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Items: 15

1.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC.

Nat Commun. 2014 Jul 10;5:4355. doi: 10.1038/ncomms5355.

2.

A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.

Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, Caron MG, Calakos N, Roth BL.

Neuropsychopharmacology. 2013 Apr;38(5):854-62. doi: 10.1038/npp.2012.251. Epub 2012 Dec 5.

3.

Predicting new molecular targets for known drugs.

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL.

Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1.

4.

p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4717-22. Epub 2006 Mar 10.

5.

Pharmacologic analysis of non-synonymous coding h5-HT2A SNPs reveals alterations in atypical antipsychotic and agonist efficacies.

Davies MA, Setola V, Strachan RT, Sheffler DJ, Salay E, Hufeisen SJ, Roth BL.

Pharmacogenomics J. 2006 Jan-Feb;6(1):42-51.

PMID:
16314884
6.
7.

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.

Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL.

J Pharmacol Exp Ther. 2004 Mar;308(3):1197-203. Epub 2004 Jan 8.

PMID:
14718611
8.

L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons.

Shi Q, Hufeisen SJ, Wroblewski JT, Nadeau JH, Roth BL.

Ann N Y Acad Sci. 2003 Nov;1003:461-3. No abstract available.

PMID:
14684489
9.
10.

In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.

Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA.

J Pharmacol Exp Ther. 2003 Oct;307(1):138-45. Epub 2003 Sep 3.

PMID:
12954796
11.

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.

Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL.

Mol Pharmacol. 2003 Jun;63(6):1223-9.

PMID:
12761331
12.

L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.

Shi Q, Savage JE, Hufeisen SJ, Rauser L, Grajkowska E, Ernsberger P, Wroblewski JT, Nadeau JH, Roth BL.

J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.

PMID:
12649361
13.

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL.

Neuropsychopharmacology. 2003 Mar;28(3):519-26.

15.

Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.

Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL.

Circulation. 2000 Dec 5;102(23):2836-41.

PMID:
11104741

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