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γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.

Luong-Gardiol N, Siddiqui I, Pizzitola I, Jeevan-Raj B, Charmoy M, Huang Y, Irmisch A, Curtet S, Angelov GS, Danilo M, Juilland M, Bornhauser B, Thome M, Hantschel O, Chalandon Y, Cazzaniga G, Bourquin JP, Huelsken J, Held W.

Cancer Cell. 2019 Apr 15;35(4):649-663.e10. doi: 10.1016/j.ccell.2019.03.005.


Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.

Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kamińska B, Huelsken J, Omberg L, Gevaert O, Colaprico A, Czerwińska P, Mazurek S, Mishra L, Heyn H, Krasnitz A, Godwin AK, Lazar AJ; Cancer Genome Atlas Research Network, Stuart JM, Hoadley KA, Laird PW, Noushmehr H, Wiznerowicz M.

Cell. 2018 Apr 5;173(2):338-354.e15. doi: 10.1016/j.cell.2018.03.034.


A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance.

Huelsken J, Hanahan D.

Cell. 2018 Feb 8;172(4):643-644. doi: 10.1016/j.cell.2018.01.028.


Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature.

Schwalie PC, Ordóñez-Morán P, Huelsken J, Deplancke B.

Stem Cells. 2017 Dec;35(12):2390-2402. doi: 10.1002/stem.2719. Epub 2017 Nov 6.


Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation.

Abbuehl JP, Tatarova Z, Held W, Huelsken J.

Cell Stem Cell. 2017 Aug 3;21(2):241-255.e6. doi: 10.1016/j.stem.2017.07.004.


Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue.

Lugli N, Dionellis VS, Ordóñez-Morán P, Kamileri I, Sotiriou SK, Huelsken J, Halazonetis TD.

Cell Rep. 2017 Jun 13;19(11):2185-2192. doi: 10.1016/j.celrep.2017.05.051.


Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.

Khurana S, Schouteden S, Manesia JK, Santamaria-Martínez A, Huelsken J, Lacy-Hulbert A, Verfaillie CM.

Nat Commun. 2016 Dec 1;7:13500. doi: 10.1038/ncomms13500.


Microfluidic co-culture platform to quantify chemotaxis of primary stem cells.

Tatárová Z, Abbuehl JP, Maerkl S, Huelsken J.

Lab Chip. 2016 May 21;16(10):1934-45. doi: 10.1039/c6lc00236f. Epub 2016 May 3.


Phage Selection of Chemically Stabilized α-Helical Peptide Ligands.

Diderich P, Bertoldo D, Dessen P, Khan MM, Pizzitola I, Held W, Huelsken J, Heinis C.

ACS Chem Biol. 2016 May 20;11(5):1422-7. doi: 10.1021/acschembio.5b00963. Epub 2016 Mar 11.


Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling.

Bertoldo D, Khan MM, Dessen P, Held W, Huelsken J, Heinis C.

ChemMedChem. 2016 Apr 19;11(8):834-9. doi: 10.1002/cmdc.201500557. Epub 2016 Jan 26.


HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.

Ordóñez-Morán P, Dafflon C, Imajo M, Nishida E, Huelsken J.

Cancer Cell. 2015 Dec 14;28(6):815-829. doi: 10.1016/j.ccell.2015.11.001.


Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.

Chiacchiera F, Rossi A, Jammula S, Piunti A, Scelfo A, Ordóñez-Morán P, Huelsken J, Koseki H, Pasini D.

Cell Stem Cell. 2016 Jan 7;18(1):91-103. doi: 10.1016/j.stem.2015.09.019. Epub 2015 Oct 29.


Complex metastatic niches: already a target for therapy?

Ordóñez-Morán P, Huelsken J.

Curr Opin Cell Biol. 2014 Dec;31:29-38. doi: 10.1016/ Epub 2014 Jul 16. Review.


Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk.

Petherick KJ, Williams AC, Lane JD, Ordóñez-Morán P, Huelsken J, Collard TJ, Smartt HJ, Batson J, Malik K, Paraskeva C, Greenhough A.

EMBO J. 2013 Jul 3;32(13):1903-16. doi: 10.1038/emboj.2013.123. Epub 2013 Jun 4.


SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.

Ordóñez-Morán P, Irmisch A, Barbáchano A, Chicote I, Tenbaum S, Landolfi S, Tabernero J, Huelsken J, Muñoz A, Pálmer HG.

Oncogene. 2014 Apr 10;33(15):1975-85. doi: 10.1038/onc.2013.140. Epub 2013 Apr 29.


Metastasis: New insights into organ-specific extravasation and metastatic niches.

Irmisch A, Huelsken J.

Exp Cell Res. 2013 Jul 1;319(11):1604-10. doi: 10.1016/j.yexcr.2013.02.012. Epub 2013 Feb 21. Review.


The niche under siege: novel targets for metastasis therapy.

Santamaria-Martínez A, Huelsken J.

J Intern Med. 2013 Aug;274(2):127-36. doi: 10.1111/joim.12024. Review.


β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

Smartt HJ, Greenhough A, Ordóñez-Morán P, Al-Kharusi M, Collard TJ, Mariadason JM, Huelsken J, Williams AC, Paraskeva C.

Br J Cancer. 2012 Oct 23;107(9):1514-7. doi: 10.1038/bjc.2012.430. Epub 2012 Oct 2.


Lrig1: a new master regulator of epithelial stem cells.

Ordóñez-Morán P, Huelsken J.

EMBO J. 2012 May 2;31(9):2064-6. doi: 10.1038/emboj.2012.73. Epub 2012 Mar 20. No abstract available.


Interactions between cancer stem cells and their niche govern metastatic colonization.

Malanchi I, Santamaria-Martínez A, Susanto E, Peng H, Lehr HA, Delaloye JF, Huelsken J.

Nature. 2011 Dec 7;481(7379):85-9. doi: 10.1038/nature10694.


β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.

Smartt HJ, Greenhough A, Ordóñez-Morán P, Talero E, Cherry CA, Wallam CA, Parry L, Al Kharusi M, Roberts HR, Mariadason JM, Clarke AR, Huelsken J, Williams AC, Paraskeva C.

Gut. 2012 Sep;61(9):1306-14. doi: 10.1136/gutjnl-2011-300817. Epub 2011 Nov 14.


Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death.

Holowacz T, Huelsken J, Dufort D, van der Kooy D.

Eur J Neurosci. 2011 Apr;33(8):1366-75. doi: 10.1111/j.1460-9568.2011.07632.x. Epub 2011 Mar 7.


Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory.

Jeannet G, Boudousquié C, Gardiol N, Kang J, Huelsken J, Held W.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9777-82. doi: 10.1073/pnas.0914127107. Epub 2010 May 10.


SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas.

Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembelé D, Martinet N, Thibault C, Huelsken J, Brambilla E, du Manoir S.

PLoS One. 2010 Jan 29;5(1):e8960. doi: 10.1371/journal.pone.0008960.


Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.


Canonical Wnt signalling plays essential roles.

Huelsken J, Held W.

Eur J Immunol. 2009 Dec;39(12):3582-3; author reply 3583-4. doi: 10.1002/eji.200838982. No abstract available.


Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R.

Dev Cell. 2009 Jul;17(1):49-61. doi: 10.1016/j.devcel.2009.05.011.


Tissue-specific stem cells: friend or foe?

Huelsken J.

Cell Res. 2009 Mar;19(3):279-81. doi: 10.1038/cr.2009.24. No abstract available.


Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1.

Braeuning A, Sanna R, Huelsken J, Schwarz M.

Drug Metab Dispos. 2009 May;37(5):1138-45. doi: 10.1124/dmd.108.026179. Epub 2009 Feb 23.


Cancer stem cells: never Wnt away from the niche.

Malanchi I, Huelsken J.

Curr Opin Oncol. 2009 Jan;21(1):41-6. doi: 10.1097/CCO.0b013e32831d1faf. Review.


Differential requirement for beta-catenin in epithelial and fiber cells during lens development.

Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU.

Dev Biol. 2008 Sep 15;321(2):420-33. doi: 10.1016/j.ydbio.2008.07.002. Epub 2008 Jul 9.


Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, Huber M, Hohl D, Cano A, Birchmeier W, Huelsken J.

Nature. 2008 Apr 3;452(7187):650-3. doi: 10.1038/nature06835.


Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels.

Xu YH, Reboulet R, Quinn B, Huelsken J, Witte D, Grabowski GA.

Mol Genet Metab. 2008 Jun;94(2):190-203. doi: 10.1016/j.ymgme.2008.01.013. Epub 2008 Mar 17.


Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.

Jeannet G, Scheller M, Scarpellino L, Duboux S, Gardiol N, Back J, Kuttler F, Malanchi I, Birchmeier W, Leutz A, Huelsken J, Held W.

Blood. 2008 Jan 1;111(1):142-9. Epub 2007 Sep 28.


Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.

Schaeper U, Vogel R, Chmielowiec J, Huelsken J, Rosario M, Birchmeier W.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81. Epub 2007 Sep 19.


Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells.

Fevr T, Robine S, Louvard D, Huelsken J.

Mol Cell Biol. 2007 Nov;27(21):7551-9. Epub 2007 Sep 4.


Beta-catenin downregulation is required for adaptive cardiac remodeling.

Baurand A, Zelarayan L, Betney R, Gehrke C, Dunger S, Noack C, Busjahn A, Huelsken J, Taketo MM, Birchmeier W, Dietz R, Bergmann MW.

Circ Res. 2007 May 11;100(9):1353-62. Epub 2007 Apr 5.


beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells.

Faraldo MM, Teulière J, Deugnier MA, Birchmeier W, Huelsken J, Thiery JP, Cano A, Glukhova MA.

FEBS Lett. 2007 Mar 6;581(5):831-6. Epub 2007 Feb 2.


Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation.

Scheller M, Huelsken J, Rosenbauer F, Taketo MM, Birchmeier W, Tenen DG, Leutz A.

Nat Immunol. 2006 Oct;7(10):1037-47. Epub 2006 Sep 3.


Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.

Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A.

Curr Biol. 2005 Sep 20;15(18):1677-83.


Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival.

Goux D, Coudert JD, Maurice D, Scarpellino L, Jeannet G, Piccolo S, Weston K, Huelsken J, Held W.

Blood. 2005 Sep 1;106(5):1726-33. Epub 2005 May 12.


Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.

Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W.

J Cell Biol. 2004 Oct 11;167(1):149-60.


beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation.

Teulière J, Faraldo MM, Shtutman M, Birchmeier W, Huelsken J, Thiery JP, Glukhova MA.

Mol Cell Biol. 2004 Oct;24(19):8649-61.


Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W.

Development. 2003 Dec;130(25):6283-94.


Role of beta-catenin in synaptic vesicle localization and presynaptic assembly.

Bamji SX, Shimazu K, Kimes N, Huelsken J, Birchmeier W, Lu B, Reichardt LF.

Neuron. 2003 Nov 13;40(4):719-31.


Deletion of beta-catenin impairs T cell development.

Xu Y, Banerjee D, Huelsken J, Birchmeier W, Sen JM.

Nat Immunol. 2003 Dec;4(12):1177-82. Epub 2003 Nov 9.


Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

Soshnikova N, Zechner D, Huelsken J, Mishina Y, Behringer RR, Taketo MM, Crenshaw EB 3rd, Birchmeier W.

Genes Dev. 2003 Aug 15;17(16):1963-8.


beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis.

Mucenski ML, Wert SE, Nation JM, Loudy DE, Huelsken J, Birchmeier W, Morrisey EE, Whitsett JA.

J Biol Chem. 2003 Oct 10;278(41):40231-8. Epub 2003 Jul 28.


The Wnt signalling pathway.

Huelsken J, Behrens J.

J Cell Sci. 2002 Nov 1;115(Pt 21):3977-8. Review. No abstract available.

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