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CRISPR/Cas9-based Dystrophin Restoration Reveals a Novel Role for Dystrophin in Bioenergetics and Stress Resistance of Muscle Progenitors.

Matre PR, Mu X, Wu J, Danila D, Hall MA, Kolonin MG, Darabi R, Huard J.

Stem Cells. 2019 Oct 1. doi: 10.1002/stem.3094. [Epub ahead of print]


Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice.

Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J.

Mol Ther Methods Clin Dev. 2019 May 30;14:64-76. doi: 10.1016/j.omtm.2019.05.011. eCollection 2019 Sep 13.


Journal of Orthopaedic Research: Special Issue on Stem Cells.

Guilak F, Sandell LJ, Huard J.

J Orthop Res. 2019 Jun;37(6):1209-1211. doi: 10.1002/jor.24338. Epub 2019 May 17. No abstract available.


Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice.

Deng Z, Gao X, Sun X, Amra S, Lu A, Cui Y, Eltzschig HK, Lei G, Huard J.

FASEB J. 2019 Aug;33(8):8809-8821. doi: 10.1096/fj.201802132RR. Epub 2019 May 1.


Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis.

Ziegler CG, Van Sloun R, Gonzalez S, Whitney KE, DePhillipo NN, Kennedy MI, Dornan GJ, Evans TA, Huard J, LaPrade RF.

Am J Sports Med. 2019 Jul;47(9):2174-2187. doi: 10.1177/0363546519832003. Epub 2019 Apr 29.


Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.

Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, Andrews R, Eltzschig H, Huard J.

FASEB J. 2019 Jul;33(7):8321-8334. doi: 10.1096/fj.201801794R. Epub 2019 Apr 10.


Variations in Blood Supply From Proximal to Distal in the Ulnar Collateral Ligament of the Elbow: A Qualitative Descriptive Cadaveric Study.

Buckley PS, Morris ER, Robbins CM, Kemler BR, Frangiamore SJ, Ciccotti MG, Huard J, LaPrade RF, Hackett TR.

Am J Sports Med. 2019 Apr;47(5):1117-1123. doi: 10.1177/0363546519831693. Epub 2019 Mar 21.


Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer.

Sinha KM, Bagheri-Yarmand R, Lahiri S, Lu Y, Zhang M, Amra S, Rizvi Y, Wan X, Navone N, Ozpolat B, Logothetis C, Gagel RF, Huard J.

Oncogene. 2019 Jun;38(25):5038-5049. doi: 10.1038/s41388-019-0774-x. Epub 2019 Mar 11.


Murine models of accelerated aging and musculoskeletal disease.

Hambright WS, Niedernhofer LJ, Huard J, Robbins PD.

Bone. 2019 Aug;125:122-127. doi: 10.1016/j.bone.2019.03.002. Epub 2019 Mar 4.


Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms.

Gao X, Tang Y, Amra S, Sun X, Cui Y, Cheng H, Wang B, Huard J.

Hum Mol Genet. 2019 May 15;28(10):1738-1751. doi: 10.1093/hmg/ddz012.


Characterization of the chondrogenic and osteogenic potential of male and female human muscle-derived stem cells: Implication for stem cell therapy.

Scibetta AC, Morris ER, Liebowitz AB, Gao X, Lu A, Philippon MJ, Huard J.

J Orthop Res. 2019 Jun;37(6):1339-1349. doi: 10.1002/jor.24231. Epub 2019 Feb 21.


TIPE2 gene transfer with adeno-associated virus 9 ameliorates dystrophic pathology in mdx mice.

Gao S, Lu A, Amra S, Guo P, Huard J.

Hum Mol Genet. 2019 May 15;28(10):1608-1619. doi: 10.1093/hmg/ddz001.


Markers of Accelerated Skeletal Muscle Regenerative Response in Murphy Roths Large Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors.

Tseng C, Sinha K, Pan H, Cui Y, Guo P, Lin CY, Yang F, Deng Z, Eltzschig HK, Lu A, Huard J.

Stem Cells. 2019 Mar;37(3):357-367. doi: 10.1002/stem.2957. Epub 2019 Jan 14.


The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study.

Mannava S, Whitney KE, Kennedy MI, King J, Dornan GJ, Klett K, Chahla J, Evans TA, Huard J, LaPrade RF.

Arthroscopy. 2019 Jan;35(1):201-210. doi: 10.1016/j.arthro.2018.07.030. Epub 2018 Nov 22.


Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration.

Gao X, Lu A, Tang Y, Schneppendahl J, Liebowitz AB, Scibetta AC, Morris ER, Cheng H, Huard C, Amra S, Wang B, Hall MA, Lowe WR, Huard J.

Stem Cell Res Ther. 2018 Nov 21;9(1):316. doi: 10.1186/s13287-018-1066-z.


Proceedings of the signature series symposium "cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," international society for cellular therapies, montreal, canada, may 2, 2018.

Piuzzi NS, Dominici M, Long M, Pascual-Garrido C, Rodeo S, Huard J, Guicheux J, McFarland R, Goodrich LR, Maddens S, Robey PG, Bauer TW, Barrett J, Barry F, Karli D, Chu CR, Weiss DJ, Martin I, Jorgensen C, Muschler GF.

Cytotherapy. 2018 Nov;20(11):1381-1400. doi: 10.1016/j.jcyt.2018.09.001. Epub 2018 Oct 10.


Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.

Chu CR, Rodeo S, Bhutani N, Goodrich LR, Huard J, Irrgang J, LaPrade RF, Lattermann C, Lu Y, Mandelbaum B, Mao J, McIntyre L, Mishra A, Muschler GF, Piuzzi NS, Potter H, Spindler K, Tokish JM, Tuan R, Zaslav K, Maloney W.

J Am Acad Orthop Surg. 2019 Jan 15;27(2):e50-e63. doi: 10.5435/JAAOS-D-18-00305.


Potential Usefulness of Losartan as an Antifibrotic Agent and Adjunct to Platelet-Rich Plasma Therapy to Improve Muscle Healing and Cartilage Repair and Prevent Adhesion Formation.

Huard J, Bolia I, Briggs K, Utsunomiya H, Lowe WR, Philippon MJ.

Orthopedics. 2018 Sep 1;41(5):e591-e597. doi: 10.3928/01477447-20180806-05. Epub 2018 Aug 10. Review.


Pre-transplantational Control of the Post-transplantational Fate of Human Pluripotent Stem Cell-Derived Cartilage.

Lee JY, Matthias N, Pothiawala A, Ang BK, Lee M, Li J, Sun D, Pigeot S, Martin I, Huard J, Huang Y, Nakayama N.

Stem Cell Reports. 2018 Aug 14;11(2):440-453. doi: 10.1016/j.stemcr.2018.06.021. Epub 2018 Jul 26.


Evaluation of Endothelial and Vascular-Derived Progenitor Cell Populations in the Proximal and Distal UCL of the Elbow: A Comparative Study.

Frangiamore SJ, Morris ER, Scibetta AC, Chahla J, Moatshe G, Civitarese D, Provencher MT, Hackett TR, Schickendantz MS, Huard J, LaPrade RF.

Orthop J Sports Med. 2018 Jun 12;6(6):2325967118777825. doi: 10.1177/2325967118777825. eCollection 2018 Jun. Erratum in: Orthop J Sports Med. 2018 Jul 30;6(7):2325967118794193. Schickendantz, Mark S [added].


Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD.

PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. eCollection 2018 Jun.


Stem cells, blood vessels, and angiogenesis as major determinants for musculoskeletal tissue repair.

Huard J.

J Orthop Res. 2019 Jun;37(6):1212-1220. doi: 10.1002/jor.24058. Epub 2018 Jun 13. Review.


Bone morphogenetic proteins for articular cartilage regeneration.

Deng ZH, Li YS, Gao X, Lei GH, Huard J.

Osteoarthritis Cartilage. 2018 Sep;26(9):1153-1161. doi: 10.1016/j.joca.2018.03.007. Epub 2018 Mar 24. Review.


Volumetric muscle loss injury repair using in situ fibrin gel cast seeded with muscle-derived stem cells (MDSCs).

Matthias N, Hunt SD, Wu J, Lo J, Smith Callahan LA, Li Y, Huard J, Darabi R.

Stem Cell Res. 2018 Mar;27:65-73. doi: 10.1016/j.scr.2018.01.008. Epub 2018 Jan 9.


Current perspectives on biological approaches for osteoarthritis.

Whitney KE, Liebowitz A, Bolia IK, Chahla J, Ravuri S, Evans TA, Philippon MJ, Huard J.

Ann N Y Acad Sci. 2017 Dec;1410(1):26-43. doi: 10.1111/nyas.13554. Review.


αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC.

Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z.


Significant Chondrocyte Viability Is Present in Acetabular Chondral Flaps Associated With Femoroacetabular Impingement.

Wright VJ, McCrum CL, Li H, Tranovich MJ, Huard J.

Am J Sports Med. 2018 Jan;46(1):149-152. doi: 10.1177/0363546517732751. Epub 2017 Oct 12.


The Use of Biological Approaches in the Treatment of Shoulder Pathology: A Critical Analysis Review.

Pogorzelski J, Godin JA, Fritz EM, Cinque ME, Chahla J, Huard J, Millett PJ.

JBJS Rev. 2017 Sep;5(9):e5. doi: 10.2106/JBJS.RVW.17.00035. Review. No abstract available.


Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice.

Proto JD, Lu A, Dorronsoro A, Scibetta A, Robbins PD, Niedernhofer LJ, Huard J.

PLoS One. 2017 Jun 22;12(6):e0179270. doi: 10.1371/journal.pone.0179270. eCollection 2017.


RhoA/ROCK inhibition improves the beneficial effects of glucocorticoid treatment in dystrophic muscle: implications for stem cell depletion.

Mu X, Tang Y, Takayama K, Chen W, Lu A, Wang B, Weiss K, Huard J.

Hum Mol Genet. 2017 Aug 1;26(15):2813-2824. doi: 10.1093/hmg/ddx117.


Not Missing the Future: A Call to Action for Investigating the Role of Regenerative Medicine Therapies in Pediatric/Adolescent Sports Injuries.

Best TM, Caplan A, Coleman M, Goodrich L, Hurd J, Kaplan LD, Noonan B, Schoettle P, Scott C, Stiene H, Huard J.

Curr Sports Med Rep. 2017 May/Jun;16(3):202-210. doi: 10.1249/JSR.0000000000000357.


Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals.

Choi Y, Meng F, Cox CS, Lally KP, Huard J, Li Y.

Int J Cell Biol. 2017;2017:5312951. doi: 10.1155/2017/5312951. Epub 2017 Apr 10. Review.


A controlled release system for simultaneous delivery of three human perivascular stem cell-derived factors for tissue repair and regeneration.

Mansurov N, Chen WCW, Awada H, Huard J, Wang Y, Saparov A.

J Tissue Eng Regen Med. 2018 Feb;12(2):e1164-e1172. doi: 10.1002/term.2451. Epub 2017 Jul 20.


Functional Neuronal Differentiation of Injury-Induced Muscle-Derived Stem Cell-Like Cells with Therapeutic Implications.

Vojnits K, Pan H, Dai X, Sun H, Tong Q, Darabi R, Huard J, Li Y.

Sci Rep. 2017 Apr 26;7(1):1177. doi: 10.1038/s41598-017-01311-4.


The superior regenerative potential of muscle-derived stem cells for articular cartilage repair is attributed to high cell survival and chondrogenic potential.

Li H, Lu A, Tang Y, Beckman S, Nakayama N, Poddar M, Hogan MV, Huard J.

Mol Ther Methods Clin Dev. 2016 Nov 30;3:16065. eCollection 2016.


Anterior Cruciate Ligament-Derived Stem Cells Transduced With BMP2 Accelerate Graft-Bone Integration After ACL Reconstruction.

Kawakami Y, Takayama K, Matsumoto T, Tang Y, Wang B, Mifune Y, Cummins JH, Warth RJ, Kuroda R, Kurosaka M, Fu FH, Huard J.

Am J Sports Med. 2017 Mar;45(3):584-597. doi: 10.1177/0363546516671707. Epub 2016 Dec 14.


Muscle Injuries and Repair: What's New on the Horizon!

Huard J, Lu A, Mu X, Guo P, Li Y.

Cells Tissues Organs. 2016;202(3-4):227-236. Epub 2016 Nov 9. Review.


Skeletal muscle derived stem cells microintegrated into a biodegradable elastomer for reconstruction of the abdominal wall.

Takanari K, Hashizume R, Hong Y, Amoroso NJ, Yoshizumi T, Gharaibeh B, Yoshida O, Nonaka K, Sato H, Huard J, Wagner WR.

Biomaterials. 2017 Jan;113:31-41. doi: 10.1016/j.biomaterials.2016.10.029. Epub 2016 Oct 18.


mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.

Takayama K, Kawakami Y, Lavasani M, Mu X, Cummins JH, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J.

J Orthop Res. 2017 Jul;35(7):1375-1382. doi: 10.1002/jor.23409. Epub 2016 Sep 22.


Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue.

Baily JE, Chen WC, Khan N, Murray IR, González Galofre ZN, Huard J, Péault B.

J Vis Exp. 2016 Oct 8;(116). doi: 10.3791/54252.


The Combined Use of Losartan and Muscle-Derived Stem Cells Significantly Improves the Functional Recovery of Muscle in a Young Mouse Model of Contusion Injuries.

Kobayashi M, Ota S, Terada S, Kawakami Y, Otsuka T, Fu FH, Huard J.

Am J Sports Med. 2016 Dec;44(12):3252-3261. Epub 2016 Aug 8.


Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma.

Mu X, Agarwal R, March D, Rothenberg A, Voigt C, Tebbets J, Huard J, Weiss K.

Sarcoma. 2016;2016:3758162. doi: 10.1155/2016/3758162. Epub 2016 Jun 9.


Biological Therapies for Cartilage Lesions in the Hip: A New Horizon.

Chahla J, LaPrade RF, Mardones R, Huard J, Philippon MJ, Nho S, Mei-Dan O, Pascual-Garrido C.

Orthopedics. 2016 Jul 1;39(4):e715-23. doi: 10.3928/01477447-20160623-01. Epub 2016 Jun 30. Review.


Cyclooxygenase-2 deficiency impairs muscle-derived stem cell-mediated bone regeneration via cellular autonomous and non-autonomous mechanisms.

Gao X, Usas A, Lu A, Kozemchak A, Tang Y, Poddar M, Sun X, Cummins JH, Huard J.

Hum Mol Genet. 2016 Aug 1;25(15):3216-3231. doi: 10.1093/hmg/ddw172. Epub 2016 Jun 27.


Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability.

Hamblett KJ, Le T, Rock BM, Rock DA, Siu S, Huard JN, Conner KP, Milburn RR, O'Neill JW, Tometsko ME, Fanslow WC.

Mol Pharm. 2016 Jul 5;13(7):2387-96. doi: 10.1021/acs.molpharmaceut.6b00153. Epub 2016 Jun 13.


Evolving paradigms in clinical pharmacology and therapeutics for the treatment of Duchenne muscular dystrophy.

Huard J, Mu X, Lu A.

Clin Pharmacol Ther. 2016 Aug;100(2):142-6. doi: 10.1002/cpt.379. Epub 2016 Jun 20. Review.


Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.

Li H, Hicks JJ, Wang L, Oyster N, Philippon MJ, Hurwitz S, Hogan MV, Huard J.

Biomaterials. 2016 May;87:147-156. doi: 10.1016/j.biomaterials.2016.02.017. Epub 2016 Feb 17.


Retinal Targets ALDH Positive Cancer Stem Cell and Alters the Phenotype of Highly Metastatic Osteosarcoma Cells.

Mu X, Patel S, Mektepbayeva D, Mahjoub A, Huard J, Weiss K.

Sarcoma. 2015;2015:784954. doi: 10.1155/2015/784954. Epub 2015 Dec 24.


Controlled dual delivery of fibroblast growth factor-2 and Interleukin-10 by heparin-based coacervate synergistically enhances ischemic heart repair.

Chen WC, Lee BG, Park DW, Kim K, Chu H, Kim K, Huard J, Wang Y.

Biomaterials. 2015 Dec;72:138-51. doi: 10.1016/j.biomaterials.2015.08.050. Epub 2015 Sep 2.


Stem cells isolated from human dental pulp and amniotic fluid improve skeletal muscle histopathology in mdx/SCID mice.

Pisciotta A, Riccio M, Carnevale G, Lu A, De Biasi S, Gibellini L, La Sala GB, Bruzzesi G, Ferrari A, Huard J, De Pol A.

Stem Cell Res Ther. 2015 Aug 28;6:156. doi: 10.1186/s13287-015-0141-y.

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