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Items: 1 to 50 of 110

1.

Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa.

Pandiyan P, Bhaskaran N, Zou M, Schneider E, Jayaraman S, Huehn J.

Front Immunol. 2019 Mar 8;10:426. doi: 10.3389/fimmu.2019.00426. eCollection 2019. Review.

2.

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.

Łyszkiewicz M, Winter SJ, Witzlau K, Föhse L, Brownlie R, Puchałka J, Verheyden NA, Kunze-Schumacher H, Imelmann E, Blume J, Raha S, Sekiya T, Yoshimura A, Frueh JT, Ullrich E, Huehn J, Weiss S, Gutierrez MG, Prinz I, Zamoyska R, Ziętara N, Krueger A.

PLoS Biol. 2019 Mar 11;17(3):e2006716. doi: 10.1371/journal.pbio.2006716. eCollection 2019 Mar.

3.

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T.

Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.

4.

Yersinia Pseudotuberculosis Modulates Regulatory T Cell Stability via Injection of Yersinia Outer Proteins in a Type III Secretion System-Dependent Manner.

Elfiky A, Bonifacius A, Pezoldt J, Pasztoi M, Chaoprasid P, Sadana P, El-Sherbeeny N, Hagras M, Scrima A, Dersch P, Huehn J.

Eur J Microbiol Immunol (Bp). 2018 Nov 28;8(4):101-106. doi: 10.1556/1886.2018.00015. eCollection 2018 Dec 23.

5.

IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes.

Prajeeth CK, Dittrich-Breiholz O, Talbot SR, Robert PA, Huehn J, Stangel M.

Front Cell Neurosci. 2018 Oct 10;12:352. doi: 10.3389/fncel.2018.00352. eCollection 2018.

6.

Thymus-derived Foxp3+ regulatory T cells upregulate RORγt expression under inflammatory conditions.

Yang J, Zou M, Pezoldt J, Zhou X, Huehn J.

J Mol Med (Berl). 2018 Dec;96(12):1387-1394. doi: 10.1007/s00109-018-1706-x. Epub 2018 Oct 24.

PMID:
30357435
7.

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.

Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry GR, Vafadarnejad E, Floess S, Arampatzi P, Buettner M, Schweer J, Fleissner D, Vital M, Pieper DH, Basic M, Dersch P, Strowig T, Hornef M, Bleich A, Bode U, Pabst O, Bajénoff M, Saliba AE, Huehn J.

Nat Commun. 2018 Sep 25;9(1):3903. doi: 10.1038/s41467-018-06423-7.

8.

Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells.

Kyburz A, Fallegger A, Zhang X, Altobelli A, Artola-Boran M, Borbet T, Urban S, Paul P, Münz C, Floess S, Huehn J, Cover TL, Blaser MJ, Taube C, Müller A.

J Allergy Clin Immunol. 2019 Apr;143(4):1496-1512.e11. doi: 10.1016/j.jaci.2018.07.046. Epub 2018 Sep 19.

PMID:
30240703
9.

Epigenetic mechanisms regulating T-cell responses.

Schmidl C, Delacher M, Huehn J, Feuerer M.

J Allergy Clin Immunol. 2018 Sep;142(3):728-743. doi: 10.1016/j.jaci.2018.07.014. Review.

PMID:
30195378
10.

Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice.

Uhde AK, Ciurkiewicz M, Herder V, Khan MA, Hensel N, Claus P, Beckstette M, Teich R, Floess S, Baumgärtner W, Jung K, Huehn J, Beineke A.

Sci Rep. 2018 Apr 17;8(1):6106. doi: 10.1038/s41598-018-24378-z.

11.

Regulation of neuroinflammatory properties of glial cells by T cell effector molecules.

Prajeeth CK, Huehn J, Stangel M.

Neural Regen Res. 2018 Feb;13(2):234-236. doi: 10.4103/1673-5374.226385. No abstract available.

12.

The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine.

Sadana P, Geyer R, Pezoldt J, Helmsing S, Huehn J, Hust M, Dersch P, Scrima A.

J Biol Chem. 2018 Jun 1;293(22):8672-8690. doi: 10.1074/jbc.RA117.001068. Epub 2018 Mar 13.

13.

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.

Essig K, Hu D, Guimaraes JC, Alterauge D, Edelmann S, Raj T, Kranich J, Behrens G, Heiseke A, Floess S, Klein J, Maiser A, Marschall S, Hrabĕ de Angelis M, Leonhardt H, Calkhoven CF, Noessner E, Brocker T, Huehn J, Krug AB, Zavolan M, Baumjohann D, Heissmeyer V.

Immunity. 2017 Dec 19;47(6):1067-1082.e12. doi: 10.1016/j.immuni.2017.11.008. Epub 2017 Dec 12.

14.

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V, Floess S, Huehn J, Owens T, Korn T, Stangel M.

J Neuroinflammation. 2017 Oct 16;14(1):204. doi: 10.1186/s12974-017-0978-3.

15.

Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells.

Pasztoi M, Pezoldt J, Beckstette M, Lipps C, Wirth D, Rohde M, Paloczi K, Buzas EI, Huehn J.

Eur J Immunol. 2017 Dec;47(12):2142-2152. doi: 10.1002/eji.201746960. Epub 2017 Sep 15.

16.

TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.

Eur J Immunol. 2017 Dec;47(12):2043-2058. doi: 10.1002/eji.201747041. Epub 2017 Sep 12.

17.

Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.

Ranjan S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Bank U, Zenclussen AC, Niemz J, Schnöder TM, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel FH, Isermann B.

Nat Commun. 2017 Aug 21;8(1):311. doi: 10.1038/s41467-017-00169-4.

18.

Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.

Kyburz A, Urban S, Altobelli A, Floess S, Huehn J, Cover TL, Müller A.

Clin Exp Allergy. 2017 Oct;47(10):1331-1341. doi: 10.1111/cea.12996. Epub 2017 Sep 11.

19.

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance.

Nikolouli E, Hardtke-Wolenski M, Hapke M, Beckstette M, Geffers R, Floess S, Jaeckel E, Huehn J.

Front Immunol. 2017 Jun 28;8:748. doi: 10.3389/fimmu.2017.00748. eCollection 2017.

20.

The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.

Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jänsch L, Huehn J.

Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun.

21.

c-REL and IκBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.

Schuster M, Plaza-Sirvent C, Matthies AM, Heise U, Jeron A, Bruder D, Visekruna A, Huehn J, Schmitz I.

J Immunol. 2017 Aug 1;199(3):920-930. doi: 10.4049/jimmunol.1600877. Epub 2017 Jun 26.

22.

Cytotoxic CD8+ T cell ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis.

Ciurkiewicz M, Herder V, Khan MA, Uhde AK, Teich R, Floess S, Baumgärtner W, Huehn J, Beineke A.

Brain Pathol. 2018 May;28(3):349-368. doi: 10.1111/bpa.12518. Epub 2017 May 12.

PMID:
28452087
23.

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.

Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.

24.

Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling.

Pasztoi M, Bonifacius A, Pezoldt J, Kulkarni D, Niemz J, Yang J, Teich R, Hajek J, Pisano F, Rohde M, Dersch P, Huehn J.

Cell Mol Life Sci. 2017 Aug;74(15):2839-2850. doi: 10.1007/s00018-017-2516-y. Epub 2017 Apr 4.

25.

Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection.

Pezoldt J, Pisano F, Heine W, Pasztoi M, Rosenheinrich M, Nuss AM, Pils MC, Prinz I, Förster R, Huehn J, Dersch P.

J Infect Dis. 2017 Sep 15;216(6):752-760. doi: 10.1093/infdis/jix037.

PMID:
28329174
26.

Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells.

Szilagyi BA, Triebus J, Kressler C, de Almeida M, Tierling S, Durek P, Mardahl M, Szilagyi A, Floess S, Huehn J, Syrbe U, Walter J, Polansky JK, Hamann A.

Mucosal Immunol. 2017 Nov;10(6):1443-1454. doi: 10.1038/mi.2017.7. Epub 2017 Feb 15.

PMID:
28198363
27.

Epigenetic orchestration of thymic Treg cell development.

Beyer M, Huehn J.

Nat Immunol. 2017 Jan 19;18(2):144-146. doi: 10.1038/ni.3660. No abstract available.

PMID:
28102221
28.

Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor.

Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E.

Am J Transplant. 2017 Apr;17(4):917-930. doi: 10.1111/ajt.14175. Epub 2017 Feb 6.

29.

Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation.

Pezoldt J, Huehn J.

Eur J Microbiol Immunol (Bp). 2016 Aug 23;6(3):219-226. eCollection 2016 Sep 29.

30.

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

Uhde AK, Herder V, Akram Khan M, Ciurkiewicz M, Schaudien D, Teich R, Floess S, Baumgärtner W, Huehn J, Beineke A.

PLoS One. 2016 Sep 9;11(9):e0161883. doi: 10.1371/journal.pone.0161883. eCollection 2016.

31.

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.

Goldstein JD, Burlion A, Zaragoza B, Sendeyo K, Polansky JK, Huehn J, Piaggio E, Salomon BL, Marodon G.

PLoS One. 2016 Apr 14;11(4):e0153682. doi: 10.1371/journal.pone.0153682. eCollection 2016. Erratum in: PLoS One. 2016;11(6):e0157629.

32.

CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.

Milanez-Almeida P, Ulas T, Pasztoi M, Glage S, Schughart K, Lutz MB, Schultze JL, Huehn J.

Eur J Microbiol Immunol (Bp). 2015 Nov 4;5(4):246-55. doi: 10.1556/1886.2015.00038. eCollection 2015 Dec.

33.

Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells.

Pasztoi M, Pezoldt J, Huehn J.

Prog Mol Biol Transl Sci. 2015;136:35-56. doi: 10.1016/bs.pmbts.2015.07.012. Epub 2015 Aug 19. Review.

PMID:
26615091
34.

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation.

Klysz D, Tai X, Robert PA, Craveiro M, Cretenet G, Oburoglu L, Mongellaz C, Floess S, Fritz V, Matias MI, Yong C, Surh N, Marie JC, Huehn J, Zimmermann V, Kinet S, Dardalhon V, Taylor N.

Sci Signal. 2015 Sep 29;8(396):ra97. doi: 10.1126/scisignal.aab2610.

PMID:
26420908
35.

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.

Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M.

Mucosal Immunol. 2016 Mar;9(2):444-57. doi: 10.1038/mi.2015.74. Epub 2015 Aug 26.

PMID:
26307665
36.

Foxp3(+) regulatory T cells are expanded in severe atopic dermatitis patients.

Roesner LM, Floess S, Witte T, Olek S, Huehn J, Werfel T.

Allergy. 2015 Dec;70(12):1656-60. doi: 10.1111/all.12712. Epub 2015 Aug 26.

PMID:
26228301
37.

Integrin αE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity.

Braun A, Dewert N, Brunnert F, Schnabel V, Hardenberg JH, Richter B, Zachmann K, Cording S, Claßen A, Brans R, Hamann A, Huehn J, Schön MP.

J Invest Dermatol. 2015 Dec;135(12):2982-2991. doi: 10.1038/jid.2015.287. Epub 2015 Jul 23.

38.

Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T.

Nat Med. 2015 Apr;21(4):414. doi: 10.1038/nm0415-414d. No abstract available.

PMID:
25849276
39.

Comment on "cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans".

Huehn J, Floess S, Ohkura N, Sakaguchi S.

J Immunol. 2015 Apr 15;194(8):3533. doi: 10.4049/jimmunol.1500248. No abstract available.

40.

Epigenetic and transcriptional control of Foxp3+ regulatory T cells.

Huehn J, Beyer M.

Semin Immunol. 2015 Feb;27(1):10-8. doi: 10.1016/j.smim.2015.02.002. Epub 2015 Mar 20. Review.

PMID:
25801206
41.

Development of a unique epigenetic signature during in vivo Th17 differentiation.

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J.

Nucleic Acids Res. 2015 Feb 18;43(3):1537-48. doi: 10.1093/nar/gkv014. Epub 2015 Jan 15.

42.

A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection.

Tebartz C, Horst SA, Sparwasser T, Huehn J, Beineke A, Peters G, Medina E.

J Immunol. 2015 Feb 1;194(3):1100-11. doi: 10.4049/jimmunol.1400196. Epub 2014 Dec 29.

43.

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.

Franckaert D, Dooley J, Roos E, Floess S, Huehn J, Luche H, Fehling HJ, Liston A, Linterman MA, Schlenner SM.

Immunol Cell Biol. 2015 Apr;93(4):417-23. doi: 10.1038/icb.2014.108. Epub 2014 Dec 23.

44.

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.

Mayer CT, Lahl K, Milanez-Almeida P, Watts D, Dittmer U, Fyhrquist N, Huehn J, Kopf M, Kretschmer K, Rouse B, Sparwasser T.

Immun Inflamm Dis. 2014 Nov;2(3):162-5. doi: 10.1002/iid3.33. Epub 2014 Oct 26.

45.

A signal integration model of thymic selection and natural regulatory T cell commitment.

Khailaie S, Robert PA, Toker A, Huehn J, Meyer-Hermann M.

J Immunol. 2014 Dec 15;193(12):5983-96. doi: 10.4049/jimmunol.1400889. Epub 2014 Nov 12.

46.

Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.

Prajeeth CK, Beineke A, Iskandar CD, Gudi V, Herder V, Gerhauser I, Haist V, Teich R, Huehn J, Baumgärtner W, Stangel M.

J Neuroinflammation. 2014 Nov 13;11:180. doi: 10.1186/s12974-014-0180-9.

47.

Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen.

Milanez-Almeida P, Meyer-Hermann M, Toker A, Khailaie S, Huehn J.

Eur J Immunol. 2015 Jan;45(1):153-66. doi: 10.1002/eji.201444480. Epub 2014 Nov 28.

48.

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T.

Nat Med. 2014 Nov;20(11):1327-33. doi: 10.1038/nm.3704. Epub 2014 Oct 5. Erratum in: Nat Med. 2015 Apr;21(4):414.

PMID:
25282359
49.

Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.

Milanez-Almeida P, Klawonn F, Meyer-Hermann M, Huehn J.

Eur J Microbiol Immunol (Bp). 2014 Sep;4(3):147-55. doi: 10.1556/EUJMI-D-14-00022. Epub 2014 Sep 11.

50.

Transcriptional control of regulatory T cells.

Delacher M, Schreiber L, Richards DM, Farah C, Feuerer M, Huehn J.

Curr Top Microbiol Immunol. 2014;381:83-124. doi: 10.1007/82_2014_373. Review.

PMID:
24831347

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