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Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy.

Li X, Jeong K, Lee Y, Guo T, Lee D, Park J, Kwon N, Na JH, Hong SK, Cha SS, Huang JD, Choi S, Kim S, Yoon J.

Theranostics. 2019 Aug 14;9(22):6412-6423. doi: 10.7150/thno.35210. eCollection 2019.


The new ichthyosauriform Chaohusaurus brevifemoralis (Reptilia, Ichthyosauromorpha) from Majiashan, Chaohu, Anhui Province, China.

Huang JD, Motani R, Jiang DY, Tintori A, Rieppel O, Zhou M, Ren XX, Zhang R.

PeerJ. 2019 Sep 9;7:e7561. doi: 10.7717/peerj.7561. eCollection 2019.


Size-Tunable Targeting-Triggered Nanophotosensitizers Based on Self-Assembly of a Phthalocyanine-Biotin Conjugate for Photodynamic Therapy.

Li D, Wang XZ, Yang LF, Li SC, Hu QY, Li X, Zheng BY, Ke MR, Huang JD.

ACS Appl Mater Interfaces. 2019 Oct 9;11(40):36435-36443. doi: 10.1021/acsami.9b13861. Epub 2019 Sep 26.


Broad and Effective Protection against Staphylococcus aureus Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens.

Deng J, Wang X, Zhang BZ, Gao P, Lin Q, Kao RY, Gustafsson K, Yuen KY, Huang JD.

mSphere. 2019 Sep 4;4(5). pii: e00362-19. doi: 10.1128/mSphere.00362-19.


Theoretical study of charge-transport and optical properties of organic crystals: 4,5,9,10-pyrenedi-imides.

Huang JD, Yu K, Huang X, Chen D, Wen J, Cheng S, Ma H.

IUCrJ. 2019 May 9;6(Pt 4):603-609. doi: 10.1107/S2052252519004706. eCollection 2019 Jul 1.


Invasive-noninvasive Sequential Ventilation for the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Huang JD, Gu TJ, Hu ZL, Zhou DF, Ying J.

Comb Chem High Throughput Screen. 2019;22(3):160-168. doi: 10.2174/1386207322666190415101408.


Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity.

Lin R, Duan Z, Sun H, Fung ML, Chen H, Wang J, Lau CF, Yang D, Liu Y, Ni Y, Wang Z, Cui J, Wu W, Yung WH, Chan YS, Lo ACY, Xia J, Shen J, Huang JD.

iScience. 2019 Mar 29;13:82-97. doi: 10.1016/j.isci.2019.02.009. Epub 2019 Feb 18.


A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating.

Ni YX, Zhou N, Xue WQ, Rong L, Yung WH, Lin RZ, Kao RY, Duan ZG, Sun HT, Gong HR, Tang XM, Liu MF, Zhang W, Qi S, Chung S, Song YQ, Huang JD.

Cell Discov. 2018 Dec 25;4:65. doi: 10.1038/s41421-018-0067-5. eCollection 2018.


In Vivo Albumin Traps Photosensitizer Monomers from Self-Assembled Phthalocyanine Nanovesicles: A Facile and Switchable Theranostic Approach.

Li X, Yu S, Lee Y, Guo T, Kwon N, Lee D, Yeom SC, Cho Y, Kim G, Huang JD, Choi S, Nam KT, Yoon J.

J Am Chem Soc. 2019 Jan 23;141(3):1366-1372. doi: 10.1021/jacs.8b12167. Epub 2019 Jan 2.


Establishment of a lethal aged mouse model of human respiratory syncytial virus infection.

Zhang K, Li C, Luo YS, Wen L, Yuan S, Wang D, Ho-Yin Wong B, Zhao X, Chiu MC, Ye ZW, Sun Z, Zhao H, Zhang X, Hu M, Yang D, Shuai H, Wang Y, He J, Bose ME, Henrickson KJ, Huang JD, Zheng B, Chu H, Zhou J.

Antiviral Res. 2019 Jan;161:125-133. doi: 10.1016/j.antiviral.2018.11.015. Epub 2018 Nov 29.


A pH-responsive stellate mesoporous silica based nanophotosensitizer for in vivo cancer diagnosis and targeted photodynamic therapy.

Lin AL, Li SZ, Xu CH, Li XS, Zheng BY, Gu JJ, Ke MR, Huang JD.

Biomater Sci. 2018 Dec 18;7(1):211-219. doi: 10.1039/c8bm00386f.


Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas.

Liu JQ, Xu Y, Xiao Q, Huang JD, Ma JJ, Lian CL, Huang MY, Du ZB, Wang CF.

Org Biomol Chem. 2018 Sep 26;16(37):8305-8310. doi: 10.1039/c8ob02082e.


A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma.

Liu L, Zong ZM, Liu Q, Jiang SS, Zhang Q, Cen LQ, Gao J, Gao XG, Huang JD, Liu Y, Yao H.

Biomaterials. 2018 Nov;184:20-30. doi: 10.1016/j.biomaterials.2018.08.064. Epub 2018 Sep 1.


A SIRT1-centered circuitry regulates breast cancer stemness and metastasis.

Shi L, Tang X, Qian M, Liu Z, Meng F, Fu L, Wang Z, Zhu WG, Huang JD, Zhou Z, Liu B.

Oncogene. 2018 Dec;37(49):6299-6315. doi: 10.1038/s41388-018-0370-5. Epub 2018 Jul 23.


Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy.

Li X, Lee D, Huang JD, Yoon J.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9885-9890. doi: 10.1002/anie.201806551. Epub 2018 Jul 4.


Synthesis and photodynamic activities of integrin-targeting silicon(IV) phthalocyanine-cRGD conjugates.

Zheng BY, Yang XQ, Zhao Y, Zheng QF, Ke MR, Lin T, Chen RX, Ho KKK, Kumar N, Huang JD.

Eur J Med Chem. 2018 Jul 15;155:24-33. doi: 10.1016/j.ejmech.2018.05.039. Epub 2018 May 26.


Progress in the development of nanosensitizers for X-ray-induced photodynamic therapy.

Ren XD, Hao XY, Li HC, Ke MR, Zheng BY, Huang JD.

Drug Discov Today. 2018 Oct;23(10):1791-1800. doi: 10.1016/j.drudis.2018.05.029. Epub 2018 May 24. Review.


Morphology of reproductive accessory glands in female Sepia pharaonis (Cephalopoda: Sepiidae) sheds light on egg encapsulation.

Huang JD, Lee SY, Chiang TY, Lu CC, Lee MF.

J Morphol. 2018 Aug;279(8):1120-1131. doi: 10.1002/jmor.20835. Epub 2018 May 6.


Live attenuated Salmonella typhimurium vaccines delivering SaEsxA and SaEsxB via type III secretion system confer protection against Staphylococcus aureus infection.

Xu C, Zhang BZ, Lin Q, Deng J, Yu B, Arya S, Yuen KY, Huang JD.

BMC Infect Dis. 2018 Apr 25;18(1):195. doi: 10.1186/s12879-018-3104-y.


New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates.

Li X, Peng XH, Zheng BD, Tang J, Zhao Y, Zheng BY, Ke MR, Huang JD.

Chem Sci. 2018 Jan 8;9(8):2098-2104. doi: 10.1039/c7sc05115h. eCollection 2018 Feb 28.


Effects of interleukin-6 and IL-6/AMPK signaling pathway on mitochondrial biogenesis and astrocytes viability under experimental septic condition.

Chen XL, Wang Y, Peng WW, Zheng YJ, Zhang TN, Wang PJ, Huang JD, Zeng QY.

Int Immunopharmacol. 2018 Jun;59:287-294. doi: 10.1016/j.intimp.2018.04.020. Epub 2018 Apr 16.


Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability.

Adam F, Kauskot A, Kurowska M, Goudin N, Munoz I, Bordet JC, Huang JD, Bryckaert M, Fischer A, Borgel D, de Saint Basile G, Christophe OD, Ménasché G.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1037-1051. doi: 10.1161/ATVBAHA.117.310373. Epub 2018 Mar 8.


Use of a Bayesian approach in the design and evaluation of NCE2s.

Wang CY, Chang LC, Lin MS, Hsiao CF, Huang JD.

J Food Drug Anal. 2018 Jan;26(1):416-421. doi: 10.1016/j.jfda.2017.07.010. Epub 2017 Sep 19.


Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy.

Chen HJ, Zhou XB, Wang AL, Zheng BY, Yeh CK, Huang JD.

Eur J Med Chem. 2018 Feb 10;145:86-95. doi: 10.1016/j.ejmech.2017.12.091. Epub 2018 Jan 2.


Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy.

Li X, Yu S, Lee D, Kim G, Lee B, Cho Y, Zheng BY, Ke MR, Huang JD, Nam KT, Chen X, Yoon J.

ACS Nano. 2018 Jan 23;12(1):681-688. doi: 10.1021/acsnano.7b07809. Epub 2017 Dec 22.


Charge-transport properties of 4-(1,2,2-tri-phenyl-vinyl)-aniline salicylaldehyde hydrazone: tight-packing induced molecular 'hardening'.

Ma H, Chai S, Chen D, Huang JD.

IUCrJ. 2017 Sep 1;4(Pt 5):695-699. doi: 10.1107/S2052252517010685. eCollection 2017 Sep 1.


rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis.

Chen WC, Wang WC, Okada Y, Chang WP, Chou YH, Chang HH, Huang JD, Chen DY, Chang WC.

Oncotarget. 2017 Jul 18;8(38):64180-64190. doi: 10.18632/oncotarget.19419. eCollection 2017 Sep 8.


In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release.

Li CJ, Ku MY, Lu CY, Tien YE, Chern WH, Huang JD.

Int J Pharm. 2017 Oct 5;531(1):306-312. doi: 10.1016/j.ijpharm.2017.08.083. Epub 2017 Aug 25.


A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity.

Li X, Zheng BY, Ke MR, Zhang Y, Huang JD, Yoon J.

Theranostics. 2017 Jul 7;7(10):2746-2756. doi: 10.7150/thno.18861. eCollection 2017.


Treatment of Neuroblastoma with an Engineered "Obligate" Anaerobic Salmonella typhimurium Strain YB1.

Ning BT, Yu B, Chan S, Chan JL, Huang JD, Chan GC.

J Cancer. 2017 Jun 3;8(9):1609-1618. doi: 10.7150/jca.18776. eCollection 2017.


Pharmacokinetics of dinalbuphine sebacate and nalbuphine in human after intramuscular injection of dinalbuphine sebacate in an extended-release formulation.

Tien YE, Huang WC, Kuo HY, Tai L, Uang YS, Chern WH, Huang JD.

Biopharm Drug Dispos. 2017 Nov;38(8):494-497. doi: 10.1002/bdd.2088. Epub 2017 Sep 14.


Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model.

Zhang BZ, Cai J, Yu B, Xiong L, Lin Q, Yang XY, Xu C, Zheng S, Kao RY, Sze K, Yuen KY, Huang JD.

J Infect Dis. 2017 Jul 15;216(2):245-253. doi: 10.1093/infdis/jix290.


[Importance of segmental lymph nodes in the pathological staging of non-small cell lung cancer].

Huang JD, Li XD, Wang RQ, Huang H, Ouyang HC, Yang H.

Zhonghua Yi Xue Za Zhi. 2017 Jun 13;97(22):1714-1718. doi: 10.3760/cma.j.issn.0376-2491.2017.22.008. Chinese.


Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic review and meta-analysis.

Huang JD, Dong CH, Shao SW, Gu TJ, Hu ZL, Ying J, Zhou DF, Xie YP.

Bull Cancer. 2017 Jul - Aug;104(7-8):675-682. doi: 10.1016/j.bulcan.2017.05.001. Epub 2017 Jun 3. Review.


Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin.

Lui NC, Tam WY, Gao C, Huang JD, Wang CC, Jiang L, Yung WH, Kwan KM.

Nat Commun. 2017 May 18;8:15079. doi: 10.1038/ncomms15079.


Pre- versus post-mass extinction divergence of Mesozoic marine reptiles dictated by time-scale dependence of evolutionary rates.

Motani R, Jiang DY, Tintori A, Ji C, Huang JD.

Proc Biol Sci. 2017 May 17;284(1854). pii: 20170241. doi: 10.1098/rspb.2017.0241.


C-Phycocyanin as a tumour-associated macrophage-targeted photosensitiser and a vehicle of phthalocyanine for enhanced photodynamic therapy.

Wan DH, Zheng BY, Ke MR, Duan JY, Zheng YQ, Yeh CK, Huang JD.

Chem Commun (Camb). 2017 Apr 6;53(29):4112-4115. doi: 10.1039/c6cc09541k.


Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.

Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E.

Cell Res. 2017 Apr;27(4):461-482. doi: 10.1038/cr.2017.34. Epub 2017 Mar 14.


Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.

Cui J, Pang J, Lin YJ, Gong H, Wang ZH, Li YX, Li J, Wang Z, Jiang P, Dai DP, Li J, Cai JP, Huang JD, Zhang TM.

FASEB J. 2017 Jun;31(6):2533-2547. doi: 10.1096/fj.201601103R. Epub 2017 Feb 27.


Pharmacokinetics and protein binding of MPT0B292.

Tien YE, Li CJ, Liou JP, Chang JY, Huang JD.

Biopharm Drug Dispos. 2017 Jul;38(5):340-350. doi: 10.1002/bdd.2067. Epub 2017 Feb 27.


'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice.

Li CX, Yu B, Shi L, Geng W, Lin QB, Ling CC, Yang M, Ng KT, Huang JD, Man K.

Oncol Lett. 2017 Jan;13(1):177-183. doi: 10.3892/ol.2016.5453. Epub 2016 Nov 30.


Synthetic circuits that process multiple light and chemical signal inputs.

Liu L, Huang W, Huang JD.

BMC Syst Biol. 2017 Jan 19;11(1):5. doi: 10.1186/s12918-016-0384-y.


A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy.

Ke MR, Chen SF, Peng XH, Zheng QF, Zheng BY, Yeh CK, Huang JD.

Eur J Med Chem. 2017 Feb 15;127:200-209. doi: 10.1016/j.ejmech.2016.12.056. Epub 2016 Dec 29.


rs657075 (CSF2) Is Associated with the Disease Phenotype (BAS-G) of Ankylosing Spondylitis.

Chen WC, Wei JC, Lu HF, Wong HS, Woon PY, Hsu YW, Huang JD, Chang WC.

Int J Mol Sci. 2017 Jan 3;18(1). pii: E83. doi: 10.3390/ijms18010083.


Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.

Munoz I, Danelli L, Claver J, Goudin N, Kurowska M, Madera-Salcedo IK, Huang JD, Fischer A, González-Espinosa C, de Saint Basile G, Blank U, Ménasché G.

J Cell Biol. 2016 Oct 24;215(2):203-216.


A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile.

Zhang BZ, Cai J, Yu B, Hua Y, Lau CC, Kao RY, Sze KH, Yuen KY, Huang JD.

BMC Infect Dis. 2016 Oct 22;16(1):596.


Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice.

Shi L, Yu B, Cai CH, Huang JD.

AMB Express. 2016 Dec;6(1):56. doi: 10.1186/s13568-016-0226-8. Epub 2016 Aug 24.


A bioshield against influenza virus infection by commensal bacteria secreting antiviral peptide.

Huang JD, Zheng BJ, Yuen KY.

Hong Kong Med J. 2016 Jun;22(3 Suppl 4):13-5. No abstract available.

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