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Discovery of 4H-chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, Which Showed Potent Activity in Ex Vivo Diabetic Retinopathy Models.

Zhao L, Li Y, Wang Y, Qiao Z, Miao Z, Yang J, Huang LY, Tian C, Li L, Chen D, Yang S.

J Med Chem. 2019 Nov 6. doi: 10.1021/acs.jmedchem.9b01143. [Epub ahead of print]


Rates and predictors of general practitioner (GP) follow-up postdischarge from a tertiary hospital cardiology unit: a retrospective cohort study.

Huang LYI, Fogarty SJ, Ng ACT, Wang WYS.

BMJ Open. 2019 Oct 30;9(10):e031627. doi: 10.1136/bmjopen-2019-031627.


Correction: Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress.

Lin YC, Wu MH, Wei TT, Lin YC, Huang WC, Huang LY, Lin YT, Chen CC.

Oncotarget. 2019 Oct 1;10(55):5724-5725. doi: 10.18632/oncotarget.27228. eCollection 2019 Oct 1.


Electrochemical Polymerization of PEDOT-Graphene Oxide-Heparin Composite Coating for Anti-fouling and Anti-clotting of Cardiovascular Stents.

Yang MC, Tsou HM, Hsiao YS, Cheng YW, Liu CC, Huang LY, Peng XY, Liu TY, Yung MC, Hsu CC.

Polymers (Basel). 2019 Sep 18;11(9). pii: E1520. doi: 10.3390/polym11091520.


Diagnosis and treatment of adult mixed-type Henoch-Schönlein purpura.

Cui J, Huang LY, Guo J, Wu CR, Zhang B.

Cent Eur J Immunol. 2019;44(2):138-143. doi: 10.5114/ceji.2019.87064. Epub 2019 Jul 30.


[Proteomic analysis of aqueous humor in acute primary angle-closure glaucoma].

Wang LM, Dong LJ, Liu X, Huang LY, Liu W, Lyu YJ, Li XR, Liu AH.

Zhonghua Yan Ke Za Zhi. 2019 Sep 11;55(9):687-694. doi: 10.3760/cma.j.issn.0412-4081.2019.09.011. Chinese.


Effects of PM2.5 on Skeletal Muscle Mass and Body Fat Mass of the Elderly in Taipei, Taiwan.

Chen CH, Huang LY, Lee KY, Wu CD, Chiang HC, Chen BY, Chin WS, Pan SC, Guo YL.

Sci Rep. 2019 Aug 1;9(1):11176. doi: 10.1038/s41598-019-47576-9.


[Effect of calcium on ion contents and expression of photosynthetic related genes in honeysuckle under salt stress].

Huang LY, Li ZZ, Ju LT, Sun PP, Wu GZ, Wu YM, Li J.

Zhongguo Zhong Yao Za Zhi. 2019 Jun;44(12):2452-2458. doi: 10.19540/j.cnki.cjcmm.20190325.106. Chinese.


Measles infection causing Bacillus Calmette-Guérin reactivation: a case report.

Muthuvelu S, Lim KS, Huang LY, Chin ST, Mohan A.

BMC Pediatr. 2019 Jul 24;19(1):251. doi: 10.1186/s12887-019-1635-z.


Preoperative breast volume evaluation of one-stage immediate breast reconstruction using three-dimensional surface imaging and a printed mold.

Chen K, Feng CJ, Ma H, Hsiao FY, Tseng LM, Tsai YF, Lin YS, Huang LY, Yu WC, Perng CK.

J Chin Med Assoc. 2019 Sep;82(9):732-739. doi: 10.1097/JCMA.0000000000000155.


Roles of neuroimage in toxic encephalopathy induced by 1, 2-Dichloroethane.

Liu J, Zhang L, He B, Zhuang JH, Xu J, Huang LY, Peng H.

Clin Neurol Neurosurg. 2019 Sep;184:105398. doi: 10.1016/j.clineuro.2019.105398. Epub 2019 Jul 9.


Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study.

Hsu CY, Huang LY, Saver JL, Wu YL, Lee JD, Chen PC, Lee M, Ovbiagele B.

Hypertens Res. 2019 Nov;42(11):1794-1800. doi: 10.1038/s41440-019-0300-0. Epub 2019 Jul 12.


Mechanism of β2AR regulation by an intracellular positive allosteric modulator.

Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B.

Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27.


One-stage Surgical Treatment of Simultaneous Osteotomy and Asymmetric Lengthening on Short Femur with Severe Deformity of Genu Valgus.

Xu HF, Xu C, Sha J, Yan YB, Li C, Liu ZC, Huang LY, Lei W.

Sci Rep. 2019 Jun 13;9(1):8602. doi: 10.1038/s41598-019-45157-4.


Association between Central Serous Chorioretinopathy and Risk of Depression: A Population-Based Cohort Study.

Chen YY, Huang LY, Liao WL, Chou P.

J Ophthalmol. 2019 May 2;2019:2749296. doi: 10.1155/2019/2749296. eCollection 2019.


Correction: Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress.

Lin YC, Wu MH, Wei TT, Lin YC, Huang WC, Huang LY, Lin YT, Chen CC.

Oncotarget. 2019 May 28;10(37):3577-3578. doi: 10.18632/oncotarget.26997. eCollection 2019 May 28.


Does public report card matter? A 10-year interrupted time series analysis on total knee replacement.

Chen TT, Hsueh YA, Liaw CK, Shih LN, Huang LY.

Eur J Public Health. 2019 Jun 9. pii: ckz112. doi: 10.1093/eurpub/ckz112. [Epub ahead of print]


CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.

Ji QK, Ma JW, Liu RH, Li XS, Shen FZ, Huang LY, Hui L, Ma YJ, Jin BZ.

Mol Med Rep. 2019 Aug;20(2):1149-1156. doi: 10.3892/mmr.2019.10349. Epub 2019 Jun 5.


Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.

Huang XL, Huang LY, Cheng YT, Li F, Zhou Q, Wu C, Shi QH, Guan ZZ, Liao J, Hong W.

Int J Mol Med. 2019 Aug;44(2):582-592. doi: 10.3892/ijmm.2019.4207. Epub 2019 May 23.


Integrative Medicine Treatment for Severe Stroke-A Case Report.

Chan CC, Huang LY, Song JX, Zhang J, Qu M, Gao L.

Chin J Integr Med. 2019 May 21. doi: 10.1007/s11655-019-3067-x. [Epub ahead of print] No abstract available.


[Regulation of exogenous calcium on photosynthetic system of honeysuckle under salt stress].

Huang LY, Li ZZ, Duan TY, Wang L, Zhang YQ, Li J.

Zhongguo Zhong Yao Za Zhi. 2019 Apr;44(8):1531-1536. doi: 10.19540/j.cnki.cjcmm.20190322.101. Chinese.


Protective effects of melatonin on mitochondrial biogenesis and mitochondrial structure and function in the HEK293-APPswe cell model of Alzheimer's disease.

Wang CF, Song CY, Wang X, Huang LY, Ding M, Yang H, Wang P, Xu LL, Xie ZH, Bi JZ.

Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3542-3550. doi: 10.26355/eurrev_201904_17723.


Biomechanical Evaluation of Three-Dimensional Printed Dynamic Hand Device for Patients With Chronic Stroke.

Huang TY, Pan LH, Yang WW, Huang LY, Sun PC, Chen CS.

IEEE Trans Neural Syst Rehabil Eng. 2019 Jun;27(6):1246-1252. doi: 10.1109/TNSRE.2019.2915260. Epub 2019 May 8.


Subjective Cognitive Decline in the Community Is Affected at Multiple Aspects of Mental Health and Life Quality: A Cross-Sectional Study of the Community Medicine of Keelung Chang Gung Memorial Hospital.

Wei YC, Huang LY, Chen CK, Lin C, Shyu YC, Chen YL, Huang WY, Lin CP.

Dement Geriatr Cogn Dis Extra. 2019 Mar 13;9(1):152-162. doi: 10.1159/000497222. eCollection 2019 Jan-Apr.


Insights into ecological role of a new deltaproteobacterial order Candidatus Acidulodesulfobacterales by metagenomics and metatranscriptomics.

Tan S, Liu J, Fang Y, Hedlund BP, Lian ZH, Huang LY, Li JT, Huang LN, Li WJ, Jiang HC, Dong HL, Shu WS.

ISME J. 2019 Aug;13(8):2044-2057. doi: 10.1038/s41396-019-0415-y. Epub 2019 Apr 8.


[Construction of Wuhan's ecological security pattern under the "quality-risk-requirement" framework].

Huang LY, Liu SH, Fang Y, Zou L.

Ying Yong Sheng Tai Xue Bao. 2019 Feb 20;30(2):615-626. doi: 10.13287/j.1001-9332.201902.014. Chinese.


Congenital Cystic Diaphragm with Diaphragmatic Eventration in a Fetus: A Case Presentation.

Zhen L, Gu CM, Huang LY, Li DZ.

Fetal Pediatr Pathol. 2019 Aug;38(4):335-339. doi: 10.1080/15513815.2019.1588440. Epub 2019 Mar 26.


Fermentation-based biotransformation of glucosinolates, phenolics and sugars in retorted broccoli puree by lactic acid bacteria.

Ye JH, Huang LY, Terefe NS, Augustin MA.

Food Chem. 2019 Jul 15;286:616-623. doi: 10.1016/j.foodchem.2019.02.030. Epub 2019 Feb 14.


Eye fixation-related fronto-parietal neural network correlates of memory retrieval.

Tsai PY, She HC, Chen SC, Huang LY, Chou WC, Duann JR, Jung TP.

Int J Psychophysiol. 2019 Apr;138:57-70. doi: 10.1016/j.ijpsycho.2019.02.008. Epub 2019 Feb 25.


Copulation Exerts Significant Effects on mRNA Expression of Cryptochrome Genes in a Moth.

Xu J, Gao B, Shi MR, Yu H, Huang LY, Chen P, Li YH.

J Insect Sci. 2019 Mar 1;19(2). pii: 3. doi: 10.1093/jisesa/iez016.


Outcomes and Impacts of 10-Year HTA Implementation in Taiwan.

Kao KL, Huang LY, Wu YH, Gau CS.

Int J Technol Assess Health Care. 2019 Feb 28:1-5. doi: 10.1017/S0266462319000011. [Epub ahead of print]


Molecular evolution of influenza B virus during 2011-2017 in Chaoyang, Beijing, suggesting the free influenza vaccine policy.

Lei N, Wang HB, Zhang YS, Zhao JH, Zhong Y, Wang YJ, Huang LY, Ma JX, Sun Q, Yang L, Shu YL, Li SM, Sun LL.

Sci Rep. 2019 Feb 21;9(1):2432. doi: 10.1038/s41598-018-38105-1.


Diagnosis of mycoplasma pneumoniae by loop-mediated isothermal amplification: systematic review and meta-analysis.

Cai ZH, Dai YY, Huang LY, Zhang WS, Guo XG.

BMC Infect Dis. 2019 Feb 19;19(1):173. doi: 10.1186/s12879-019-3799-4.


lncRNA small nucleolar RNA host gene 20 predicts poor prognosis in glioma and promotes cell proliferation by silencing P21.

Li XS, Shen FZ, Huang LY, Hui L, Liu RH, Ma YJ, Jin BZ.

Onco Targets Ther. 2019 Jan 24;12:805-814. doi: 10.2147/OTT.S192641. eCollection 2019.


Metagenomic analysis of the inhibitory effect of chromium on microbial communities and removal efficiency in A2O sludge.

Sun FL, Fan LL, Wang YS, Huang LY.

J Hazard Mater. 2019 Apr 15;368:523-529. doi: 10.1016/j.jhazmat.2019.01.076. Epub 2019 Jan 23.


Golgin-160 and GMAP210 play an important role in U251 cells migration and invasion initiated by GDNF.

Tang CX, Luan L, Zhang L, Wang Y, Liu XF, Wang J, Xiong Y, Wang D, Huang LY, Gao DS.

PLoS One. 2019 Jan 29;14(1):e0211501. doi: 10.1371/journal.pone.0211501. eCollection 2019.


Prenatal diagnosis of 17q12 deletion syndrome: a retrospective case series.

Jing XY, Huang LY, Zhen L, Han J, Li DZ.

J Obstet Gynaecol. 2019 Apr;39(3):323-327. doi: 10.1080/01443615.2018.1519693. Epub 2019 Jan 11.


Adenoid cystic carcinoma of the vagina: A case report.

Zhang LZ, Huang LY, Huang AL, Liu JX, Yang F.

Medicine (Baltimore). 2019 Jan;98(1):e13852. doi: 10.1097/MD.0000000000013852.


Endoscopic full-thickness resection for gastric gastrointestinal stromal tumor originating from the muscularis propria.

Huang J, Xian XS, Huang LY, Zhang B, Wu CR, Cui J.

Rev Assoc Med Bras (1992). 2018 Nov;64(11):1002-1006. doi: 10.1590/1806-9282.64.11.1002.


Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease.

Chen KR, Yu CK, Kung SH, Chen SH, Chang CF, Ho TC, Lee YP, Chang HC, Huang LY, Lo SY, Chang JC, Ling P.

Viruses. 2018 Dec 5;10(12). pii: E689. doi: 10.3390/v10120689.


Structural analysis reveals a "molecular calipers" mechanism for a LATERAL ORGAN BOUNDARIES DOMAIN transcription factor protein from wheat.

Chen WF, Wei XB, Rety S, Huang LY, Liu NN, Dou SX, Xi XG.

J Biol Chem. 2019 Jan 4;294(1):142-156. doi: 10.1074/jbc.RA118.003956. Epub 2018 Nov 13.


Warfarin-resistant left ventricular thrombus completely dissolved by rivaroxaban.

Huang LY, Chang TH, Wu CH, Tsai TN.

Br J Hosp Med (Lond). 2018 Nov 2;79(11):648-649. doi: 10.12968/hmed.2018.79.11.648. No abstract available.


Designing a nanoparticle-containing polymeric substrate for detecting cancer cells by computer simulations.

Huang LY, Yu YS, Lu X, Ding HM, Ma YQ.

Nanoscale. 2019 Jan 31;11(5):2170-2178. doi: 10.1039/c8nr06340k.


Early prenatal detection of short-rib polydactyly syndrome in a monochorionic diamniotic twin pregnancy.

Zhen L, Huang LY, Li DZ.

Congenit Anom (Kyoto). 2019 Sep;59(5):181-182. doi: 10.1111/cga.12317. Epub 2018 Nov 15. No abstract available.


Hemocompatibility and anti-fouling behavior of multilayer biopolymers immobilized on gold-thiolized drug-eluting cardiovascular stents.

Huang LY, Yang MC, Tsou HM, Liu TY.

Colloids Surf B Biointerfaces. 2019 Jan 1;173:470-477. doi: 10.1016/j.colsurfb.2018.10.014. Epub 2018 Oct 9.


SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.

Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W.

Nat Commun. 2018 Sep 3;9(1):3569. doi: 10.1038/s41467-018-06038-y.


Decreased intracellular chloride promotes ADP induced platelet activation through inhibition of cAMP/PKA instead of activation of Lyn/PI3K/Akt pathway.

Huang LY, Li PP, Li YJ, Zhao WQ, Shang WK, Wang YL, Gao DS, Li HC, Ma P.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1740-1746. doi: 10.1016/j.bbrc.2018.07.107. Epub 2018 Aug 16.


HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.

Chen YS, Chang CW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC, Lo JF.

Theranostics. 2018 Jun 13;8(14):3841-3855. doi: 10.7150/thno.25784. eCollection 2018.


Early prenatal detection of Bardet-Biedl syndrome in a case with postaxial polydactyly and hyperechoic kidneys confirmed by next generation sequencing.

Li QY, Huang LY, Li DZ.

Congenit Anom (Kyoto). 2019 Jul;59(4):142-144. doi: 10.1111/cga.12306. Epub 2018 Aug 22. No abstract available.


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