Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 23

1.

Structure of a human cap-dependent 48S translation pre-initiation complex.

Eliseev B, Yeramala L, Leitner A, Karuppasamy M, Raimondeau E, Huard K, Alkalaeva E, Aebersold R, Schaffitzel C.

Nucleic Acids Res. 2018 Mar 16;46(5):2678-2689. doi: 10.1093/nar/gky054.

2.

Dual function of UPF3B in early and late translation termination.

Neu-Yilik G, Raimondeau E, Eliseev B, Yeramala L, Amthor B, Deniaud A, Huard K, Kerschgens K, Hentze MW, Schaffitzel C, Kulozik AE.

EMBO J. 2017 Oct 16;36(20):2968-2986. doi: 10.15252/embj.201797079. Epub 2017 Sep 12.

3.

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).

Huard K, Ahn K, Amor P, Beebe DA, Borzilleri KA, Chrunyk BA, Coffey SB, Cong Y, Conn EL, Culp JS, Dowling MS, Gorgoglione MF, Gutierrez JA, Knafels JD, Lachapelle EA, Pandit J, Parris KD, Perez S, Pfefferkorn JA, Price DA, Raymer B, Ross TT, Shavnya A, Smith AC, Subashi TA, Tesz GJ, Thuma BA, Tu M, Weaver JD, Weng Y, Withka JM, Xing G, Magee TV.

J Med Chem. 2017 Sep 28;60(18):7835-7849. doi: 10.1021/acs.jmedchem.7b00947. Epub 2017 Sep 11.

PMID:
28853885
4.

Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile.

Futatsugi K, Huard K, Kung DW, Pettersen JC, Flynn DA, Gosset JR, Aspnes GE, Barnes RJ, Cabral S, Dowling MS, Fernando DP, Goosen TC, Gorczyca WP, Hepworth D, Herr M, Lavergne S, Li Q, Niosi M, Orr STM, Pardo ID, Perez SM, Purkal J, Schmahai TJ, Shirai N, Shoieb AM, Zhou J, Goodwin B.

Medchemcomm. 2016 Nov 22;8(4):771-779. doi: 10.1039/c6md00564k. eCollection 2017 Apr 1.

5.

A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.

Chang G, Huard K, Kauffman GW, Stepan AF, Keefer CE.

Bioorg Med Chem. 2017 Jan 1;25(1):381-388. doi: 10.1016/j.bmc.2016.11.004. Epub 2016 Nov 2.

PMID:
27840138
6.

Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.

Pajor AM, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM.

Mol Pharmacol. 2016 Dec;90(6):755-765. Epub 2016 Sep 28.

7.

Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.

Riccardi K, Li Z, Brown JA, Gorgoglione MF, Niosi M, Gosset J, Huard K, Erion DM, Di L.

Drug Metab Dispos. 2016 Oct;44(10):1633-42. doi: 10.1124/dmd.116.071837. Epub 2016 Jul 14.

8.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

Huard K, Gosset JR, Montgomery JI, Gilbert A, Hayward MM, Magee TV, Cabral S, Uccello DP, Bahnck K, Brown J, Purkal J, Gorgoglione M, Lanba A, Futatsugi K, Herr M, Genung NE, Aspnes G, Polivkova J, Garcia-Irizarry CN, Li Q, Canterbury D, Niosi M, Vera NB, Li Z, Khunte B, Siderewicz J, Rolph T, Erion DM.

J Med Chem. 2016 Feb 11;59(3):1165-75. doi: 10.1021/acs.jmedchem.5b01752. Epub 2016 Jan 27.

PMID:
26734723
9.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).

Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM.

Sci Rep. 2015 Dec 1;5:17391. doi: 10.1038/srep17391.

10.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

Huard K, Londregan AT, Tesz G, Bahnck KB, Magee TV, Hepworth D, Polivkova J, Coffey SB, Pabst BA, Gosset JR, Nigam A, Kou K, Sun H, Lee K, Herr M, Boehm M, Carpino PA, Goodwin B, Perreault C, Li Q, Jorgensen CC, Tkalcevic GT, Subashi TA, Ahn K.

J Med Chem. 2015 Sep 24;58(18):7164-72. doi: 10.1021/acs.jmedchem.5b01008. Epub 2015 Sep 8.

PMID:
26258602
11.

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.

Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C.

Nucleic Acids Res. 2015 Sep 3;43(15):7600-11. doi: 10.1093/nar/gkv668. Epub 2015 Jun 30.

12.

Ribosome-SRP-FtsY cotranslational targeting complex in the closed state.

von Loeffelholz O, Jiang Q, Ariosa A, Karuppasamy M, Huard K, Berger I, Shan SO, Schaffitzel C.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3943-8. doi: 10.1073/pnas.1424453112. Epub 2015 Mar 16.

13.

Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC.

Schulze RJ, Komar J, Botte M, Allen WJ, Whitehouse S, Gold VA, Lycklama A Nijeholt JA, Huard K, Berger I, Schaffitzel C, Collinson I.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4844-9. doi: 10.1073/pnas.1315901111. Epub 2014 Feb 18.

14.

Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.

Griffith DA, Dow RL, Huard K, Edmonds DJ, Bagley SW, Polivkova J, Zeng D, Garcia-Irizarry CN, Southers JA, Esler W, Amor P, Loomis K, McPherson K, Bahnck KB, Préville C, Banks T, Moore DE, Mathiowetz AM, Menhaji-Klotz E, Smith AC, Doran SD, Beebe DA, Dunn MF.

J Med Chem. 2013 Sep 12;56(17):7110-9. doi: 10.1021/jm401033t. Epub 2013 Aug 27.

PMID:
23981033
15.

Structural basis of signal sequence surveillance and selection by the SRP-FtsY complex.

von Loeffelholz O, Knoops K, Ariosa A, Zhang X, Karuppasamy M, Huard K, Schoehn G, Berger I, Shan SO, Schaffitzel C.

Nat Struct Mol Biol. 2013 May;20(5):604-10. doi: 10.1038/nsmb.2546. Epub 2013 Apr 7.

16.

Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors.

Huard K, Bagley SW, Menhaji-Klotz E, Préville C, Southers JA Jr, Smith AC, Edmonds DJ, Lucas JC, Dunn MF, Allanson NM, Blaney EL, Garcia-Irizarry CN, Kohrt JT, Griffith DA, Dow RL.

J Org Chem. 2012 Nov 16;77(22):10050-7. doi: 10.1021/jo3014808. Epub 2012 Nov 5.

PMID:
23127254
17.

N-tosyloxycarbamates as reagents in rhodium-catalyzed C-H amination reactions.

Huard K, Lebel H.

Chemistry. 2008;14(20):6222-30. doi: 10.1002/chem.200702027.

PMID:
18512829
18.

Src promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling.

Archer-Lahlou E, Audet N, Amraei MG, Huard K, Paquin-Gobeil M, Pineyro G.

J Cell Mol Med. 2009 Jan;13(1):147-63. doi: 10.1111/j.1582-4934.2008.00308.x. Epub 2008 Mar 19.

19.
20.

N-tosyloxycarbamates as a source of metal nitrenes: rhodium-catalyzed C-H insertion and aziridination reactions.

Lebel H, Huard K, Lectard S.

J Am Chem Soc. 2005 Oct 19;127(41):14198-9.

PMID:
16218610
21.

Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells.

Huard K, Bourgeois P, Rhainds D, Falstrault L, Cohn JS, Brissette L.

Int J Biochem Cell Biol. 2005 Jun;37(6):1308-18.

PMID:
15778093
22.

Highly efficient synthesis of terminal alkenes from ketones.

Lebel H, Guay D, Paquet V, Huard K.

Org Lett. 2004 Sep 2;6(18):3047-50.

PMID:
15330584
23.

Localization and regulation of SR-BI in membrane rafts of HepG2 cells.

Rhainds D, Bourgeois P, Bourret G, Huard K, Falstrault L, Brissette L.

J Cell Sci. 2004 Jul 1;117(Pt 15):3095-105.

Supplemental Content

Support Center