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Items: 48


Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.

Galle-Treger L, Moreau M, Ballaire R, Poupel L, Huby T, Sasso E, Troise F, Poti F, Lesnik P, Le Goff W, Gautier EL, Huby T.

Cardiovasc Res. 2019 May 22. pii: cvz138. doi: 10.1093/cvr/cvz138. [Epub ahead of print]


Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice.

Béliard S, Le Goff W, Saint-Charles F, Poupel L, Deswaerte V, Bouchareychas L, Huby T, Lesnik P.

Int J Obes (Lond). 2017 Dec;41(12):1805-1814. doi: 10.1038/ijo.2017.179. Epub 2017 Aug 3.


Plasmodium P36 determines host cell receptor usage during sporozoite invasion.

Manzoni G, Marinach C, Topçu S, Briquet S, Grand M, Tolle M, Gransagne M, Lescar J, Andolina C, Franetich JF, Zeisel MB, Huby T, Rubinstein E, Snounou G, Mazier D, Nosten F, Baumert TF, Silvie O.

Elife. 2017 May 16;6. pii: e25903. doi: 10.7554/eLife.25903.


αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice.

Vancraeynest D, Roelants V, Bouzin C, Hanin FX, Walrand S, Bol V, Bol A, Pouleur AC, Pasquet A, Gerber B, Lesnik P, Huby T, Jamar F, Vanoverschelde JL.

EJNMMI Res. 2016 Dec;6(1):29. doi: 10.1186/s13550-016-0184-9. Epub 2016 Mar 24.


Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity.

Jacobsen MJ, Mentzel CM, Olesen AS, Huby T, Jørgensen CB, Barrès R, Fredholm M, Simar D.

J Diabetes Res. 2016;2016:8539057. doi: 10.1155/2016/8539057. Epub 2015 Dec 21.


Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport.

El Khoury P, Waldmann E, Huby T, Gall J, Couvert P, Lacorte JM, Chapman J, Frisdal E, Lesnik P, Parhofer KG, Le Goff W, Guerin M.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):285-94. doi: 10.1161/ATVBAHA.115.306834. Epub 2015 Dec 17.


Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.

Pant SD, Karlskov-Mortensen P, Jacobsen MJ, Cirera S, Kogelman LJ, Bruun CS, Mark T, Jørgensen CB, Grarup N, Appel EV, Galjatovic EA, Hansen T, Pedersen O, Guerin M, Huby T, Lesnik P, Meuwissen TH, Kadarmideen HN, Fredholm M.

PLoS One. 2015 Sep 8;10(9):e0137356. doi: 10.1371/journal.pone.0137356. eCollection 2015.


Lipoprotein-Free Mitotane Exerts High Cytotoxic Activity in Adrenocortical Carcinoma.

Hescot S, Seck A, Guerin M, Cockenpot F, Huby T, Broutin S, Young J, Paci A, Baudin E, Lombès M.

J Clin Endocrinol Metab. 2015 Aug;100(8):2890-8. doi: 10.1210/JC.2015-2080. Epub 2015 Jun 29.


Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE.

Bouchareychas L, Pirault J, Saint-Charles F, Deswaerte V, Le Roy T, Jessup W, Giral P, Le Goff W, Huby T, Gautier EL, Lesnik P.

Cardiovasc Res. 2015 Oct 1;108(1):111-23. doi: 10.1093/cvr/cvv177. Epub 2015 Jun 19.


Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity.

Frisdal E, Le Lay S, Hooton H, Poupel L, Olivier M, Alili R, Plengpanich W, Villard EF, Gilibert S, Lhomme M, Superville A, Miftah-Alkhair L, Chapman MJ, Dallinga-Thie GM, Venteclef N, Poitou C, Tordjman J, Lesnik P, Kontush A, Huby T, Dugail I, Clement K, Guerin M, Le Goff W.

Diabetes. 2015 Mar;64(3):840-55. doi: 10.2337/db14-0245. Epub 2014 Sep 23.


Adrenocortical scavenger receptor class B type I deficiency exacerbates endotoxic shock and precipitates sepsis-induced mortality in mice.

Gilibert S, Galle-Treger L, Moreau M, Saint-Charles F, Costa S, Ballaire R, Couvert P, Carrié A, Lesnik P, Huby T.

J Immunol. 2014 Jul 15;193(2):817-26. doi: 10.4049/jimmunol.1303164. Epub 2014 Jun 16.


Bcl-x inactivation in macrophages accelerates progression of advanced atherosclerotic lesions in Apoe(-/-) mice.

Shearn AI, Deswaerte V, Gautier EL, Saint-Charles F, Pirault J, Bouchareychas L, Rucker EB 3rd, Beliard S, Chapman J, Jessup W, Huby T, Lesnik P.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1142-9. doi: 10.1161/ATVBAHA.111.239111. Epub 2012 Mar 1.


Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry.

Maillard P, Walic M, Meuleman P, Roohvand F, Huby T, Le Goff W, Leroux-Roels G, Pécheur EI, Budkowska A.

PLoS One. 2011;6(10):e26637. doi: 10.1371/journal.pone.0026637. Epub 2011 Oct 21.


Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor BI.

Zhao Y, Pennings M, Vrins CL, Calpe-Berdiel L, Hoekstra M, Kruijt JK, Ottenhoff R, Hildebrand RB, van der Sluis R, Jessup W, Le Goff W, Chapman MJ, Huby T, Groen AK, Van Berkel TJ, Van Eck M.

Atherosclerosis. 2011 Oct;218(2):314-22. doi: 10.1016/j.atherosclerosis.2011.07.096. Epub 2011 Jul 27.


Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response.

Frisdal E, Lesnik P, Olivier M, Robillard P, Chapman MJ, Huby T, Guerin M, Le Goff W.

J Biol Chem. 2011 Sep 2;286(35):30926-36. doi: 10.1074/jbc.M111.264325. Epub 2011 Jul 8.


Cholesteryl ester transfer protein expression partially attenuates the adverse effects of SR-BI receptor deficiency on cholesterol metabolism and atherosclerosis.

El Bouhassani M, Gilibert S, Moreau M, Saint-Charles F, Tréguier M, Poti F, Chapman MJ, Le Goff W, Lesnik P, Huby T.

J Biol Chem. 2011 May 13;286(19):17227-38. doi: 10.1074/jbc.M111.220483. Epub 2011 Mar 20.


P2Y13 receptor is critical for reverse cholesterol transport.

Fabre AC, Malaval C, Ben Addi A, Verdier C, Pons V, Serhan N, Lichtenstein L, Combes G, Huby T, Briand F, Collet X, Nijstad N, Tietge UJ, Robaye B, Perret B, Boeynaems JM, Martinez LO.

Hepatology. 2010 Oct;52(4):1477-83. doi: 10.1002/hep.23897.


Role of scavenger receptor class B type I in hepatitis C virus entry: kinetics and molecular determinants.

Catanese MT, Ansuini H, Graziani R, Huby T, Moreau M, Ball JK, Paonessa G, Rice CM, Cortese R, Vitelli A, Nicosia A.

J Virol. 2010 Jan;84(1):34-43. doi: 10.1128/JVI.02199-08.


Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis.

Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ, Lesnik P.

Circulation. 2009 May 5;119(17):2367-75. doi: 10.1161/CIRCULATIONAHA.108.807537. Epub 2009 Apr 20.


Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice.

Prieur X, Lesnik P, Moreau M, Rodríguez JC, Doucet C, Chapman MJ, Huby T.

Biochim Biophys Acta. 2009 Aug;1791(8):764-71. doi: 10.1016/j.bbalip.2009.03.015. Epub 2009 Apr 9.


Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.

Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P.

Circulation. 2009 Apr 7;119(13):1795-804. doi: 10.1161/CIRCULATIONAHA.108.806158. Epub 2009 Mar 23.


Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.

Couvert P, Giral P, Dejager S, Gu J, Huby T, Chapman MJ, Bruckert E, Carrié A.

Pharmacogenomics. 2008 Sep;9(9):1217-27. doi: 10.2217/14622416.9.9.1217.


Scavenger receptor BI boosts hepatocyte permissiveness to Plasmodium infection.

Yalaoui S, Huby T, Franetich JF, Gego A, Rametti A, Moreau M, Collet X, Siau A, van Gemert GJ, Sauerwein RW, Luty AJ, Vaillant JC, Hannoun L, Chapman J, Mazier D, Froissard P.

Cell Host Microbe. 2008 Sep 11;4(3):283-92. doi: 10.1016/j.chom.2008.07.013.


Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock.

Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Chapman MJ, Lesnik P.

J Immunol. 2008 May 15;180(10):6941-6.


Coexpression of CLA-1 and human PDZK1 in murine liver modulates HDL cholesterol metabolism.

Komori H, Arai H, Kashima T, Huby T, Kita T, Ueda Y.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1298-303. doi: 10.1161/ATVBAHA.108.165845. Epub 2008 Apr 10.


Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.

Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M.

Circ Res. 2008 Jan 4;102(1):113-20. Epub 2007 Oct 25.


Secretion of apolipoprotein E from macrophages occurs via a protein kinase A and calcium-dependent pathway along the microtubule network.

Kockx M, Guo DL, Huby T, Lesnik P, Kay J, Sabaretnam T, Jary E, Hill M, Gaus K, Chapman J, Stow JL, Jessup W, Kritharides L.

Circ Res. 2007 Sep 14;101(6):607-16. Epub 2007 Jul 27.


High-avidity monoclonal antibodies against the human scavenger class B type I receptor efficiently block hepatitis C virus infection in the presence of high-density lipoprotein.

Catanese MT, Graziani R, von Hahn T, Moreau M, Huby T, Paonessa G, Santini C, Luzzago A, Rice CM, Cortese R, Vitelli A, Nicosia A.

J Virol. 2007 Aug;81(15):8063-71. Epub 2007 May 16.


Enhanced immune system activation and arterial inflammation accelerates atherosclerosis in lupus-prone mice.

Gautier EL, Huby T, Ouzilleau B, Doucet C, Saint-Charles F, Gremy G, Chapman MJ, Lesnik P.

Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1625-31. Epub 2007 Apr 19.


LDL particle subspecies are distinct in their capacity to mediate free cholesterol efflux via the SR-BI/Cla-1 receptor.

Tréguier M, Moreau M, Sposito A, Chapman MJ, Huby T.

Biochim Biophys Acta. 2007 Feb;1771(2):129-38. Epub 2006 Dec 20.


Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity.

Grove J, Huby T, Stamataki Z, Vanwolleghem T, Meuleman P, Farquhar M, Schwarz A, Moreau M, Owen JS, Leroux-Roels G, Balfe P, McKeating JA.

J Virol. 2007 Apr;81(7):3162-9. Epub 2007 Jan 10.


Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues.

Huby T, Doucet C, Dachet C, Ouzilleau B, Ueda Y, Afzal V, Rubin E, Chapman MJ, Lesnik P.

J Clin Invest. 2006 Oct;116(10):2767-76. Epub 2006 Sep 7.


The interaction of natural hepatitis C virus with human scavenger receptor SR-BI/Cla1 is mediated by ApoB-containing lipoproteins.

Maillard P, Huby T, Andréo U, Moreau M, Chapman J, Budkowska A.

FASEB J. 2006 Apr;20(6):735-7. Epub 2006 Feb 13.


Thyroid hormone regulates the hypotriglyceridemic gene APOA5.

Prieur X, Huby T, Coste H, Schaap FG, Chapman MJ, Rodríguez JC.

J Biol Chem. 2005 Jul 29;280(30):27533-43. Epub 2005 Jun 7.


Transcription factor sterol regulatory element binding protein 2 regulates scavenger receptor Cla-1 gene expression.

Tréguier M, Doucet C, Moreau M, Dachet C, Thillet J, Chapman MJ, Huby T.

Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2358-64. Epub 2004 Oct 14.


Regulation of the expression of the apolipoprotein(a) gene: evidence for a regulatory role of the 5' distal apolipoprotein(a) transcription control region enhancer in yeast artificial chromosome transgenic mice.

Huby T, Afzal V, Doucet C, Lawn RM, Gong EL, Chapman MJ, Thillet J, Rubin EM.

Arterioscler Thromb Vasc Biol. 2003 Sep 1;23(9):1633-9. Epub 2003 Jul 3.


Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.

Schoonjans K, Annicotte JS, Huby T, Botrugno OA, Fayard E, Ueda Y, Chapman J, Auwerx J.

EMBO Rep. 2002 Dec;3(12):1181-7. Epub 2002 Nov 21.


Functional analysis of the chimpanzee and human apo(a) promoter sequences: identification of sequence variations responsible for elevated transcriptional activity in chimpanzee.

Huby T, Dachet C, Lawn RM, Wickings J, Chapman MJ, Thillet J.

J Biol Chem. 2001 Jun 22;276(25):22209-14. Epub 2001 Apr 11.


Molecular cloning of the cDNA encoding the carboxy-terminal domain of chimpanzee apolipoprotein(a): an Asp57 --> Asn mutation in kringle IV-10 is associated with poor fibrin binding.

Chenivesse X, Huby T, Wickins J, Chapman J, Thillet J.

Biochemistry. 1998 May 19;37(20):7213-23. Erratum in: Biochemistry 1999 Feb 9;38(6):1950.


Pathophysiological implication of the structural domains of lipoprotein(a).

Huby T, Chapman J, Thillet J.

Atherosclerosis. 1997 Aug;133(1):1-6. Review.


Expression of a recombinant kringle V of human apolipoprotein(a): antibody characterization and species specificity.

Chenivesse X, Huby T, Chapman J, Franco D, Thillet J.

Protein Expr Purif. 1996 Sep;8(2):145-50.


Non-enzymatic glycation of lipoprotein(a) in vitro and in vivo.

Doucet C, Huby T, Ruiz J, Chapman MJ, Thillet J.

Atherosclerosis. 1995 Nov;118(1):135-43.


Characterization of the N-terminal and C-terminal domains of human apolipoprotein(a): relevance to fibrin binding.

Huby T, Schröder W, Doucet C, Chapman J, Thillet J.

Biochemistry. 1995 Jun 6;34(22):7385-93.


Lipoprotein (a): implication in atherothrombosis.

Chapman MJ, Huby T, Nigon F, Thillet J.

Atherosclerosis. 1994 Oct;110 Suppl:S69-75. Review.


Association of elevated lipoprotein(a) levels and coronary heart disease in NIDDM patients. Relationship with apolipoprotein(a) phenotypes.

Ruiz J, Thillet J, Huby T, James RW, Erlich D, Flandre P, Froguel P, Chapman J, Passa P.

Diabetologia. 1994 Jun;37(6):585-91.


Structural domains of apolipoprotein(a) and its interaction with apolipoprotein B-100 in the lipoprotein(a) particle.

Huby T, Doucet C, Dieplinger H, Chapman J, Thillet J.

Biochemistry. 1994 Mar 22;33(11):3335-41.


Lipoprotein[a] in the chimpanezee: relationship of apo[a] phenotype to elevated plasma Lp[a] levels.

Doucet C, Huby T, Chapman J, Thillet J.

J Lipid Res. 1994 Feb;35(2):263-70.

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