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Items: 39

1.

Abuse liability assessment for biologic drugs - All molecules are not created equal.

de Zafra CLZ, Markgraf CG, Compton DR, Hudzik TJ.

Regul Toxicol Pharmacol. 2018 Feb;92:165-172. doi: 10.1016/j.yrtph.2017.11.019. Epub 2017 Dec 2.

PMID:
29199066
2.

Considerations on nonclinical approaches to modeling risk factors of suicidal ideation and behavior.

Goody SMG, Cannon KE, Liu M, Kallman MJ, Martinolle JP, Mazelin-Winum L, Giarola A, Ardayfio P, Moyer JA, Teuns G, Hudzik TJ.

Regul Toxicol Pharmacol. 2017 Oct;89:288-301. doi: 10.1016/j.yrtph.2017.07.030. Epub 2017 Jul 27. Review.

PMID:
28757322
3.

Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR).

Hudzik TJ, Basso AM, Lynch JJ 3rd, Bracken WM, Mohler EG, Kohlhaas KL, Xu H, Haig G, Gault L.

Pharmacol Biochem Behav. 2017 Jul;158:22-31. doi: 10.1016/j.pbb.2017.05.010. Epub 2017 Jun 1.

4.

A retrospective evaluation of species-specific sensitivity for neurological signs in toxicological studies: Is the dog more sensitive than the non-human primate?

Backes K, Lorenz H, Laplanche L, Hudzik TJ, Potschka H, Hempel K.

Toxicol Lett. 2016 Jan 22;243:78-87. doi: 10.1016/j.toxlet.2015.12.007. Epub 2015 Dec 28.

PMID:
26732424
5.

The Utility of Impulsive Bias and Altered Decision Making as Predictors of Drug Efficacy and Target Selection: Rethinking Behavioral Screening for Antidepressant Drugs.

Marek GJ, Day M, Hudzik TJ.

J Pharmacol Exp Ther. 2016 Mar;356(3):534-48. doi: 10.1124/jpet.115.229922. Epub 2015 Dec 23. Review.

PMID:
26699144
6.

Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.

Roberts RA, Aschner M, Calligaro D, Guilarte TR, Hanig JP, Herr DW, Hudzik TJ, Jeromin A, Kallman MJ, Liachenko S, Lynch JJ 3rd, Miller DB, Moser VC, O'Callaghan JP, Slikker W Jr, Paule MG.

Toxicol Sci. 2015 Dec;148(2):332-40. doi: 10.1093/toxsci/kfv188. Review.

7.

Effects of the δ opioid agonist AZD2327 upon operant behaviors and assessment of its potential for abuse.

Hudzik TJ, Pietras MR, Caccese R, Bui KH, Yocca F, Paronis CA, Swedberg MD.

Pharmacol Biochem Behav. 2014 Sep;124:48-57. doi: 10.1016/j.pbb.2014.05.009. Epub 2014 May 22.

PMID:
24857840
8.

Assessment of the abuse liability of ABT-288, a novel histamine H₃ receptor antagonist.

Hudzik TJ, Basso A, Boyce-Rustay JM, Bracken W, Browman KE, Drescher K, Esbenshade TA, Loberg LI, Lynch JJ 3rd, Brioni JD.

Psychopharmacology (Berl). 2013 Jul;228(2):187-97. doi: 10.1007/s00213-013-3027-7. Epub 2013 Feb 28.

PMID:
23455597
9.

Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications.

McCauley JP Jr, Dantzman CL, King MM, Ernst GE, Wang X, Brush K, Palmer WE, Frietze W, Andisik DW, Hoesch V, Doring K, Hulsizer J, Bui KH, Liu J, Hudzik TJ, Wesolowski SS.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1169-73. doi: 10.1016/j.bmcl.2011.11.088. Epub 2011 Dec 7.

PMID:
22197139
10.

4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: identifying clinical candidates.

Dantzman CL, King MM, Ernst GE, Wang X, McCauley JP Jr, Andisik DW, Brush K, Bui KH, Frietze W, Hoesch V, Liu J, Palmer WE, Spear N, Hudzik TJ, Wesolowski SS.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1174-8. doi: 10.1016/j.bmcl.2011.11.089. Epub 2011 Nov 30.

PMID:
22197137
11.

Preclinical pharmacology of AZD2327: a highly selective agonist of the δ-opioid receptor.

Hudzik TJ, Maciag C, Smith MA, Caccese R, Pietras MR, Bui KH, Coupal M, Adam L, Payza K, Griffin A, Smagin G, Song D, Swedberg MD, Brown W.

J Pharmacol Exp Ther. 2011 Jul;338(1):195-204. doi: 10.1124/jpet.111.179432. Epub 2011 Mar 28.

PMID:
21444630
12.

Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse.

Simmons MA, Werkheiser JL, Hudzik TJ.

Pharmacol Biochem Behav. 2010 Jan;94(3):410-5. doi: 10.1016/j.pbb.2009.10.002. Epub 2009 Oct 17.

PMID:
19840815
13.

Rat middle cerebral artery occlusion: correlations between histopathology, T2-weighted magnetic resonance imaging, and behavioral indices.

Peeling J, Corbett D, Del Bigio MR, Hudzik TJ, Campbell TM, Palmer GC.

J Stroke Cerebrovasc Dis. 2001 Jul-Aug;10(4):166-77.

PMID:
17903821
14.

Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.

Horchler CL, McCauley JP Jr, Hall JE, Snyder DH, Craig Moore W, Hudzik TJ, Chapdelaine MJ.

Bioorg Med Chem. 2007 Jan 15;15(2):939-50. Epub 2006 Oct 20.

PMID:
17126021
15.

Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist.

Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C.

J Pharmacol Exp Ther. 2003 Mar;304(3):1072-84.

PMID:
12604684
16.

T2-weighted MRI correlates with long-term histopathology, neurology scores, and skilled motor behavior in a rat stroke model.

Palmer GC, Peeling J, Corbett D, Del Bigio MR, Hudzik TJ.

Ann N Y Acad Sci. 2001 Jun;939:283-96.

PMID:
11462782
17.
18.

Disruption of acquisition and performance of operant response-duration differentiation by unilateral nigrostriatal lesions.

Hudzik TJ, Howell A, Georger M, Cross AJ.

Behav Brain Res. 2000 Sep;114(1-2):65-77.

PMID:
10996048
19.

Antiparkinson potential of delta-opioid receptor agonists.

Hudzik TJ, Howell A, Payza K, Cross AJ.

Eur J Pharmacol. 2000 May 19;396(2-3):101-7.

PMID:
10822062
20.

Long-term functional end points following middle cerebral artery occlusion in the rat.

Hudzik TJ, Borrelli A, Bialobok P, Widzowski D, Sydserff S, Howell A, Gendron P, Corbett D, Miller J, Palmer GC.

Pharmacol Biochem Behav. 2000 Mar;65(3):553-62.

PMID:
10683498
21.

The low-affinity, use-dependent NMDA receptor antagonist AR-R 15896AR. An update of progress in stroke.

Palmer GC, Cregan EF, Bialobok P, Sydserff SG, Hudzik TJ, McCarthy DJ.

Ann N Y Acad Sci. 1999;890:406-20. Review.

PMID:
10668446
22.

Behavioral effects of AR-R 15849, a highly selective CCK-A agonist.

Simmons RD, Kaiser FC, Hudzik TJ.

Pharmacol Biochem Behav. 1999 Mar;62(3):549-57.

PMID:
10080250
23.
24.

[S]-AR-R 15896AR-A novel anticonvulsant: acute safety, pharmacokinetic and pharmacodynamic properties.

Palmer GC, Murray RJ, Cramer CL, Stagnitto ML, Knowles MK, Freedman LR, Eismann MS, Mahmood N, Balestra M, Borrelli AR, Hudzik TJ, McCarthy DJ.

J Pharmacol Exp Ther. 1999 Jan;288(1):121-32.

PMID:
9862762
25.

Acute heat stress model of seizures in weanling rats: influence of prototypic anti-seizure compounds.

Palmer GC, Borrelli AR, Hudzik TJ, Sparber S.

Epilepsy Res. 1998 May;30(3):203-17.

PMID:
9657648
26.
27.

sigma2 Site-mediated inhibition of electrically evoked guinea pig ileum longitudinal muscle/myenteric plexus contractions.

Kinney GG, Harris EW, Ray R, Hudzik TJ.

Eur J Pharmacol. 1995 Dec 29;294(2-3):547-53.

PMID:
8750717
28.

Drug effects on response-duration differentiation. IV: Effects of trimethyltin.

Hudzik TJ, McMillan DE.

Neurotoxicol Teratol. 1995 Nov-Dec;17(6):665-71.

PMID:
8747748
30.

Drug effects on response duration differentiation. I: Differential effects of drugs of abuse.

Hudzik TJ, McMillan DE.

Psychopharmacology (Berl). 1994 May;114(4):620-7.

PMID:
7855224
31.

Drug effects on response-duration differentiation. II: Selective effects of antidepressant drugs.

Hudzik TJ, McMillan DE.

J Pharmacol Exp Ther. 1994 Mar;268(3):1335-42.

PMID:
8138948
32.

Titrating matching-to-sample performance in pigeons: effects of diazepam, morphine, and cholinergic agents.

Wenger GR, Hudzik TJ, Wright DW.

Pharmacol Biochem Behav. 1993 Oct;46(2):435-43.

PMID:
8265699
33.

Effects of cocaine self-administration on ethanol, food and water intake in the rat.

Hudzik TJ, Wessinger WD, McMillan DE.

Drug Alcohol Depend. 1993 Oct;33(3):225-33.

PMID:
8261887
34.

Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers.

Hudzik TJ, De Costa BR, McMillan DE.

Eur J Pharmacol. 1993 May 19;236(2):279-87.

PMID:
8100532
35.
36.

Effects of cocaine and ethylcocaine on schedule-controlled responding in rats.

Shelnutt S, Hudzik TJ, Lattin DL, McMillan DE.

Pharmacol Biochem Behav. 1992 Oct;43(2):509-11.

PMID:
1438488
37.

Interaction of sigma and PCP-like drugs on operant behaviors in the rat.

Hudzik TJ, Slifer BL.

Psychopharmacology (Berl). 1992;108(1-2):115-22.

PMID:
1410131
38.

Sigma ligand-induced emesis in the pigeon.

Hudzik TJ.

Pharmacol Biochem Behav. 1992 Jan;41(1):215-7.

PMID:
1347173
39.

The role of dopamine in the effects of pentazocine and tripelennamine.

Hudzik TJ, Slifer BL.

Pharmacol Biochem Behav. 1990 Jul;36(3):547-54.

PMID:
1974066

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