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HIF-1α is a key mediator of the lung inflammatory potential of lithium-ion battery particles.

Sironval V, Palmai-Pallag M, Vanbever R, Huaux F, Mejia J, Lucas S, Lison D, van den Brule S.

Part Fibre Toxicol. 2019 Sep 18;16(1):35. doi: 10.1186/s12989-019-0319-z.


The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?

Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins R, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F.

Part Fibre Toxicol. 2019 Aug 16;16(1):32. doi: 10.1186/s12989-019-0315-3.


Cationic Nanoliposomes Are Efficiently Taken up by Alveolar Macrophages but Have Little Access to Dendritic Cells and Interstitial Macrophages in the Normal and CpG-Stimulated Lungs.

Vanbever R, Loira-Pastoriza C, Dauguet N, Hérin C, Ibouraadaten S, Vanvarenberg K, Ucakar B, Tyteca D, Huaux F.

Mol Pharm. 2019 May 6;16(5):2048-2059. doi: 10.1021/acs.molpharmaceut.9b00033. Epub 2019 Apr 25.


Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.

Stancu IC, Cremers N, Vanrusselt H, Couturier J, Vanoosthuyse A, Kessels S, Lodder C, Brône B, Huaux F, Octave JN, Terwel D, Dewachter I.

Acta Neuropathol. 2019 Apr;137(4):599-617. doi: 10.1007/s00401-018-01957-y. Epub 2019 Feb 5.


Absence of early metabolic response assessed by 18F-FDG PET/CT after initiation of antifibrotic drugs in IPF patients.

Bondue B, Castiaux A, Van Simaeys G, Mathey C, Sherer F, Egrise D, Lacroix S, Huaux F, Doumont G, Goldman S.

Respir Res. 2019 Jan 15;20(1):10. doi: 10.1186/s12931-019-0974-5.


Emerging Role of Immunosuppression in Diseases Induced by Micro- and Nano-Particles: Time to Revisit the Exclusive Inflammatory Scenario.

Huaux F.

Front Immunol. 2018 Nov 19;9:2364. doi: 10.3389/fimmu.2018.02364. eCollection 2018. Review.


New interplay between interstitial and alveolar macrophages explains pulmonary alveolar proteinosis (PAP) induced by indium tin oxide particles.

Huaux F, De Gussem V, Lebrun A, Yakoub Y, Palmai-Pallag M, Ibouraadaten S, Uwambayinema F, Lison D.

Arch Toxicol. 2018 Apr;92(4):1349-1361. doi: 10.1007/s00204-018-2168-1. Epub 2018 Feb 26.


Association of Endotoxin and Allergens with Respiratory and Skin Symptoms: A Descriptive Study in Laboratory Animal Workers.

Oppliger A, Barresi F, Maggi M, Schmid-Grendelmeier P, Huaux F, Hotz P, Dressel H.

Ann Work Expo Health. 2017 Aug 1;61(7):822-835. doi: 10.1093/annweh/wxx048.


CCR2+ monocytic myeloid-derived suppressor cells (M-MDSCs) inhibit collagen degradation and promote lung fibrosis by producing transforming growth factor-β1.

Lebrun A, Lo Re S, Chantry M, Izquierdo Carerra X, Uwambayinema F, Ricci D, Devosse R, Ibouraadaten S, Brombin L, Palmai-Pallag M, Yakoub Y, Pasparakis M, Lison D, Huaux F.

J Pathol. 2017 Nov;243(3):320-330. doi: 10.1002/path.4956. Epub 2017 Sep 21.


Can serum cytokine profile discriminate irritant-induced and allergen-induced symptoms? A cross-sectional study in workers mostly exposed to laboratory animals.

Lemaire M, Oppliger A, Hotz P, Renauld JC, Braun J, Maggi M, Barresi F, Schmid-Grendelmeier P, Huaux F, Dressel H.

Occup Environ Med. 2017 Aug;74(8):592-600. doi: 10.1136/oemed-2016-104137. Epub 2017 Apr 17.


Vardenafil reduces macrophage pro-inflammatory overresponses in cystic fibrosis through PDE5- and CFTR-dependent mechanisms.

Noel S, Panin N, Beka M, Dhooghe B, Huaux F, Leal T.

Clin Sci (Lond). 2017 Jun 1;131(11):1107-1121. doi: 10.1042/CS20160749. Epub 2017 Feb 14.


The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis.

Hautem N, Morelle J, Sow A, Corbet C, Feron O, Goffin E, Huaux F, Devuyst O.

J Am Soc Nephrol. 2017 Jul;28(7):2038-2052. doi: 10.1681/ASN.2016070729. Epub 2017 Feb 13.


Azithromycin Attenuates Pseudomonas-Induced Lung Inflammation by Targeting Bacterial Proteins Secreted in the Cultured Medium.

Leal T, Bergamini G, Huaux F, Panin N, Noel S, Dhooghe B, Haaf JB, Mauri P, Motta S, Di Silvestre D, Melotti P, Sorio C.

Front Immunol. 2016 Nov 15;7:499. eCollection 2016.


Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells.

Huaux F, d'Ursel de Bousies V, Parent MA, Orsi M, Uwambayinema F, Devosse R, Ibouraadaten S, Yakoub Y, Panin N, Palmai-Pallag M, van der Bruggen P, Bailly C, Marega R, Marbaix E, Lison D.

Part Fibre Toxicol. 2016 Aug 23;13(1):46. doi: 10.1186/s12989-016-0158-0.


Glufosinate aerogenic exposure induces glutamate and IL-1 receptor dependent lung inflammation.

Maillet I, Perche O, Pâris A, Richard O, Gombault A, Herzine A, Pichon J, Huaux F, Mortaud S, Ryffel B, Quesniaux VF, Montécot-Dubourg C.

Clin Sci (Lond). 2016 Nov 1;130(21):1939-54. doi: 10.1042/CS20160530. Epub 2016 Aug 22.


The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles.

Rabolli V, Lison D, Huaux F.

Part Fibre Toxicol. 2016 Aug 12;13(1):40. doi: 10.1186/s12989-016-0150-8. Review.


Inflammasome, IL-1 and inflammation in ozone-induced lung injury.

Michaudel C, Couturier-Maillard A, Chenuet P, Maillet I, Mura C, Couillin I, Gombault A, Quesniaux VF, Huaux F, Ryffel B.

Am J Clin Exp Immunol. 2016 Mar 23;5(1):33-40. eCollection 2016. Review.


Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease.

Couturier J, Stancu IC, Schakman O, Pierrot N, Huaux F, Kienlen-Campard P, Dewachter I, Octave JN.

J Neuroinflammation. 2016 Jan 27;13:20. doi: 10.1186/s12974-016-0477-y.


Age influence on mice lung tissue response to Aspergillus fumigatus chronic exposure.

Lemieszek MK, Dutkiewicz J, Golec M, Chilosi M, Skórska C, Huaux F, Pastena C, Pedica F, Sitkowska J, Lisowska W, Cholewa G, Zwoliński J, Mackiewicz B, Góra-Florek A, Ziesche R, Milanowski J.

Ann Agric Environ Med. 2015;22(1):69-75. doi: 10.5604/12321966.1141371.


Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.

Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ.

PLoS One. 2015 Feb 26;10(2):e0117398. doi: 10.1371/journal.pone.0117398. eCollection 2015.


PET/CT with 18F-FDG- and 18F-FBEM-labeled leukocytes for metabolic activity and leukocyte recruitment monitoring in a mouse model of pulmonary fibrosis.

Bondue B, Sherer F, Van Simaeys G, Doumont G, Egrise D, Yakoub Y, Huaux F, Parmentier M, Rorive S, Sauvage S, Lacroix S, Vosters O, De Vuyst P, Goldman S.

J Nucl Med. 2015 Jan;56(1):127-32. doi: 10.2967/jnumed.114.147421.


The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles.

Rabolli V, Badissi AA, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, Lebrun A, De Gussem V, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F.

Part Fibre Toxicol. 2014 Dec 13;11:69. doi: 10.1186/s12989-014-0069-x.


IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.

Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld JC, Lison D.

J Pathol. 2015 Apr;235(5):698-709. doi: 10.1002/path.4487. Epub 2015 Jan 20.


PDGF-D expression is down-regulated by TGFβ in fibroblasts.

Charni Chaabane S, Coomans de Brachène A, Essaghir A, Velghe A, Lo Re S, Stockis J, Lucas S, Khachigian LM, Huaux F, Demoulin JB.

PLoS One. 2014 Oct 3;9(10):e108656. doi: 10.1371/journal.pone.0108656. eCollection 2014.


Occupational asthma phenotypes identified by increased fractional exhaled nitric oxide after exposure to causal agents.

Lemiere C, NGuyen S, Sava F, D'Alpaos V, Huaux F, Vandenplas O.

J Allergy Clin Immunol. 2014 Nov;134(5):1063-7. doi: 10.1016/j.jaci.2014.08.017. Epub 2014 Sep 26.


Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.

Re SL, Giordano G, Yakoub Y, Devosse R, Uwambayinema F, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F.

PLoS One. 2014 Jul 22;9(7):e99383. doi: 10.1371/journal.pone.0099383. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116134. Giordano, Giulia [added].


Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation.

Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F.

J Biol Chem. 2014 May 16;289(20):13937-47. doi: 10.1074/jbc.M113.534594. Epub 2014 Apr 3.


Lung inflammation in cystic fibrosis: pathogenesis and novel therapies.

Dhooghe B, Noël S, Huaux F, Leal T.

Clin Biochem. 2014 May;47(7-8):539-46. doi: 10.1016/j.clinbiochem.2013.12.020. Epub 2013 Dec 29. Review.


Asthma related to cleaning agents: a clinical insight.

Vandenplas O, D'Alpaos V, Evrard G, Jamart J, Thimpont J, Huaux F, Renauld JC.

BMJ Open. 2013 Sep 19;3(9):e003568. doi: 10.1136/bmjopen-2013-003568.


Age influence on hypersensitivity pneumonitis induced in mice by exposure to Pantoea agglomerans.

Lemieszek MK, Chilosi M, Golec M, Skórska C, Dinnyes A, Mashayekhi K, Vierlinger K, Huaux F, Wielscher M, Hofner M, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwoliński J, Milanowski J, Mackiewicz B, Góra-Florek A, Ziesche R, Dutkiewicz J.

Inhal Toxicol. 2013 Sep;25(11):640-50. doi: 10.3109/08958378.2013.827284.


Lung inflammation and thymic atrophy after bleomycin are controlled by the prostaglandin D2 receptor DP1.

van den Brule S, Huaux F, Uwambayinema F, Ibouraadaten S, Yakoub Y, Palmai-Pallag M, Trottein F, Renauld JC, Lison D.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):212-22. doi: 10.1165/rcmb.2012-0520OC.


Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis.

Huaux F, Noel S, Dhooghe B, Panin N, Lo Re S, Lison D, Wallemacq P, Marbaix E, Scholte BJ, Lebecque P, Leal T.

PLoS One. 2013 May 29;8(5):e64341. doi: 10.1371/journal.pone.0064341. Print 2013.


CD4+ T lymphocytes in lung fibrosis: diverse subsets, diverse functions.

Lo Re S, Lison D, Huaux F.

J Leukoc Biol. 2013 Apr;93(4):499-510. doi: 10.1189/jlb.0512261. Epub 2012 Nov 16. Review.


Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice.

Lubamba B, Huaux F, Lebacq J, Marbaix E, Dhooghe B, Panin N, Wallemacq P, Leal T.

J Cyst Fibros. 2012 Jul;11(4):266-73. doi: 10.1016/j.jcf.2012.03.003. Epub 2012 Apr 12.


Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis.

Lo Re S, Lecocq M, Uwambayinema F, Yakoub Y, Delos M, Demoulin JB, Lucas S, Sparwasser T, Renauld JC, Lison D, Huaux F.

Am J Respir Crit Care Med. 2011 Dec 1;184(11):1270-81. doi: 10.1164/rccm.201103-0516OC. Epub 2011 Aug 25.


IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis.

Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I.

PLoS One. 2011;6(8):e23185. doi: 10.1371/journal.pone.0023185. Epub 2011 Aug 16.


Mouse model of hypersensitivity pneumonitis after inhalation exposure to different microbial antigens associated with organic dusts.

Lemieszek M, Chilosi M, Golec M, Skórska C, Huaux F, Yakoub Y, Pastena C, Daniele I, Cholewa G, Sitkowska J, Lisowska W, Zwoliński J, Milanowski J, Mackiewicz B, Góra A, Dutkiewicz J.

Ann Agric Environ Med. 2011;18(1):159-68.


In vitro studies: Ups and downs of cellular uptake.

Lison D, Huaux F.

Nat Nanotechnol. 2011 Jun 6;6(6):332-3. doi: 10.1038/nnano.2011.81. No abstract available.


Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice.

Rabolli V, Lo Re S, Uwambayinema F, Yakoub Y, Lison D, Huaux F.

Toxicol Lett. 2011 Jun 10;203(2):127-34. doi: 10.1016/j.toxlet.2011.03.009. Epub 2011 Mar 23.


Nicotinamide enhances apoptosis of G(M)-CSF-treated neutrophils and attenuates endotoxin-induced airway inflammation in mice.

Fernandes CA, Fievez L, Ucakar B, Neyrinck AM, Fillee C, Huaux F, Delzenne NM, Bureau F, Vanbever R.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L354-61. doi: 10.1152/ajplung.00198.2010. Epub 2010 Dec 3.


Influence of size, surface area and microporosity on the in vitro cytotoxic activity of amorphous silica nanoparticles in different cell types.

Rabolli V, Thomassen LC, Princen C, Napierska D, Gonzalez L, Kirsch-Volders M, Hoet PH, Huaux F, Kirschhock CE, Martens JA, Lison D.

Nanotoxicology. 2010 Sep;4(3):307-18. doi: 10.3109/17435390.2010.482749.


The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice.

van den Brule S, Wallemme L, Uwambayinema F, Huaux F, Lison D.

J Pharmacol Exp Ther. 2010 Nov;335(2):472-9. doi: 10.1124/jpet.110.169250. Epub 2010 Aug 18.


Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.

Giordano G, van den Brûle S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, Couillin I, Ryffel B, Michiels T, Renauld JC, Lison D, Huaux F.

Toxicol Sci. 2010 Aug;116(2):682-92. doi: 10.1093/toxsci/kfq158. Epub 2010 May 31.


IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F.

J Immunol. 2010 Jun 1;184(11):6367-77. doi: 10.4049/jimmunol.0900459. Epub 2010 Apr 26.


Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model.

Luangsay S, Wittamer V, Bondue B, De Henau O, Rouger L, Brait M, Franssen JD, de Nadai P, Huaux F, Parmentier M.

J Immunol. 2009 Nov 15;183(10):6489-99. doi: 10.4049/jimmunol.0901037. Epub 2009 Oct 19.


Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat.

Muller J, Delos M, Panin N, Rabolli V, Huaux F, Lison D.

Toxicol Sci. 2009 Aug;110(2):442-8. doi: 10.1093/toxsci/kfp100. Epub 2009 May 8.


Azithromycin fails to reduce increased expression of neutrophil-related cytokines in primary-cultured epithelial cells from cystic fibrosis mice.

Gavilanes X, Huaux F, Meyer M, Lebecque P, Marbaix E, Lison D, Scholte B, Wallemacq P, Leal T.

J Cyst Fibros. 2009 May;8(3):203-10. doi: 10.1016/j.jcf.2009.03.003. Epub 2009 Apr 3.


Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis.

Meyer M, Huaux F, Gavilanes X, van den Brûle S, Lebecque P, Lo Re S, Lison D, Scholte B, Wallemacq P, Leal T.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):590-602. doi: 10.1165/rcmb.2008-0155OC. Epub 2009 Feb 24.


Sputum eosinophilia: an early marker of bronchial response to occupational agents.

Vandenplas O, D'Alpaos V, Heymans J, Jamart J, Thimpont J, Huaux F, Lison D, Renauld JC.

Allergy. 2009 May;64(5):754-61. doi: 10.1111/j.1398-9995.2008.01896.x. Epub 2009 Feb 12.


Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity.

Lison D, Laloy J, Corazzari I, Muller J, Rabolli V, Panin N, Huaux F, Fenoglio I, Fubini B.

Toxicol Sci. 2009 Apr;108(2):472-81. doi: 10.1093/toxsci/kfp014. Epub 2009 Jan 28.


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