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Items: 38


Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.

Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous BA, Breakefield XO.

Mol Ther Methods Clin Dev. 2019 Aug 16;15:18-26. doi: 10.1016/j.omtm.2019.08.003. eCollection 2019 Dec 13.


Experimental evidence for the age dependence of tau protein spread in the brain.

Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT.

Sci Adv. 2019 Jun 26;5(6):eaaw6404. doi: 10.1126/sciadv.aaw6404. eCollection 2019 Jun.


The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, Hyman B, Perry VH, Fiers M, De Strooper B.

Cell Rep. 2019 Apr 23;27(4):1293-1306.e6. doi: 10.1016/j.celrep.2019.03.099.


Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality.

Hudry E, Vandenberghe LH.

Neuron. 2019 Apr 3;102(1):263. doi: 10.1016/j.neuron.2019.03.020. No abstract available.


Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality.

Hudry E, Vandenberghe LH.

Neuron. 2019 Mar 6;101(5):839-862. doi: 10.1016/j.neuron.2019.02.017. Review. Erratum in: Neuron. 2019 Apr 3;102(1):263.


Opposing Roles of apolipoprotein E in aging and neurodegeneration.

Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT.

Life Sci Alliance. 2019 Feb 13;2(1). pii: e201900325. doi: 10.26508/lsa.201900325. Print 2019 Feb.


Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.

Hudry E, Andres-Mateos E, Lerner EP, Volak A, Cohen O, Hyman BT, Maguire CA, Vandenberghe LH.

Mol Ther Methods Clin Dev. 2018 Jul 23;10:197-209. doi: 10.1016/j.omtm.2018.07.006. eCollection 2018 Sep 21.


In Vivo Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease.

Kelly P, Hudry E, Hou SS, Bacskai BJ.

Front Aging Neurosci. 2018 Jul 19;10:219. doi: 10.3389/fnagi.2018.00219. eCollection 2018. Review.


A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform and cell type.

Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, Wegmann S, Hudry E, Hyman BT.

J Biol Chem. 2018 Aug 24;293(34):13247-13256. doi: 10.1074/jbc.RA117.001388. Epub 2018 Jun 27.


Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.

Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, Clark TW, Betensky RA, Hyman BT, Hudry E.

J Neurochem. 2018 Oct;147(1):24-39. doi: 10.1111/jnc.14469. Epub 2018 Sep 7.


Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.

Volak A, LeRoy SG, Natasan JS, Park DJ, Cheah PS, Maus A, Fitzpatrick Z, Hudry E, Pinkham K, Gandhi S, Hyman BT, Mu D, GuhaSarkar D, Stemmer-Rachamimov AO, Sena-Esteves M, Badr CE, Maguire CA.

J Neurooncol. 2018 Sep;139(2):293-305. doi: 10.1007/s11060-018-2889-2. Epub 2018 May 16.


Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM.

J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30.


Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis.

Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE.

Sci Rep. 2018 Jan 18;8(1):1144. doi: 10.1038/s41598-018-19641-2.


Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis.

Ayciriex S, Djelti F, Alves S, Regazzetti A, Gaudin M, Varin J, Langui D, Bièche I, Hudry E, Dargère D, Aubourg P, Auzeil N, Laprévote O, Cartier N.

Front Mol Neurosci. 2017 Jul 11;10:211. doi: 10.3389/fnmol.2017.00211. eCollection 2017.


Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.

Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT.

J Biol Chem. 2017 Sep 8;292(36):14720-14729. doi: 10.1074/jbc.M117.784264. Epub 2017 Jul 6.


Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.

Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ.

Mol Neurodegener. 2017 Mar 21;12(1):27. doi: 10.1186/s13024-017-0169-9.


New Therapeutic Avenue for ALS: Avoiding a Fatal Encounter of TDP-43 at the Mitochondria.

Hudry E.

Mol Ther. 2017 Jan 4;25(1):10-11. doi: 10.1016/j.ymthe.2016.12.001. Epub 2017 Jan 4. No abstract available.


Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9.

Dashkoff J, Lerner EP, Truong N, Klickstein JA, Fan Z, Mu D, Maguire CA, Hyman BT, Hudry E.

Mol Ther Methods Clin Dev. 2016 Dec 7;3:16081. eCollection 2016.


Exosome-associated AAV vector as a robust and convenient neuroscience tool.

Hudry E, Martin C, Gandhi S, György B, Scheffer DI, Mu D, Merkel SF, Mingozzi F, Fitzpatrick Z, Dimant H, Masek M, Ragan T, Tan S, Brisson AR, Ramirez SH, Hyman BT, Maguire CA.

Gene Ther. 2016 Nov;23(11):819. doi: 10.1038/gt.2016.65. No abstract available.


Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells.

Merkel SF, Andrews AM, Lutton EM, Mu D, Hudry E, Hyman BT, Maguire CA, Ramirez SH.

J Neurochem. 2017 Jan;140(2):216-230. doi: 10.1111/jnc.13861. Epub 2016 Dec 15.


Viral vectors for therapy of neurologic diseases.

Choudhury SR, Hudry E, Maguire CA, Sena-Esteves M, Breakefield XO, Grandi P.

Neuropharmacology. 2017 Jul 1;120:63-80. doi: 10.1016/j.neuropharm.2016.02.013. Epub 2016 Feb 21. Review.


Exosome-associated AAV vector as a robust and convenient neuroscience tool.

Hudry E, Martin C, Gandhi S, György B, Scheffer DI, Mu D, Merkel SF, Mingozzi F, Fitzpatrick Z, Dimant H, Masek M, Ragan T, Tan S, Brisson AR, Ramirez SH, Hyman BT, Maguire CA.

Gene Ther. 2016 Apr;23(4):380-92. doi: 10.1038/gt.2016.11. Epub 2016 Feb 2. Erratum in: Gene Ther. 2016 Nov;23 (11):819.


Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques.

Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15556-61. doi: 10.1073/pnas.1516779112. Epub 2015 Dec 7.


Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR Jr, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG.

Alzheimers Dement. 2015 Oct;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887. Epub 2015 Aug 19. No abstract available.


CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.

Djelti F, Braudeau J, Hudry E, Dhenain M, Varin J, Bièche I, Marquer C, Chali F, Ayciriex S, Auzeil N, Alves S, Langui D, Potier MC, Laprevote O, Vidaud M, Duyckaerts C, Miles R, Aubourg P, Cartier N.

Brain. 2015 Aug;138(Pt 8):2383-98. doi: 10.1093/brain/awv166. Epub 2015 Jul 2.


Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.

Eikermann-Haerter K, Arbel-Ornath M, Yalcin N, Yu ES, Kuchibhotla KV, Yuzawa I, Hudry E, Willard CR, Climov M, Keles F, Belcher AM, Sengul B, Negro A, Rosen IA, Arreguin A, Ferrari MD, van den Maagdenberg AM, Bacskai BJ, Ayata C.

Ann Neurol. 2015 Aug;78(2):193-210. doi: 10.1002/ana.24449. Epub 2015 Jul 6.


A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.

Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E.

J Biol Chem. 2015 Jan 23;290(4):1966-78. doi: 10.1074/jbc.M114.586602. Epub 2014 Dec 2.


Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.

Liao F, Hori Y, Hudry E, Bauer AQ, Jiang H, Mahan TE, Lefton KB, Zhang TJ, Dearborn JT, Kim J, Culver JP, Betensky R, Wozniak DF, Hyman BT, Holtzman DM.

J Neurosci. 2014 May 21;34(21):7281-92. doi: 10.1523/JNEUROSCI.0646-14.2014.


RNA aptamer probes as optical imaging agents for the detection of amyloid plaques.

Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT.

PLoS One. 2014 Feb 26;9(2):e89901. doi: 10.1371/journal.pone.0089901. eCollection 2014.


Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT.

Sci Transl Med. 2013 Nov 20;5(212):212ra161. doi: 10.1126/scitranslmed.3007000.


Mouse gender influences brain transduction by intravascularly administered AAV9.

Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA.

Mol Ther. 2013 Aug;21(8):1470-1. doi: 10.1038/mt.2013.95. No abstract available.


Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models.

Arbel-Ornath M, Hudry E, Eikermann-Haerter K, Hou S, Gregory JL, Zhao L, Betensky RA, Frosch MP, Greenberg SM, Bacskai BJ.

Acta Neuropathol. 2013 Sep;126(3):353-64. doi: 10.1007/s00401-013-1145-2. Epub 2013 Jul 2.


Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.

Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT.

J Neurosci. 2012 Apr 11;32(15):5298-309. doi: 10.1523/JNEUROSCI.0227-12.2012.


Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.

Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT.

J Neurosci. 2012 Feb 29;32(9):3176-92. doi: 10.1523/JNEUROSCI.6439-11.2012.


Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.

DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, Rodríguez M, Sánchez MB, Hyman BT, Gómez-Isla T.

Neurobiol Dis. 2012 Jan;45(1):425-37. doi: 10.1016/j.nbd.2011.09.002. Epub 2011 Sep 13.


Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.

Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT.

J Neurosci. 2010 Feb 17;30(7):2636-49. doi: 10.1523/JNEUROSCI.4456-09.2010.


Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

Hudry E, Van Dam D, Kulik W, De Deyn PP, Stet FS, Ahouansou O, Benraiss A, Delacourte A, Bougnères P, Aubourg P, Cartier N.

Mol Ther. 2010 Jan;18(1):44-53. doi: 10.1038/mt.2009.175. Epub 2009 Aug 4.


A human immunoglobulin in myeloma protein with anti-gastric parietal cell autoantigen activity.

Micouin C, Rivat C, Bensa JC, Stoebner P, Favre M, Hudry E.

Clin Exp Immunol. 1977 Jan;27(1):78-84.

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