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Hypercapnia Alters Alveolar Epithelial Repair by a pH-Dependent and Adenylate Cyclase-Mediated Mechanism.

Cortes-Puentes GA, Westerly B, Schiavo D, Wang S, Stroetz R, Walters B, Hubmayr RD, Oeckler RA.

Sci Rep. 2019 Jan 23;9(1):349. doi: 10.1038/s41598-018-36951-7.


Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, Sapin V, Matthay MA, Constantin JM, Calfee CS.

Intensive Care Med. 2018 Sep;44(9):1388-1399. doi: 10.1007/s00134-018-5327-1. Epub 2018 Jul 26.


Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair.

Nagre N, Cong X, Ji HL, Schreiber JM, Fu H, Pepper I, Warren S, Sill JM, Hubmayr RD, Zhao X.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):635-647. doi: 10.1165/rcmb.2017-0364OC.


Reply: Transpulmonary Pressure Meaning: Babel or Conceptual Evolution?

Loring SH, Topulos GP, Hubmayr RD.

Am J Respir Crit Care Med. 2017 May 15;195(10):1405-1406. doi: 10.1164/rccm.201701-0028LE. No abstract available.


Quantitative assessment of lung stiffness in patients with interstitial lung disease using MR elastography.

Marinelli JP, Levin DL, Vassallo R, Carter RE, Hubmayr RD, Ehman RL, McGee KP.

J Magn Reson Imaging. 2017 Aug;46(2):365-374. doi: 10.1002/jmri.25579. Epub 2017 Jan 24.


Plasma membrane wounding and repair in pulmonary diseases.

Cong X, Hubmayr RD, Li C, Zhao X.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L371-L391. doi: 10.1152/ajplung.00486.2016. Epub 2017 Jan 6. Review.


Transpulmonary Pressure: The Importance of Precise Definitions and Limiting Assumptions.

Loring SH, Topulos GP, Hubmayr RD.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1452-1457. Review.


TRIM72 modulates caveolar endocytosis in repair of lung cells.

Nagre N, Wang S, Kellett T, Kanagasabai R, Deng J, Nishi M, Shilo K, Oeckler RA, Yalowich JC, Takeshima H, Christman J, Hubmayr RD, Zhao X.

Am J Physiol Lung Cell Mol Physiol. 2016 Mar 1;310(5):L452-64. doi: 10.1152/ajplung.00089.2015. Epub 2015 Dec 4.


Understanding lung protection.

Hubmayr RD, Pannu S.

Intensive Care Med. 2015 Dec;41(12):2184-6. No abstract available.


Volume Delivered During Recruitment Maneuver Predicts Lung Stress in Acute Respiratory Distress Syndrome.

Beitler JR, Majumdar R, Hubmayr RD, Malhotra A, Thompson BT, Owens RL, Loring SH, Talmor D.

Crit Care Med. 2016 Jan;44(1):91-9. doi: 10.1097/CCM.0000000000001355.


Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL; TRALI Study Group.

Transfusion. 2015 Aug;55(8):1838-46. doi: 10.1111/trf.13021. Epub 2015 Feb 23.


Safe mechanical ventilation in patients without acute respiratory distress syndrome (ARDS).

Pannu SR, Hubmayr RD.

Minerva Anestesiol. 2015 Sep;81(9):1031-40. Epub 2015 Jan 19. Review.


Extravascular lung water and pulmonary vascular permeability index as markers predictive of postoperative acute respiratory distress syndrome: a prospective cohort investigation.

Kor DJ, Warner DO, Carter RE, Meade LA, Wilson GA, Li M, Hamersma MJ, Hubmayr RD, Mauermann WJ, Gajic O.

Crit Care Med. 2015 Mar;43(3):665-73. doi: 10.1097/CCM.0000000000000765.


Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR.

Transfusion. 2015 May;55(5):947-52. doi: 10.1111/trf.12954. Epub 2014 Dec 8.


Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome.

Cartin-Ceba R, Hubmayr RD, Qin R, Peters S, Determann RM, Schultz MJ, Gajic O.

J Crit Care. 2015 Feb;30(1):219.e1-7. doi: 10.1016/j.jcrc.2014.09.001. Epub 2014 Sep 6.


The hidden consequences of ventilator management decisions.

Hubmayr RD, Oeckler RA.

Respir Care. 2014 Aug;59(8):1302-5. doi: 10.4187/respcare.03366.


TRIM72 is required for effective repair of alveolar epithelial cell wounding.

Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L449-59. doi: 10.1152/ajplung.00172.2014. Epub 2014 Aug 8.


Still looking for best PEEP.

Hubmayr RD, Malhotra A.

Anesthesiology. 2014 Sep;121(3):445-6. doi: 10.1097/ALN.0000000000000374. No abstract available.


Regional lung strain and the metabolic signature of injury*.

Hubmayr RD.

Crit Care Med. 2014 Jul;42(7):1745-6. doi: 10.1097/CCM.0000000000000383. No abstract available.


The hemodynamic effects of prone positioning in patients with acute respiratory distress syndrome remain to be defined.

Albert RK, Hubmayr RD.

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1567. doi: 10.1164/rccm.201401-0007LE. No abstract available.


Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P; Transfusion-Related Acute Lung Injury Study Group.

Crit Care Med. 2014 Jul;42(7):1676-87. doi: 10.1097/CCM.0000000000000323.


Estimation of the absolute shear stiffness of human lung parenchyma using (1) H spin echo, echo planar MR elastography.

Mariappan YK, Glaser KJ, Levin DL, Vassallo R, Hubmayr RD, Mottram C, Ehman RL, McGee KP.

J Magn Reson Imaging. 2014 Nov;40(5):1230-7. doi: 10.1002/jmri.24479. Epub 2013 Nov 13.


Volutrauma and regional ventilation revisited.

Hubmayr RD.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1388-9. doi: 10.1164/rccm.201311-1993ED. No abstract available.


Regenerative medicine: why does it matter?

Hubmayr RD.

Physiology (Bethesda). 2013 Nov;28(6):366-7. doi: 10.1152/physiol.00054.2013. No abstract available.


Biophysical determinants of alveolar epithelial plasma membrane wounding associated with mechanical ventilation.

Hussein O, Walters B, Stroetz R, Valencia P, McCall D, Hubmayr RD.

Am J Physiol Lung Cell Mol Physiol. 2013 Oct 1;305(7):L478-84. doi: 10.1152/ajplung.00437.2012. Epub 2013 Aug 30. Erratum in: Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L808.


Temporal trends of ventilator-associated pneumonia incidence and the effect of implementing health-care bundles in a suburban community.

Ding S, Kilickaya O, Senkal S, Gajic O, Hubmayr RD, Li G.

Chest. 2013 Nov;144(5):1461-1468. doi: 10.1378/chest.12-1675.


Rebuttal from Jeremy R. Beitler, Rolf D. Hubmayr and Atul Malhotra.

Beitler JR, Hubmayr RD, Malhotra A.

J Physiol. 2013 Jun 1;591(11):2773. doi: 10.1113/jphysiol.2013.255646. No abstract available.


CrossTalk opposing view: there is not added benefit to providing permissive hypercapnia in the treatment of ARDS.

Beitler JR, Hubmayr RD, Malhotra A.

J Physiol. 2013 Jun 1;591(11):2767-9. doi: 10.1113/jphysiol.2013.252619. No abstract available.


Risk factors and outcomes in transfusion-associated circulatory overload.

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P; TRALI Study Group.

Am J Med. 2013 Apr;126(4):357.e29-38. doi: 10.1016/j.amjmed.2012.08.019. Epub 2013 Jan 26.


Magnetic resonance assessment of parenchymal elasticity in normal and edematous, ventilator-injured lung.

McGee KP, Mariappan YK, Hubmayr RD, Carter RE, Bao Z, Levin DL, Manduca A, Ehman RL.

J Appl Physiol (1985). 2012 Aug 15;113(4):666-76. doi: 10.1152/japplphysiol.01628.2011. Epub 2012 Jun 7.


Does oxygen tune cellular mechanotransduction?

Hubmayr RD.

Am J Physiol Lung Cell Mol Physiol. 2012 Jun 15;302(12):L1233-4. doi: 10.1152/ajplung.00121.2012. Epub 2012 Apr 20. No abstract available.


Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial.

Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O.

Am J Respir Crit Care Med. 2012 Apr 15;185(8):842-50. doi: 10.1164/rccm.201107-1332OC. Epub 2012 Jan 26.


Epithelial to mesenchymal transition: a new twist to biotrauma?.

Sharma AK, Hubmayr RD.

Crit Care Med. 2012 Feb;40(2):682-3. doi: 10.1097/CCM.0b013e318232d1a8. No abstract available.


Hypercapnia: a nonpermissive environment for the lung.

Vadász I, Hubmayr RD, Nin N, Sporn PH, Sznajder JI.

Am J Respir Cell Mol Biol. 2012 Apr;46(4):417-21. doi: 10.1165/rcmb.2011-0395PS. Epub 2012 Jan 12. Review.


Inhaled carbon monoxide attenuates myocardial inflammatory cytokine expression in a rat model of cardiopulmonary bypass.

Pulido JN, Neal JR, Mantilla CB, Agarwal S, Lee WY, Scott PD, Hubmayr RD, Zhan WZ, Sieck GC, Farrugia G, Ereth MH.

J Extra Corpor Technol. 2011 Sep;43(3):137-43.


The role of purinergic signaling on deformation induced injury and repair responses of alveolar epithelial cells.

Belete HA, Hubmayr RD, Wang S, Singh RD.

PLoS One. 2011;6(11):e27469. doi: 10.1371/journal.pone.0027469. Epub 2011 Nov 8.


Decision support tool for early differential diagnosis of acute lung injury and cardiogenic pulmonary edema in medical critically ill patients.

Schmickl CN, Shahjehan K, Li G, Dhokarh R, Kashyap R, Janish C, Alsara A, Jaffe AS, Hubmayr RD, Gajic O.

Chest. 2012 Jan;141(1):43-50. doi: 10.1378/chest.11-1496. Epub 2011 Oct 26.


Dopamine inhibits pulmonary edema through the VEGF-VEGFR2 axis in a murine model of acute lung injury.

Vohra PK, Hoeppner LH, Sagar G, Dutta SK, Misra S, Hubmayr RD, Mukhopadhyay D.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 15;302(2):L185-92. doi: 10.1152/ajplung.00274.2010. Epub 2011 Oct 14.


Poloxamer 188 facilitates the repair of alveolus resident cells in ventilator-injured lungs.

Plataki M, Lee YD, Rasmussen DL, Hubmayr RD.

Am J Respir Crit Care Med. 2011 Oct 15;184(8):939-47. doi: 10.1164/rccm.201104-0647OC. Epub 2011 Jul 21.


Point: Is low tidal volume mechanical ventilation preferred for all patients on ventilation? Yes.

Hubmayr RD.

Chest. 2011 Jul;140(1):9-11. doi: 10.1378/chest.11-0825. No abstract available.


Calculation of shear stiffness in noise dominated magnetic resonance elastography data based on principal frequency estimation.

McGee KP, Lake D, Mariappan Y, Hubmayr RD, Manduca A, Ansell K, Ehman RL.

Phys Med Biol. 2011 Jul 21;56(14):4291-309. doi: 10.1088/0031-9155/56/14/006. Epub 2011 Jun 23.


Straining to make mechanical ventilation safe and simple.

Hubmayr RD.

Am J Respir Crit Care Med. 2011 May 15;183(10):1289-90. doi: 10.1164/rccm.201102-0195ED. No abstract available.


MR elastography of human lung parenchyma: technical development, theoretical modeling and in vivo validation.

Mariappan YK, Glaser KJ, Hubmayr RD, Manduca A, Ehman RL, McGee KP.

J Magn Reson Imaging. 2011 Jun;33(6):1351-61. doi: 10.1002/jmri.22550.


Magnetic resonance elastography of the lung parenchyma in an in situ porcine model with a noninvasive mechanical driver: correlation of shear stiffness with trans-respiratory system pressures.

Mariappan YK, Kolipaka A, Manduca A, Hubmayr RD, Ehman RL, Araoz P, McGee KP.

Magn Reson Med. 2012 Jan;67(1):210-7. doi: 10.1002/mrm.22976. Epub 2011 May 16.


The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components.

Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM; National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II.

Transfusion. 2011 Oct;51(10):2078-91. doi: 10.1111/j.1537-2995.2011.03120.x. Epub 2011 Mar 29.


Diaphragm curvature modulates the relationship between muscle shortening and volume displacement.

Greybeck BJ, Wettergreen M, Hubmayr RD, Boriek AM.

Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R76-82. doi: 10.1152/ajpregu.00673.2010. Epub 2011 Mar 23.


Should mechanical ventilation be guided by esophageal pressure measurements?

Plataki M, Hubmayr RD.

Curr Opin Crit Care. 2011 Jun;17(3):275-80. doi: 10.1097/MCC.0b013e328344dda6. Review.


Sizing the lung of mechanically ventilated patients.

Mattingley JS, Holets SR, Oeckler RA, Stroetz RW, Buck CF, Hubmayr RD.

Crit Care. 2011;15(1):R60. doi: 10.1186/cc10034. Epub 2011 Feb 14.


Endocytic response of type I alveolar epithelial cells to hypertonic stress.

Wang S, Singh RD, Godin L, Pagano RE, Hubmayr RD.

Am J Physiol Lung Cell Mol Physiol. 2011 Apr;300(4):L560-8. doi: 10.1152/ajplung.00309.2010. Epub 2011 Jan 21.

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