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Items: 1 to 50 of 114


Zinc deficiency alters the susceptibility of pancreatic beta cells (INS-1) to arsenic exposure.

Cao AL, Beaver LM, Wong CP, Hudson LG, Ho E.

Biometals. 2019 Dec;32(6):845-859. doi: 10.1007/s10534-019-00217-0. Epub 2019 Sep 21.


Dual Actions of Ketorolac in Metastatic Ovarian Cancer.

Hudson LG, Cook LS, Grimes MM, Muller CY, Adams SF, Wandinger-Ness A.

Cancers (Basel). 2019 Jul 24;11(8). pii: E1049. doi: 10.3390/cancers11081049. Review.


Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation.

Zhou X, Ding X, Shen J, Yang D, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2019 Sep 1;378:114602. doi: 10.1016/j.taap.2019.114602. Epub 2019 May 29.


Zinc Deficiency and Arsenic Exposure Can Act Both Independently or Cooperatively to Affect Zinc Status, Oxidative Stress, and Inflammatory Response.

Wong CP, Dashner-Titus EJ, Alvarez SC, Chase TT, Hudson LG, Ho E.

Biol Trace Elem Res. 2019 Oct;191(2):370-381. doi: 10.1007/s12011-019-1631-z. Epub 2019 Jan 11.


Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome.

Gaulke CA, Rolshoven J, Wong CP, Hudson LG, Ho E, Sharpton TJ.

mSphere. 2018 Dec 5;3(6). pii: e00521-18. doi: 10.1128/mSphere.00521-18.


Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.

Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A.

Cancers (Basel). 2018 Sep 27;10(10). pii: E358. doi: 10.3390/cancers10100358. Review.


Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants.

Dashner-Titus EJ, Hoover J, Li L, Lee JH, Du R, Liu KJ, Traber MG, Ho E, Lewis J, Hudson LG.

Free Radic Biol Med. 2018 Aug 20;124:484-492. doi: 10.1016/j.freeradbiomed.2018.04.579. Epub 2018 Apr 30.


The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.

Peretti AS, Dominguez D, Grimes MM, Hathaway HJ, Prossnitz ER, Rivera MR, Wandinger-Ness A, Kusewitt DF, Hudson LG.

Am J Pathol. 2018 Feb;188(2):515-524. doi: 10.1016/j.ajpath.2017.10.018. Epub 2017 Nov 21.


Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue.

Ding X, Zhou X, Cooper KL, Huestis J, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2017 Sep 15;331:108-115. doi: 10.1016/j.taap.2017.05.031. Epub 2017 May 25.


Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.

Xu H, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblo M, Aleksunes LM, Burchiel SW.

Toxicol Sci. 2017 Jul 1;158(1):127-139. doi: 10.1093/toxsci/kfx075.


Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.

Huestis J, Zhou X, Chen L, Feng C, Hudson LG, Liu KJ.

J Inorg Biochem. 2016 Oct;163:45-52. doi: 10.1016/j.jinorgbio.2016.08.003. Epub 2016 Aug 2.


Differential sensitivities of bone marrow, spleen and thymus to genotoxicity induced by environmentally relevant concentrations of arsenite.

Xu H, McClain S, Medina S, Lauer FT, Douillet C, Liu KJ, Hudson LG, Stýblo M, Burchiel SW.

Toxicol Lett. 2016 Nov 16;262:55-61. doi: 10.1016/j.toxlet.2016.09.008. Epub 2016 Sep 19.


S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite.

Zhou X, Cooper KL, Huestis J, Xu H, Burchiel SW, Hudson LG, Liu KJ.

Oncotarget. 2016 Dec 6;7(49):80482-80492. doi: 10.18632/oncotarget.12613.


Constrained inference of protein interaction networks for invadopodium formation in cancer.

Wang H, Leung M, Wandinger-Ness A, Hudson LG, Song M.

IET Syst Biol. 2016 Apr;10(2):76-85. doi: 10.1049/iet-syb.2015.0009.


Environmentally relevant concentrations of arsenite and monomethylarsonous acid inhibit IL-7/STAT5 cytokine signaling pathways in mouse CD3+CD4-CD8- double negative thymus cells.

Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW.

Toxicol Lett. 2016 Apr 15;247:62-8. doi: 10.1016/j.toxlet.2016.02.014. Epub 2016 Feb 24.


Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer.

von Maltzan K, Li Y, Rundhaug JE, Hudson LG, Fischer SM, Kusewitt DF.

J Clin Med. 2016 Feb 3;5(2). pii: E21. doi: 10.3390/jcm5020021.


Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.

Cooper KL, Dashner EJ, Tsosie R, Cho YM, Lewis J, Hudson LG.

Toxicol Appl Pharmacol. 2016 Jan 15;291:13-20. doi: 10.1016/j.taap.2015.11.017. Epub 2015 Nov 25.


Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A.

PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015.


Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells.

Ezeh PC, Xu H, Lauer FT, Liu KJ, Hudson LG, Burchiel SW.

Toxicol Sci. 2016 Feb;149(2):289-99. doi: 10.1093/toxsci/kfv233. Epub 2015 Oct 30.


Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells.

Xu H, Zhou X, Wen X, Lauer FT, Liu KJ, Hudson LG, Aleksunes LM, Burchiel SW.

Toxicol Sci. 2016 Jan;149(1):31-41. doi: 10.1093/toxsci/kfv211. Epub 2015 Oct 5.


Contributions of the Epidermal Growth Factor Receptor to Acquisition of Platinum Resistance in Ovarian Cancer Cells.

Granados ML, Hudson LG, Samudio-Ruiz SL.

PLoS One. 2015 Sep 9;10(9):e0136893. doi: 10.1371/journal.pone.0136893. eCollection 2015.


R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.

Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A.

Mol Cancer Ther. 2015 Oct;14(10):2215-27. doi: 10.1158/1535-7163.MCT-15-0419. Epub 2015 Jul 23.


A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.

Guo Y, Kenney SR, Cook L, Adams SF, Rutledge T, Romero E, Oprea TI, Sklar LA, Bedrick E, Wiggins CL, Kang H, Lomo L, Muller CY, Wandinger-Ness A, Hudson LG.

Clin Cancer Res. 2015 Nov 15;21(22):5064-72. doi: 10.1158/1078-0432.CCR-15-0461. Epub 2015 Jun 12.


Selective Sensitization of Zinc Finger Protein Oxidation by Reactive Oxygen Species through Arsenic Binding.

Zhou X, Cooper KL, Sun X, Liu KJ, Hudson LG.

J Biol Chem. 2015 Jul 24;290(30):18361-9. doi: 10.1074/jbc.M115.663906. Epub 2015 Jun 10.


Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses.

Morris KT, Castillo EF, Ray AL, Weston LL, Nofchissey RA, Hanson JA, Samedi VG, Pinchuk IV, Hudson LG, Beswick EJ.

Oncotarget. 2015 Sep 8;6(26):22338-47.


Conference Summary and Recent Advances: the 8th Conference on Metal Toxicity and Carcinogenesis.

Zhou X, Burchiel SW, Hudson LG, Liu KJ.

Biol Trace Elem Res. 2015 Jul;166(1):1-6. doi: 10.1007/s12011-015-0363-y. Epub 2015 May 16. No abstract available.


Arsenite Interacts with Dibenzo[def,p]chrysene (DBC) at Low Levels to Suppress Bone Marrow Lymphoid Progenitors in Mice.

Ezeh PC, Lauer FT, Liu KJ, Hudson LG, Burchiel SW.

Biol Trace Elem Res. 2015 Jul;166(1):82-8. doi: 10.1007/s12011-015-0279-6. Epub 2015 Mar 6.


Role of the epidermal growth factor receptor in ultraviolet radiation induction of Snail family transcription factors.

Shirley SH, Hammiller B, Hansen LA, Crysup B, Hudson LG, Kusewitt DF.

J Dermatol Sci. 2014 Nov;76(2):149-51. doi: 10.1016/j.jdermsci.2014.09.001. Epub 2014 Sep 16. No abstract available.


Differential susceptibility of human peripheral blood T cells to suppression by environmental levels of sodium arsenite and monomethylarsonous acid.

Burchiel SW, Lauer FT, Beswick EJ, Gandolfi AJ, Parvez F, Liu KJ, Hudson LG.

PLoS One. 2014 Oct 1;9(10):e109192. doi: 10.1371/journal.pone.0109192. eCollection 2014.


Arsenite selectively inhibits mouse bone marrow lymphoid progenitor cell development in vivo and in vitro and suppresses humoral immunity in vivo.

Ezeh PC, Lauer FT, MacKenzie D, McClain S, Liu KJ, Hudson LG, Gandolfi AJ, Burchiel SW.

PLoS One. 2014 Apr 8;9(4):e93920. doi: 10.1371/journal.pone.0093920. eCollection 2014.


Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins.

Zhou X, Sun X, Mobarak C, Gandolfi AJ, Burchiel SW, Hudson LG, Liu KJ.

Chem Res Toxicol. 2014 Apr 21;27(4):690-8. doi: 10.1021/tx500022j. Epub 2014 Mar 19.


Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair.

Sun X, Zhou X, Du L, Liu W, Liu Y, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2014 Jan 15;274(2):313-8. doi: 10.1016/j.taap.2013.11.010. Epub 2013 Nov 22.


Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic.

Cooper KL, Yager JW, Hudson LG.

Toxicol Lett. 2014 Jan 30;224(3):407-15. doi: 10.1016/j.toxlet.2013.11.010. Epub 2013 Nov 21.


Glyoxal leads to defective keratinocyte migration and down-regulation of Snai2.

Quan KK, Kusewitt DF, Hudson LG.

J Dermatol Sci. 2014 Feb;73(2):166-9. doi: 10.1016/j.jdermsci.2013.10.001. Epub 2013 Oct 18. No abstract available.


Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.

Wang F, Zhou X, Liu W, Sun X, Chen C, Hudson LG, Jian Liu K.

Free Radic Biol Med. 2013 Aug;61:249-56. doi: 10.1016/j.freeradbiomed.2013.04.019. Epub 2013 Apr 18.


Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc.

Cooper KL, King BS, Sandoval MM, Liu KJ, Hudson LG.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):81-8. doi: 10.1016/j.taap.2013.03.008. Epub 2013 Mar 21.


Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A.

J Biol Chem. 2013 Mar 22;288(12):8531-43. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6837.


Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair.

King BS, Cooper KL, Liu KJ, Hudson LG.

J Biol Chem. 2012 Nov 16;287(47):39824-33. doi: 10.1074/jbc.M112.393504. Epub 2012 Oct 4.


Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure.

Qin XJ, Liu W, Li YN, Sun X, Hai CX, Hudson LG, Liu KJ.

Toxicol Sci. 2012 May;127(1):120-9. doi: 10.1093/toxsci/kfs099. Epub 2012 Mar 2.


Differential downregulation of e-cadherin and desmoglein by epidermal growth factor.

Chavez MG, Buhr CA, Petrie WK, Wandinger-Ness A, Kusewitt DF, Hudson LG.

Dermatol Res Pract. 2012;2012:309587. doi: 10.1155/2012/309587. Epub 2012 Jan 16.


Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs.

Zhou X, Sun X, Cooper KL, Wang F, Liu KJ, Hudson LG.

J Biol Chem. 2011 Jul 1;286(26):22855-63. doi: 10.1074/jbc.M111.232926. Epub 2011 May 5.


Integrin regulation of beta-catenin signaling in ovarian carcinoma.

Burkhalter RJ, Symowicz J, Hudson LG, Gottardi CJ, Stack MS.

J Biol Chem. 2011 Jul 1;286(26):23467-75. doi: 10.1074/jbc.M110.199539. Epub 2011 Apr 25.


Corrigendum to "Immunotoxicity and biodistribution analysis of arsenic trioxide in C57B1/6 mice following a 2-week inhalation exposure": [Toxicol. Appl. Pharmacol. 241 (2009) 253-259].

Burchiel SW, Mitchell LA, Lauer FT, Sun X, McDonald JD, Hudson LG, Liu KJ.

Toxicol Appl Pharmacol. 2010 Aug 1;246(3):188. doi: 10.1016/j.taap.2010.05.001. No abstract available.


The skinny on Slug.

Shirley SH, Hudson LG, He J, Kusewitt DF.

Mol Carcinog. 2010 Oct;49(10):851-61. doi: 10.1002/mc.20674. Review.


Microarray analysis of cutaneous squamous cell carcinomas reveals enhanced expression of epidermal differentiation complex genes.

Hudson LG, Gale JM, Padilla RS, Pickett G, Alexander BE, Wang J, Kusewitt DF.

Mol Carcinog. 2010 Jul;49(7):619-29. doi: 10.1002/mc.20636.


Low-dose synergistic immunosuppression of T-dependent antibody responses by polycyclic aromatic hydrocarbons and arsenic in C57BL/6J murine spleen cells.

Li Q, Lauer FT, Liu KJ, Hudson LG, Burchiel SW.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):344-51. doi: 10.1016/j.taap.2010.03.020. Epub 2010 Mar 28.


The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2.

Zeineldin R, Ning Y, Hudson LG.

J Histochem Cytochem. 2010 Jun;58(6):529-41. doi: 10.1369/jhc.2010.955104. Epub 2010 Feb 15.

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