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Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II.

Kaiser A, Krüger T, Eiselt G, Bechler J, Kniemeyer O, Huber O, Schmidt M.

Cells. 2020 Feb 12;9(2). pii: E427. doi: 10.3390/cells9020427.


Wnt Glycation Inhibits Canonical Signaling.

Ye Z, Mittag S, Schmidt M, Simm A, Horstkorte R, Huber O.

Cells. 2019 Oct 25;8(11). pii: E1320. doi: 10.3390/cells8111320.


Apoptotic Fragmentation of Tricellulin.

Janke S, Mittag S, Reiche J, Huber O.

Int J Mol Sci. 2019 Oct 1;20(19). pii: E4882. doi: 10.3390/ijms20194882.


A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.

Maurer M, Gresnigt MS, Last A, Wollny T, Berlinghof F, Pospich R, Cseresnyes Z, Medyukhina A, Graf K, Gröger M, Raasch M, Siwczak F, Nietzsche S, Jacobsen ID, Figge MT, Hube B, Huber O, Mosig AS.

Biomaterials. 2019 Nov;220:119396. doi: 10.1016/j.biomaterials.2019.119396. Epub 2019 Aug 2.


CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways.

Knutti N, Huber O, Friedrich K.

Mol Cell Biochem. 2019 Jan;451(1-2):197-209. doi: 10.1007/s11010-018-3406-9. Epub 2018 Jul 18.


AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report.

Mikesch JH, Hartmann W, Angenendt L, Huber O, Schliemann C, Arteaga MF, Wardelmann E, Rudack C, Berdel WE, Stenner M, Grünewald I.

Cell Oncol (Dordr). 2018 Aug;41(4):455-462. doi: 10.1007/s13402-018-0382-8. Epub 2018 Jun 5.


Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - Influence of α1-adrenergic signalling.

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Matziolis G, Schubert H, Schwab M, Huber O, Lemke C, Schmidt M.

PLoS One. 2018 May 29;13(5):e0196363. doi: 10.1371/journal.pone.0196363. eCollection 2018.


Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.

Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS.

Sci Rep. 2018 May 14;8:46988. doi: 10.1038/srep46988.


Corrigendum to "Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review" [Crit. Rev. Oncol./Hematol. 124, April (2018), 61-65].

Kam TY, Kountouri M, Roth A, Frossard JL, Huber O, Mönig S, Zilli T.

Crit Rev Oncol Hematol. 2018 Aug;128:139. doi: 10.1016/j.critrevonc.2018.04.004. Epub 2018 May 4. No abstract available.


Endoscopic resection with adjuvant chemo-radiotherapy for superficial esophageal squamous cell carcinoma: A critical review.

Kam TY, Kountouri M, Roth A, Frossard JL, Huber O, Mönig S, Zilli T.

Crit Rev Oncol Hematol. 2018 Apr;124:61-65. doi: 10.1016/j.critrevonc.2018.02.011. Epub 2018 Mar 2. Review. Erratum in: Crit Rev Oncol Hematol. 2018 May 3;:.


A Continuum Damage Mechanics Model for the Static and Cyclic Fatigue of Cellular Composites.

Diel S, Huber O.

Materials (Basel). 2017 Aug 15;10(8). pii: E951. doi: 10.3390/ma10080951.


Recurrence Patterns and Long-term Results After Induction Chemotherapy, Chemoradiotherapy, and Curative Surgery in Patients With Locally Advanced Esophageal Cancer.

Steffen T, Dietrich D, Schnider A, Kettelhack C, Huber O, Marti WR, Furrer M, Gloor B, Schiesser M, Thierstein S, Brauchli P, Ruhstaller T; Swiss Group for Clinical Cancer Research (SAKK).

Ann Surg. 2019 Jan;269(1):83-87. doi: 10.1097/SLA.0000000000002435.


Evaluation-Dependent Representation in Risk Defusing.

Huber O.

Front Psychol. 2017 May 23;8:836. doi: 10.3389/fpsyg.2017.00836. eCollection 2017. No abstract available.


Redistribution of Cerebral Blood Flow during Severe Hypovolemia and Reperfusion in a Sheep Model: Critical Role of α1-Adrenergic Signaling.

Schiffner R, Bischoff SJ, Lehmann T, Rakers F, Rupprecht S, Reiche J, Matziolis G, Schubert H, Schwab M, Huber O, Schmidt M.

Int J Mol Sci. 2017 May 11;18(5). pii: E1031. doi: 10.3390/ijms18051031.


Tricellulin is a target of the ubiquitin ligase Itch.

Jennek S, Mittag S, Reiche J, Westphal JK, Seelk S, Dörfel MJ, Pfirrmann T, Friedrich K, Schütz A, Heinemann U, Huber O.

Ann N Y Acad Sci. 2017 Jun;1397(1):157-168. doi: 10.1111/nyas.13349. Epub 2017 Apr 24.


The expression of sialyltransferases is regulated by the bioavailability and biosynthesis of sialic acids.

Bork K, Weidemann W, Berneck B, Kuchta M, Bennmann D, Thate A, Huber O, Gnanapragassam VS, Horstkorte R.

Gene Expr Patterns. 2017 Jan;23-24:52-58. doi: 10.1016/j.gep.2017.03.003. Epub 2017 Mar 27.


Trefoil factor 3 mediates resistance to apoptosis in colon carcinoma cells by a regulatory RNA axis.

Hanisch C, Sharbati J, Kutz-Lohroff B, Huber O, Einspanier R, Sharbati S.

Cell Death Dis. 2017 Mar 9;8(3):e2660. doi: 10.1038/cddis.2017.84. No abstract available.


Exclusive neoadjuvant chemotherapy in locally advanced resectable gastric and gastro-esophageal junction adenocarcinoma.

Fernandez E, Cacheux W, Frossard JL, Koessler T, Abou M, Moniez M, Huber O, Puppa G, Roth A.

Dig Liver Dis. 2017 May;49(5):552-556. doi: 10.1016/j.dld.2016.12.025. Epub 2017 Jan 16.


TFF3-dependent resistance of human colorectal adenocarcinoma cells HT-29/B6 to apoptosis is mediated by miR-491-5p regulation of lncRNA PRINS.

Hanisch C, Sharbati J, Kutz-Lohroff B, Huber O, Einspanier R, Sharbati S.

Cell Death Discov. 2017 Jan 30;3:16106. doi: 10.1038/cddiscovery.2016.106. eCollection 2017.


SUMOylation regulates the intracellular fate of ZO-2.

Wetzel F, Mittag S, Cano-Cortina M, Wagner T, Krämer OH, Niedenthal R, Gonzalez-Mariscal L, Huber O.

Cell Mol Life Sci. 2017 Jan;74(2):373-392. doi: 10.1007/s00018-016-2352-5. Epub 2016 Sep 7.


[Management of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy].

Balaphas A, Belfontali V, Ris F, Lanitis A, Meier RP, Amram ML, Roth A, Huber O, Berney T, Morel P.

Rev Med Suisse. 2016 Jun 15;12(523):1190-4. French.


An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development.

Raasch M, Rennert K, Jahn T, Gärtner C, Schönfelder G, Huber O, Seiler AE, Mosig AS.

Biomicrofluidics. 2016 Jul 5;10(4):044102. doi: 10.1063/1.4955184. eCollection 2016 Jul.


A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway.

Mittag S, Valenta T, Weiske J, Bloch L, Klingel S, Gradl D, Wetzel F, Chen Y, Petersen I, Basler K, Huber O.

Cell Discov. 2016 Jan 5;2:15039. doi: 10.1038/celldisc.2015.39. eCollection 2016.


Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model.

Bischoff SJ, Schmidt M, Lehmann T, Irintchev A, Schubert H, Jung C, Schwab M, Huber O, Matziolis G, Schiffner R.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H613-20. doi: 10.1152/ajpheart.00118.2016. Epub 2016 Jul 8.


Real-time monitoring of hypertrophy in HL-1 cardiomyocytes by impedance measurements reveals different modes of growth.

Bloch L, Ndongson-Dongmo B, Kusch A, Dragun D, Heller R, Huber O.

Cytotechnology. 2016 Oct;68(5):1897-907. doi: 10.1007/s10616-016-0001-3. Epub 2016 Jul 5.


Characterization of SKAP/kinastrin isoforms: the N-terminus defines tissue specificity and Pontin binding.

Cindric Vranesic A, Reiche J, Hoischen C, Wohlmann A, Bratsch J, Friedrich K, Günes B, Cappallo-Obermann H, Kirchhoff C, Diekmann S, Günes C, Huber O.

Hum Mol Genet. 2016 Jul 1;25(13):2838-2852. Epub 2016 May 11.


Recruitment of CD16(+) monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine.

Rennert K, Heisig K, Groeger M, Wallert M, Funke H, Lorkowski S, Huber O, Mosig AS.

Cytokine. 2016 Jul;83:41-52. doi: 10.1016/j.cyto.2016.03.017. Epub 2016 Mar 28.


Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.

Gröger M, Rennert K, Giszas B, Weiß E, Dinger J, Funke H, Kiehntopf M, Peters FT, Lupp A, Bauer M, Claus RA, Huber O, Mosig AS.

Sci Rep. 2016 Feb 23;6:21868. doi: 10.1038/srep21868. Erratum in: Sci Rep. 2018 May 14;8:46988.


Preoperative versus postoperative docetaxel-cisplatin-fluorouracil (TCF) chemotherapy in locally advanced resectable gastric carcinoma: 10-year follow-up of the SAKK 43/99 phase III trial.

Fazio N, Biffi R, Maibach R, Hayoz S, Thierstein S, Brauchli P, Bernhard J, Stupp R, Andreoni B, Renne G, Crosta C, Morant R, Chiappa A, Luca F, Zampino MG, Huber O, Goldhirsch A, de Braud F, Roth AD; Swiss Group for Clinical Cancer Research SAKK; European Institute of Oncology, Milan, Italy.

Ann Oncol. 2016 Apr;27(4):668-73. doi: 10.1093/annonc/mdv620. Epub 2015 Dec 27.


A microfluidically perfused three dimensional human liver model.

Rennert K, Steinborn S, Gröger M, Ungerböck B, Jank AM, Ehgartner J, Nietzsche S, Dinger J, Kiehntopf M, Funke H, Peters FT, Lupp A, Gärtner C, Mayr T, Bauer M, Huber O, Mosig AS.

Biomaterials. 2015 Dec;71:119-131. doi: 10.1016/j.biomaterials.2015.08.043. Epub 2015 Aug 25.


Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.

Multhaup G, Huber O, Buée L, Galas MC.

J Biol Chem. 2015 Sep 25;290(39):23515-22. doi: 10.1074/jbc.R115.677211. Epub 2015 Aug 21. Review.


Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time.

Sellmann C, Priebs J, Landmann M, Degen C, Engstler AJ, Jin CJ, Gärttner S, Spruss A, Huber O, Bergheim I.

J Nutr Biochem. 2015 Nov;26(11):1183-92. doi: 10.1016/j.jnutbio.2015.05.011. Epub 2015 Jun 16.


150th Anniversary Series: Desmosomes and the Hallmarks of Cancer.

Huber O, Petersen I.

Cell Commun Adhes. 2015;22(1):15-28. doi: 10.3109/15419061.2015.1039642. Epub 2015 Jul 2. Review.


Roux-en-Y gastric bypass for super obese patients: what approach?

Buchs NC, Azagury DE, Pugin F, Jung MK, Huber O, Chassot G, Morel P.

Int J Med Robot. 2016 Jun;12(2):276-82. doi: 10.1002/rcs.1660. Epub 2015 Apr 19.


Does perioperative nutrition and oral carbohydrate load sustainably preserve muscle mass after bariatric surgery? A randomized control trial.

Azagury DE, Ris F, Pichard C, Volonté F, Karsegard L, Huber O.

Surg Obes Relat Dis. 2015 Jul-Aug;11(4):920-6. doi: 10.1016/j.soard.2014.10.016. Epub 2014 Oct 22.


Twelve key nutritional issues in bariatric surgery.

Thibault R, Huber O, Azagury DE, Pichard C.

Clin Nutr. 2016 Feb;35(1):12-7. doi: 10.1016/j.clnu.2015.02.012. Epub 2015 Mar 3. Review.


Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions.

Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, Becker H, Lorkowski S, Funke H, Mosig A.

Biofabrication. 2015 Mar 2;7(1):015013. doi: 10.1088/1758-5090/7/1/015013.


Impairments in an early stage of the decision-making process in patients with ventromedial prefrontal damage: preliminary results.

Eggen C, Huber O, Bär A, Huber OW, Perrig WJ, Müri R, Gutbrod K.

Neurocase. 2015;21(4):509-19. doi: 10.1080/13554794.2014.944545. Epub 2014 Aug 1.


Laparoscopic versus robotic Roux-en-Y gastric bypass: lessons and long-term follow-up learned from a large prospective monocentric study.

Buchs NC, Morel P, Azagury DE, Jung M, Chassot G, Huber O, Hagen ME, Pugin F.

Obes Surg. 2014 Dec;24(12):2031-9. doi: 10.1007/s11695-014-1335-6.


Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G.

J Biol Chem. 2014 Jul 18;289(29):20182-91. doi: 10.1074/jbc.M114.564690. Epub 2014 May 30.


Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

Pergola C, Gaboriaud-Kolar N, Jestädt N, König S, Kritsanida M, Schaible AM, Li H, Garscha U, Weinigel C, Barz D, Albring KF, Huber O, Skaltsounis AL, Werz O.

J Med Chem. 2014 May 8;57(9):3715-23. doi: 10.1021/jm401740w. Epub 2014 Apr 17.


Robotic revisional bariatric surgery: a comparative study with laparoscopic and open surgery.

Buchs NC, Pugin F, Azagury DE, Huber O, Chassot G, Morel P.

Int J Med Robot. 2014 Jun;10(2):213-7. doi: 10.1002/rcs.1549. Epub 2013 Oct 24.


Plastic surgery improves long-term weight control after bariatric surgery.

Balagué N, Combescure C, Huber O, Pittet-Cuénod B, Modarressi A.

Plast Reconstr Surg. 2013 Oct;132(4):826-33. doi: 10.1097/PRS.0b013e31829fe531.


Berberine acts as a natural inhibitor of Wnt/β-catenin signaling--identification of more active 13-arylalkyl derivatives.

Albring KF, Weidemüller J, Mittag S, Weiske J, Friedrich K, Geroni MC, Lombardi P, Huber O.

Biofactors. 2013 Nov-Dec;39(6):652-62. doi: 10.1002/biof.1133. Epub 2013 Aug 24.


CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity.

Dörfel MJ, Westphal JK, Bellmann C, Krug SM, Cording J, Mittag S, Tauber R, Fromm M, Blasig IE, Huber O.

Cell Commun Signal. 2013 Jun 10;11(1):40. doi: 10.1186/1478-811X-11-40.


The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.

Rosenbaum J, Baek SH, Dutta A, Houry WA, Huber O, Hupp TR, Matias PM.

Sci Signal. 2013 Mar 12;6(266):mr1. doi: 10.1126/scisignal.2003906.


Subcutaneous migration of a central venous catheter.

Samaras D, Braudé P, Huber O, Pichard C.

Clin Nutr. 2013 Aug;32(4):666-7. doi: 10.1016/j.clnu.2012.11.015. Epub 2012 Dec 11. No abstract available.


In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization.

Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig IE.

J Cell Sci. 2013 Jan 15;126(Pt 2):554-64. doi: 10.1242/jcs.114306. Epub 2012 Nov 30.


Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.

Bautista-García P, Reyes JL, Martín D, Namorado MC, Chavez-Munguía B, Soria-Castro E, Huber O, González-Mariscal L.

Am J Physiol Renal Physiol. 2013 Jan 1;304(1):F77-87. doi: 10.1152/ajprenal.00089.2012. Epub 2012 Oct 3.

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