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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (GISTs) and Acute Myeloid Leukemia (AML).

Lin WH, Wu S, Yeh TK, Chen CT, Song JS, Shiao HY, Kuo CC, Hsu T, Lu CT, Wang PC, Wu TS, Peng YH, Lin HY, Chen CP, Weng YL, Kung FC, Wu MH, Su YC, Huang KW, Chou LH, Hsueh CC, Yen KJ, Kuo PC, Huang CL, Chen LT, Shih C, Tsai HJ, Jiaang WT.

J Med Chem. 2019 Nov 13. doi: 10.1021/acs.jmedchem.9b01229. [Epub ahead of print]


AFC1 Compound Attenuated MI/R-Induced Ventricular Remodeling via Inhibiting PDGFR and STAT Pathway.

Liu J, Zhou X, Meng Q, Huang KW, Liu J, Tie J, Zhuang R, Chen G, Zhang Y, Wei L, Huang L, Li CG, Wang B, Fan H, Liu Z.

Front Pharmacol. 2019 Oct 15;10:1142. doi: 10.3389/fphar.2019.01142. eCollection 2019.


Utilizing genome-scale models to optimize nutrient supply for sustained algal growth and lipid productivity.

Li CT, Yelsky J, Chen Y, Zuñiga C, Eng R, Jiang L, Shapiro A, Huang KW, Zengler K, Betenbaugh MJ.

NPJ Syst Biol Appl. 2019 Sep 24;5:33. doi: 10.1038/s41540-019-0110-7. eCollection 2019.


Effects of Aspirin or Clopidogrel on Colorectal Cancer Chemoprevention in Patients with Type 2 Diabetes Mellitus.

Kuan YC, Huang KW, Lin CL, Luo JC, Kao CH.

Cancers (Basel). 2019 Sep 29;11(10). pii: E1468. doi: 10.3390/cancers11101468.


Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC.

Yoon S, Huang KW, Andrikakou P, Vasconcelos D, Swiderski P, Reebye V, Sodergren M, Habib N, Rossi JJ.

Mol Ther Nucleic Acids. 2019 Aug 22;18:142-154. doi: 10.1016/j.omtn.2019.08.017. [Epub ahead of print]


Performance and Stability Improvement of Layered NCM Lithium-Ion Batteries at High Voltage by a Microporous Al2O3 Sol-Gel Coating.

Wu Y, Li M, Wahyudi W, Sheng G, Miao X, Anthopoulos TD, Huang KW, Li Y, Lai Z.

ACS Omega. 2019 Aug 19;4(9):13972-13980. doi: 10.1021/acsomega.9b01706. eCollection 2019 Aug 27.


Nonoxidative Dehydrogenation of Methanol to Methyl Formate through Highly Stable and Reusable CuMgO-Based Catalysts.

Yuan DJ, Hengne AM, Saih Y, Huang KW.

ACS Omega. 2019 Jan 23;4(1):1854-1860. doi: 10.1021/acsomega.8b03069. eCollection 2019 Jan 31.


Molecular and anatomical organization of the dorsal raphe nucleus.

Huang KW, Ochandarena NE, Philson AC, Hyun M, Birnbaum JE, Cicconet M, Sabatini BL.

Elife. 2019 Aug 14;8. pii: e46464. doi: 10.7554/eLife.46464.


Interrogating the steric outcome during H2 heterolysis: in-plane steric effects in the regioselective protonation of the PN3P-pincer ligand.

Yao C, Zhang T, Zhou C, Huang KW.

Dalton Trans. 2019 Sep 14;48(34):12817-12821. doi: 10.1039/c9dt03003d. Epub 2019 Aug 12.


CO2 hydrogenation by phosphorus-nitrogen PN3P-pincer iridium hydride complexes: elucidation of the deactivation pathway.

Pan Y, Guan C, Li H, Chakraborty P, Zhou C, Huang KW.

Dalton Trans. 2019 Sep 14;48(34):12812-12816. doi: 10.1039/c9dt01319a. Epub 2019 Aug 12.


Short-Term Proton Pump Inhibitor Use and Hepatic Encephalopathy Risk in Patients with Decompensated Cirrhosis.

Kuan YC, Huang KW, Lin CL, Luo JC, Kao CH.

J Clin Med. 2019 Jul 25;8(8). pii: E1108. doi: 10.3390/jcm8081108.


Elevated TNIP3 mRNA Expression in TNF-α-Secreting Cells from Patients with Major Depressive Disorder.

Huang KW, Wu MK, Hung YY.

Neuroimmunomodulation. 2019;26(3):153-158. doi: 10.1159/000501083. Epub 2019 Jul 15.


Graptopetalum paraguayense Inhibits Liver Fibrosis by Blocking TGF-β Signaling In Vivo and In Vitro.

Hsu WH, Liao SC, Chyan YJ, Huang KW, Hsu SL, Chen YC, Siu ML, Chang CC, Chung YS, Huang CF.

Int J Mol Sci. 2019 May 27;20(10). pii: E2592. doi: 10.3390/ijms20102592.


Design and Mechanistic Study of Highly Durable Carbon-Coated Cobalt Diphosphide Core-Shell Nanostructure Electrocatalysts for the Efficient and Stable Oxygen Evolution Reaction.

Alsabban MM, Yang X, Wahyudi W, Fu JH, Hedhili MN, Ming J, Yang CW, Nadeem MA, Idriss H, Lai Z, Li LJ, Tung V, Huang KW.

ACS Appl Mater Interfaces. 2019 Jun 12;11(23):20752-20761. doi: 10.1021/acsami.9b01847. Epub 2019 May 31.


Imaging defects and their evolution in a metal-organic framework at sub-unit-cell resolution.

Liu L, Chen Z, Wang J, Zhang D, Zhu Y, Ling S, Huang KW, Belmabkhout Y, Adil K, Zhang Y, Slater B, Eddaoudi M, Han Y.

Nat Chem. 2019 Jul;11(7):622-628. doi: 10.1038/s41557-019-0263-4. Epub 2019 May 13.


Improved quantitative assessment of HBV-associated liver fibrosis using second-harmonic generation microscopy with feature selection.

Hsiao CY, Teng X, Su TH, Lee PH, Kao JH, Huang KW.

Clin Res Hepatol Gastroenterol. 2019 May 7. pii: S2210-7401(19)30093-2. doi: 10.1016/j.clinre.2019.04.003. [Epub ahead of print]


Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus.

Mandelbaum G, Taranda J, Haynes TM, Hochbaum DR, Huang KW, Hyun M, Umadevi Venkataraju K, Straub C, Wang W, Robertson K, Osten P, Sabatini BL.

Neuron. 2019 May 8;102(3):636-652.e7. doi: 10.1016/j.neuron.2019.02.035. Epub 2019 Mar 21.


Positive Immuno-Modulation Following Radiofrequency Assisted Liver Resection in Hepatocellular Carcinoma.

Huang KW, Jayant K, Lee PH, Yang PC, Hsiao CY, Habib N, Sodergren MH.

J Clin Med. 2019 Mar 19;8(3). pii: E385. doi: 10.3390/jcm8030385.


Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice.

Zhou J, Li H, Xia X, Herrera A, Pollock N, Reebye V, Sodergren MH, Dorman S, Littman BH, Doogan D, Huang KW, Habib R, Blakey D, Habib NA, Rossi JJ.

Mol Ther. 2019 May 8;27(5):999-1016. doi: 10.1016/j.ymthe.2019.02.018. Epub 2019 Feb 26.


Dearomatization of 3-Nitroindoles by a Phosphine-Catalyzed Enantioselective [3+2] Annulation Reaction.

Li K, Gonçalves TP, Huang KW, Lu Y.

Angew Chem Int Ed Engl. 2019 Apr 8;58(16):5427-5431. doi: 10.1002/anie.201900248. Epub 2019 Mar 14.


A prospective, multi-institution assessment of irreversible electroporation for treatment of locally advanced pancreatic adenocarcinoma: initial outcomes from the AHPBA pancreatic registry.

Holland MM, Bhutiani N, Kruse EJ, Weiss MJ, Christein JD, White RR, Huang KW, Martin RCG 2nd.

HPB (Oxford). 2019 Aug;21(8):1024-1031. doi: 10.1016/j.hpb.2018.12.004. Epub 2019 Feb 5.


Cyclometalated Iridium-PhanePhos Complexes Are Active Catalysts in Enantioselective Allene-Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters.

Schwartz LA, Holmes M, Brito GA, Gonçalves TP, Richardson J, Ruble JC, Huang KW, Krische MJ.

J Am Chem Soc. 2019 Feb 6;141(5):2087-2096. doi: 10.1021/jacs.8b11868. Epub 2019 Jan 25.


Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinoma.

Zhao X, Reebye V, Hitchen P, Fan J, Jiang H, Sætrom P, Rossi J, Habib NA, Huang KW.

Oncogene. 2019 May;38(18):3446-3457. doi: 10.1038/s41388-018-0665-6. Epub 2019 Jan 14.


Enhanced Reactivity of Aluminum Complexes Containing P-Bridged Biphenolate Ligands in Ring-Opening Polymerization Catalysis.

Zou XR, Chang YN, Huang KW, Liang LC.

Front Chem. 2018 Dec 13;6:607. doi: 10.3389/fchem.2018.00607. eCollection 2018.


Structural analysis of transient reaction intermediate in formic acid dehydrogenation catalysis using two-dimensional IR spectroscopy.

Zhang Y, Chen X, Zheng B, Guo X, Pan Y, Chen H, Li H, Min S, Guan C, Huang KW, Zheng J.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12395-12400. doi: 10.1073/pnas.1809342115. Epub 2018 Nov 19.


A Systematic Review and Meta-Analysis Comparing Liver Resection with the Rf-Based Device Habib™-4X with the Clamp-Crush Technique.

Jayant K, Sodergren MH, Reccia I, Kusano T, Zacharoulis D, Spalding D, Pai M, Jiao LR, Huang KW.

Cancers (Basel). 2018 Nov 8;10(11). pii: E428. doi: 10.3390/cancers10110428. Review.


Structural insights into the duplex DNA processing of TREX2.

Cheng HL, Lin CT, Huang KW, Wang S, Lin YT, Toh SI, Hsiao YY.

Nucleic Acids Res. 2018 Dec 14;46(22):12166-12176. doi: 10.1093/nar/gky970.


A Pseudodearomatized PN3P*Ni-H Complex as a Ligand and σ-Nucleophilic Catalyst.

Li H, Gonçalves TP, Hu J, Zhao Q, Gong D, Lai Z, Wang Z, Zheng J, Huang KW.

J Org Chem. 2018 Dec 21;83(24):14969-14977. doi: 10.1021/acs.joc.8b02205. Epub 2018 Nov 5.


Glaulactams A-C, daphniphyllum alkaloids from Daphniphyllum glaucescens.

Chao CH, Cheng JC, Gonçalves TP, Huang KW, Lin CC, Huang HC, Hwang SY, Wu YC.

Sci Rep. 2018 Oct 18;8(1):15417. doi: 10.1038/s41598-018-33748-6.


Monomeric nickel hydroxide stabilized by a sterically demanding phosphorus-nitrogen PN3P-pincer ligand: synthesis, reactivity and catalysis.

Yao C, Chakraborty P, Aresu E, Li H, Guan C, Zhou C, Liang LC, Huang KW.

Dalton Trans. 2018 Nov 22;47(45):16057-16065. doi: 10.1039/c8dt03403f.


Crystalline 2D Covalent Organic Framework Membranes for High-Flux Organic Solvent Nanofiltration.

Shinde DB, Sheng G, Li X, Ostwal M, Emwas AH, Huang KW, Lai Z.

J Am Chem Soc. 2018 Oct 31;140(43):14342-14349. doi: 10.1021/jacs.8b08788. Epub 2018 Oct 17.


Cobalt-Catalyzed Selective Hydrogenation of Nitriles to Secondary Imines.

Li H, Al-Dakhil A, Lupp D, Gholap SS, Lai Z, Liang LC, Huang KW.

Org Lett. 2018 Oct 19;20(20):6430-6435. doi: 10.1021/acs.orglett.8b02744. Epub 2018 Oct 1.


Efficient electrochemical transformation of CO2 to C2/C3 chemicals on benzimidazole-functionalized copper surfaces.

Zhong S, Yang X, Cao Z, Dong X, Kozlov SM, Falivene L, Huang JK, Zhou X, Hedhili MN, Lai Z, Huang KW, Han Y, Cavallo L, Li LJ.

Chem Commun (Camb). 2018 Oct 4;54(80):11324-11327. doi: 10.1039/c8cc04735a.


Single-Site Ruthenium Pincer Complex Knitted into Porous Organic Polymers for Dehydrogenation of Formic Acid.

Wang X, Ling EAP, Guan C, Zhang Q, Wu W, Liu P, Zheng N, Zhang D, Lopatin S, Lai Z, Huang KW.

ChemSusChem. 2018 Oct 24;11(20):3591-3598. doi: 10.1002/cssc.201801980. Epub 2018 Oct 9.


Diverse catalytic reactivity of a dearomatized PN3P*-nickel hydride pincer complex towards CO2 reduction.

Li H, Gonçalves TP, Zhao Q, Gong D, Lai Z, Wang Z, Zheng J, Huang KW.

Chem Commun (Camb). 2018 Oct 9;54(81):11395-11398. doi: 10.1039/c8cc05948a.


Irreversible Electroporation: A Novel Ultrasound-guided Modality for Non-thermal Tumor Ablation.

Hsiao CY, Huang KW.

J Med Ultrasound. 2017 Oct-Dec;25(4):195-200. doi: 10.1016/j.jmu.2017.08.003. Epub 2017 Oct 6. Review.


Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction.

Wei PL, Lee LT, Tseng LM, Huang KW.

Sci Rep. 2018 Jul 3;8(1):10002. doi: 10.1038/s41598-018-28215-1.


Comparison of Radiofrequency Ablation and Transarterial Chemoembolization for Hepatocellular Carcinoma in the Caudate Lobe.

Lee BC, Liu KL, Wu CH, Huang KW, Ho CM, Hu RH, Ho MC, Wu YM, Lee PH, Liang PC.

Cardiovasc Intervent Radiol. 2018 Nov;41(11):1699-1707. doi: 10.1007/s00270-018-1978-0. Epub 2018 Jun 26.


Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens.

Barrientos C, Knowland D, Wu MMJ, Lilascharoen V, Huang KW, Malenka RC, Lim BK.

Biol Psychiatry. 2018 Dec 15;84(12):893-904. doi: 10.1016/j.biopsych.2018.04.019. Epub 2018 May 9.


The efficacy of combination of induction chemotherapy and irreversible electroporation ablation for patients with locally advanced pancreatic adenocarcinoma.

Huang KW, Yang PC, Pua U, Kim MD, Li SP, Qiu YD, Song TQ, Liang PC.

J Surg Oncol. 2018 Jul;118(1):31-36. doi: 10.1002/jso.25110. Epub 2018 Jun 7.


Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma.

Huang KW, Lai YT, Chern GJ, Huang SF, Tsai CL, Sung YC, Chiang CC, Hwang PB, Ho TL, Huang RL, Shiue TY, Chen Y, Wang SK.

Biomacromolecules. 2018 Jun 11;19(6):2330-2339. doi: 10.1021/acs.biomac.8b00358. Epub 2018 May 29.


Dimerization of Terminal Aryl Alkynes Catalyzed by Iron(II) Amine-Pyrazolyl Tripodal Complexes with E/Z Selectivity Controlled by tert-Butoxide.

Xue F, Song X, Lin TT, Munkerup K, Albawardi SF, Huang KW, Hor TSA, Zhao J.

ACS Omega. 2018 May 9;3(5):5071-5077. doi: 10.1021/acsomega.8b00539. eCollection 2018 May 31.


Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1.

Huang KW, Liu TC, Liang RY, Chu LY, Cheng HL, Chu JW, Hsiao YY.

PLoS Biol. 2018 May 7;16(5):e2005653. doi: 10.1371/journal.pbio.2005653. eCollection 2018 May.


Leptin signaling axis specifically associates with clinical prognosis and is multifunctional in regulating cancer progression.

Lin TC, Huang KW, Liu CW, Chang YC, Lin WM, Yang TY, Hsiao M.

Oncotarget. 2018 Mar 30;9(24):17210-17219. doi: 10.18632/oncotarget.24966. eCollection 2018 Mar 30. Review.


Lipofection of plasmid DNA into human mast cell lines using lipid nanoparticles generated by microfluidic mixing.

Duguay BA, Huang KW, Kulka M.

J Leukoc Biol. 2018 Sep;104(3):587-596. doi: 10.1002/JLB.3TA0517-192R. Epub 2018 Apr 18.


Ni-Sn-Supported ZrO2 Catalysts Modified by Indium for Selective CO2 Hydrogenation to Methanol.

Hengne AM, Samal AK, Enakonda LR, Harb M, Gevers LE, Anjum DH, Hedhili MN, Saih Y, Huang KW, Basset JM.

ACS Omega. 2018 Apr 2;3(4):3688-3701. doi: 10.1021/acsomega.8b00211. eCollection 2018 Apr 30.


Acoustic Radiation Force Impulse US Imaging: Liver Stiffness in Patients with Chronic Hepatitis B with and without Antiviral Therapy.

Su TH, Liao CH, Liu CH, Huang KW, Tseng TC, Yang HC, Liu CJ, Chen PJ, Chen DS, Kao JH.

Radiology. 2018 Jul;288(1):293-299. doi: 10.1148/radiol.2018171116. Epub 2018 Mar 27.


Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer.

Reebye V, Huang KW, Lin V, Jarvis S, Cutilas P, Dorman S, Ciriello S, Andrikakou P, Voutila J, Saetrom P, Mintz PJ, Reccia I, Rossi JJ, Huber H, Habib R, Kostomitsopoulos N, Blakey DC, Habib NA.

Oncogene. 2018 Jun;37(24):3216-3228. doi: 10.1038/s41388-018-0126-2. Epub 2018 Mar 7.


High-flux water desalination with interfacial salt sieving effect in nanoporous carbon composite membranes.

Chen W, Chen S, Liang T, Zhang Q, Fan Z, Yin H, Huang KW, Zhang X, Lai Z, Sheng P.

Nat Nanotechnol. 2018 Apr;13(4):345-350. doi: 10.1038/s41565-018-0067-5. Epub 2018 Mar 5.


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