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Items: 1 to 50 of 58

1.

Glutamine independence is a selectable feature of pluripotent stem cells.

Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS.

Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3. Epub 2019 Jul 8.

2.

Decoding pluripotency: Genetic screens to interrogate the acquisition, maintenance, and exit of pluripotency.

Li QV, Rosen BP, Huangfu D.

Wiley Interdiscip Rev Syst Biol Med. 2020 Jan;12(1):e1464. doi: 10.1002/wsbm.1464. Epub 2019 Aug 13. Review.

PMID:
31407519
3.

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation.

Lee K, Cho H, Rickert RW, Li QV, Pulecio J, Leslie CS, Huangfu D.

Cell Rep. 2019 Jul 9;28(2):382-393.e7. doi: 10.1016/j.celrep.2019.06.034.

4.

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation.

Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, Witkin M, Koche R, Betel D, Chen S, Massagué J, Garippa R, Evans T, Beer MA, Huangfu D.

Nat Genet. 2019 Jun;51(6):999-1010. doi: 10.1038/s41588-019-0408-9. Epub 2019 May 20.

5.

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells.

Teijeiro V, Yang D, Majumdar S, González F, Rickert RW, Xu C, Koche R, Verma N, Lai EC, Huangfu D.

Stem Cell Reports. 2018 Sep 11;11(3):616-625. doi: 10.1016/j.stemcr.2018.07.013. Epub 2018 Aug 23.

6.

Discovery of a drug candidate for GLIS3-associated diabetes.

Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, Huangfu D, Chen S.

Nat Commun. 2018 Jul 11;9(1):2681. doi: 10.1038/s41467-018-04918-x.

7.

Decoding the noncoding genome via large-scale CRISPR screens.

Shukla A, Huangfu D.

Curr Opin Genet Dev. 2018 Oct;52:70-76. doi: 10.1016/j.gde.2018.06.001. Epub 2018 Jun 15. Review.

8.

Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217. Review.

9.

Publisher Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.

Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D.

Nat Genet. 2018 May;50(5):764. doi: 10.1038/s41588-017-0024-5.

PMID:
29255266
10.

Author Correction: TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.

Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D.

Nat Genet. 2018 May;50(5):764. doi: 10.1038/s41588-017-0025-4.

PMID:
29255265
11.

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.

Verma N, Pan H, Doré LC, Shukla A, Li QV, Pelham-Webb B, Teijeiro V, González F, Krivtsov A, Chang CJ, Papapetrou EP, He C, Elemento O, Huangfu D.

Nat Genet. 2018 Jan;50(1):83-95. doi: 10.1038/s41588-017-0002-y. Epub 2017 Dec 4. Erratum in: Nat Genet. 2017 Dec 18;:. Nat Genet. 2017 Dec 18;:.

12.

CRISPR/Cas9-Based Engineering of the Epigenome.

Pulecio J, Verma N, Mejía-Ramírez E, Huangfu D, Raya A.

Cell Stem Cell. 2017 Oct 5;21(4):431-447. doi: 10.1016/j.stem.2017.09.006. Review.

13.
14.

Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.

Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D.

Cell Stem Cell. 2017 May 4;20(5):675-688.e6. doi: 10.1016/j.stem.2017.01.001. Epub 2017 Feb 9.

15.

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.

Wang Q, Zou Y, Nowotschin S, Kim SY, Li QV, Soh CL, Su J, Zhang C, Shu W, Xi Q, Huangfu D, Hadjantonakis AK, Massagué J.

Cell Stem Cell. 2017 Jan 5;20(1):70-86. doi: 10.1016/j.stem.2016.10.002. Epub 2016 Nov 23.

16.

CRISPR/Cas-Mediated Knockin in Human Pluripotent Stem Cells.

Verma N, Zhu Z, Huangfu D.

Methods Mol Biol. 2017;1513:119-140.

17.
18.

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes.

Zhu Z, Li QV, Lee K, Rosen BP, González F, Soh CL, Huangfu D.

Cell Stem Cell. 2016 Jun 2;18(6):755-68. doi: 10.1016/j.stem.2016.03.015. Epub 2016 Apr 28.

19.

Mechanisms underlying the formation of induced pluripotent stem cells.

González F, Huangfu D.

Wiley Interdiscip Rev Dev Biol. 2016 Jan-Feb;5(1):39-65. doi: 10.1002/wdev.206. Epub 2015 Sep 18. Review.

20.

A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells.

Zhu Z, Verma N, González F, Shi ZD, Huangfu D.

Stem Cell Reports. 2015 Jun 9;4(6):1103-11. doi: 10.1016/j.stemcr.2015.04.016. Epub 2015 May 28.

21.

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.

Kotini AG, Chang CJ, Boussaad I, Delrow JJ, Dolezal EK, Nagulapally AB, Perna F, Fishbein GA, Klimek VM, Hawkins RD, Huangfu D, Murry CE, Graubert T, Nimer SD, Papapetrou EP.

Nat Biotechnol. 2015 Jun;33(6):646-55. doi: 10.1038/nbt.3178. Epub 2015 Mar 23.

22.

Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring Unit.

Chen Y, Ruan ZX, Wang F, Huangfu DS, Sun PH, Lin J, Chen WM.

Chem Biol Drug Des. 2015 Oct;86(4):682-90. doi: 10.1111/cbdd.12537. Epub 2015 Mar 6.

PMID:
25677093
23.

The iCRISPR platform for rapid genome editing in human pluripotent stem cells.

Zhu Z, González F, Huangfu D.

Methods Enzymol. 2014;546:215-50. doi: 10.1016/B978-0-12-801185-0.00011-8.

24.

Stem cell epigenetics: looking forward.

Benitah SA, Bracken A, Dou Y, Huangfu D, Ivanova N, Koseki H, Laurent L, Lim DA, Meshorer E, Pombo A, Sander M, Xu GL.

Cell Stem Cell. 2014 Jun 5;14(6):706-9. No abstract available.

25.

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.

González F, Zhu Z, Shi ZD, Lelli K, Verma N, Li QV, Huangfu D.

Cell Stem Cell. 2014 Aug 7;15(2):215-226. doi: 10.1016/j.stem.2014.05.018. Epub 2014 Jun 12.

26.

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.

González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D.

Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.

27.

3D-QSAR and molecular docking for the discovery of ketolide derivatives.

Ruan ZX, Huangfu DS, Xu XJ, Sun PH, Chen WM.

Expert Opin Drug Discov. 2013 Apr;8(4):427-44. doi: 10.1517/17460441.2013.774369. Epub 2013 Feb 26. Review.

PMID:
23441865
28.

Human pluripotent stem cells: an emerging model in developmental biology.

Zhu Z, Huangfu D.

Development. 2013 Feb;140(4):705-17. doi: 10.1242/dev.086165. Review.

29.

Glucose and aging control the quiescence period that follows pancreatic beta cell replication.

Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y.

Development. 2010 Oct;137(19):3205-13. doi: 10.1242/dev.054304.

30.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K.

Cell Stem Cell. 2009 Nov 6;5(5):491-503. doi: 10.1016/j.stem.2009.09.012. Epub 2009 Oct 8.

31.

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA.

Nat Biotechnol. 2008 Nov;26(11):1269-75. doi: 10.1038/nbt.1502. Epub 2008 Oct 12.

PMID:
18849973
32.

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.

Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA.

Nat Biotechnol. 2008 Jul;26(7):795-7. doi: 10.1038/nbt1418. Epub 2008 Jun 22.

33.

All beta cells contribute equally to islet growth and maintenance.

Brennand K, Huangfu D, Melton D.

PLoS Biol. 2007 Jul;5(7):e163. Epub 2007 May 29.

34.
35.

Cilia and Hedgehog responsiveness in the mouse.

Huangfu D, Anderson KV.

Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11325-30. Epub 2005 Aug 1.

36.

Analysis of mouse embryonic patterning and morphogenesis by forward genetics.

García-García MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9. Epub 2005 Mar 8.

37.

Hedgehog signalling in the mouse requires intraflagellar transport proteins.

Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV.

Nature. 2003 Nov 6;426(6962):83-7.

PMID:
14603322
38.

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

Caspary T, García-García MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL, Anderson KV.

Curr Biol. 2002 Sep 17;12(18):1628-32.

39.

Alpha 2-adrenergic autoreceptors in A5 and A6 neurons of neonate rats.

Huangfu D, Guyenet PG.

Am J Physiol. 1997 Nov;273(5):H2290-5. doi: 10.1152/ajpheart.1997.273.5.H2290.

PMID:
9374765
40.

Autoactivity of A5 neurons: role of subthreshold oscillations and persistent Na+ current.

Huangfu D, Guyenet PG.

Am J Physiol. 1997 Nov;273(5):H2280-9. doi: 10.1152/ajpheart.1997.273.5.H2280.

PMID:
9374764
41.

Bulbospinal C1-adrenergic neurons: electrophysiological properties in the neonate rat.

Guyenet PG, Li YW, Huangfu D, Schreihofer AM.

Adv Pharmacol. 1998;42:638-41. No abstract available.

PMID:
9327983
42.

Effect of cholinergic agonists on bulbospinal C1 neurons in rats.

Huangfu D, Schreihofer M, Guyenet PG.

Am J Physiol. 1997 Jan;272(1 Pt 2):R249-58.

PMID:
9039016
43.

Mechanism of the hypotensive action of anandamide in anesthetized rats.

Varga K, Lake KD, Huangfu D, Guyenet PG, Kunos G.

Hypertension. 1996 Oct;28(4):682-6.

PMID:
8843898
44.

Role of medulla oblongata in generation of sympathetic and vagal outflows.

Guyenet PG, Koshiya N, Huangfu D, Baraban SC, Stornetta RL, Li YW.

Prog Brain Res. 1996;107:127-44. Review. No abstract available.

PMID:
8782517
45.

Alpha-2 adrenergic receptors. Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine.

Stornetta RL, Huangfu D, Rosin DL, Lynch KR, Guyenet PG.

Ann N Y Acad Sci. 1995 Jul 12;763:541-51. Review. No abstract available.

PMID:
7677372
46.

Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.

Huangfu D, Goodwin WB, Guyenet PG.

Am J Physiol. 1995 Jun;268(6 Pt 2):R1429-41.

PMID:
7611519
47.

Epibatidine, an alkaloid from the poison frog Epipedobates tricolor, is a powerful ganglionic depolarizing agent.

Fisher M, Huangfu D, Shen TY, Guyenet PG.

J Pharmacol Exp Ther. 1994 Aug;270(2):702-7.

PMID:
8071862
48.

Role of serotonin and catecholamines in sympathetic responses evoked by stimulation of rostral medulla.

Huangfu D, Hwang LJ, Riley TA, Guyenet PG.

Am J Physiol. 1994 Feb;266(2 Pt 2):R338-52.

PMID:
8141388
49.

Central respiratory control of A5 and A6 pontine noradrenergic neurons.

Guyenet PG, Koshiya N, Huangfu D, Verberne AJ, Riley TA.

Am J Physiol. 1993 Jun;264(6 Pt 2):R1035-44.

PMID:
8322954
50.

Ventrolateral medulla and sympathetic chemoreflex in the rat.

Koshiya N, Huangfu D, Guyenet PG.

Brain Res. 1993 Apr 23;609(1-2):174-84.

PMID:
8508301

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