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CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.

Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, Lionakis MS.

Nat Immunol. 2019 May;20(5):559-570. doi: 10.1038/s41590-019-0377-2. Epub 2019 Apr 17.


Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.

Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A.

Cell. 2019 Mar 7;176(6):1340-1355.e15. doi: 10.1016/j.cell.2019.01.041. Epub 2019 Feb 21.


Integrity under stress: Host membrane remodelling and damage by fungal pathogens.

Westman J, Hube B, Fairn GD.

Cell Microbiol. 2019 Apr;21(4):e13016. doi: 10.1111/cmi.13016. Epub 2019 Mar 7. Review.


Editorial: Immunity to Human Fungal Pathogens: Mechanisms of Host Recognition, Protection, Pathology, and Fungal Interference.

Templeton SP, Rivera A, Hube B, Jacobsen ID.

Front Immunol. 2018 Oct 15;9:2337. doi: 10.3389/fimmu.2018.02337. eCollection 2018. No abstract available.


The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.

Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B.

Nat Commun. 2018 Oct 15;9(1):4260. doi: 10.1038/s41467-018-06607-1.


Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization.

Westman J, Moran G, Mogavero S, Hube B, Grinstein S.

MBio. 2018 Sep 11;9(5). pii: e01226-18. doi: 10.1128/mBio.01226-18.


Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha.

Schirbel A, Shouval DS, Hebecker B, Hube B, Sturm A, Werner L.

Eur J Immunol. 2018 Nov;48(11):1826-1837. doi: 10.1002/eji.201847586. Epub 2018 Oct 19.


The needle and the damage done.

Brunke S, Hube B.

Nat Microbiol. 2018 Aug;3(8):860-861. doi: 10.1038/s41564-018-0194-7. No abstract available.


IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms.

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL.

J Immunol. 2018 Jul 15;201(2):627-634. doi: 10.4049/jimmunol.1800515. Epub 2018 Jun 11.


Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers.

Allert S, Förster TM, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S, Hube B.

MBio. 2018 Jun 5;9(3). pii: e00915-18. doi: 10.1128/mBio.00915-18.


Biphasic zinc compartmentalisation in a human fungal pathogen.

Crawford AC, Lehtovirta-Morley LE, Alamir O, Niemiec MJ, Alawfi B, Alsarraf M, Skrahina V, Costa ACBP, Anderson A, Yellagunda S, Ballou ER, Hube B, Urban CF, Wilson D.

PLoS Pathog. 2018 May 4;14(5):e1007013. doi: 10.1371/journal.ppat.1007013. eCollection 2018 May.


Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence.

Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, Ho J, Kichik N, Gaffen SL, Hube B, Naglik JR.

MBio. 2018 Jan 23;9(1). pii: e02178-17. doi: 10.1128/mBio.02178-17.


Candida albicans Hap43 Domains Are Required under Iron Starvation but Not Excess.

Skrahina V, Brock M, Hube B, Brunke S.

Front Microbiol. 2017 Dec 1;8:2388. doi: 10.3389/fmicb.2017.02388. eCollection 2017.


Zinc Limitation Induces a Hyper-Adherent Goliath Phenotype in Candida albicans.

Malavia D, Lehtovirta-Morley LE, Alamir O, Weiß E, Gow NAR, Hube B, Wilson D.

Front Microbiol. 2017 Nov 14;8:2238. doi: 10.3389/fmicb.2017.02238. eCollection 2017.


Candida albicans-epithelial interactions and induction of mucosal innate immunity.

Naglik JR, König A, Hube B, Gaffen SL.

Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17. Review.


Metabolic adaptation of intracellular bacteria and fungi to macrophages.

Sprenger M, Kasper L, Hensel M, Hube B.

Int J Med Microbiol. 2018 Jan;308(1):215-227. doi: 10.1016/j.ijmm.2017.11.001. Epub 2017 Nov 7. Review.


Candidalysin Drives Epithelial Signaling, Neutrophil Recruitment, and Immunopathology at the Vaginal Mucosa.

Richardson JP, Willems HME, Moyes DL, Shoaie S, Barker KS, Tan SL, Palmer GE, Hube B, Naglik JR, Peters BM.

Infect Immun. 2018 Jan 22;86(2). pii: e00645-17. doi: 10.1128/IAI.00645-17. Print 2018 Feb.


Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.

Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL.

Sci Immunol. 2017 Nov 3;2(17). pii: eaam8834. doi: 10.1126/sciimmunol.aam8834.


Metals in fungal virulence.

Gerwien F, Skrahina V, Kasper L, Hube B, Brunke S.

FEMS Microbiol Rev. 2018 Jan 1;42(1). doi: 10.1093/femsre/fux050. Review.


Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion.

Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, Stevens P, Wagener J, Hebecker B, Hube B, Bracher F, Sohn K, Schaller M.

PLoS One. 2017 Oct 12;12(10):e0184438. doi: 10.1371/journal.pone.0184438. eCollection 2017.


When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi.

Yu Y, Hube B, Kämper J, Meyer V, Krappmann S.

Virulence. 2017 Oct 3;8(7):1435-1444. doi: 10.1080/21505594.2017.1356502. Epub 2017 Jul 19.


The Fungal Pathogen Candida glabrata Does Not Depend on Surface Ferric Reductases for Iron Acquisition.

Gerwien F, Safyan A, Wisgott S, Brunke S, Kasper L, Hube B.

Front Microbiol. 2017 Jun 8;8:1055. doi: 10.3389/fmicb.2017.01055. eCollection 2017.


Fungi that Infect Humans.

Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.FUNK-0014-2016. Review.


The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and in vivo fitness of Candida albicans.

Ramírez-Zavala B, Mottola A, Haubenreißer J, Schneider S, Allert S, Brunke S, Ohlsen K, Hube B, Morschhäuser J.

Mol Microbiol. 2017 Jun;104(6):989-1007. doi: 10.1111/mmi.13674. Epub 2017 Apr 18.


Candida albicans morphology: still in focus.

Jacobsen ID, Hube B.

Expert Rev Anti Infect Ther. 2017 Apr;15(4):327-330. doi: 10.1080/14787210.2017.1290524. Epub 2017 Feb 21. No abstract available.


Widespread Inter- and Intra-Domain Horizontal Gene Transfer of d-Amino Acid Metabolism Enzymes in Eukaryotes.

Naranjo-Ortíz MA, Brock M, Brunke S, Hube B, Marcet-Houben M, Gabaldón T.

Front Microbiol. 2016 Dec 20;7:2001. doi: 10.3389/fmicb.2016.02001. eCollection 2016.


Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating.

Cassone A, Vecchiarelli A, Hube B.

PLoS Pathog. 2016 Dec 22;12(12):e1005992. doi: 10.1371/journal.ppat.1005992. eCollection 2016 Dec. Review. No abstract available.


Corrigendum: Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions.

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID.

Sci Rep. 2016 Dec 19;6:39423. doi: 10.1038/srep39423. No abstract available.


Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells.

Jakab Á, Mogavero S, Förster TM, Pekmezovic M, Jablonowski N, Dombrádi V, Pócsi I, Hube B.

Microbiology. 2016 Dec;162(12):2116-2125. doi: 10.1099/mic.0.000383. Epub 2016 Oct 20.


Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation.

Böttcher B, Pöllath C, Staib P, Hube B, Brunke S.

Front Microbiol. 2016 Oct 27;7:1697. eCollection 2016.


Dual-species transcriptional profiling during systemic candidiasis reveals organ-specific host-pathogen interactions.

Hebecker B, Vlaic S, Conrad T, Bauer M, Brunke S, Kapitan M, Linde J, Hube B, Jacobsen ID.

Sci Rep. 2016 Nov 3;6:36055. doi: 10.1038/srep36055. Erratum in: Sci Rep. 2016 Dec 19;6:39423.


A Novel Hybrid Iron Regulation Network Combines Features from Pathogenic and Nonpathogenic Yeasts.

Gerwien F, Safyan A, Wisgott S, Hille F, Kaemmer P, Linde J, Brunke S, Kasper L, Hube B.

MBio. 2016 Oct 18;7(5). pii: e01782-16. doi: 10.1128/mBio.01782-16.


The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage.

Wilson D, Naglik JR, Hube B.

PLoS Pathog. 2016 Oct 20;12(10):e1005867. doi: 10.1371/journal.ppat.1005867. eCollection 2016 Oct. Review. No abstract available.


Global Identification of Biofilm-Specific Proteolysis in Candida albicans.

Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ.

MBio. 2016 Sep 13;7(5). pii: e01514-16. doi: 10.1128/mBio.01514-16.


A functional link between hyphal maintenance and quorum sensing in Candida albicans.

Polke M, Sprenger M, Scherlach K, Albán-Proaño MC, Martin R, Hertweck C, Hube B, Jacobsen ID.

Mol Microbiol. 2017 Feb;103(4):595-617. doi: 10.1111/mmi.13526. Epub 2016 Oct 11.


Enemies and brothers in arms: Candida albicans and gram-positive bacteria.

Förster TM, Mogavero S, Dräger A, Graf K, Polke M, Jacobsen ID, Hube B.

Cell Microbiol. 2016 Dec;18(12):1709-1715. doi: 10.1111/cmi.12657. Epub 2016 Sep 14. Review.


Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition.

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 Aug 5;15(8):2394-406. doi: 10.1021/acs.jproteome.5b01065. Epub 2016 Jul 22.


Virulence factors in fungal pathogens of man.

Brunke S, Mogavero S, Kasper L, Hube B.

Curr Opin Microbiol. 2016 Aug;32:89-95. doi: 10.1016/j.mib.2016.05.010. Epub 2016 May 31. Review.


In vivo induction of neutrophil chemotaxis by secretory aspartyl proteinases of Candida albicans.

Gabrielli E, Sabbatini S, Roselletti E, Kasper L, Perito S, Hube B, Cassone A, Vecchiarelli A, Pericolini E.

Virulence. 2016 Oct 2;7(7):819-25. doi: 10.1080/21505594.2016.1184385. Epub 2016 Apr 29.


In Vivo Transcriptional Profiling of Human Pathogenic Fungi during Infection: Reflecting the Real Life?

Allert S, Brunke S, Hube B.

PLoS Pathog. 2016 Apr 14;12(4):e1005471. doi: 10.1371/journal.ppat.1005471. eCollection 2016 Apr. Review. No abstract available.


Candidalysin is a fungal peptide toxin critical for mucosal infection.

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR.

Nature. 2016 Apr 7;532(7597):64-8. doi: 10.1038/nature17625. Epub 2016 Mar 30.


Pleiotropic effects of the vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence.

Khandelwal NK, Kaemmer P, Förster TM, Singh A, Coste AT, Andes DR, Hube B, Sanglard D, Chauhan N, Kaur R, d'Enfert C, Mondal AK, Prasad R.

Biochem J. 2016 Jun 1;473(11):1537-52. doi: 10.1042/BCJ20160024. Epub 2016 Mar 29.


Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota.

Höfs S, Mogavero S, Hube B.

J Microbiol. 2016 Mar;54(3):149-69. doi: 10.1007/s12275-016-5514-0. Epub 2016 Feb 27. Review.


Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence.

Kasper L, Seider K, Hube B.

FEMS Yeast Res. 2015 Aug;15(5):fov042. doi: 10.1093/femsyr/fov042. Epub 2015 Jun 10. Review.


Virulence profile: Bernhard Hube.

Hube B.

Virulence. 2015;6(5):523-5. doi: 10.1080/21505594.2015.1058654. No abstract available.


Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice.

Pericolini E, Gabrielli E, Amacker M, Kasper L, Roselletti E, Luciano E, Sabbatini S, Kaeser M, Moser C, Hube B, Vecchiarelli A, Cassone A.

MBio. 2015 Jun 2;6(3):e00724. doi: 10.1128/mBio.00724-15.


Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis.

Böttcher B, Palige K, Jacobsen ID, Hube B, Brunke S.

Eukaryot Cell. 2015 Jul;14(7):661-70. doi: 10.1128/EC.00078-15. Epub 2015 May 22.


Antifungal activity of clotrimazole against Candida albicans depends on carbon sources, growth phase and morphology.

Kasper L, Miramón P, Jablonowski N, Wisgott S, Wilson D, Brunke S, Hube B.

J Med Microbiol. 2015 Jul;64(7):714-23. doi: 10.1099/jmm.0.000082. Epub 2015 May 14.


Candida survival strategies.

Polke M, Hube B, Jacobsen ID.

Adv Appl Microbiol. 2015;91:139-235. doi: 10.1016/bs.aambs.2014.12.002. Epub 2015 Feb 24. Review.


Comparative genomic analysis reveals a critical role of de novo nucleotide biosynthesis for Saccharomyces cerevisiae virulence.

Pérez-Torrado R, Llopis S, Perrone B, Gómez-Pastor R, Hube B, Querol A.

PLoS One. 2015 Mar 27;10(3):e0122382. doi: 10.1371/journal.pone.0122382. eCollection 2015.

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