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Draft Genome Sequences of Type Strains of Gordonibacter faecihominis, Paraeggerthella hongkongensis, Parvibacter caecicola,Slackia equolifaciens, Slackia faecicanis, and Slackia isoflavoniconvertens.

Danylec N, Stoll DA, Dötsch A, Huch M.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01532-18. doi: 10.1128/MRA.01532-18. eCollection 2019 Jan.


Draft Genome Sequence of Salmonella enterica subsp. enterica Serovar Enteritidis MS 501, a Potential Human Pathogen Isolated from Red Lettuce (Lactuca sativa var. capitata) in Karlsruhe, Germany.

Stoll DA, Danylec N, Dötsch A, Becker B, Huch M.

Microbiol Resour Announc. 2018 Aug 2;7(4). pii: e00938-18. doi: 10.1128/MRA.00938-18. eCollection 2018 Aug.


Microbial Contamination of Organically and Conventionally Produced Fresh Vegetable Salads and Herbs from Retail Markets in Southwest Germany.

Becker B, Stoll D, Schulz P, Kulling S, Huch M.

Foodborne Pathog Dis. 2018 Nov 28. doi: 10.1089/fpd.2018.2541. [Epub ahead of print]


Definitions for adult stem cells debated.

Muñoz-Cánoves P, Huch M.

Nature. 2018 Nov;563(7731):328-329. doi: 10.1038/d41586-018-07175-6. No abstract available.


Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells.

Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, Bonfanti P, Göttgens B, Huch M, Simons B, Philpott A.

Sci Rep. 2018 Oct 18;8(1):15374. doi: 10.1038/s41598-018-33838-5.


Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD.

Dev Cell. 2018 Aug 6;46(3):360-375.e5. doi: 10.1016/j.devcel.2018.06.028. Epub 2018 Jul 26.


Universality of clone dynamics during tissue development.

Rulands S, Lescroart F, Chabab S, Hindley CJ, Prior N, Sznurkowska MK, Huch M, Philpott A, Blanpain C, Simons BD.

Nat Phys. 2018 May;14(5):469-474. doi: 10.1038/s41567-018-0055-6. Epub 2018 Feb 26.


Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential.

Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJP.

Stem Cell Reports. 2018 Mar 13;10(3):712-724. doi: 10.1016/j.stemcr.2018.02.005.


Rubneribacter badeniensis gen. nov., sp. nov. and Enteroscipio rubneri gen. nov., sp. nov., new members of the Eggerthellaceae isolated from human faeces.

Danylec N, Göbl A, Stoll DA, Hetzer B, Kulling SE, Huch M.

Int J Syst Evol Microbiol. 2018 May;68(5):1533-1540. doi: 10.1099/ijsem.0.002705. Epub 2018 Mar 14.


The balancing act of the liver: tissue regeneration versus fibrosis.

Cordero-Espinoza L, Huch M.

J Clin Invest. 2018 Jan 2;128(1):85-96. doi: 10.1172/JCI93562. Epub 2018 Jan 2. Review.


Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U.

Gastroenterology. 2018 Mar;154(4):1080-1095. doi: 10.1053/j.gastro.2017.11.002. Epub 2017 Nov 21.


Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M.

Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13.


Draft Genome Sequence of Lactobacillus fermentum BFE 6620, a Potential Starter Culture for African Vegetable Foods, Isolated from Fermented Cassava.

Wafula EN, Brinks E, Becker B, Huch M, Trierweiler B, Mathara JM, Oguntoyinbo FA, Cho GS, Franz CMAP.

Genome Announc. 2017 Aug 17;5(33). pii: e00801-17. doi: 10.1128/genomeA.00801-17.


Metabolism of Foodborne Heterocyclic Aromatic Amines by Lactobacillus reuteri DSM 20016.

Beer F, Urbat F, Steck J, Huch M, Bunzel D, Bunzel M, Kulling SE.

J Agric Food Chem. 2017 Aug 16;65(32):6797-6811. doi: 10.1021/acs.jafc.7b01663. Epub 2017 Aug 8.


Presence of Human Pathogens in Produce from Retail Markets in Northern Germany.

Fiedler G, Kabisch J, Böhnlein C, Huch M, Becker B, Cho GS, Franz CMAP.

Foodborne Pathog Dis. 2017 Sep;14(9):502-509. doi: 10.1089/fpd.2016.2258. Epub 2017 Jun 8.


Cancer: Tumours build their niche.

Huch M, Rawlins EL.

Nature. 2017 May 18;545(7654):292-293. doi: 10.1038/nature22494. Epub 2017 May 10. No abstract available.


Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A.

Dev Cell. 2017 May 8;41(3):274-286.e5. doi: 10.1016/j.devcel.2017.04.004. Epub 2017 Apr 27.


Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis.

Kruitwagen HS, Oosterhoff LA, Vernooij IGWH, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B.

Stem Cell Reports. 2017 Apr 11;8(4):822-830. doi: 10.1016/j.stemcr.2017.02.015. Epub 2017 Mar 23.


The hope and the hype of organoid research.

Huch M, Knoblich JA, Lutolf MP, Martinez-Arias A.

Development. 2017 Mar 15;144(6):938-941. doi: 10.1242/dev.150201. Review.


Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation.

Koo BK, Huch M.

Dev Biol. 2016 Dec 15;420(2):197-198. doi: 10.1016/j.ydbio.2016.10.017. Epub 2016 Oct 27. No abstract available.


Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R.

Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.


Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.

Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H, Koo BK, Huch M.

Nat Protoc. 2016 Sep;11(9):1724-43. doi: 10.1038/nprot.2016.097. Epub 2016 Aug 25.


Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes.

Wills ES, Cnossen WR, Veltman JA, Woestenenk R, Steehouwer M, Salomon J, Te Morsche RH, Huch M, Hehir-Kwa JY, Banning MJ, Pfundt R, Roepman R, Hoischen A, Drenth JP.

Eur J Hum Genet. 2016 Dec;24(12):1707-1714. doi: 10.1038/ejhg.2016.97. Epub 2016 Aug 24.


Produce from Africa's Gardens: Potential for Leafy Vegetable and Fruit Fermentations.

Oguntoyinbo FA, Fusco V, Cho GS, Kabisch J, Neve H, Bockelmann W, Huch M, Frommherz L, Trierweiler B, Becker B, Benomar N, Gálvez A, Abriouel H, Holzapfel WH, Franz CM.

Front Microbiol. 2016 Jul 5;7:981. doi: 10.3389/fmicb.2016.00981. eCollection 2016. Review.


Organoids from adult liver and pancreas: Stem cell biology and biomedical utility.

Hindley CJ, Cordero-Espinoza L, Huch M.

Dev Biol. 2016 Dec 15;420(2):251-261. doi: 10.1016/j.ydbio.2016.06.039. Epub 2016 Jun 27. Review.


Quantification of Slackia and Eggerthella spp. in Human Feces and Adhesion of Representatives Strains to Caco-2 Cells.

Cho GS, Ritzmann F, Eckstein M, Huch M, Briviba K, Behsnilian D, Neve H, Franz CM.

Front Microbiol. 2016 May 9;7:658. doi: 10.3389/fmicb.2016.00658. eCollection 2016.


Cellular plasticity in the adult liver and stomach.

Aloia L, McKie MA, Huch M.

J Physiol. 2016 Sep 1;594(17):4815-25. doi: 10.1113/JP271769. Epub 2016 May 10. Review.


Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.

Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E.

Sci Rep. 2016 Feb 26;6:22154. doi: 10.1038/srep22154.


The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?

Huch M, Dollé L.

Hepatology. 2016 Aug;64(2):652-62. doi: 10.1002/hep.28469. Epub 2016 Mar 17. Review.


Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.

Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM.

Open Biol. 2015 Dec;5(12):150209. doi: 10.1098/rsob.150209.


Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids.

Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RRG, Clevers H, de Bruin A, Rothuizen J, Penning LC, Schotanus BA.

Stem Cell Reports. 2015 Nov 10;5(5):895-907. doi: 10.1016/j.stemcr.2015.09.002. Epub 2015 Oct 8.


Modeling mouse and human development using organoid cultures.

Huch M, Koo BK.

Development. 2015 Sep 15;142(18):3113-25. doi: 10.1242/dev.118570. Review.


Structural Transformation of 8-5-Coupled Dehydrodiferulates by Human Intestinal Microbiota.

Schendel RR, Karrer C, Bunzel D, Huch M, Hildebrand AA, Kulling SE, Bunzel M.

J Agric Food Chem. 2015 Sep 16;63(36):7975-85. doi: 10.1021/acs.jafc.5b03234. Epub 2015 Sep 3.


Building stomach in a dish.

Huch M.

Nat Cell Biol. 2015 Aug;17(8):966-7. doi: 10.1038/ncb3211.


Stability of Individual Maillard Reaction Products in the Presence of the Human Colonic Microbiota.

Hellwig M, Bunzel D, Huch M, Franz CM, Kulling SE, Henle T.

J Agric Food Chem. 2015 Aug 5;63(30):6723-30. doi: 10.1021/acs.jafc.5b01391. Epub 2015 Jul 24.


Regenerative biology: The versatile and plastic liver.

Huch M.

Nature. 2015 Jan 8;517(7533):155-6. doi: 10.1038/517155a. No abstract available.


Organoid models of human and mouse ductal pancreatic cancer.

Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA.

Cell. 2015 Jan 15;160(1-2):324-38. doi: 10.1016/j.cell.2014.12.021. Epub 2014 Dec 31.


Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.


Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.

Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J.

Nat Commun. 2014 Dec 11;5:5728. doi: 10.1038/ncomms6728.


Influence of a probiotic Lactobacillus casei strain on the colonisation with potential pathogenic streptococci and Staphylococcus aureus in the nasopharyngeal space of healthy men with a low baseline NK cell activity.

Franz CM, Huch M, Seifert S, Kramlich J, Bub A, Cho GS, Watzl B.

Med Microbiol Immunol. 2015 Aug;204(4):527-38. doi: 10.1007/s00430-014-0366-x. Epub 2014 Nov 23.


The plastic liver: differentiated cells, stem cells, every cell?

Hindley CJ, Mastrogiovanni G, Huch M.

J Clin Invest. 2014 Dec;124(12):5099-102. doi: 10.1172/JCI78372. Epub 2014 Nov 17.


In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, Kujala P, Vries R, Peters PJ, Clevers H.

Gastroenterology. 2015 Jan;148(1):126-136.e6. doi: 10.1053/j.gastro.2014.09.042. Epub 2014 Oct 13.


African fermented foods and probiotics.

Franz CM, Huch M, Mathara JM, Abriouel H, Benomar N, Reid G, Galvez A, Holzapfel WH.

Int J Food Microbiol. 2014 Nov 3;190:84-96. doi: 10.1016/j.ijfoodmicro.2014.08.033. Epub 2014 Aug 30. Review.


Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR.

Nature. 2014 Sep 18;513(7518):422-425. doi: 10.1038/nature13448. Epub 2014 Jun 29.


Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H.

Cell. 2013 Oct 10;155(2):357-68. doi: 10.1016/j.cell.2013.09.008.


Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H.

EMBO J. 2013 Oct 16;32(20):2708-21. doi: 10.1038/emboj.2013.204. Epub 2013 Sep 17.


Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine.

Huch M, Boj SF, Clevers H.

Regen Med. 2013 Jul;8(4):385-7. doi: 10.2217/rme.13.39. No abstract available.


Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P.

Cell Rep. 2013 Jun 27;3(6):1885-92. doi: 10.1016/j.celrep.2013.06.009.


Streptococcus rubneri sp. nov., isolated from the human throat.

Huch M, De Bruyne K, Cleenwerck I, Bub A, Cho GS, Watzl B, Snauwaert I, Franz CM, Vandamme P.

Int J Syst Evol Microbiol. 2013 Nov;63(Pt 11):4026-32. doi: 10.1099/ijs.0.048538-0. Epub 2013 Jun 7.


In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H.

Nature. 2013 Feb 14;494(7436):247-50. doi: 10.1038/nature11826. Epub 2013 Jan 27.

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