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Items: 34


New Molecular Scaffolds for Fluorescent Voltage Indicators.

Boggess SC, Gandhi SS, Siemons BA, Huebsch N, Healy KE, Miller EW.

ACS Chem Biol. 2019 Mar 15;14(3):390-396. doi: 10.1021/acschembio.8b00978. Epub 2019 Feb 8.


Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.

Tveito A, Jæger KH, Huebsch N, Charrez B, Edwards AG, Wall S, Healy KE.

Sci Rep. 2018 Dec 4;8(1):17626. doi: 10.1038/s41598-018-35858-7.


Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.

Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S.

Biotechnol Bioeng. 2018 Aug;115(8):1958-1970. doi: 10.1002/bit.26709. Epub 2018 Apr 27.


In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect.

Cipitria A, Boettcher K, Schoenhals S, Garske DS, Schmidt-Bleek K, Ellinghaus A, Dienelt A, Peters A, Mehta M, Madl CM, Huebsch N, Mooney DJ, Duda GN.

Acta Biomater. 2017 Sep 15;60:50-63. doi: 10.1016/j.actbio.2017.07.032. Epub 2017 Jul 21.


A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR.

JCI Insight. 2017 Jul 20;2(14). pii: 94623. doi: 10.1172/jci.insight.94623. eCollection 2017 Jul 20.


Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR.

Sci Rep. 2016 Apr 20;6:24726. doi: 10.1038/srep24726.


CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, Gilbert LA, Krogan NJ, Sheikh SP, Weissman JS, Qi LS, So PL, Conklin BR.

Cell Stem Cell. 2016 Apr 7;18(4):541-53. doi: 10.1016/j.stem.2016.01.022. Epub 2016 Mar 10.


Hydrogels with tunable stress relaxation regulate stem cell fate and activity.

Chaudhuri O, Gu L, Klumpers D, Darnell M, Bencherif SA, Weaver JC, Huebsch N, Lee HP, Lippens E, Duda GN, Mooney DJ.

Nat Mater. 2016 Mar;15(3):326-34. doi: 10.1038/nmat4489. Epub 2015 Nov 30.


Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation.

Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ.

Nat Mater. 2015 Dec;14(12):1269-77. doi: 10.1038/nmat4407. Epub 2015 Sep 14.


Self-organizing human cardiac microchambers mediated by geometric confinement.

Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE.

Nat Commun. 2015 Jul 14;6:7413. doi: 10.1038/ncomms8413.


Human iPSC-based cardiac microphysiological system for drug screening applications.

Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE.

Sci Rep. 2015 Mar 9;5:8883. doi: 10.1038/srep08883.


Substrate stress relaxation regulates cell spreading.

Chaudhuri O, Gu L, Darnell M, Klumpers D, Bencherif SA, Weaver JC, Huebsch N, Mooney DJ.

Nat Commun. 2015 Feb 19;6:6364. doi: 10.1038/ncomms7365.


Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE.

Tissue Eng Part C Methods. 2015 May;21(5):467-79. doi: 10.1089/ten.TEC.2014.0283. Epub 2015 Jan 14.


Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy.

Huebsch N, Kearney CJ, Zhao X, Kim J, Cezar CA, Suo Z, Mooney DJ.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9762-7. doi: 10.1073/pnas.1405469111. Epub 2014 Jun 24.


Three-dimensional filamentous human diseased cardiac tissue model.

Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE.

Biomaterials. 2014 Feb;35(5):1367-77. doi: 10.1016/j.biomaterials.2013.10.052. Epub 2013 Nov 21.


Recovery from hind limb ischemia enhances rhBMP-2-mediated segmental bone defect repair in a rat composite injury model.

Uhrig BA, Boerckel JD, Willett NJ, Li MT, Huebsch N, Guldberg RE.

Bone. 2013 Aug;55(2):410-7. doi: 10.1016/j.bone.2013.04.027. Epub 2013 May 7.


Attenuated human bone morphogenetic protein-2-mediated bone regeneration in a rat model of composite bone and muscle injury.

Willett NJ, Li MT, Uhrig BA, Boerckel JD, Huebsch N, Lundgren TL, Warren GL, Guldberg RE.

Tissue Eng Part C Methods. 2013 Apr;19(4):316-25. doi: 10.1089/ten.TEC.2012.0290. Epub 2012 Nov 2.


Characterization of a composite injury model of severe lower limb bone and nerve trauma.

Uhrig BA, Clements IP, Boerckel JD, Huebsch N, Bellamkonda RV, Guldberg RE.

J Tissue Eng Regen Med. 2014 Jun;8(6):432-41. doi: 10.1002/term.1537. Epub 2012 Jun 11.


Adipose tissue engineering using injectable, oxidized alginate hydrogels.

Kim WS, Mooney DJ, Arany PR, Lee K, Huebsch N, Kim J.

Tissue Eng Part A. 2012 Apr;18(7-8):737-43. doi: 10.1089/ten.TEA.2011.0250. Epub 2012 Jan 16.


Mechanical regulation of vascular growth and tissue regeneration in vivo.

Boerckel JD, Uhrig BA, Willett NJ, Huebsch N, Guldberg RE.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E674-80. doi: 10.1073/pnas.1107019108. Epub 2011 Aug 29.


Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects.

Kolambkar YM, Boerckel JD, Dupont KM, Bajin M, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE.

Bone. 2011 Sep;49(3):485-92. doi: 10.1016/j.bone.2011.05.010. Epub 2011 May 18.


Stress-relaxation behavior in gels with ionic and covalent crosslinks.

Zhao X, Huebsch N, Mooney DJ, Suo Z.

J Appl Phys. 2010 Mar 15;107(6):63509. Epub 2010 Mar 23.


[Cell-traction mediated configuration of the cell/extracellular-matrix interface plays a key role in stem cell fate].

Bencherif SA, Guillemot F, Huebsch N, Edwards DA, Mooney DJ.

Med Sci (Paris). 2011 Jan;27(1):19-21. doi: 10.1051/medsci/201127119. French. No abstract available.


Active scaffolds for on-demand drug and cell delivery.

Zhao X, Kim J, Cezar CA, Huebsch N, Lee K, Bouhadir K, Mooney DJ.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):67-72. doi: 10.1073/pnas.1007862108. Epub 2010 Dec 13.


An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects.

Kolambkar YM, Dupont KM, Boerckel JD, Huebsch N, Mooney DJ, Hutmacher DW, Guldberg RE.

Biomaterials. 2011 Jan;32(1):65-74. doi: 10.1016/j.biomaterials.2010.08.074. Epub 2010 Sep 22.


Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate.

Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ.

Nat Mater. 2010 Jun;9(6):518-26. doi: 10.1038/nmat2732. Epub 2010 Apr 25.


Inspiration and application in the evolution of biomaterials.

Huebsch N, Mooney DJ.

Nature. 2009 Nov 26;462(7272):426-32. doi: 10.1038/nature08601. Review.


Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device.

Chueh BH, Zheng Y, Torisawa YS, Hsiao AY, Ge C, Hsiong S, Huebsch N, Franceschi R, Mooney DJ, Takayama S.

Biomed Microdevices. 2010 Feb;12(1):145-51. doi: 10.1007/s10544-009-9369-6.


Infection-mimicking materials to program dendritic cells in situ.

Ali OA, Huebsch N, Cao L, Dranoff G, Mooney DJ.

Nat Mater. 2009 Feb;8(2):151-8. doi: 10.1038/nmat2357. Epub 2009 Jan 11.


Cyclic arginine-glycine-aspartate peptides enhance three-dimensional stem cell osteogenic differentiation.

Hsiong SX, Boontheekul T, Huebsch N, Mooney DJ.

Tissue Eng Part A. 2009 Feb;15(2):263-72. doi: 10.1089/ten.tea.2007.0411.


Integrin-adhesion ligand bond formation of preosteoblasts and stem cells in three-dimensional RGD presenting matrices.

Hsiong SX, Huebsch N, Fischbach C, Kong HJ, Mooney DJ.

Biomacromolecules. 2008 Jul;9(7):1843-51. doi: 10.1021/bm8000606. Epub 2008 Jun 10.


Noninvasive probing of the spatial organization of polymer chains in hydrogels using fluorescence resonance energy transfer (FRET).

Kong HJ, Kim CJ, Huebsch N, Weitz D, Mooney DJ.

J Am Chem Soc. 2007 Apr 18;129(15):4518-9. Epub 2007 Mar 24. No abstract available.


Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensions.

Huebsch ND, Mooney DJ.

Biomaterials. 2007 May;28(15):2424-37. Epub 2007 Jan 16. Review.


Analysis of sterilization protocols for peptide-modified hydrogels.

Huebsch N, Gilbert M, Healy KE.

J Biomed Mater Res B Appl Biomater. 2005 Jul;74(1):440-7.


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