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Items: 22

1.

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.

Cromwell CR, Sung K, Park J, Krysler AR, Jovel J, Kim SK, Hubbard BP.

Nat Commun. 2018 Apr 13;9(1):1448. doi: 10.1038/s41467-018-03927-0.

2.

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.

Salla M, Aguayo-Ortiz R, Danmaliki GI, Zare A, Said A, Moore J, Pandya V, Manaloor R, Fong S, Blankstein AR, Gibson SB, Garcia LR, Meier P, Bhullar KS, Hubbard BP, Fiteh Y, Vliagoftis H, Goping IS, Brocks D, Hwang P, Velázquez-Martínez CA, Baksh S.

J Pharmacol Exp Ther. 2018 May;365(2):354-367. doi: 10.1124/jpet.117.247163. Epub 2018 Mar 19.

PMID:
29555876
3.

Kinase-targeted cancer therapies: progress, challenges and future directions.

Bhullar KS, Lagarón NO, McGowan EM, Parmar I, Jha A, Hubbard BP, Rupasinghe HPV.

Mol Cancer. 2018 Feb 19;17(1):48. doi: 10.1186/s12943-018-0804-2. Review.

4.

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA.

Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242.

5.

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A.

Cell Rep. 2016 Sep 6;16(10):2641-2650. doi: 10.1016/j.celrep.2016.08.006. Epub 2016 Aug 25.

6.

Synthesis and Assay of SIRT1-Activating Compounds.

Dai H, Ellis JL, Sinclair DA, Hubbard BP.

Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9.

7.

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity.

Hubbard BP, Badran AH, Zuris JA, Guilinger JP, Davis KM, Chen L, Tsai SQ, Sander JD, Joung JK, Liu DR.

Nat Methods. 2015 Oct;12(10):939-42. doi: 10.1038/nmeth.3515. Epub 2015 Aug 10.

8.

Lifespan and healthspan extension by resveratrol.

Bhullar KS, Hubbard BP.

Biochim Biophys Acta. 2015 Jun;1852(6):1209-18. doi: 10.1016/j.bbadis.2015.01.012. Epub 2015 Jan 29. Review.

9.

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Hubbard BP, Sinclair DA.

Trends Pharmacol Sci. 2014 Mar;35(3):146-54. doi: 10.1016/j.tips.2013.12.004. Epub 2014 Jan 16. Review.

10.

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA.

Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037.

11.

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.

Hubbard BP, Sinclair DA.

Methods Mol Biol. 2013;1077:167-77. doi: 10.1007/978-1-62703-637-5_11.

12.

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA.

Cell Cycle. 2013 Jul 15;12(14):2233-40. doi: 10.4161/cc.25268.

13.

Identification of a SIRT1 mutation in a family with type 1 diabetes.

Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY.

Cell Metab. 2013 Mar 5;17(3):448-455. doi: 10.1016/j.cmet.2013.02.001.

14.

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA.

Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097.

15.

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.

Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y.

Cell Cycle. 2013 Jan 15;12(2):263-70. doi: 10.4161/cc.23056. Epub 2012 Jan 15.

16.
17.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA.

Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003.

18.

SRT1720 improves survival and healthspan of obese mice.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R.

Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Erratum in: Sci Rep. 2013;3():1131.

19.

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.

Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP.

Biochim Biophys Acta. 2012 Feb;1822(2):185-95. doi: 10.1016/j.bbadis.2011.10.008. Epub 2011 Oct 17.

20.

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.

Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R.

J Biol Chem. 2011 Jun 3;286(22):19270-9. doi: 10.1074/jbc.M110.200311. Epub 2011 Apr 5.

21.

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.

22.

Characterization of murine SIRT3 transcript variants and corresponding protein products.

Yang Y, Hubbard BP, Sinclair DA, Tong Q.

J Cell Biochem. 2010 Nov 1;111(4):1051-8. doi: 10.1002/jcb.22795.

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