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Identifying 'non-progressors' among patients with arthralgia.

Hueber AJ, Krönke G.

Nat Rev Rheumatol. 2020 Feb 27. doi: 10.1038/s41584-020-0400-x. [Epub ahead of print] No abstract available.


Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis.

Simon D, Tascilar K, Kleyer A, Bayat S, Kampylafka E, Sokolova M, Zevkovic A, Hueber AJ, Rech J, Schuster L, Engel K, Sticherling M, Schett G.

Arthritis Rheumatol. 2020 Feb 26. doi: 10.1002/art.41239. [Epub ahead of print]


Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

Simon D, Kleyer A, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Schett G.

Arthritis Rheumatol. 2020 Feb 18. doi: 10.1002/art.41229. [Epub ahead of print]


JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ.

Sci Transl Med. 2020 Feb 12;12(530). pii: eaay4447. doi: 10.1126/scitranslmed.aay4447.


Perceived Stress Levels in Adult Patients With Uveitis.

Grajewski RS, Boelke AC, Adler W, Pape A, Schroedl F, Hueber A, Albus C, Vitinius F, Heindl LM.

Front Psychiatry. 2020 Jan 8;10:916. doi: 10.3389/fpsyt.2019.00916. eCollection 2019.


[Cell death for maintaining epithelial homeostasis].

Gagnoux-Palacios L, Hueber AO.

Med Sci (Paris). 2019 Nov;35(11):830-833. doi: 10.1051/medsci/2019164. Epub 2019 Dec 17. French. No abstract available.


Structural insights into heme binding to IL-36α proinflammatory cytokine.

Wißbrock A, Goradia NB, Kumar A, Paul George AA, Kühl T, Bellstedt P, Ramachandran R, Hoffmann P, Galler K, Popp J, Neugebauer U, Hampel K, Zimmermann B, Adam S, Wiendl M, Krönke G, Hamza I, Heinemann SH, Frey S, Hueber AJ, Ohlenschläger O, Imhof D.

Sci Rep. 2019 Nov 15;9(1):16893. doi: 10.1038/s41598-019-53231-0.


Factors and Situations Affecting the Value of Patient Preference Studies: Semi-Structured Interviews in Europe and the US.

Whichello C, van Overbeeke E, Janssens R, Schölin Bywall K, Russo S, Veldwijk J, Cleemput I, Juhaeri J, Levitan B, Kübler J, Smith M, Hermann R, Englbrecht M, Hueber AJ, Comanescu A, Harding S, Simoens S, Huys I, de Bekker-Grob EW.

Front Pharmacol. 2019 Sep 18;10:1009. doi: 10.3389/fphar.2019.01009. eCollection 2019.


[Hand pain, muscle pain and swollen lips].

d'Oliveira I, Döltz S, Manger K, Hueber AJ.

Z Rheumatol. 2019 Sep;78(7):656-659. doi: 10.1007/s00393-019-0679-7. German. No abstract available.


Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation-data from the prospective IVEPSA study.

Kampylafka E, Simon D, d'Oliveira I, Linz C, Lerchen V, Englbrecht M, Rech J, Kleyer A, Sticherling M, Schett G, Hueber AJ.

Arthritis Res Ther. 2019 Jul 26;21(1):178. doi: 10.1186/s13075-019-1957-0.


Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients.

Simon D, Kleyer A, Bayat S, Tascilar K, Kampylafka E, Meinderink T, Schuster L, Petrov R, Liphardt AM, Rech J, Schett G, Hueber AJ.

Arthritis Res Ther. 2019 Jul 3;21(1):162. doi: 10.1186/s13075-019-1938-3.


Patient Preferences in the Medical Product Life Cycle: What do Stakeholders Think? Semi-Structured Qualitative Interviews in Europe and the USA.

Janssens R, Russo S, van Overbeeke E, Whichello C, Harding S, Kübler J, Juhaeri J, Bywall KS, Comanescu A, Hueber A, Englbrecht M, Nikolenko N, Pravettoni G, Simoens S, Stevens H, Hermann R, Levitan B, Cleemput I, de Bekker-Grob E, Veldwijk J, Huys I.

Patient. 2019 Oct;12(5):513-526. doi: 10.1007/s40271-019-00367-w.


TRAIL and FasL Functions in Cancer and Autoimmune Diseases: Towards an Increasing Complexity.

Rossin A, Miloro G, Hueber AO.

Cancers (Basel). 2019 May 8;11(5). pii: E639. doi: 10.3390/cancers11050639. Review.


The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals.

Berlin A, Simon D, Tascilar K, Figueiredo C, Bayat S, Finzel S, Klaus E, Rech J, Hueber AJ, Kleyer A, Schett G.

Osteoarthritis Cartilage. 2019 Jul;27(7):1043-1047. doi: 10.1016/j.joca.2019.01.019. Epub 2019 Mar 16.


Perceptions of first-degree relatives of patients with rheumatoid arthritis about lifestyle modifications and pharmacological interventions to reduce the risk of rheumatoid arthritis development: a qualitative interview study.

Simons G, Stack RJ, Stoffer-Marx M, Englbrecht M, Mosor E, Buckley CD, Kumar K, Hansson M, Hueber A, Stamm T, Falahee M, Raza K.

BMC Rheumatol. 2018 Nov 6;2:31. doi: 10.1186/s41927-018-0038-3. eCollection 2018.


I Would Never Take Preventive Medication! Perspectives and Information Needs of People Who Underwent Predictive Tests for Rheumatoid Arthritis.

Mosor E, Stoffer-Marx M, Steiner G, Raza K, Stack RJ, Simons G, Falahee M, Skingle D, Dobrin M, Schett G, Englbrecht M, Smolen JS, Kjeken I, Hueber AJ, Stamm TA.

Arthritis Care Res (Hoboken). 2020 Mar;72(3):360-368. doi: 10.1002/acr.23841.


["Virtual rheumatology" : A new teaching concept for rheumatology of the future?]

Kleyer A, Simon D, Hartmann F, Schuster L, Hueber AJ.

Z Rheumatol. 2019 Mar;78(2):112-115. doi: 10.1007/s00393-019-0594-y. German. No abstract available.


Modular Lattice Constructs for Biological Joint Resurfacing.

Gelse K, Biggemann J, Stumpf M, Halmheu M, Grüneboom A, Kleyer A, Scholtysek C, Pachowsky ML, Hueber A, Krönke G, Fey T.

Tissue Eng Part A. 2019 Jul;25(13-14):1053-1062. doi: 10.1089/ten.TEA.2018.0231. Epub 2019 Mar 18.


[Use of medical apps and online platforms among German rheumatologists : Results of the 2016 and 2018 DGRh conference surveys and research conducted by rheumadocs].

Knitza J, Vossen D, Geffken I, Krusche M, Meyer M, Sewerin P, Kleyer A, Hueber AJ; Arbeitskreis Junge Rheumatologen.

Z Rheumatol. 2019 Nov;78(9):839-846. doi: 10.1007/s00393-018-0578-3. German.


Cost-effective Tapering Algorithm in Patients with Rheumatoid Arthritis: Combination of Multibiomarker Disease Activity Score and Autoantibody Status.

Hagen M, Englbrecht M, Haschka J, Reiser M, Kleyer A, Hueber A, Manger B, Figueiredo C, Cobra JF, Tony HP, Finzel S, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Lorenz HM, Nüsslein H, Alten R, Henes J, Krüger K, Schett G, Rech J.

J Rheumatol. 2019 May;46(5):460-466. doi: 10.3899/jrheum.180028. Epub 2018 Dec 1.


[Depression as comorbidity of rheumatoid arthritis].

Baerwald C, Manger B, Hueber A.

Z Rheumatol. 2019 Apr;78(3):243-248. doi: 10.1007/s00393-018-0568-5. Review. German.


Low-Dose Radiotherapy Ameliorates Advanced Arthritis in hTNF-α tg Mice by Particularly Positively Impacting on Bone Metabolism.

Deloch L, Derer A, Hueber AJ, Herrmann M, Schett GA, Wölfelschneider J, Hahn J, Rühle PF, Stillkrieg W, Fuchs J, Fietkau R, Frey B, Gaipl US.

Front Immunol. 2018 Sep 18;9:1834. doi: 10.3389/fimmu.2018.01834. eCollection 2018.


Cell polarity and adherens junction formation inhibit epithelial Fas cell death receptor signaling.

Gagnoux-Palacios L, Awina H, Audebert S, Rossin A, Mondin M, Borgese F, Planas-Botey C, Mettouchi A, Borg JP, Hueber AO.

J Cell Biol. 2018 Nov 5;217(11):3839-3852. doi: 10.1083/jcb.201805071. Epub 2018 Sep 21.


Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration.

Simon D, Kleyer A, Faustini F, Englbrecht M, Haschka J, Berlin A, Kraus S, Hueber AJ, Kocijan R, Sticherling M, Rech J, Schett G.

Arthritis Res Ther. 2018 Aug 31;20(1):203. doi: 10.1186/s13075-018-1691-z.


Resolution of synovitis and arrest of catabolic and anabolic bone changes in patients with psoriatic arthritis by IL-17A blockade with secukinumab: results from the prospective PSARTROS study.

Kampylafka E, d'Oliveira I, Linz C, Lerchen V, Stemmler F, Simon D, Englbrecht M, Sticherling M, Rech J, Kleyer A, Schett G, Hueber AJ.

Arthritis Res Ther. 2018 Jul 27;20(1):153. doi: 10.1186/s13075-018-1653-5.


A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin.

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath MF, Sticherling M, Rech J, Hueber AJ, Engelke K, Schett G.

Bone. 2018 Nov;116:87-93. doi: 10.1016/j.bone.2018.07.017. Epub 2018 Jul 23.


Effects of ustekinumab versus tumor necrosis factor inhibition on enthesitis: Results from the enthesial clearance in psoriatic arthritis (ECLIPSA) study.

Araujo EG, Englbrecht M, Hoepken S, Finzel S, Kampylafka E, Kleyer A, Bayat S, Schoenau V, Hueber A, Rech J, Schett G.

Semin Arthritis Rheum. 2019 Feb;48(4):632-637. doi: 10.1016/j.semarthrit.2018.05.011. Epub 2018 Jun 13.


[Novel molecular mechanisms in the pathophysiology of psoriatic arthritis].

Simon D, Kampylafka E, Hueber AJ.

Z Rheumatol. 2018 Nov;77(9):776-782. doi: 10.1007/s00393-018-0503-9. Review. German.


ALIGNed on adherence: subanalysis of adherence in immune-mediated inflammatory diseases in the DACH region of the global ALIGN study.

Kolios AGA, Hueber AJ, Michetti P, Mrowietz U, Mustak-Blagusz M, Sator PG, Reinshagen M, Wilsmann-Theis D, Gomis-Kleindienst S, Luckey U, Rössler A, Schiefke I.

J Eur Acad Dermatol Venereol. 2019 Jan;33(1):234-241. doi: 10.1111/jdv.15179. Epub 2018 Aug 22.


Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures.

Stemmler F, Simon D, Liphardt AM, Englbrecht M, Rech J, Hueber AJ, Engelke K, Schett G, Kleyer A.

Ann Rheum Dis. 2018 Jul;77(7):973-980. doi: 10.1136/annrheumdis-2017-212404. Epub 2018 Feb 23.


[Big data in imaging].

Sewerin P, Ostendorf B, Hueber AJ, Kleyer A.

Z Rheumatol. 2018 Apr;77(3):203-208. doi: 10.1007/s00393-018-0422-9. Review. German.


Flagellin increases death receptor-mediated cell death in a RIP1-dependent manner.

Hancz D, Szabo A, Molnar T, Varga Z, Hancz A, Gregus A, Hueber AO, Rajnavolgyi E, Koncz G.

Immunol Lett. 2018 Jan;193:42-50. doi: 10.1016/j.imlet.2017.11.007. Epub 2017 Nov 23.


Evidence for genetic overlap between adult onset Still's disease and hereditary periodic fever syndromes.

Sighart R, Rech J, Hueber A, Blank N, Löhr S, Reis A, Sticht H, Hüffmeier U.

Rheumatol Int. 2018 Jan;38(1):111-120. doi: 10.1007/s00296-017-3885-0. Epub 2017 Nov 20.


Suppression of Th17-polarized airway inflammation by rapamycin.

Joean O, Hueber A, Feller F, Jirmo AC, Lochner M, Dittrich AM, Albrecht M.

Sci Rep. 2017 Nov 10;7(1):15336. doi: 10.1038/s41598-017-15750-6.


Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).

Figueiredo CP, Kleyer A, Simon D, Stemmler F, d'Oliveira I, Weissenfels A, Museyko O, Friedberger A, Hueber AJ, Haschka J, Englbrecht M, Pereira RMR, Rech J, Schett G, Engelke K.

Semin Arthritis Rheum. 2018 Apr;47(5):611-618. doi: 10.1016/j.semarthrit.2017.09.011. Epub 2017 Sep 23.


Unilateral plantar erythema nodosum in sarcoidosis.

Hueber AJ, Schett G, Manger B.

Arthritis Rheumatol. 2018 Feb;70(2):297. doi: 10.1002/art.40341. Epub 2018 Jan 5. No abstract available.


The Btk-dependent PIP5K1γ lipid kinase activation by Fas counteracts FasL-induced cell death.

Rossin A, Lounnas N, Durivault J, Miloro G, Gagnoux-Palacios L, Hueber AO.

Apoptosis. 2017 Nov;22(11):1344-1352. doi: 10.1007/s10495-017-1415-x.


Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.

Schmitt V, Hahn M, Kästele V, Wagner O, Wiendl M, Derer A, Taddeo A, Hahne S, Radbruch A, Jäck HM, Schuh W, Mielenz D, Gay S, Schett G, Hueber AJ, Frey S.

Eur J Immunol. 2017 Dec;47(12):2101-2112. doi: 10.1002/eji.201646788. Epub 2017 Sep 22.


Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction.

Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes IB, Wirtz S, Gaipl US, Krönke G, Schett G, Frey S, Hueber AJ.

Front Immunol. 2017 Jun 28;8:722. doi: 10.3389/fimmu.2017.00722. eCollection 2017.


Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors.

Chen J, Chaurio RA, Maueröder C, Derer A, Rauh M, Kost A, Liu Y, Mo X, Hueber A, Bilyy R, Herrmann M, Zhao Y, Muñoz LE.

Front Immunol. 2017 Apr 27;8:504. doi: 10.3389/fimmu.2017.00504. eCollection 2017.


Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis.

Werner D, Simon D, Englbrecht M, Stemmler F, Simon C, Berlin A, Haschka J, Renner N, Buder T, Engelke K, Hueber AJ, Rech J, Schett G, Kleyer A.

Arthritis Rheumatol. 2017 Aug;69(8):1580-1587. doi: 10.1002/art.40148. Epub 2017 Jun 26.


Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage.

Kleyer A, Beyer L, Simon C, Stemmler F, Englbrecht M, Beyer C, Rech J, Manger B, Krönke G, Schett G, Hueber AJ.

Arthritis Res Ther. 2017 Feb 10;19(1):34. doi: 10.1186/s13075-017-1234-z.


Detection of S-Acylated CD95 by Acyl-Biotin Exchange.

Rossin A, Hueber AO.

Methods Mol Biol. 2017;1557:189-198. doi: 10.1007/978-1-4939-6780-3_17.


Site-Specific Detection of Tyrosine Phosphorylated CD95 Following Protein Separation by Conventional and Phospho-Protein Affinity SDS-PAGE.

Chakrabandhu K, Huault S, Hueber AO.

Methods Mol Biol. 2017;1557:173-188. doi: 10.1007/978-1-4939-6780-3_16.


The novel interleukin-1 cytokine family members in inflammatory diseases.

Hahn M, Frey S, Hueber AJ.

Curr Opin Rheumatol. 2017 Mar;29(2):208-213. doi: 10.1097/BOR.0000000000000361. Review.


Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.

Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7.


Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis.

Simon D, Kleyer A, Stemmler F, Simon C, Berlin A, Hueber AJ, Haschka J, Renner N, Figueiredo C, Neuhuber W, Buder T, Englbrecht M, Rech J, Engelke K, Schett G.

J Bone Miner Res. 2017 Apr;32(4):722-730. doi: 10.1002/jbmr.3025. Epub 2016 Nov 18.


Gout mimicking rheumatoid arthritis.

Petsch C, Araujo E, Hueber A, Schett G, Manger B, Rech J.

Semin Arthritis Rheum. 2017 Feb;46(4):e15. doi: 10.1016/j.semarthrit.2016.08.003. Epub 2016 Aug 16. No abstract available.


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