zhao MG, Kaang BK, Collingridge GL, Zhuo M.

Neuron. 2015 Jan 21;85(2):377-89. doi: 10.1016/j.neuron.2014.12.021. Epub 2014 Dec 31. Erratum in: Neuron. 2015 May 20;86(4):1109.

46.

PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity.

Diering GH, Gustina AS, Huganir RL.

Neuron. 2014 Nov 19;84(4):790-805. doi: 10.1016/j.neuron.2014.09.024. Epub 2014 Oct 23.

47.

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity.

Olivito L, Saccone P, Perri V, Bachman JL, Fragapane P, Mele A, Huganir RL, De Leonibus E.

Brain Struct Funct. 2016 Jan;221(1):591-603. doi: 10.1007/s00429-014-0927-1. Epub 2014 Nov 8.

48.

Postsynaptic insertion of AMPA receptor onto cortical pyramidal neurons in the anterior cingulate cortex after peripheral nerve injury.

Chen T, Wang W, Dong YL, Zhang MM, Wang J, Koga K, Liao YH, Li JL, Budisantoso T, Shigemoto R, Itakura M, Huganir RL, Li YQ, Zhuo M.

Mol Brain. 2014 Oct 31;7:76. doi: 10.1186/s13041-014-0076-8.

49.

Stress induces pain transition by potentiation of AMPA receptor phosphorylation.

Li C, Yang Y, Liu S, Fang H, Zhang Y, Furmanski O, Skinner J, Xing Y, Johns RA, Huganir RL, Tao F.

J Neurosci. 2014 Oct 8;34(41):13737-46. doi: 10.1523/JNEUROSCI.2130-14.2014.

50.

GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.

Qiu S, Zhang M, Liu Y, Guo Y, Zhao H, Song Q, Zhao M, Huganir RL, Luo J, Xu H, Zhuo M.

J Neurosci. 2014 Oct 1;34(40):13505-15. doi: 10.1523/JNEUROSCI.1431-14.2014.

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