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Items: 1 to 50 of 233

1.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ.

Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10.

PMID:
30639099
2.

Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).

Gu X, Bridges MD, Yan Y, de Waal PW, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K.

J Biol Chem. 2018 Nov 2;293(44):16994-17007. doi: 10.1074/jbc.RA118.004101. Epub 2018 Sep 11.

PMID:
30206123
3.

DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.

Stadtmueller BM, Bridges MD, Dam KM, Lerch MT, Huey-Tubman KE, Hubbell WL, Bjorkman PJ.

Immunity. 2018 Aug 21;49(2):235-246.e4. doi: 10.1016/j.immuni.2018.06.017. Epub 2018 Jul 31.

4.

Gi- and Gs-coupled GPCRs show different modes of G-protein binding.

Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2383-2388. doi: 10.1073/pnas.1721896115. Epub 2018 Feb 20.

5.

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.

Bergdoll LA, Lerch MT, Patrick JW, Belardo K, Altenbach C, Bisignano P, Laganowsky A, Grabe M, Hubbell WL, Abramson J.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E172-E179. doi: 10.1073/pnas.1715464115. Epub 2017 Dec 26.

6.

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE.

Cell. 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.

7.

Conformational equilibria of light-activated rhodopsin in nanodiscs.

Van Eps N, Caro LN, Morizumi T, Kusnetzow AK, Szczepek M, Hofmann KP, Bayburt TH, Sligar SG, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3268-E3275. doi: 10.1073/pnas.1620405114. Epub 2017 Apr 3.

8.

A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein.

Wheatley NM, Eden KD, Ngo J, Rosinski JS, Sawaya MR, Cascio D, Collazo M, Hoveida H, Hubbell WL, Yeates TO.

J Mol Biol. 2016 Oct 9;428(20):4013-4030. doi: 10.1016/j.jmb.2016.07.015. Epub 2016 Jul 25.

9.

Biophysical and Biochemical Characterization of Avian Secretory Component Provides Structural Insights into the Evolution of the Polymeric Ig Receptor.

Stadtmueller BM, Yang Z, Huey-Tubman KE, Roberts-Mataric H, Hubbell WL, Bjorkman PJ.

J Immunol. 2016 Aug 15;197(4):1408-14. doi: 10.4049/jimmunol.1600463. Epub 2016 Jul 13.

10.

A triarylmethyl spin label for long-range distance measurement at physiological temperatures using T1 relaxation enhancement.

Yang Z, Bridges MD, López CJ, Rogozhnikova OY, Trukhin DV, Brooks EK, Tormyshev V, Halpern HJ, Hubbell WL.

J Magn Reson. 2016 Aug;269:50-54. doi: 10.1016/j.jmr.2016.05.006. Epub 2016 May 10.

11.

Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy.

Davydov DR, Yang Z, Davydova N, Halpert JR, Hubbell WL.

Biophys J. 2016 Apr 12;110(7):1485-1498. doi: 10.1016/j.bpj.2016.02.026.

12.

Steric trapping reveals a cooperativity network in the intramembrane protease GlpG.

Guo R, Gaffney K, Yang Z, Kim M, Sungsuwan S, Huang X, Hubbell WL, Hong H.

Nat Chem Biol. 2016 May;12(5):353-360. doi: 10.1038/nchembio.2048. Epub 2016 Mar 21.

13.

The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.

Stadtmueller BM, Huey-Tubman KE, López CJ, Yang Z, Hubbell WL, Bjorkman PJ.

Elife. 2016 Mar 4;5. pii: e10640. doi: 10.7554/eLife.10640.

14.

Exploring Structure, Dynamics, and Topology of Nitroxide Spin-Labeled Proteins Using Continuous-Wave Electron Paramagnetic Resonance Spectroscopy.

Altenbach C, López CJ, Hideg K, Hubbell WL.

Methods Enzymol. 2015;564:59-100. doi: 10.1016/bs.mie.2015.08.006. Epub 2015 Sep 8.

PMID:
26477248
15.

High-Pressure EPR and Site-Directed Spin Labeling for Mapping Molecular Flexibility in Proteins.

Lerch MT, Yang Z, Altenbach C, Hubbell WL.

Methods Enzymol. 2015;564:29-57. doi: 10.1016/bs.mie.2015.07.004. Epub 2015 Sep 9.

PMID:
26477247
16.

Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins.

Yang Z, Bridges M, Lerch MT, Altenbach C, Hubbell WL.

Methods Enzymol. 2015;564:3-27. doi: 10.1016/bs.mie.2015.07.016. Epub 2015 Aug 15.

PMID:
26477246
17.

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.

18.

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE.

Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264.

19.

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK.

Cell. 2015 May 21;161(5):1101-1111. doi: 10.1016/j.cell.2015.04.043. Epub 2015 May 14. Erratum in: Cell. 2015 Sep 10;162(6):1431.

20.

Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure.

Lerch MT, López CJ, Yang Z, Kreitman MJ, Horwitz J, Hubbell WL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2437-46. doi: 10.1073/pnas.1506505112. Epub 2015 Apr 27.

21.

The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.

Van Eps N, Thomas CJ, Hubbell WL, Sprang SR.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1404-9. doi: 10.1073/pnas.1423878112. Epub 2015 Jan 20.

22.

Stationary-phase EPR for exploring protein structure, conformation, and dynamics in spin-labeled proteins.

López CJ, Fleissner MR, Brooks EK, Hubbell WL.

Biochemistry. 2014 Nov 18;53(45):7067-75. doi: 10.1021/bi5011128. Epub 2014 Nov 5.

23.

Long-range distance measurements in proteins at physiological temperatures using saturation recovery EPR spectroscopy.

Yang Z, Jiménez-Osés G, López CJ, Bridges MD, Houk KN, Hubbell WL.

J Am Chem Soc. 2014 Oct 29;136(43):15356-65. doi: 10.1021/ja5083206. Epub 2014 Oct 17.

24.

Differential dynamics of extracellular and cytoplasmic domains in denatured States of rhodopsin.

Dutta A, Altenbach C, Mangahas S, Yanamala N, Gardner E, Hubbell WL, Klein-Seetharaman J.

Biochemistry. 2014 Nov 25;53(46):7160-9. doi: 10.1021/bi401557e. Epub 2014 Nov 10.

25.

Structural and energetic determinants of adhesive binding specificity in type I cadherins.

Vendome J, Felsovalyi K, Song H, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4175-84. doi: 10.1073/pnas.1416737111. Epub 2014 Sep 24.

26.

Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance.

Lerch MT, Yang Z, Brooks EK, Hubbell WL.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1201-10. doi: 10.1073/pnas.1403179111. Epub 2014 Mar 18.

27.

High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population.

Schredelseker J, Paz A, López CJ, Altenbach C, Leung CS, Drexler MK, Chen JN, Hubbell WL, Abramson J.

J Biol Chem. 2014 May 2;289(18):12566-77. doi: 10.1074/jbc.M113.497438. Epub 2014 Mar 13.

28.

Self-association of arrestin family members.

Chen Q, Zhuo Y, Kim M, Hanson SM, Francis DJ, Vishnivetskiy SA, Altenbach C, Klug CS, Hubbell WL, Gurevich VV.

Handb Exp Pharmacol. 2014;219:205-23. doi: 10.1007/978-3-642-41199-1_11.

29.

Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin.

Lerch MT, Horwitz J, McCoy J, Hubbell WL.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4714-22. doi: 10.1073/pnas.1320124110. Epub 2013 Nov 18.

30.

Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants.

López CJ, Yang Z, Altenbach C, Hubbell WL.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4306-15. doi: 10.1073/pnas.1318754110. Epub 2013 Oct 28.

31.

Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.

Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Altenbach C, Hong Y, Hanson SM, Palazzo MC, Chen J, Hubbell WL, Gurevich EV, Gurevich VV.

Cell Signal. 2013 Dec;25(12):2613-24. doi: 10.1016/j.cellsig.2013.08.022. Epub 2013 Sep 3.

32.

Technological advances in site-directed spin labeling of proteins.

Hubbell WL, López CJ, Altenbach C, Yang Z.

Curr Opin Struct Biol. 2013 Oct;23(5):725-33. doi: 10.1016/j.sbi.2013.06.008. Epub 2013 Jul 11. Review.

33.

EPR relaxation-enhancement-based distance measurements on orthogonally spin-labeled T4-lysozyme.

Razzaghi S, Brooks EK, Bordignon E, Hubbell WL, Yulikov M, Jeschke G.

Chembiochem. 2013 Sep 23;14(14):1883-90. doi: 10.1002/cbic.201300165. Epub 2013 Jun 14.

34.

Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins.

Toledo Warshaviak D, Khramtsov VV, Cascio D, Altenbach C, Hubbell WL.

J Magn Reson. 2013 Jul;232:53-61. doi: 10.1016/j.jmr.2013.04.013. Epub 2013 Apr 30.

35.

Orthogonal spin labeling and Gd(III)-nitroxide distance measurements on bacteriophage T4-lysozyme.

Garbuio L, Bordignon E, Brooks EK, Hubbell WL, Jeschke G, Yulikov M.

J Phys Chem B. 2013 Mar 21;117(11):3145-53. doi: 10.1021/jp401806g. Epub 2013 Mar 8.

36.

Engineering visual arrestin-1 with special functional characteristics.

Vishnivetskiy SA, Chen Q, Palazzo MC, Brooks EK, Altenbach C, Iverson TM, Hubbell WL, Gurevich VV.

J Biol Chem. 2013 Feb 1;288(5):3394-405. doi: 10.1074/jbc.M112.445437. Epub 2012 Dec 17.

37.

Conformation of receptor-bound visual arrestin.

Kim M, Vishnivetskiy SA, Van Eps N, Alexander NS, Cleghorn WM, Zhan X, Hanson SM, Morizumi T, Ernst OP, Meiler J, Gurevich VV, Hubbell WL.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18407-12. doi: 10.1073/pnas.1216304109. Epub 2012 Oct 22.

38.

Probing Protein Secondary Structure using EPR: Investigating a Dynamic Region of Visual Arrestin.

Francis DJ, Hubbell WL, Klug CS.

Appl Magn Reson. 2012 Oct;43(3):405-419.

39.

Mapping molecular flexibility of proteins with site-directed spin labeling: a case study of myoglobin.

López CJ, Oga S, Hubbell WL.

Biochemistry. 2012 Aug 21;51(33):6568-83. doi: 10.1021/bi3005686. Epub 2012 Aug 9.

40.

Pulsed ESR dipolar spectroscopy for distance measurements in immobilized spin labeled proteins in liquid solution.

Yang Z, Liu Y, Borbat P, Zweier JL, Freed JH, Hubbell WL.

J Am Chem Soc. 2012 Jun 20;134(24):9950-2. doi: 10.1021/ja303791p. Epub 2012 Jun 11.

41.

A rigid disulfide-linked nitroxide side chain simplifies the quantitative analysis of PRE data.

Fawzi NL, Fleissner MR, Anthis NJ, Kálai T, Hideg K, Hubbell WL, Clore GM.

J Biomol NMR. 2011 Sep;51(1-2):105-14. doi: 10.1007/s10858-011-9545-x. Epub 2011 Sep 27.

42.

Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy.

Fleissner MR, Bridges MD, Brooks EK, Cascio D, Kálai T, Hideg K, Hubbell WL.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16241-6. doi: 10.1073/pnas.1111420108. Epub 2011 Sep 12.

43.

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.

Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9420-4. doi: 10.1073/pnas.1105810108. Epub 2011 May 23.

44.

Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon.

Januszyk K, Fleissner MR, Atchabahian L, Shieh FK, Altenbach C, Martin SL, Guo F, Hubbell WL, Clubb RT.

Protein Sci. 2011 Jul;20(7):1231-43. doi: 10.1002/pro.651. Epub 2011 Jun 14.

45.

Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.

Vishnivetskiy SA, Gimenez LE, Francis DJ, Hanson SM, Hubbell WL, Klug CS, Gurevich VV.

J Biol Chem. 2011 Jul 8;286(27):24288-99. doi: 10.1074/jbc.M110.213835. Epub 2011 Apr 6.

46.

Robust self-association is a common feature of mammalian visual arrestin-1.

Kim M, Hanson SM, Vishnivetskiy SA, Song X, Cleghorn WM, Hubbell WL, Gurevich VV.

Biochemistry. 2011 Mar 29;50(12):2235-42. doi: 10.1021/bi1018607. Epub 2011 Feb 18.

47.

High-pressure EPR reveals conformational equilibria and volumetric properties of spin-labeled proteins.

McCoy J, Hubbell WL.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1331-6. doi: 10.1073/pnas.1017877108. Epub 2011 Jan 4.

48.

Conformational analysis of a nitroxide side chain in an α-helix with density functional theory.

Warshaviak DT, Serbulea L, Houk KN, Hubbell WL.

J Phys Chem B. 2011 Jan 20;115(2):397-405. doi: 10.1021/jp108871m. Epub 2010 Dec 17.

49.

Electron paramagnetic resonance studies of functionally active, nitroxide spin-labeled peptide analogues of the C-terminus of a G-protein alpha subunit.

Van Eps N, Anderson LL, Kisselev OG, Baranski TJ, Hubbell WL, Marshall GR.

Biochemistry. 2010 Aug 17;49(32):6877-86. doi: 10.1021/bi100846c.

50.

Multifrequency electron spin resonance study of the dynamics of spin labeled T4 lysozyme.

Zhang Z, Fleissner MR, Tipikin DS, Liang Z, Moscicki JK, Earle KA, Hubbell WL, Freed JH.

J Phys Chem B. 2010 Apr 29;114(16):5503-21. doi: 10.1021/jp910606h.

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