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Items: 1 to 50 of 161

1.

Unravelling Receptor and RGD Motif Dependence of Retargeted Adenoviral Vectors using Advanced Tumor Model Systems.

Chernyavska M, Schmid M, Freitag PC, Palacio-Castañeda V, Piruska A, Huck WTS, Plückthun A, Verdurmen WPR.

Sci Rep. 2019 Dec 6;9(1):18568. doi: 10.1038/s41598-019-54939-9.

2.

Dynamic Environments as a Tool to Preserve Desired Output in a Chemical Reaction Network.

Maguire OR, Wong ASY, Baltussen MG, van Duppen P, Pogodaev AA, Huck WTS.

Chemistry. 2019 Dec 6. doi: 10.1002/chem.201904725. [Epub ahead of print]

PMID:
31808965
3.

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression.

van der Linden AJ, Yelleswarapu M, Pieters PA, Swank Z, Huck WTS, Maerkl SJ, de Greef TFA.

J Vis Exp. 2019 Oct 6;(152). doi: 10.3791/59655.

PMID:
31633684
4.

Modular Design of Small Enzymatic Reaction Networks Based on Reversible and Cleavable Inhibitors.

Pogodaev AA, Fernández Regueiro CL, Jakštaitė M, Hollander MJ, Huck WTS.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14539-14543. doi: 10.1002/anie.201907995. Epub 2019 Sep 4.

PMID:
31397527
5.

Robustness, Entrainment, and Hybridization in Dissipative Molecular Networks, and the Origin of Life.

Cafferty BJ, Wong ASY, Semenov SN, Belding L, Gmür S, Huck WTS, Whitesides GM.

J Am Chem Soc. 2019 May 22;141(20):8289-8295. doi: 10.1021/jacs.9b02554. Epub 2019 May 9.

PMID:
31035761
6.

Branched DNA Architectures Produced by PCR-Based Assembly as Gene Compartments for Cell-Free Gene-Expression Reactions.

Guo X, Bai L, Li F, Huck WTS, Yang D.

Chembiochem. 2019 Oct 15;20(20):2597-2603. doi: 10.1002/cbic.201900094. Epub 2019 Jun 24.

PMID:
30938476
7.

Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells.

Gerlach JP, van Buggenum JAG, Tanis SEJ, Hogeweg M, Heuts BMH, Muraro MJ, Elze L, Rivello F, Rakszewska A, van Oudenaarden A, Huck WTS, Stunnenberg HG, Mulder KW.

Sci Rep. 2019 Feb 6;9(1):1469. doi: 10.1038/s41598-018-37977-7.

8.

Catalytic transport of molecular cargo using diffusive binding along a polymer track.

Zheng L, Zhao H, Han Y, Qian H, Vukovic L, Mecinović J, Král P, Huck WTS.

Nat Chem. 2019 Apr;11(4):359-366. doi: 10.1038/s41557-018-0204-7. Epub 2019 Jan 21.

PMID:
30664718
9.

Cell-free microcompartmentalised transcription-translation for the prototyping of synthetic communication networks.

Dubuc E, Pieters PA, van der Linden AJ, van Hest JC, Huck WT, de Greef TF.

Curr Opin Biotechnol. 2019 Aug;58:72-80. doi: 10.1016/j.copbio.2018.10.006. Epub 2018 Dec 26. Review.

10.

Cellular Volume and Matrix Stiffness Direct Stem Cell Behavior in a 3D Microniche.

Bao M, Xie J, Katoele N, Hu X, Wang B, Piruska A, Huck WTS.

ACS Appl Mater Interfaces. 2019 Jan 16;11(2):1754-1759. doi: 10.1021/acsami.8b19396. Epub 2019 Jan 4.

11.

Sigma Factor-Mediated Tuning of Bacterial Cell-Free Synthetic Genetic Oscillators.

Yelleswarapu M, van der Linden AJ, van Sluijs B, Pieters PA, Dubuc E, de Greef TFA, Huck WTS.

ACS Synth Biol. 2018 Dec 21;7(12):2879-2887. doi: 10.1021/acssynbio.8b00300. Epub 2018 Nov 19.

12.

Bottom-Up Construction of an Adaptive Enzymatic Reaction Network.

Helwig B, van Sluijs B, Pogodaev AA, Postma SGJ, Huck WTS.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14065-14069. doi: 10.1002/anie.201806944. Epub 2018 Oct 1.

PMID:
30183118
13.

Recent Advances in Engineering the Stem Cell Microniche in 3D.

Bao M, Xie J, Huck WTS.

Adv Sci (Weinh). 2018 Jun 13;5(8):1800448. doi: 10.1002/advs.201800448. eCollection 2018 Aug. Review.

14.

Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells.

Wimmers F, Subedi N, van Buuringen N, Heister D, Vivié J, Beeren-Reinieren I, Woestenenk R, Dolstra H, Piruska A, Jacobs JFM, van Oudenaarden A, Figdor CG, Huck WTS, de Vries IJM, Tel J.

Nat Commun. 2018 Aug 20;9(1):3317. doi: 10.1038/s41467-018-05784-3.

15.

Microfluidic-Assisted Fabrication of Clay Microgels for Cell-Free Protein Synthesis.

Jiao Y, Liu Y, Luo D, Huck WTS, Yang D.

ACS Appl Mater Interfaces. 2018 Sep 5;10(35):29308-29313. doi: 10.1021/acsami.8b09324. Epub 2018 Aug 23.

PMID:
30102514
16.

Dissipative adaptation in driven self-assembly leading to self-dividing fibrils.

Te Brinke E, Groen J, Herrmann A, Heus HA, Rivas G, Spruijt E, Huck WTS.

Nat Nanotechnol. 2018 Sep;13(9):849-855. doi: 10.1038/s41565-018-0192-1. Epub 2018 Jul 16.

PMID:
30013214
17.

Macromolecularly Crowded Protocells from Reversibly Shrinking Monodisperse Liposomes.

Deng NN, Vibhute MA, Zheng L, Zhao H, Yelleswarapu M, Huck WTS.

J Am Chem Soc. 2018 Jun 20;140(24):7399-7402. doi: 10.1021/jacs.8b03123. Epub 2018 Jun 12.

18.

3D microniches reveal the importance of cell size and shape.

Bao M, Xie J, Piruska A, Huck WTS.

Nat Commun. 2017 Dec 6;8(1):1962. doi: 10.1038/s41467-017-02163-2.

19.

Rational design and dynamics of self-propelled colloidal bead chains: from rotators to flagella.

Vutukuri HR, Bet B, van Roij R, Dijkstra M, Huck WTS.

Sci Rep. 2017 Dec 1;7(1):16758. doi: 10.1038/s41598-017-16731-5.

20.

Photochemical Control over Oscillations in Chemical Reaction Networks.

Pogodaev AA, Wong ASY, Huck WTS.

J Am Chem Soc. 2017 Nov 1;139(43):15296-15299. doi: 10.1021/jacs.7b08109. Epub 2017 Oct 19.

21.

Adaptation trajectories during adhesion and spreading affect future cell states.

Bruekers SMC, Bao M, Hendriks JMA, Mulder KW, Huck WTS.

Sci Rep. 2017 Sep 26;7(1):12308. doi: 10.1038/s41598-017-12467-4.

22.

Grip on complexity in chemical reaction networks.

Wong ASY, Huck WTS.

Beilstein J Org Chem. 2017 Jul 28;13:1486-1497. doi: 10.3762/bjoc.13.147. eCollection 2017. Review.

23.

Microfluidic Formation of Monodisperse Coacervate Organelles in Liposomes.

Deng NN, Huck WTS.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9736-9740. doi: 10.1002/anie.201703145. Epub 2017 Jul 18.

24.

Molecular Engineering of Robustness and Resilience in Enzymatic Reaction Networks.

Wong ASY, Pogodaev AA, Vialshin IN, Helwig B, Huck WTS.

J Am Chem Soc. 2017 Jun 21;139(24):8146-8151. doi: 10.1021/jacs.7b00632. Epub 2017 Jun 13.

25.

Collagen Gels with Different Fibrillar Microarchitectures Elicit Different Cellular Responses.

Xie J, Bao M, Bruekers SMC, Huck WTS.

ACS Appl Mater Interfaces. 2017 Jun 14;9(23):19630-19637. doi: 10.1021/acsami.7b03883. Epub 2017 Jun 2.

26.

Preprogramming Complex Hydrogel Responses using Enzymatic Reaction Networks.

Postma SG, Vialshin IN, Gerritsen CY, Bao M, Huck WT.

Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1794-1798. doi: 10.1002/anie.201610875. Epub 2017 Jan 10.

PMID:
28071851
27.

Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models.

Deng NN, Yelleswarapu M, Zheng L, Huck WT.

J Am Chem Soc. 2017 Jan 18;139(2):587-590. doi: 10.1021/jacs.6b10977. Epub 2016 Dec 20.

PMID:
27978623
28.

A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement.

Nijemeisland M, Abdelmohsen LK, Huck WT, Wilson DA, van Hest JC.

ACS Cent Sci. 2016 Nov 23;2(11):843-849. Epub 2016 Nov 9.

29.

Dynamic self-organization of side-propelling colloidal rods: experiments and simulations.

Vutukuri HR, Preisler Z, Besseling TH, van Blaaderen A, Dijkstra M, Huck WT.

Soft Matter. 2016 Dec 6;12(48):9657-9665.

PMID:
27869286
30.

The nanotechnology of life-inspired systems.

Grzybowski BA, Huck WT.

Nat Nanotechnol. 2016 Jul 6;11(7):585-92. doi: 10.1038/nnano.2016.116.

PMID:
27380745
31.

Protein Synthesis in Coupled and Uncoupled Cell-Free Prokaryotic Gene Expression Systems.

Hansen MM, Ventosa Rosquelles M, Yelleswarapu M, Maas RJ, van Vugt-Jonker AJ, Heus HA, Huck WT.

ACS Synth Biol. 2016 Dec 16;5(12):1433-1440. Epub 2016 Jul 5.

PMID:
27306580
32.

A Method for Detecting Circulating Tumor Cells Based on the Measurement of Single-Cell Metabolism in Droplet-Based Microfluidics.

Del Ben F, Turetta M, Celetti G, Piruska A, Bulfoni M, Cesselli D, Huck WT, Scoles G.

Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8581-4. doi: 10.1002/anie.201602328. Epub 2016 Jun 1.

PMID:
27247024
33.

Monodisperse Uni- and Multicompartment Liposomes.

Deng NN, Yelleswarapu M, Huck WT.

J Am Chem Soc. 2016 Jun 22;138(24):7584-91. doi: 10.1021/jacs.6b02107. Epub 2016 Jun 9.

PMID:
27243596
34.

Quantitative Single-Cell mRNA Analysis in Hydrogel Beads.

Rakszewska A, Stolper RJ, Kolasa AB, Piruska A, Huck WT.

Angew Chem Int Ed Engl. 2016 Jun 1;55(23):6698-701. doi: 10.1002/anie.201601969. Epub 2016 Apr 14.

PMID:
27075637
35.

Bio-Inspired Renewable Surface-Initiated Polymerization from Permanently Embedded Initiators.

Du T, Li B, Wang X, Yu B, Pei X, Huck WT, Zhou F.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4260-4. doi: 10.1002/anie.201600080. Epub 2016 Feb 24.

PMID:
26915991
36.

Biocompatible fluorinated polyglycerols for droplet microfluidics as an alternative to PEG-based copolymer surfactants.

Wagner O, Thiele J, Weinhart M, Mazutis L, Weitz DA, Huck WT, Haag R.

Lab Chip. 2016 Jan 7;16(1):65-9. doi: 10.1039/c5lc00823a. Epub 2015 Dec 2.

PMID:
26626826
37.

Cell-Like Nanostructured Environments Alter Diffusion and Reaction Kinetics in Cell-Free Gene Expression.

Hansen MM, Paffenholz S, Foschepoth D, Heus HA, Thiele J, Huck WT.

Chembiochem. 2016 Feb 2;17(3):228-32. doi: 10.1002/cbic.201500560. Epub 2015 Dec 17.

PMID:
26603600
38.

Macromolecular crowding creates heterogeneous environments of gene expression in picolitre droplets.

Hansen MM, Meijer LH, Spruijt E, Maas RJ, Rosquelles MV, Groen J, Heus HA, Huck WT.

Nat Nanotechnol. 2016 Feb;11(2):191-7. doi: 10.1038/nnano.2015.243. Epub 2015 Oct 26.

39.

Deformation of double emulsions under conditions of flow cytometry hydrodynamic focusing.

Ma S, Huck WT, Balabani S.

Lab Chip. 2015 Nov 21;15(22):4291-301. doi: 10.1039/c5lc00693g.

PMID:
26394745
40.

Associative Interactions in Crowded Solutions of Biopolymers Counteract Depletion Effects.

Groen J, Foschepoth D, te Brinke E, Boersma AJ, Imamura H, Rivas G, Heus HA, Huck WT.

J Am Chem Soc. 2015 Oct 14;137(40):13041-8. doi: 10.1021/jacs.5b07898. Epub 2015 Sep 29.

PMID:
26383885
41.

Influence of molecular structure on the properties of out-of-equilibrium oscillating enzymatic reaction networks.

Wong AS, Postma SG, Vialshin IN, Semenov SN, Huck WT.

J Am Chem Soc. 2015 Sep 30;137(38):12415-20. doi: 10.1021/jacs.5b08129. Epub 2015 Sep 17.

PMID:
26352485
42.

Programmable chemical reaction networks: emulating regulatory functions in living cells using a bottom-up approach.

van Roekel HW, Rosier BJ, Meijer LH, Hilbers PA, Markvoort AJ, Huck WT, de Greef TF.

Chem Soc Rev. 2015 Nov 7;44(21):7465-83. doi: 10.1039/c5cs00361j. Review.

PMID:
26214155
43.

The microenvironment of double emulsions in rectangular microchannels.

Ma S, Sherwood JM, Huck WT, Balabani S.

Lab Chip. 2015 May 21;15(10):2327-34. doi: 10.1039/c5lc00346f.

44.

Rational design of functional and tunable oscillating enzymatic networks.

Semenov SN, Wong AS, van der Made RM, Postma SG, Groen J, van Roekel HW, de Greef TF, Huck WT.

Nat Chem. 2015 Feb;7(2):160-5. doi: 10.1038/nchem.2142. Epub 2015 Jan 12.

PMID:
25615670
45.

Alterations in red blood cell deformability during storage: a microfluidic approach.

Cluitmans JC, Chokkalingam V, Janssen AM, Brock R, Huck WT, Bosman GJ.

Biomed Res Int. 2014;2014:764268. doi: 10.1155/2014/764268. Epub 2014 Sep 10.

46.

On the flow topology inside droplets moving in rectangular microchannels.

Ma S, Sherwood JM, Huck WT, Balabani S.

Lab Chip. 2014 Sep 21;14(18):3611-20. doi: 10.1039/c4lc00671b. Epub 2014 Jul 29.

47.

Mechanically strong, fluorescent hydrogels from zwitterionic, fully π-conjugated polymers.

Elmalem E, Biedermann F, Scherer MR, Koutsioubas A, Toprakcioglu C, Biffi G, Huck WT.

Chem Commun (Camb). 2014 Aug 18;50(64):8930-3. doi: 10.1039/c4cc03167a.

PMID:
24975807
48.

Complexity of molecular crowding in cell-free enzymatic reaction networks.

Spruijt E, Sokolova E, Huck WT.

Nat Nanotechnol. 2014 Jun;9(6):406-7. doi: 10.1038/nnano.2014.110. No abstract available.

PMID:
24894471
49.

An electro-coalescence chip for effective emulsion breaking in droplet microfluidics.

Chokkalingam V, Ma Y, Thiele J, Schalk W, Tel J, Huck WT.

Lab Chip. 2014 Jul 21;14(14):2398-402. doi: 10.1039/c4lc00365a.

PMID:
24889537
50.

Threshold sensing through a synthetic enzymatic reaction-diffusion network.

Semenov SN, Markvoort AJ, de Greef TF, Huck WT.

Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8066-9. doi: 10.1002/anie.201402327. Epub 2014 Apr 2.

PMID:
24700482

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