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Items: 1 to 50 of 67

1.

LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.

West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC.

Nucleic Acids Res. 2019 Apr 15. pii: gkz263. doi: 10.1093/nar/gkz263. [Epub ahead of print]

PMID:
30982887
2.

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

Roewenstrunk J, Di Vona C, Chen J, Borras E, Dong C, Arató K, Sabidó E, Huen MSY, de la Luna S.

Sci Rep. 2019 Apr 12;9(1):6014. doi: 10.1038/s41598-019-42445-x.

3.

PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, Loong JH, Ching YP, Yuan YF, Xie D, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, Guan XY, Huen MSY, Ma S.

Cell Rep. 2018 Oct 16;25(3):690-701.e8. doi: 10.1016/j.celrep.2018.09.053.

4.

Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription.

Chen Y, Li J, Cao F, Lam J, Cheng CC, Yu CH, Huen MS.

Nucleic Acids Res. 2018 Nov 2;46(19):10119-10131. doi: 10.1093/nar/gky775.

5.

RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair.

An L, Dong C, Li J, Chen J, Yuan J, Huang J, Chan KM, Yu CH, Huen MSY.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8286-E8295. doi: 10.1073/pnas.1804823115. Epub 2018 Aug 13.

6.

C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling.

Jiang J, Tang S, Xia J, Wen J, Chen S, Shu X, Huen MSY, Deng Y.

Oncogene. 2018 May;37(22):2992-3005. doi: 10.1038/s41388-018-0166-7. Epub 2018 Mar 13.

7.

BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability.

Han J, Ruan C, Huen MSY, Wang J, Xie A, Fu C, Liu T, Huang J.

Nat Commun. 2017 Nov 13;8(1):1470. doi: 10.1038/s41467-017-01759-y.

8.

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.

Lou J, Chen H, Han J, He H, Huen MSY, Feng XH, Liu T, Huang J.

Nat Commun. 2017 Oct 17;8(1):985. doi: 10.1038/s41467-017-01151-w.

9.

Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma.

Liu J, Lv L, Gong J, Tan Y, Zhu Y, Dai Y, Pan X, Huen MSY, Li B, Tsao SW, Huo J, Cheung ALM.

Int J Cancer. 2018 Jan 1;142(1):145-155. doi: 10.1002/ijc.31040. Epub 2017 Sep 28.

10.

Loss of ΔNp63α promotes mitotic exit in epithelial cells.

Hau PM, Yip YL, Huen MSY, Tsao SW.

FEBS Lett. 2017 Jun;591(11):1624. doi: 10.1002/1873-3468.12674. No abstract available.

11.

Dual-utility NLS drives RNF169-dependent DNA damage responses.

An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881. doi: 10.1073/pnas.1616602114. Epub 2017 Mar 21.

12.
13.

TRAIP regulates replication fork recovery and progression via PCNA.

Feng W, Guo Y, Huang J, Deng Y, Zang J, Huen MS.

Cell Discov. 2016 Jun 28;2:16016. doi: 10.1038/celldisc.2016.16. eCollection 2016.

14.

The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair.

Ng HM, Wei L, Lan L, Huen MS.

J Biol Chem. 2016 Jul 29;291(31):16197-207. doi: 10.1074/jbc.M116.731927. Epub 2016 Jun 10.

15.

Structure of the human dimeric ATM kinase.

Lau WC, Li Y, Liu Z, Gao Y, Zhang Q, Huen MS.

Cell Cycle. 2016;15(8):1117-24. doi: 10.1080/15384101.2016.1158362.

16.

H1 provides the missing link.

Huen MS, Chen J.

Cell Res. 2016 Jan;26(1):5-6. doi: 10.1038/cr.2015.138. Epub 2015 Nov 24.

17.

Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA.

Lau WC, Li Y, Zhang Q, Huen MS.

Sci Rep. 2015 Oct 27;5:15759. doi: 10.1038/srep15759.

18.

ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.

Guo Y, Feng W, Sy SM, Huen MS.

J Biol Chem. 2015 Nov 13;290(46):27545-56. doi: 10.1074/jbc.M115.672626. Epub 2015 Sep 29.

19.

Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage.

Yang J, Deng W, Hau PM, Liu J, Lau VM, Cheung AL, Huen MS, Tsao SW.

Lab Invest. 2015 Aug;95(8):937-50. doi: 10.1038/labinvest.2015.69. Epub 2015 Jun 1.

20.

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.

Hodge CD, Edwards RA, Markin CJ, McDonald D, Pulvino M, Huen MS, Zhao J, Spyracopoulos L, Hendzel MJ, Glover JN.

ACS Chem Biol. 2015 Jul 17;10(7):1718-28. doi: 10.1021/acschembio.5b00222. Epub 2015 May 1.

21.

Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population.

Chen H, Xu J, Zhou Y, Gao Y, Wang G, Xia J, Huen MS, Siok WT, Jiang Y, Tan LH, Sun Y.

BMC Genet. 2015 Feb 3;16:7. doi: 10.1186/s12863-015-0172-5.

22.

Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells.

Hau PM, Deng W, Jia L, Yang J, Tsurumi T, Chiang AK, Huen MS, Tsao SW.

J Virol. 2015 Jan;89(1):652-68. doi: 10.1128/JVI.01437-14. Epub 2014 Oct 29.

23.

Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population.

Sun Y, Gao Y, Zhou Y, Chen H, Wang G, Xu J, Xia J, Huen MS, Siok WT, Jiang Y, Tan LH.

Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):627-34. doi: 10.1002/ajmg.b.32267. Epub 2014 Sep 17.

PMID:
25230923
24.

Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population.

Chen H, Wang G, Xia J, Zhou Y, Gao Y, Xu J, Huen MS, Siok WT, Jiang Y, Tan LH, Sun Y.

Behav Brain Funct. 2014 Sep 1;10(1):29. doi: 10.1186/1744-9081-10-29.

25.

The human SRCAP chromatin remodeling complex promotes DNA-end resection.

Dong S, Han J, Chen H, Liu T, Huen MSY, Yang Y, Guo C, Huang J.

Curr Biol. 2014 Sep 22;24(18):2097-2110. doi: 10.1016/j.cub.2014.07.081. Epub 2014 Aug 28.

26.

SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.

Han J, Liu T, Huen MS, Hu L, Chen Z, Huang J.

J Cell Biol. 2014 Jun 23;205(6):811-27. doi: 10.1083/jcb.201311007.

27.

F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).

Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL.

J Biol Chem. 2014 Aug 1;289(31):21508-18. doi: 10.1074/jbc.M114.560342. Epub 2014 Jun 16.

28.

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks.

Sy SM, Jiang J, O WS, Deng Y, Huen MS.

Nucleic Acids Res. 2013 Oct;41(18):8572-80. doi: 10.1093/nar/gkt622. Epub 2013 Jul 17.

29.

Structural basis for role of ring finger protein RNF168 RING domain.

Zhang X, Chen J, Wu M, Wu H, Arokiaraj AW, Wang C, Zhang W, Tao Y, Huen MS, Zang J.

Cell Cycle. 2013 Jan 15;12(2):312-21. doi: 10.4161/cc.23104. Epub 2012 Jan 15.

30.

Nucleolar exit of RNF8 and BRCA1 in response to DNA damage.

Guerra-Rebollo M, Mateo F, Franke K, Huen MS, Lopitz-Otsoa F, Rodríguez MS, Plans V, Thomson TM.

Exp Cell Res. 2012 Nov 1;318(18):2365-76. doi: 10.1016/j.yexcr.2012.07.003. Epub 2012 Jul 16.

PMID:
22814251
31.

Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage.

Chen J, Feng W, Jiang J, Deng Y, Huen MS.

J Biol Chem. 2012 Aug 10;287(33):27715-22. doi: 10.1074/jbc.M112.373530. Epub 2012 Jun 25.

32.

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.

Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4491-6. doi: 10.1073/pnas.1118720109. Epub 2012 Mar 6.

33.

Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure.

Shao Z, Li F, Sy SM, Yan W, Zhang Z, Gong D, Wen B, Huen MS, Gong Q, Wu J, Shi Y.

J Struct Biol. 2012 Feb;177(2):459-68. doi: 10.1016/j.jsb.2011.11.022. Epub 2011 Dec 1.

PMID:
22154951
34.

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S.

Nat Struct Mol Biol. 2011 Nov 20;18(12):1400-7. doi: 10.1038/nsmb.2172.

35.

Mequindox induced cellular DNA damage via generation of reactive oxygen species.

Liu J, Ouyang M, Jiang J, Mu P, Wu J, Yang Q, Zhang C, Xu W, Wang L, Huen MS, Deng Y.

Mutat Res. 2012 Jan 24;741(1-2):70-5. doi: 10.1016/j.mrgentox.2011.10.012. Epub 2011 Nov 7.

PMID:
22094289
36.

RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.

Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J.

DNA Repair (Amst). 2012 Feb 1;11(2):131-8. doi: 10.1016/j.dnarep.2011.10.012. Epub 2011 Oct 28.

37.

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.

Lok GT, Sy SM, Dong SS, Ching YP, Tsao SW, Thomson TM, Huen MS.

Nucleic Acids Res. 2012 Jan;40(1):196-205. doi: 10.1093/nar/gkr655. Epub 2011 Sep 12.

38.

Loss of ΔNp63α promotes mitotic exit in epithelial cells.

Hau PM, Yip YL, Huen MS, Tsao SW.

FEBS Lett. 2011 Sep 2;585(17):2720-6. doi: 10.1016/j.febslet.2011.07.030. Epub 2011 Aug 3. Erratum in: FEBS Lett. 2017 Jun;591(11):1624.

39.

Id1 interacts and stabilizes the Epstein-Barr virus latent membrane protein 1 (LMP1) in nasopharyngeal epithelial cells.

Hau PM, Tsang CM, Yip YL, Huen MS, Tsao SW.

PLoS One. 2011;6(6):e21176. doi: 10.1371/journal.pone.0021176. Epub 2011 Jun 20.

40.

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.

Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY.

BMC Cancer. 2011 May 26;11:199. doi: 10.1186/1471-2407-11-199.

41.

Critical roles of ring finger protein RNF8 in replication stress responses.

Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS.

J Biol Chem. 2011 Jun 24;286(25):22355-61. doi: 10.1074/jbc.M111.232041. Epub 2011 May 10.

42.

The 53BP1-EXPAND1 connection in chromatin structure regulation.

Sy SM, Chen J, Huen MS.

Nucleus. 2010 Nov-Dec;1(6):472-4. doi: 10.4161/nucl.1.6.13059. Epub 2010 Jul 18.

43.

Impact of G₂ checkpoint defect on centromeric instability.

Deng W, Tsao SW, Mak GW, Tsang CM, Ching YP, Guan XY, Huen MS, Cheung AL.

Oncogene. 2011 Mar 17;30(11):1281-9. doi: 10.1038/onc.2010.508. Epub 2010 Nov 8.

PMID:
21057540
44.

SON is a spliceosome-associated factor required for mitotic progression.

Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J.

Cell Cycle. 2010 Jul 1;9(13):2679-85. doi: 10.4161/cc.9.13.12151.

45.

ATM Creates a veil of transcriptional silence.

Huen MS, Chen J.

Cell. 2010 Jun 11;141(6):924-6. doi: 10.1016/j.cell.2010.05.035.

46.

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.

J Exp Med. 2010 May 10;207(5):973-81. doi: 10.1084/jem.20092308. Epub 2010 Apr 12.

47.

Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.

Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J.

Mol Cell. 2010 Mar 26;37(6):854-64. doi: 10.1016/j.molcel.2009.12.040.

48.

BRCA1 and its toolbox for the maintenance of genome integrity.

Huen MS, Sy SM, Chen J.

Nat Rev Mol Cell Biol. 2010 Feb;11(2):138-48. doi: 10.1038/nrm2831. Epub 2009 Dec 23. Review.

49.

Assembly of checkpoint and repair machineries at DNA damage sites.

Huen MS, Chen J.

Trends Biochem Sci. 2010 Feb;35(2):101-8. doi: 10.1016/j.tibs.2009.09.001. Epub 2009 Oct 28. Review.

50.

Cell death caused by single-stranded oligodeoxynucleotide-mediated targeted genomic sequence modification.

Liu C, Wang Z, Huen MS, Lu LY, Liu DP, Huang JD.

Oligonucleotides. 2009 Sep;19(3):281-6. doi: 10.1089/oli.2009.0191.

PMID:
19653881

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