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Items: 46

1.

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.

Krichel C, Möckel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergräber OH, Willbold D, Neudecker P.

Sci Rep. 2019 Oct 2;9(1):14167. doi: 10.1038/s41598-019-48155-8.

2.

Positional proteomics for identification of secreted proteoforms released by site-specific processing of membrane proteins.

Niedermaier S, Huesgen PF.

Biochim Biophys Acta Proteins Proteom. 2019 Dec;1867(12):140138. doi: 10.1016/j.bbapap.2018.09.004. Epub 2018 Sep 20. Review.

PMID:
31526490
3.

Sensitive Determination of Proteolytic Proteoforms in Limited Microscale Proteome Samples.

Weng SSH, Demir F, Ergin EK, Dirnberger S, Uzozie A, Tuscher D, Nierves L, Tsui J, Huesgen PF, Lange PF.

Mol Cell Proteomics. 2019 Nov;18(11):2335-2347. doi: 10.1074/mcp.TIR119.001560. Epub 2019 Aug 30.

4.

Deep Profiling of the Cleavage Specificity and Human Substrates of Snake Venom Metalloprotease HF3 by Proteomic Identification of Cleavage Site Specificity (PICS) Using Proteome Derived Peptide Libraries and Terminal Amine Isotopic Labeling of Substrates (TAILS) N-Terminomics.

Zelanis A, Oliveira AK, Prudova A, Huesgen PF, Tashima AK, Kizhakkedathu J, Overall CM, Serrano SMT.

J Proteome Res. 2019 Sep 6;18(9):3419-3428. doi: 10.1021/acs.jproteome.9b00325. Epub 2019 Aug 8.

PMID:
31337208
5.

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH).

Drescher HK, Weiskirchen R, Fülöp A, Hopf C, de San Román EG, Huesgen PF, de Bruin A, Bongiovanni L, Christ A, Tolba R, Trautwein C, Kroy DC.

Front Physiol. 2019 Jun 25;10:770. doi: 10.3389/fphys.2019.00770. eCollection 2019.

6.

DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis.

Huber CV, Jakobs BD, Mishra LS, Niedermaier S, Stift M, Winter G, Adamska I, Funk C, Huesgen PF, Funck D.

J Exp Bot. 2019 Oct 15;70(19):5423-5436. doi: 10.1093/jxb/erz294.

7.

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers.

Elfgen A, Hupert M, Bochinsky K, Tusche M, González de San Román Martin E, Gering I, Sacchi S, Pollegioni L, Huesgen PF, Hartmann R, Santiago-Schübel B, Kutzsche J, Willbold D.

Sci Rep. 2019 Apr 5;9(1):5715. doi: 10.1038/s41598-019-41993-6.

8.

A fungal substrate mimicking molecule suppresses plant immunity via an inter-kingdom conserved motif.

Misas Villamil JC, Mueller AN, Demir F, Meyer U, Ökmen B, Schulze Hüynck J, Breuer M, Dauben H, Win J, Huesgen PF, Doehlemann G.

Nat Commun. 2019 Apr 5;10(1):1576. doi: 10.1038/s41467-019-09472-8.

9.

New beginnings and new ends: methods for large-scale characterization of protein termini and their use in plant biology.

Perrar A, Dissmeyer N, Huesgen PF.

J Exp Bot. 2019 Apr 12;70(7):2021-2038. doi: 10.1093/jxb/erz104.

10.

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana.

Soares A, Niedermaier S, Faro R, Loos A, Manadas B, Faro C, Huesgen PF, Cheung AY, Simões I.

J Exp Bot. 2019 Apr 12;70(7):2157-2171. doi: 10.1093/jxb/erz059.

PMID:
30778561
11.

Sirtilins - the new old members of the vitamin K-dependent coagulation factor family.

Dahms SO, Demir F, Huesgen PF, Thorn K, Brandstetter H.

J Thromb Haemost. 2019 Mar;17(3):470-481. doi: 10.1111/jth.14384. Epub 2019 Feb 13.

12.

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.

Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM.

Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

PMID:
30522767
13.

Heterologous expression and characterization of a novel serine protease from Daphnia magna: A possible role in susceptibility to toxic cyanobacteria.

Lange J, Demir F, Huesgen PF, Baumann U, von Elert E, Pichlo C.

Aquat Toxicol. 2018 Dec;205:140-147. doi: 10.1016/j.aquatox.2018.09.013. Epub 2018 Sep 26.

PMID:
30384195
14.

The podocyte protease web: uncovering the gatekeepers of glomerular disease.

Rinschen MM, Huesgen PF, Koch RE.

Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1812-F1816. doi: 10.1152/ajprenal.00380.2018. Epub 2018 Sep 19. Review.

15.

Dual function of a secreted fungalysin metalloprotease in Ustilago maydis.

Ökmen B, Kemmerich B, Hilbig D, Wemhöner R, Aschenbroich J, Perrar A, Huesgen PF, Schipper K, Doehlemann G.

New Phytol. 2018 Oct;220(1):249-261. doi: 10.1111/nph.15265. Epub 2018 Jun 19.

16.

Molecular composition of the human primary visual cortex profiled by multimodal mass spectrometry imaging.

González de San Román E, Bidmon HJ, Malisic M, Susnea I, Küppers A, Hübbers R, Wree A, Nischwitz V, Amunts K, Huesgen PF.

Brain Struct Funct. 2018 Jul;223(6):2767-2783. doi: 10.1007/s00429-018-1660-y. Epub 2018 Apr 10.

17.

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

Rinschen MM, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T.

J Am Soc Nephrol. 2017 Oct;28(10):2867-2878. doi: 10.1681/ASN.2016101119. Epub 2017 Jul 19.

18.

Quantitative proteomics in plant protease substrate identification.

Demir F, Niedermaier S, Villamor JG, Huesgen PF.

New Phytol. 2018 May;218(3):936-943. doi: 10.1111/nph.14587. Epub 2017 May 11. Review.

19.

Profiling of Protein N-Termini and Their Modifications in Complex Samples.

Demir F, Niedermaier S, Kizhakkedathu JN, Huesgen PF.

Methods Mol Biol. 2017;1574:35-50. doi: 10.1007/978-1-4939-6850-3_4.

PMID:
28315242
20.

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.

Biniossek ML, Niemer M, Maksimchuk K, Mayer B, Fuchs J, Huesgen PF, McCafferty DG, Turk B, Fritz G, Mayer J, Haecker G, Mach L, Schilling O.

Mol Cell Proteomics. 2016 Jul;15(7):2515-24. doi: 10.1074/mcp.O115.056671. Epub 2016 Apr 27.

21.

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans.

Leal AR, Cruz R, Bur D, Huesgen PF, Faro R, Manadas B, Wlodawer A, Faro C, Simões I.

Sci Rep. 2016 Mar 31;6:23869. doi: 10.1038/srep23869.

22.

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun.

23.

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Keller UAD, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM.

Matrix Biol. 2016 Jan;49:37-60. doi: 10.1016/j.matbio.2015.09.003. Epub 2015 Sep 25.

24.

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

Zelanis A, Huesgen PF, Oliveira AK, Tashima AK, Serrano SM, Overall CM.

J Proteomics. 2015 Jan 15;113:260-7. doi: 10.1016/j.jprot.2014.10.002. Epub 2014 Oct 14.

PMID:
25452133
25.

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM.

Nat Methods. 2015 Jan;12(1):55-8. doi: 10.1038/nmeth.3177. Epub 2014 Nov 24.

26.
27.

Ensembles of protein termini and specific proteolytic signatures as candidate biomarkers of disease.

Huesgen PF, Lange PF, Overall CM.

Proteomics Clin Appl. 2014 Jun;8(5-6):338-50. doi: 10.1002/prca.201300104. Epub 2014 Mar 27. Review.

PMID:
24497460
28.

Family-wide characterization of matrix metalloproteinases from Arabidopsis thaliana reveals their distinct proteolytic activity and cleavage site specificity.

Marino G, Huesgen PF, Eckhard U, Overall CM, Schröder WP, Funk C.

Biochem J. 2014 Jan 15;457(2):335-46. doi: 10.1042/BJ20130196.

PMID:
24156403
29.

Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.

Eckhard U, Huesgen PF, Brandstetter H, Overall CM.

J Proteomics. 2014 Apr 4;100:102-14. doi: 10.1016/j.jprot.2013.10.004. Epub 2013 Oct 11.

30.

Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids.

Huesgen PF, Alami M, Lange PF, Foster LJ, Schröder WP, Overall CM, Green BR.

PLoS One. 2013 Sep 16;8(9):e74483. doi: 10.1371/journal.pone.0074483. eCollection 2013.

31.

Structure of the mycosin-1 protease from the mycobacterial ESX-1 protein type VII secretion system.

Solomonson M, Huesgen PF, Wasney GA, Watanabe N, Gruninger RJ, Prehna G, Overall CM, Strynadka NC.

J Biol Chem. 2013 Jun 14;288(24):17782-90. doi: 10.1074/jbc.M113.462036. Epub 2013 Apr 25.

32.

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

Laurent-Matha V, Huesgen PF, Masson O, Derocq D, Prébois C, Gary-Bobo M, Lecaille F, Rebière B, Meurice G, Oréar C, Hollingsworth RE, Abrahamson M, Lalmanach G, Overall CM, Liaudet-Coopman E.

FASEB J. 2012 Dec;26(12):5172-81. doi: 10.1096/fj.12-205229. Epub 2012 Aug 16.

33.

The family of Deg/HtrA proteases in plants.

Schuhmann H, Huesgen PF, Adamska I.

BMC Plant Biol. 2012 Apr 20;12:52. doi: 10.1186/1471-2229-12-52.

34.

TopFIND 2.0--linking protein termini with proteolytic processing and modifications altering protein function.

Lange PF, Huesgen PF, Overall CM.

Nucleic Acids Res. 2012 Jan;40(Database issue):D351-61. doi: 10.1093/nar/gkr1025. Epub 2011 Nov 18.

35.

N- and C-terminal degradomics: new approaches to reveal biological roles for plant proteases from substrate identification.

Huesgen PF, Overall CM.

Physiol Plant. 2012 May;145(1):5-17. doi: 10.1111/j.1399-3054.2011.01536.x. Epub 2011 Dec 7. Review.

PMID:
22023699
36.

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis.

Schilling O, Huesgen PF, Barré O, Overall CM.

Methods Mol Biol. 2011;781:59-69. doi: 10.1007/978-1-61779-276-2_4.

PMID:
21877277
37.

Development of soluble ester-linked aldehyde polymers for proteomics.

Beaudette P, Rossi NA, Huesgen PF, Yu X, Shenoi RA, Doucet A, Overall CM, Kizhakkedathu JN.

Anal Chem. 2011 Sep 1;83(17):6500-10. doi: 10.1021/ac200419p. Epub 2011 Aug 11.

PMID:
21774540
38.

Recombinant Deg/HtrA proteases from Synechocystis sp. PCC 6803 differ in substrate specificity, biochemical characteristics and mechanism.

Huesgen PF, Miranda H, Lam X, Perthold M, Schuhmann H, Adamska I, Funk C.

Biochem J. 2011 May 1;435(3):733-42. doi: 10.1042/BJ20102131.

39.

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

Schilling O, Huesgen PF, Barré O, Auf dem Keller U, Overall CM.

Nat Protoc. 2011 Jan;6(1):111-20. doi: 10.1038/nprot.2010.178. Epub 2011 Jan 6.

PMID:
21212787
40.

Proteome-wide analysis of protein carboxy termini: C terminomics.

Schilling O, Barré O, Huesgen PF, Overall CM.

Nat Methods. 2010 Jul;7(7):508-11. doi: 10.1038/nmeth.1467. Epub 2010 Jun 6.

PMID:
20526347
41.

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria.

Huesgen PF, Schuhmann H, Adamska I.

Res Microbiol. 2009 Nov;160(9):726-32. doi: 10.1016/j.resmic.2009.08.005. Epub 2009 Sep 2. Review.

PMID:
19732828
42.

Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana.

Haussuehl K, Huesgen PF, Meier M, Dessi P, Glaser E, Adamski J, Adamska I.

Biochem J. 2009 Oct 12;423(3):333-41. doi: 10.1042/BJ20091023.

PMID:
19694617
43.

The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis.

Schuhmann H, Huesgen PF, Gietl C, Adamska I.

Plant Physiol. 2008 Dec;148(4):1847-56. doi: 10.1104/pp.108.125377. Epub 2008 Oct 24.

45.

Dual specificities of the glyoxysomal/peroxisomal processing protease Deg15 in higher plants.

Helm M, Lück C, Prestele J, Hierl G, Huesgen PF, Fröhlich T, Arnold GJ, Adamska I, Görg A, Lottspeich F, Gietl C.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11501-6. Epub 2007 Jun 25.

46.

Photodamaged D1 protein is degraded in Arabidopsis mutants lacking the Deg2 protease.

Huesgen PF, Schuhmann H, Adamska I.

FEBS Lett. 2006 Dec 22;580(30):6929-32. Epub 2006 Dec 4.

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