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Items: 1 to 50 of 133

1.

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr.

Atherosclerosis. 2018 Aug 30;277:145-154. doi: 10.1016/j.atherosclerosis.2018.08.042. [Epub ahead of print]

PMID:
30212683
2.

HIPK2-Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death.

Shang Y, Zhang J, Huang EJ.

J Neurosci. 2018 Apr 18;38(16):4006-4019. doi: 10.1523/JNEUROSCI.3577-17.2018. Epub 2018 Mar 26.

PMID:
29581378
3.

The relationship between age, axial length and retinal nerve fiber layer thickness in the normal elderly population in Taiwan: The Chiayi eye study in Taiwan.

Chen CY, Huang EJ, Kuo CN, Wu PL, Chen CL, Wu PC, Wu SH, King YC, Lai CH.

PLoS One. 2018 Mar 9;13(3):e0194116. doi: 10.1371/journal.pone.0194116. eCollection 2018.

4.

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.

Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A.

Nature. 2018 Mar 15;555(7696):377-381. doi: 10.1038/nature25975. Epub 2018 Mar 7.

PMID:
29513649
5.

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2849-E2858. doi: 10.1073/pnas.1722344115. Epub 2018 Mar 6.

6.

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski JQ, Miller BL, Seeley WW.

Neurology. 2018 Mar 20;90(12):e1047-e1056. doi: 10.1212/WNL.0000000000005163. Epub 2018 Feb 16.

PMID:
29453245
7.

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.

Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K.

Neuron. 2017 Dec 6;96(5):1003-1012.e7. doi: 10.1016/j.neuron.2017.10.008. Epub 2017 Nov 2.

8.

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW.

Brain. 2017 Dec 1;140(12):3329-3345. doi: 10.1093/brain/awx254.

PMID:
29053860
9.

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.

Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG.

Cell Rep. 2017 Oct 10;21(2):517-532. doi: 10.1016/j.celrep.2017.09.047.

10.

An RNA interference screen identifies druggable regulators of MeCP2 stability.

Lombardi LM, Zaghlula M, Sztainberg Y, Baker SA, Klisch TJ, Tang AA, Huang EJ, Zoghbi HY.

Sci Transl Med. 2017 Aug 23;9(404). pii: eaaf7588. doi: 10.1126/scitranslmed.aaf7588.

11.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. doi: 10.1126/scitranslmed.aag0394.

12.

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.

Rakotomamonjy J, Brunner M, Jüschke C, Zang K, Huang EJ, Reichardt LF, Chenn A.

Neural Dev. 2017 May 8;12(1):7. doi: 10.1186/s13064-017-0085-2.

13.

Progranulin, lysosomal regulation and neurodegenerative disease.

Kao AW, McKay A, Singh PP, Brunet A, Huang EJ.

Nat Rev Neurosci. 2017 Jun;18(6):325-333. doi: 10.1038/nrn.2017.36. Epub 2017 Apr 24. Review.

14.

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.

Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K.

Neurochem Int. 2017 Oct;109:106-116. doi: 10.1016/j.neuint.2017.04.006. Epub 2017 Apr 20.

PMID:
28434973
15.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.

16.

Testing the Amyloid Hypothesis with a Humanized AD Mouse Model.

Cahill MK, Huang EJ.

Neuron. 2017 Mar 8;93(5):987-989. doi: 10.1016/j.neuron.2017.02.044. Review.

17.

Precipitous Deterioration of Motor Function, Cognition, and Behavior.

Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD.

JAMA Neurol. 2017 May 1;74(5):591-596. doi: 10.1001/jamaneurol.2016.6159.

18.

Typical and atypical pathology in primary progressive aphasia variants.

Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML.

Ann Neurol. 2017 Mar;81(3):430-443. doi: 10.1002/ana.24885. Epub 2017 Mar 20.

19.

Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.

Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL.

Elife. 2017 Jan 10;6. pii: e19032. doi: 10.7554/eLife.19032.

20.
21.

Inequality in treatment benefits: Can we determine if a new treatment benefits the many or the few?

Huang EJ, Fang EX, Hanley DF, Rosenblum M.

Biostatistics. 2017 Apr 1;18(2):308-324. doi: 10.1093/biostatistics/kxw049.

22.

TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning.

Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler JL, Ding JB, Huang EJ.

Cell Rep. 2016 Dec 20;17(12):3233-3245. doi: 10.1016/j.celrep.2016.11.068.

23.

Extensive migration of young neurons into the infant human frontal lobe.

Paredes MF, James D, Gil-Perotin S, Kim H, Cotter JA, Ng C, Sandoval K, Rowitch DH, Xu D, McQuillen PS, Garcia-Verdugo JM, Huang EJ, Alvarez-Buylla A.

Science. 2016 Oct 7;354(6308). pii: aaf7073.

24.
25.

Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis.

Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, Lee VM, Trojanowski JQ, Chan JR, Huang EJ.

Neuron. 2016 Jul 6;91(1):41-55. doi: 10.1016/j.neuron.2016.05.021. Epub 2016 Jun 16.

26.

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.

Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV Jr, Paz JT, Barres BA, Huang EJ.

Cell. 2016 May 5;165(4):921-35. doi: 10.1016/j.cell.2016.04.001. Epub 2016 Apr 21.

27.

Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis.

Shang Y, Huang EJ.

Brain Res. 2016 Sep 15;1647:65-78. doi: 10.1016/j.brainres.2016.03.036. Epub 2016 Mar 28. Review.

28.

Deep vein thrombosis due to continuous prone positioning after retinal detachment surgery.

Wang CP, Huang EJ, Kuo CN, Lai CH.

Taiwan J Ophthalmol. 2016 Apr-Jun;6(2):96-97. doi: 10.1016/j.tjo.2015.05.002. Epub 2015 Aug 6.

29.

Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia.

Kim EJ, Sidhu M, Gaus SE, Huang EJ, Hof PR, Miller BL, DeArmond SJ, Seeley WW.

Cereb Cortex. 2016 Apr;26(4):1843. doi: 10.1093/cercor/bhw012. Epub 2016 Jan 20. No abstract available.

PMID:
26796215
30.

Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.

Luo SX, Huang EJ.

Am J Pathol. 2016 Mar;186(3):478-88. doi: 10.1016/j.ajpath.2015.09.023. Epub 2015 Dec 24. Review.

31.

Ventral midbrain dopaminergic neurons: From neurogenesis to neurodegeneration.

Huang EJ.

FEBS Lett. 2015 Dec 21;589(24 Pt A):3691-2. doi: 10.1016/j.febslet.2015.11.008. Epub 2015 Nov 12. No abstract available.

32.

Modeling ALS and FTD with iPSC-derived neurons.

Lee S, Huang EJ.

Brain Res. 2017 Feb 1;1656:88-97. doi: 10.1016/j.brainres.2015.10.003. Epub 2015 Oct 14. Review.

33.

Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons.

Kim JI, Ganesan S, Luo SX, Wu YW, Park E, Huang EJ, Chen L, Ding JB.

Science. 2015 Oct 2;350(6256):102-6. doi: 10.1126/science.aac4690.

34.

Axial length and subfoveal choroidal thickness in individuals with age-related macular degeneration.

Wang CP, Lai CH, Huang EJ, Wu PL, Chen CL, Chen CY, King YC, Wu PC, Kuo CN.

Taiwan J Ophthalmol. 2015 Oct-Dec;5(4):169-176. doi: 10.1016/j.tjo.2015.10.002. Epub 2015 Nov 30.

35.

Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series.

Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD.

Neurol Clin Pract. 2015 Aug;5(4):285-295.

36.

Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections.

Fontana MF, Baccarella A, Kellar D, Oniskey TK, Terinate P, Rosenberg SD, Huang EJ, Herbert DR, Kim CC.

Parasite Immunol. 2015 Sep;37(9):470-8. doi: 10.1111/pim.12215.

37.

The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features.

Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD.

Brain. 2015 Sep;138(Pt 9):2732-49. doi: 10.1093/brain/awv191. Epub 2015 Jul 2.

38.

Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.

Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EM, Qiu H, Huang EJ, Ringe D, Petsko GA, Finkbeiner S.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7821-6. doi: 10.1073/pnas.1509744112. Epub 2015 Jun 8.

39.

Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome.

Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ.

Acta Neuropathol. 2015 Aug;130(2):171-83. doi: 10.1007/s00401-015-1441-0. Epub 2015 May 15.

40.

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.

Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin LW, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust W.

Brain. 2015 Jul;138(Pt 7):2020-33. doi: 10.1093/brain/awv112. Epub 2015 May 6.

41.

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.

Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW.

Nat Commun. 2015 Jan 27;6:6171. doi: 10.1038/ncomms7171.

42.

Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO.

Gelfand JM, Cotter J, Klingman J, Huang EJ, Cree BA.

Neurol Neuroimmunol Neuroinflamm. 2014 Oct 9;1(3):e34. doi: 10.1212/NXI.0000000000000034. eCollection 2014 Oct.

43.

Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.

Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K.

J Neurosci. 2014 Oct 22;34(43):14304-17. doi: 10.1523/JNEUROSCI.0930-14.2014.

44.

Activity-dependent FUS dysregulation disrupts synaptic homeostasis.

Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78. doi: 10.1073/pnas.1406162111. Epub 2014 Oct 16.

45.

Postnatal growth of the human pons: a morphometric and immunohistochemical analysis.

Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A.

J Comp Neurol. 2015 Feb 15;523(3):449-62. doi: 10.1002/cne.23690. Epub 2014 Dec 2.

46.

Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.

Nielsen CM, Cuervo H, Ding VW, Kong Y, Huang EJ, Wang RA.

Development. 2014 Oct;141(19):3782-92. doi: 10.1242/dev.108951. Epub 2014 Sep 10.

47.

CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.

Hsieh CL, Niemi EC, Wang SH, Lee CC, Bingham D, Zhang J, Cozen ML, Charo I, Huang EJ, Liu J, Nakamura MC.

J Neurotrauma. 2014 Oct 15;31(20):1677-88. doi: 10.1089/neu.2013.3252. Epub 2014 Jul 21.

48.

Prevalence and risk factors for age-related macular degeneration in the elderly Chinese population in south-western Taiwan: the Puzih eye study.

Huang EJ, Wu SH, Lai CH, Kuo CN, Wu PL, Chen CL, Chen CY, King YC, Wu PC.

Eye (Lond). 2014 Jun;28(6):705-14. doi: 10.1038/eye.2014.55. Epub 2014 Mar 14.

49.

Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer.

Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH.

Nat Neurosci. 2014 Apr;17(4):506-12. doi: 10.1038/nn.3676. Epub 2014 Mar 9. Erratum in: Nat Neurosci. 2014 Dec;17(12):1841.

50.

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.

Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ.

J Clin Invest. 2014 Mar;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10.

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