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Items: 1 to 50 of 410

1.

Corrigendum to "RiPP antibiotics: biosynthesis and engineering potential" [Curr Opin Microbiol 45 (2018) 61-69].

Hudson GA, Mitchell DA.

Curr Opin Microbiol. 2019 Jul 11. pii: S1369-5274(19)30037-2. doi: 10.1016/j.mib.2019.06.001. [Epub ahead of print] No abstract available.

PMID:
31303539
2.

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides.

Hudson GA, Burkhart BJ, DiCaprio AJ, Schwalen CJ, Kille B, Pogorelov TV, Mitchell DA.

J Am Chem Soc. 2019 May 22;141(20):8228-8238. doi: 10.1021/jacs.9b01519. Epub 2019 May 13.

PMID:
31059252
3.

Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19.

4.

Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.

Kanagasundaram NS, Baudouin SV, Rowling S, Prabhu M, Dark JH, Goodship THJ, Chinnery PF, Hudson G.

Sci Rep. 2019 Feb 19;9(1):2279. doi: 10.1038/s41598-018-37944-2.

5.

A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts.

Guyatt AL, Brennan RR, Burrows K, Guthrie PAI, Ascione R, Ring SM, Gaunt TR, Pyle A, Cordell HJ, Lawlor DA, Chinnery PF, Hudson G, Rodriguez S.

Hum Genomics. 2019 Jan 31;13(1):6. doi: 10.1186/s40246-018-0190-2.

6.

Six weeks of oral Echinacea purpurea supplementation does not enhance the production of serum erythropoietin or erythropoietic status in recreationally active males with above-average aerobic fitness.

Martin TD, Green MS, Whitehead MT, Scheett TP, Webster MJ, Hudson GM.

Appl Physiol Nutr Metab. 2019 Jul;44(7):791-795. doi: 10.1139/apnm-2018-0783. Epub 2019 Jan 4.

PMID:
30608872
7.

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits.

Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF, Arking DE, Chasman DI, Young K, Ligthart S, Hill WD, Weiss S, Luan J, Giulianini F, Li-Gao R, Hartwig FP, Lin SJ, Wang L, Richardson TG, Yao J, Fernandez EP, Ghanbari M, Wojczynski MK, Lee WJ, Argos M, Armasu SM, Barve RA, Ryan KA, An P, Baranski TJ, Bielinski SJ, Bowden DW, Broeckel U, Christensen K, Chu AY, Corley J, Cox SR, Uitterlinden AG, Rivadeneira F, Cropp CD, Daw EW, van Heemst D, de Las Fuentes L, Gao H, Tzoulaki I, Ahluwalia TS, de Mutsert R, Emery LS, Erzurumluoglu AM, Perry JA, Fu M, Forouhi NG, Gu Z, Hai Y, Harris SE, Hemani G, Hunt SC, Irvin MR, Jonsson AE, Justice AE, Kerrison ND, Larson NB, Lin KH, Love-Gregory LD, Mathias RA, Lee JH, Nauck M, Noordam R, Ong KK, Pankow J, Patki A, Pattie A, Petersmann A, Qi Q, Ribel-Madsen R, Rohde R, Sandow K, Schnurr TM, Sofer T, Starr JM, Taylor AM, Teumer A, Timpson NJ, de Haan HG, Wang Y, Weeke PE, Williams C, Wu H, Yang W, Zeng D, Witte DR, Weir BS, Wareham NJ, Vestergaard H, Turner ST, Torp-Pedersen C, Stergiakouli E, Sheu WH, Rosendaal FR, Ikram MA, Franco OH, Ridker PM, Perls TT, Pedersen O, Nohr EA, Newman AB, Linneberg A, Langenberg C, Kilpeläinen TO, Kardia SLR, Jørgensen ME, Jørgensen T, Sørensen TIA, Homuth G, Hansen T, Goodarzi MO, Deary IJ, Christensen C, Chen YI, Chakravarti A, Brandslund I, Bonnelykke K, Taylor KD, Wilson JG, Rodriguez S, Davies G, Horta BL, Thyagarajan B, Rao DC, Grarup N, Davila-Roman VG, Hudson G, Guo X, Arnett DK, Hayward C, Vaidya D, Mook-Kanamori DO, Tiwari HK, Levy D, Loos RJF, Dehghan A, Elliott P, Malik AN, Scott RA, Becker DM, de Andrade M, Province MA, Meigs JB, Rotter JI, North KE.

Am J Hum Genet. 2019 Jan 3;104(1):112-138. doi: 10.1016/j.ajhg.2018.12.001. Epub 2018 Dec 27.

8.

Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin.

DiCaprio AJ, Firouzbakht A, Hudson GA, Mitchell DA.

J Am Chem Soc. 2019 Jan 9;141(1):290-297. doi: 10.1021/jacs.8b09928. Epub 2018 Dec 27.

PMID:
30589265
9.

Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage.

Crilly S, Njegic A, Laurie SE, Fotiou E, Hudson G, Barrington J, Webb K, Young HL, Badrock AP, Hurlstone A, Rivers-Auty J, Parry-Jones AR, Allan SM, Kasher PR.

Version 2. F1000Res. 2018 Oct 8 [revised 2018 Jan 1];7:1617. doi: 10.12688/f1000research.16473.2. eCollection 2018.

10.

Community engagement: A central feature of NOSM's socially accountable distributed medical education.

Strasser R, Hogenbirk J, Jacklin K, Maar M, Hudson G, Warry W, Cheu H, Dubé T, Carson D.

Can Med Educ J. 2018 Mar 27;9(1):e33-e43. eCollection 2018 Mar.

11.

Effects of Adherence to a Higher Protein Diet on Weight Loss, Markers of Health, and Functional Capacity in Older Women Participating in a Resistance-Based Exercise Program.

Galbreath M, Campbell B, LaBounty P, Bunn J, Dove J, Harvey T, Hudson G, Gutierrez JL, Levers K, Galvan E, Jagim A, Greenwood L, Cooke MB, Greenwood M, Rasmussen C, Kreider RB.

Nutrients. 2018 Aug 11;10(8). pii: E1070. doi: 10.3390/nu10081070.

12.

Cell-free mitochondrial DNA in progressive multiple sclerosis.

Lowes H, Pyle A, Duddy M, Hudson G.

Mitochondrion. 2019 May;46:307-312. doi: 10.1016/j.mito.2018.07.008. Epub 2018 Aug 8.

13.

Assessing mitochondrial heteroplasmy using next generation sequencing: A note of caution.

Santibanez-Koref M, Griffin H, Turnbull DM, Chinnery PF, Herbert M, Hudson G.

Mitochondrion. 2019 May;46:302-306. doi: 10.1016/j.mito.2018.08.003. Epub 2018 Aug 9.

14.

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics.

Schwalen CJ, Hudson GA, Kille B, Mitchell DA.

J Am Chem Soc. 2018 Aug 1;140(30):9494-9501. doi: 10.1021/jacs.8b03896. Epub 2018 Jul 20.

15.

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.

Burns DT, Donkervoort S, Müller JS, Knierim E, Bharucha-Goebel D, Faqeih EA, Bell SK, AlFaifi AY, Monies D, Millan F, Retterer K, Dyack S, MacKay S, Morales-Gonzalez S, Giunta M, Munro B, Hudson G, Scavina M, Baker L, Massini TC, Lek M, Hu Y, Ezzo D, AlKuraya FS, Kang PB, Griffin H, Foley AR, Schuelke M, Horvath R, Bönnemann CG.

Am J Hum Genet. 2018 May 3;102(5):858-873. doi: 10.1016/j.ajhg.2018.03.011.

16.

Correction: Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.

Wei W, Gomez-Duran A, Hudson G, Chinnery PF.

PLoS Genet. 2018 May 4;14(5):e1007364. doi: 10.1371/journal.pgen.1007364. eCollection 2018 May.

17.

Author Correction: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WWC, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Aug;20(8):991. doi: 10.1038/s41556-018-0064-9.

PMID:
29674682
18.

RiPP antibiotics: biosynthesis and engineering potential.

Hudson GA, Mitchell DA.

Curr Opin Microbiol. 2018 Oct;45:61-69. doi: 10.1016/j.mib.2018.02.010. Epub 2018 Mar 10. Review. Erratum in: Curr Opin Microbiol. 2019 Jul 11;:.

PMID:
29533845
19.

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WCW, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Feb;20(2):144-151. doi: 10.1038/s41556-017-0017-8. Epub 2018 Jan 15. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

20.

Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.

Wei W, Gomez-Duran A, Hudson G, Chinnery PF.

PLoS Genet. 2017 Dec 18;13(12):e1007126. doi: 10.1371/journal.pgen.1007126. eCollection 2017 Dec. Erratum in: PLoS Genet. 2018 May 4;14 (5):e1007364.

21.

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily.

Schwalen CJ, Hudson GA, Kosol S, Mahanta N, Challis GL, Mitchell DA.

J Am Chem Soc. 2017 Dec 20;139(50):18154-18157. doi: 10.1021/jacs.7b09899. Epub 2017 Dec 4.

22.

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.

Zhang Z, Mahanta N, Hudson GA, Mitchell DA, van der Donk WA.

J Am Chem Soc. 2017 Dec 27;139(51):18623-18631. doi: 10.1021/jacs.7b10203. Epub 2017 Dec 15.

23.

Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12928-12933. doi: 10.1073/pnas.1716035114. Epub 2017 Nov 20.

24.

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

Bury AG, Pyle A, Elson JL, Greaves L, Morris CM, Hudson G, Pienaar IS.

Ann Neurol. 2017 Dec;82(6):1016-1021. doi: 10.1002/ana.25099. Epub 2017 Dec 4.

PMID:
29149768
25.

Correction to Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis.

Mahanta N, Hudson GA, Mitchell DA.

Biochemistry. 2017 Nov 14;56(45):6072. doi: 10.1021/acs.biochem.7b01056. Epub 2017 Nov 2. No abstract available.

PMID:
29094593
26.

Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis.

Mahanta N, Hudson GA, Mitchell DA.

Biochemistry. 2017 Oct 10;56(40):5229-5244. doi: 10.1021/acs.biochem.7b00771. Epub 2017 Sep 22. Review. Erratum in: Biochemistry. 2017 Nov 14;56(45):6072.

27.

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products.

Burkhart BJ, Kakkar N, Hudson GA, van der Donk WA, Mitchell DA.

ACS Cent Sci. 2017 Jun 28;3(6):629-638. doi: 10.1021/acscentsci.7b00141. Epub 2017 Jun 6.

28.

metabolic profiling of Parkinson's disease and mild cognitive impairment.

Burté F, Houghton D, Lowes H, Pyle A, Nesbitt S, Yarnall A, Yu-Wai-Man P, Burn DJ, Santibanez-Koref M, Hudson G.

Mov Disord. 2017 Jun;32(6):927-932. doi: 10.1002/mds.26992. Epub 2017 Apr 10.

29.

Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA.

Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19.

30.

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA.

J Am Chem Soc. 2017 Mar 29;139(12):4310-4313. doi: 10.1021/jacs.7b00693. Epub 2017 Mar 21.

31.

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

Connor TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH.

PLoS Genet. 2017 Mar 7;13(3):e1006620. doi: 10.1371/journal.pgen.1006620. eCollection 2017 Mar.

32.

Quantifying sperm egg interaction to assess the breeding efficiency through artificial insemination in guinea fowls.

Hudson GH, Omprakash AV, Premavalli K, Dhinakar Raj G.

Br Poult Sci. 2017 Apr;58(2):192-199. doi: 10.1080/00071668.2016.1262004. Epub 2017 Jan 24.

PMID:
28043159
33.

Repeated unpredictable threats without harm impair spatial working memory in the Barnes maze.

Kim DJ, St Louis N, Molaro RA, Hudson GT, Chorley RC, Anderson BJ.

Neurobiol Learn Mem. 2017 Jan;137:92-100. doi: 10.1016/j.nlm.2016.11.014. Epub 2016 Nov 21.

PMID:
27884756
34.

Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins.

Maxson T, Tietz JI, Hudson GA, Guo XR, Tai HC, Mitchell DA.

J Am Chem Soc. 2016 Nov 23;138(46):15157-15166. Epub 2016 Nov 14.

35.

Reduced mitochondrial DNA is not a biomarker of depression in Parkinson's disease.

Pyle A, Lowes H, Brennan R, Kurzawa-Akanbi M, Yarnall A, Burn D, Hudson G.

Mov Disord. 2016 Dec;31(12):1923-1924. doi: 10.1002/mds.26825. Epub 2016 Oct 18. No abstract available.

PMID:
27753152
36.

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin.

Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA.

J Am Chem Soc. 2016 Dec 7;138(48):15511-15514. doi: 10.1021/jacs.6b08987. Epub 2016 Oct 13.

37.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Gaur V, Connor T, Sanigorski A, Martin SD, Bruce CR, Henstridge DC, Bond ST, McEwen KA, Kerr-Bayles L, Ashton TD, Fleming C, Wu M, Pike Winer LS, Chen D, Hudson GM, Schwabe JWR, Baar K, Febbraio MA, Gregorevic P, Pfeffer FM, Walder KR, Hargreaves M, McGee SL.

Cell Rep. 2016 Sep 13;16(11):2802-2810. doi: 10.1016/j.celrep.2016.08.005.

38.

Exome sequencing in dementia with Lewy bodies.

Keogh MJ, Kurzawa-Akanbi M, Griffin H, Douroudis K, Ayers KL, Hussein RI, Hudson G, Pyle A, Cordell HJ, Attems J, McKeith IG, O'Brien JT, Burn DJ, Morris CM, Thomas AJ, Chinnery PF.

Transl Psychiatry. 2016 Feb 2;6:e728. doi: 10.1038/tp.2015.220.

39.

Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck.

Wilson IJ, Carling PJ, Alston CL, Floros VI, Pyle A, Hudson G, Sallevelt SC, Lamperti C, Carelli V, Bindoff LA, Samuels DC, Wonnapinij P, Zeviani M, Taylor RW, Smeets HJ, Horvath R, Chinnery PF.

Hum Mol Genet. 2016 Mar 1;25(5):1031-41. doi: 10.1093/hmg/ddv626. Epub 2016 Jan 5.

40.

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin.

Hudson GA, Zhang Z, Tietz JI, Mitchell DA, van der Donk WA.

J Am Chem Soc. 2015 Dec 30;137(51):16012-5. doi: 10.1021/jacs.5b10194. Epub 2015 Dec 21.

41.

Reply: Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion.

Yu-Wai-Man P, Hudson G, Klopstock T, Chinnery PF.

Brain. 2016 Mar;139(Pt 3):e18. doi: 10.1093/brain/awv340. Epub 2015 Dec 10. No abstract available.

42.

Somatic mtDNA variation is an important component of Parkinson's disease.

Coxhead J, Kurzawa-Akanbi M, Hussain R, Pyle A, Chinnery P, Hudson G.

Neurobiol Aging. 2016 Feb;38:217.e1-217.e6. doi: 10.1016/j.neurobiolaging.2015.10.036. Epub 2015 Nov 6.

43.

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease.

Pyle A, Anugrha H, Kurzawa-Akanbi M, Yarnall A, Burn D, Hudson G.

Neurobiol Aging. 2016 Feb;38:216.e7-216.e10. doi: 10.1016/j.neurobiolaging.2015.10.033. Epub 2015 Nov 5.

44.

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.

Pyle A, Brennan R, Kurzawa-Akanbi M, Yarnall A, Thouin A, Mollenhauer B, Burn D, Chinnery PF, Hudson G.

Ann Neurol. 2015 Dec;78(6):1000-4. doi: 10.1002/ana.24515. Epub 2015 Nov 13.

45.

Inherited mtDNA variations are not strong risk factors in human prion disease.

Hudson G, Uphill J, Hummerich H, Blevins J, Gambetti P, Zerr I, Collinge J, Mead S, Chinnery PF.

Neurobiol Aging. 2015 Oct;36(10):2908.e1-3. doi: 10.1016/j.neurobiolaging.2015.07.005. Epub 2015 Jul 10.

46.

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis.

Burkhart BJ, Hudson GA, Dunbar KL, Mitchell DA.

Nat Chem Biol. 2015 Aug;11(8):564-70. doi: 10.1038/nchembio.1856. Epub 2015 Jul 13.

47.

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.

Hudson GM, Watson PJ, Fairall L, Jamieson AG, Schwabe JW.

J Biol Chem. 2015 Jul 17;290(29):18237-44. doi: 10.1074/jbc.M115.661058. Epub 2015 Jun 8.

48.

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans.

Pyle A, Hudson G, Wilson IJ, Coxhead J, Smertenko T, Herbert M, Santibanez-Koref M, Chinnery PF.

PLoS Genet. 2015 May 14;11(5):e1005040. doi: 10.1371/journal.pgen.1005040. eCollection 2015 May.

49.

Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes.

Johnson CA, Hudson GA, Hardebeck LK, Jolley EA, Ren Y, Lewis M, Znosko BM.

Bioorg Med Chem. 2015 Jul 1;23(13):3586-91. doi: 10.1016/j.bmc.2015.04.030. Epub 2015 Apr 17.

PMID:
25960324
50.

Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.

Carbutt S, Duff J, Yarnall A, Burn DJ, Hudson G.

Neurosci Lett. 2015 May 6;594:66-9. doi: 10.1016/j.neulet.2015.03.048. Epub 2015 Mar 26.

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