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Items: 1 to 50 of 378

1.

Combination of 5-fluorouracil and thymoquinone targets stem cell gene signature in colorectal cancer cells.

Ndreshkjana B, Çapci A, Klein V, Chanvorachote P, Muenzner JK, Huebner K, Steinmann S, Erlenbach-Wuensch K, Geppert CI, Agaimy A, Ballout F, El-Baba C, Gali-Muhtasib H, Roehe AV, Hartmann A, Tsogoeva SB, Schneider-Stock R.

Cell Death Dis. 2019 May 16;10(6):379. doi: 10.1038/s41419-019-1611-4.

2.

Effects of a Saccharomyces cerevisiae fermentation product on liver abscesses, fecal microbiome, and resistome in feedlot cattle raised without antibiotics.

Huebner KL, Martin JN, Weissend CJ, Holzer KL, Parker JK, Lakin SM, Doster E, Weinroth MD, Abdo Z, Woerner DR, Metcalf JL, Geornaras I, Bryant TC, Morley PS, Belk KE.

Sci Rep. 2019 Feb 22;9(1):2559. doi: 10.1038/s41598-019-39181-7.

3.

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Druck T, Cheung DG, Park D, Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Raso C, Green K, Huebner K, Croce CM.

Cell Death Dis. 2019 Feb 15;10(3):147. doi: 10.1038/s41419-019-1414-7.

4.

PREFACE.

Huebner K.

Genes Chromosomes Cancer. 2019 May;58(5):257-259. doi: 10.1002/gcc.22722. Epub 2019 Jan 28. No abstract available.

PMID:
30578698
5.

Ortho-Biologics for Osteoarthritis.

Huebner K, Frank RM, Getgood A.

Clin Sports Med. 2019 Jan;38(1):123-141. doi: 10.1016/j.csm.2018.09.002. Review.

PMID:
30466718
6.

Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.

Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11091-E11100. doi: 10.1073/pnas.1813956115. Epub 2018 Nov 5.

7.

FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.

Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC.

PMID:
30107138
8.

Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs.

Kiss DL, Baez WD, Huebner K, Bundschuh R, Schoenberg DR.

BMC Res Notes. 2018 Mar 14;11(1):178. doi: 10.1186/s13104-018-3278-9.

9.

Substantial variation in the hepatitis B surface antigen (HBsAg) in hepatitis B virus (HBV)-positive patients from South Africa: Reliable detection of HBV by the Elecsys HBsAg II assay.

Gencay M, Vermeulen M, Neofytos D, Westergaard G, Pabinger S, Kriegner A, Seffner A, Gohl P, Huebner K, Nauck M, Kaminski WE.

J Clin Virol. 2018 Apr;101:38-43. doi: 10.1016/j.jcv.2018.01.011. Epub 2018 Feb 6.

10.

Impact of FHIT loss on the translation of cancer-associated mRNAs.

Kiss DL, Baez W, Huebner K, Bundschuh R, Schoenberg DR.

Mol Cancer. 2017 Dec 28;16(1):179. doi: 10.1186/s12943-017-0749-x.

11.

The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles.

Volinia S, Druck T, Paisie CA, Schrock MS, Huebner K.

Oncotarget. 2017 Nov 6;8(60):102199-102211. doi: 10.18632/oncotarget.22321. eCollection 2017 Nov 24.

12.

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM.

J Biol Chem. 2017 Aug 25;292(34):14279. doi: 10.1074/jbc.A117.709062. No abstract available.

13.

Acute Mountain Sickness.

Prince TS, Huebner K.

StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Jan-.
2019 Feb 8.

14.

What Is Your Diagnosis?

Emerson SE, Callan RJ, Barrell EA, Huebner KL, Vilander AC, Frank C.

J Am Vet Med Assoc. 2017 Jun 15;250(12):1363-1365. doi: 10.2460/javma.250.12.1363. No abstract available.

PMID:
28569626
15.

Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione.

Peracchi A, Veiga-da-Cunha M, Kuhara T, Ellens KW, Paczia N, Stroobant V, Seliga AK, Marlaire S, Jaisson S, Bommer GT, Sun J, Huebner K, Linster CL, Cooper AJL, Van Schaftingen E.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242. doi: 10.1073/pnas.1613736114. Epub 2017 Apr 3.

16.

Fhit down-regulation is an early event in pancreatic carcinogenesis.

Fassan M, Rusev B, Corbo V, Gasparini P, Luchini C, Vicentini C, Mafficini A, Paiella S, Salvia R, Cataldo I, Scarpa A, Huebner K.

Virchows Arch. 2017 Jun;470(6):647-653. doi: 10.1007/s00428-017-2105-3. Epub 2017 Mar 13.

17.

Evaluation of horn bud wound healing following cautery disbudding of preweaned dairy calves treated with aluminum-based aerosol bandage.

Huebner KL, Kunkel AK, McConnel CS, Callan RJ, Dinsmore RP, Caixeta LS.

J Dairy Sci. 2017 May;100(5):3922-3929. doi: 10.3168/jds.2016-12192. Epub 2017 Mar 2.

18.

Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.

Karras JR, Schrock MS, Batar B, Huebner K.

Cytogenet Genome Res. 2016;150(3-4):208-216. doi: 10.1159/000455753. Epub 2017 Feb 16. Review.

19.

Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.

Kiss DL, Waters CE, Ouda IM, Saldivar JC, Karras JR, Amin ZA, Mahrous S, Druck T, Bundschuh RA, Schoenberg DR, Huebner K.

Biochim Biophys Acta Gene Regul Mech. 2017 Mar;1860(3):374-382. doi: 10.1016/j.bbagrm.2017.01.005. Epub 2017 Jan 14.

20.

Wwox-Brca1 interaction: role in DNA repair pathway choice.

Schrock MS, Batar B, Lee J, Druck T, Ferguson B, Cho JH, Akakpo K, Hagrass H, Heerema NA, Xia F, Parvin JD, Aldaz CM, Huebner K.

Oncogene. 2017 Apr 20;36(16):2215-2227. doi: 10.1038/onc.2016.389. Epub 2016 Nov 21.

21.

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Schrock MS, Karras JR, Guggenbiller MJ, Druck T, Batar B, Huebner K.

Adv Biol Regul. 2017 Jan;63:167-176. doi: 10.1016/j.jbior.2016.09.008. Epub 2016 Sep 26.

PMID:
27773744
22.

Fhit loss-associated initiation and progression of neoplasia in vitro.

Karras JR, Schrock MS, Batar B, Zhang J, La Perle K, Druck T, Huebner K.

Cancer Sci. 2016 Nov;107(11):1590-1598. doi: 10.1111/cas.13032. Epub 2016 Oct 3.

23.

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.

Sun J, Shen R, Schrock MS, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Fong LY, Huebner K.

Cancer Med. 2016 Aug;5(8):2032-42. doi: 10.1002/cam4.768. Epub 2016 May 17.

24.

Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse.

Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters CE, Saldivar JC, Druck T, Huebner K.

Cancer Sci. 2016 Apr;107(4):528-35. doi: 10.1111/cas.12887. Epub 2016 Feb 23.

25.

Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.

Steinmann S, Gali-Muhtasib H, Huebner K, Al-Halabi R, Abou Merhi R, Aman P, Agaimy A, Haller F, Schneider-Stock R.

Cancer Lett. 2015 Oct 28;367(2):147-56. doi: 10.1016/j.canlet.2015.07.025. Epub 2015 Jul 28.

PMID:
26225840
26.

TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation.

Drasin DJ, Guarnieri AL, Neelakantan D, Kim J, Cabrera JH, Wang CA, Zaberezhnyy V, Gasparini P, Cascione L, Huebner K, Tan AC, Ford HL.

Cancer Res. 2015 May 1;75(9):1908-21. doi: 10.1158/0008-5472.CAN-14-2394. Epub 2015 Feb 25.

27.

WWOX: a fragile tumor suppressor.

Schrock MS, Huebner K.

Exp Biol Med (Maywood). 2015 Mar;240(3):296-304. doi: 10.1177/1535370214561590. Epub 2014 Dec 22. Review.

28.

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.

Waters CE, Saldivar JC, Amin ZA, Schrock MS, Huebner K.

Oncotarget. 2015 Feb 20;6(5):3409-19.

29.

FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.

Suh SS, Yoo JY, Cui R, Kaur B, Huebner K, Lee TK, Aqeilan RI, Croce CM.

PLoS Genet. 2014 Oct 23;10(10):e1004652. doi: 10.1371/journal.pgen.1004652. eCollection 2014 Oct.

30.

Pluripotent stem cell miRNAs and metastasis in invasive breast cancer.

Volinia S, Nuovo G, Drusco A, Costinean S, Abujarour R, Desponts C, Garofalo M, Baffa R, Aeqilan R, Maharry K, Sana ME, Di Leva G, Gasparini P, Dama P, Marchesini J, Galasso M, Manfrini M, Zerbinati C, CorrĂ  F, Wise T, Wojcik SE, Previati M, Pichiorri F, Zanesi N, Alder H, Palatini J, Huebner KF, Shapiro CL, Negrini M, Vecchione A, Rosenberg AL, Croce CM, Garzon R.

J Natl Cancer Inst. 2014 Oct 11;106(12). pii: dju324. doi: 10.1093/jnci/dju324. Print 2014 Dec. Erratum in: J Natl Cancer Inst. 2014 Nov:106(11):dju373doi:10.1093/jnci/dju373. Garzon, Maria Elena Sana Ramiro [Corrected to Garzon, Ramiro and Sana, Maria Elena].

31.

Severe hyponatremia in a 1-week-old male infant.

Huebner K, Davis TK, Jackson T, Dawson J.

Clin Pediatr (Phila). 2015 Apr;54(4):396-400. doi: 10.1177/0009922814553437. Epub 2014 Oct 9. No abstract available.

PMID:
25305263
32.

The FHIT gene product: tumor suppressor and genome "caretaker".

Waters CE, Saldivar JC, Hosseini SA, Huebner K.

Cell Mol Life Sci. 2014 Dec;71(23):4577-87. doi: 10.1007/s00018-014-1722-0. Epub 2014 Oct 5. Review.

33.

Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.

Karras JR, Paisie CA, Huebner K.

Cancers (Basel). 2014 Jun 4;6(2):1208-19. doi: 10.3390/cancers6021208.

34.

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers.

Gasparini P, Cascione L, Fassan M, Lovat F, Guler G, Balci S, Irkkan C, Morrison C, Croce CM, Shapiro CL, Huebner K.

Oncotarget. 2014 Mar 15;5(5):1174-84.

35.

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.

Gasparini P, Lovat F, Fassan M, Casadei L, Cascione L, Jacob NK, Carasi S, Palmieri D, Costinean S, Shapiro CL, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4536-41. doi: 10.1073/pnas.1402604111. Epub 2014 Mar 10. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 7;114(10 ):E2065.

36.

Histone H1 phosphorylation in breast cancer.

Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MA.

J Proteome Res. 2014 May 2;13(5):2453-67. doi: 10.1021/pr401248f. Epub 2014 Apr 7.

37.

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options.

Gasparini P, Fassan M, Cascione L, Guler G, Balci S, Irkkan C, Paisie C, Lovat F, Morrison C, Zhang J, Scarpa A, Croce CM, Shapiro CL, Huebner K.

PLoS One. 2014 Feb 5;9(2):e88525. doi: 10.1371/journal.pone.0088525. eCollection 2014.

38.

Dexamethasone inhibits inflammation and cartilage damage in a new model of post-traumatic osteoarthritis.

Huebner KD, Shrive NG, Frank CB.

J Orthop Res. 2014 Apr;32(4):566-72. doi: 10.1002/jor.22568. Epub 2013 Dec 30.

39.

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.

Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhang J, Huebner K.

PLoS One. 2013 Nov 14;8(11):e80730. doi: 10.1371/journal.pone.0080730. eCollection 2013.

40.

Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: a preliminary study.

Li X, Malcolm RJ, Huebner K, Hanlon CA, Taylor JJ, Brady KT, George MS, See RE.

Drug Alcohol Depend. 2013 Dec 1;133(2):641-6. doi: 10.1016/j.drugalcdep.2013.08.012. Epub 2013 Aug 26.

41.

Common chromosome fragile sites in human and murine epithelial cells and FHIT/FRA3B loss-induced global genome instability.

Hosseini SA, Horton S, Saldivar JC, Miuma S, Stampfer MR, Heerema NA, Huebner K.

Genes Chromosomes Cancer. 2013 Nov;52(11):1017-29. doi: 10.1002/gcc.22097. Epub 2013 Aug 9.

42.

New surgical model of post-traumatic osteoarthritis: isolated intra-articular bone injury in the rabbit.

Huebner KD, Shrive NG, Frank CB.

J Orthop Res. 2013 Jun;31(6):914-20. doi: 10.1002/jor.22284. Epub 2013 Feb 19.

43.

Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.

Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, Ferro A, Alder H, He G, Vecchione A, Croce CM, Shapiro CL, Huebner K.

PLoS One. 2013;8(2):e55910. doi: 10.1371/journal.pone.0055910. Epub 2013 Feb 6.

44.

Initiation of genome instability and preneoplastic processes through loss of Fhit expression.

Saldivar JC, Miuma S, Bene J, Hosseini SA, Shibata H, Sun J, Wheeler LJ, Mathews CK, Huebner K.

PLoS Genet. 2012;8(11):e1003077. doi: 10.1371/journal.pgen.1003077. Epub 2012 Nov 29.

45.

Characterization of the role of Fhit in suppression of DNA damage.

Saldivar JC, Bene J, Hosseini SA, Miuma S, Horton S, Heerema NA, Huebner K.

Adv Biol Regul. 2013 Jan;53(1):77-85. doi: 10.1016/j.jbior.2012.10.003. Epub 2012 Oct 11.

46.

Osteoarthritis develops in the operated joint of an ovine model following ACL reconstruction with immediate anatomic reattachment of the native ACL.

O'Brien EJ, Beveridge JE, Huebner KD, Heard BJ, Tapper JE, Shrive NG, Frank CB.

J Orthop Res. 2013 Jan;31(1):35-43. doi: 10.1002/jor.22187. Epub 2012 Jul 13.

47.

Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.

Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM, Fong LY.

Carcinogenesis. 2012 Sep;33(9):1736-44. doi: 10.1093/carcin/bgs204. Epub 2012 Jun 10.

48.

Stem cell-related markers in primary breast cancers and associated metastatic lesions.

Guler G, Balci S, Costinean S, Ussakli CH, Irkkan C, Suren D, Sari E, Altundag K, Ozisik Y, Jones S, Bacher J, Shapiro CL, Huebner K.

Mod Pathol. 2012 Jul;25(7):949-55. doi: 10.1038/modpathol.2012.37. Epub 2012 Mar 2.

49.

Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.

Volinia S, Galasso M, Sana ME, Wise TF, Palatini J, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3024-9. doi: 10.1073/pnas.1200010109. Epub 2012 Feb 6.

50.

Post-natal molecular adaptations in anteromedial and posterolateral bundles of the ovine anterior cruciate ligament: one structure with two parts or two distinct ligaments?

Huebner KD, O'Brien EJ, Heard BJ, Chung M, Achari Y, Shrive NG, Frank CB.

Connect Tissue Res. 2012;53(4):277-84. doi: 10.3109/03008207.2011.637652. Epub 2011 Dec 7.

PMID:
22148917

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