Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 227


Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma.

Blombery P, Birkinshaw RW, Nguyen T, Gong JN, Thompson ER, Xu Z, Westerman DA, Czabotar PE, Dickinson M, Huang DCS, Seymour JF, Roberts AW.

Br J Haematol. 2019 Jun 24. doi: 10.1111/bjh.16069. [Epub ahead of print] No abstract available.


Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.

Birkinshaw RW, Gong JN, Luo CS, Lio D, White CA, Anderson MA, Blombery P, Lessene G, Majewski IJ, Thijssen R, Roberts AW, Huang DCS, Colman PM, Czabotar PE.

Nat Commun. 2019 Jun 3;10(1):2385. doi: 10.1038/s41467-019-10363-1.


Preparation and in vitro absorption studies of a novel polysaccharide‑iron (III) complex from Flammulina velutipes.

Cheng C, Huang DC, Zhao LY, Cao CJ, Chen GT.

Int J Biol Macromol. 2019 Jul 1;132:801-810. doi: 10.1016/j.ijbiomac.2019.04.015. Epub 2019 Apr 3.


Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product.

Zhang MC, Gu SH, Liu GP, Li CC, Xu HM, Wu ZX, Ye BP, Lu YY, Huang DC, Wang ZX, Jiang F.

Comb Chem High Throughput Screen. 2019;22(1):35-40. doi: 10.2174/1386207322666190307125015.


Immunomodulatory activities of proteins from Astragalus membranaceus waste.

Huang H, Luo SH, Huang DC, Cheng SJ, Cao CJ, Chen GT.

J Sci Food Agric. 2019 Jun;99(8):4174-4181. doi: 10.1002/jsfa.9650. Epub 2019 Mar 21.


KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs.

Liu H, Sun M, Liu Z, Kong C, Kong W, Ye J, Gong J, Huang DCS, Qian F.

J Control Release. 2019 Feb 28;296:40-53. doi: 10.1016/j.jconrel.2019.01.014. Epub 2019 Jan 15.


Genetic effects of vascular endothelial growth factor and its receptor 2 on feather maturity in three chicken breeds.

Tan SW, Li PZ, Li H, Yu H, Zhang ZF, Zeng Z, Huang DC.

Br Poult Sci. 2019 Apr;60(2):109-114. doi: 10.1080/00071668.2018.1564244. Epub 2019 Feb 20.


Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.

Blombery P, Anderson MA, Gong JN, Thijssen R, Birkinshaw RW, Thompson ER, Teh CE, Nguyen T, Xu Z, Flensburg C, Lew TE, Majewski IJ, Gray DHD, Westerman DA, Tam CS, Seymour JF, Czabotar PE, Huang DCS, Roberts AW.

Cancer Discov. 2019 Mar;9(3):342-353. doi: 10.1158/2159-8290.CD-18-1119. Epub 2018 Dec 4.


The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.

Vince JE, De Nardo D, Gao W, Vince AJ, Hall C, McArthur K, Simpson D, Vijayaraj S, Lindqvist LM, Bouillet P, Rizzacasa MA, Man SM, Silke J, Masters SL, Lessene G, Huang DCS, Gray DHD, Kile BT, Shao F, Lawlor KE.

Cell Rep. 2018 Nov 27;25(9):2339-2353.e4. doi: 10.1016/j.celrep.2018.10.103.


VDAC2 enables BAX to mediate apoptosis and limit tumor development.

Chin HS, Li MX, Tan IKL, Ninnis RL, Reljic B, Scicluna K, Dagley LF, Sandow JJ, Kelly GL, Samson AL, Chappaz S, Khaw SL, Chang C, Morokoff A, Brinkmann K, Webb A, Hockings C, Hall CM, Kueh AJ, Ryan MT, Kluck RM, Bouillet P, Herold MJ, Gray DHD, Huang DCS, van Delft MF, Dewson G.

Nat Commun. 2018 Nov 26;9(1):4976. doi: 10.1038/s41467-018-07309-4.


Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma.

Agarwal R, Chan YC, Tam CS, Hunter T, Vassiliadis D, Teh CE, Thijssen R, Yeh P, Wong SQ, Ftouni S, Lam EYN, Anderson MA, Pott C, Gilan O, Bell CC, Knezevic K, Blombery P, Rayeroux K, Zordan A, Li J, Huang DCS, Wall M, Seymour JF, Gray DHD, Roberts AW, Dawson MA, Dawson SJ.

Nat Med. 2019 Jan;25(1):119-129. doi: 10.1038/s41591-018-0243-z. Epub 2018 Nov 19.


Infection with flaviviruses requires BCLXL for cell survival.

Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y.

PLoS Pathog. 2018 Sep 27;14(9):e1007299. doi: 10.1371/journal.ppat.1007299. eCollection 2018 Sep.


CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells.

Nie M, Wang Y, Guo C, Li X, Wang Y, Deng Y, Yao B, Gui T, Ma C, Liu M, Wang P, Wang R, Tan R, Fang M, Chen B, He Y, Huang DCS, Ju J, Zhao Q.

J Biol Chem. 2018 Nov 9;293(45):17454-17463. doi: 10.1074/jbc.RA118.004028. Epub 2018 Sep 26.


AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980.


IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos.

Fedele PL, Willis SN, Liao Y, Low MS, Rautela J, Segal DH, Gong JN, Huntington ND, Shi W, Huang DCS, Grigoriadis G, Tellier J, Nutt SL.

Blood. 2018 Nov 15;132(20):2166-2178. doi: 10.1182/blood-2018-05-850727. Epub 2018 Sep 18.


Nonlinear Polyfused Aromatics with Extended π-Conjugation from Phenanthrotriphenylene, Tetracene, and Pentacene: Syntheses, Crystal Packings, and Properties.

Kumar S, Huang DC, Venkateswarlu S, Tao YT.

J Org Chem. 2018 Oct 5;83(19):11614-11622. doi: 10.1021/acs.joc.8b01582. Epub 2018 Sep 5.


Gender Variation in the Shape of Superior Talar Dome: A Cadaver Measurement Based on Chinese Population.

Zhao DH, Huang DC, Zhang GH, Shi JQ, Wang C, Geng X, Wang X, Ma X.

Biomed Res Int. 2018 Jul 4;2018:6087871. doi: 10.1155/2018/6087871. eCollection 2018.


Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma.

Song TL, Nairismägi ML, Laurensia Y, Lim JQ, Tan J, Li ZM, Pang WL, Kizhakeyil A, Wijaya GC, Huang DC, Nagarajan S, Chia BK, Cheah D, Liu YH, Zhang F, Rao HL, Tang T, Wong EK, Bei JX, Iqbal J, Grigoropoulos NF, Ng SB, Chng WJ, Teh BT, Tan SY, Verma NK, Fan H, Lim ST, Ong CK.

Blood. 2018 Sep 13;132(11):1146-1158. doi: 10.1182/blood-2018-01-829424. Epub 2018 Jul 27.


A Phase I/Randomized Phase II Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Nintedanib versus Sorafenib in Asian Patients with Advanced Hepatocellular Carcinoma.

Yen CJ, Kim TY, Feng YH, Chao Y, Lin DY, Ryoo BY, Huang DC, Schnell D, Hocke J, Loembé AB, Cheng AL.

Liver Cancer. 2018 May;7(2):165-178. doi: 10.1159/000486460. Epub 2018 Mar 15.


BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming.

Kim EJY, Anko ML, Flensberg C, Majewski IJ, Geng FS, Firas J, Huang DCS, van Delft MF, Heath JK.

Stem Cell Reports. 2018 Feb 13;10(2):331-338. doi: 10.1016/j.stemcr.2017.12.019. Epub 2018 Jan 18.


Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.

Sharp PP, Garnier JM, Hatfaludi T, Xu Z, Segal D, Jarman KE, Jousset H, Garnham A, Feutrill JT, Cuzzupe A, Hall P, Taylor S, Walkley CR, Tyler D, Dawson MA, Czabotar P, Wilks AF, Glaser S, Huang DCS, Burns CJ.

ACS Med Chem Lett. 2017 Nov 14;8(12):1298-1303. doi: 10.1021/acsmedchemlett.7b00389. eCollection 2017 Dec 14.


NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.

Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q.

Nat Commun. 2017 Oct 13;8(1):928. doi: 10.1038/s41467-017-00988-5.


Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia.

McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS, Burns CJ, Croker BA.

Oncotarget. 2017 Jul 28;8(35):57948-57963. doi: 10.18632/oncotarget.19678. eCollection 2017 Aug 29.


Monitoring hand, foot and mouth disease by combining search engine query data and meteorological factors.

Huang DC, Wang JF.

Sci Total Environ. 2018 Jan 15;612:1293-1299. doi: 10.1016/j.scitotenv.2017.09.017. Epub 2017 Sep 8.


Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer.

Merino D, Whittle JR, Vaillant F, Serrano A, Gong JN, Giner G, Maragno AL, Chanrion M, Schneider E, Pal B, Li X, Dewson G, Gräsel J, Liu K, Lalaoui N, Segal D, Herold MJ, Huang DCS, Smyth GK, Geneste O, Lessene G, Visvader JE, Lindeman GJ.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam7049. doi: 10.1126/scitranslmed.aam7049.


Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

Teh TC, Nguyen NY, Moujalled DM, Segal D, Pomilio G, Rijal S, Jabbour A, Cummins K, Lackovic K, Blombery P, Thompson E, Ekert PG, Lessene G, Glaser SP, Huang DCS, Roberts AW, Guthridge MA, Wei AH.

Leukemia. 2018 Feb;32(2):303-312. doi: 10.1038/leu.2017.243. Epub 2017 Jul 28.


Effects of Tumor Necrosis Factor Blocker on Salicylate-Induced Tinnitus in Mice.

Hwang JH, Huang DC, Lu YC, Yang WS, Liu TC.

Int Tinnitus J. 2017 Jun 1;21(1):24-29. doi: 10.5935/0946-5448.20170006.


Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax.

Anderson MA, Tam C, Lew TE, Juneja S, Juneja M, Westerman D, Wall M, Lade S, Gorelik A, Huang DCS, Seymour JF, Roberts AW.

Blood. 2017 Jun 22;129(25):3362-3370. doi: 10.1182/blood-2017-01-763003. Epub 2017 May 4.


DR5 and caspase-8 are dispensable in ER stress-induced apoptosis.

Glab JA, Doerflinger M, Nedeva C, Jose I, Mbogo GW, Paton JC, Paton AW, Kueh AJ, Herold MJ, Huang DC, Segal D, Brumatti G, Puthalakath H.

Cell Death Differ. 2017 May;24(5):944-950. doi: 10.1038/cdd.2017.53. Epub 2017 Apr 14.


Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM.

Cell Death Differ. 2017 May;24(5):878-888. doi: 10.1038/cdd.2017.30. Epub 2017 Mar 31.


Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia.

Roberts AW, Stilgenbauer S, Seymour JF, Huang DCS.

Clin Cancer Res. 2017 Aug 15;23(16):4527-4533. doi: 10.1158/1078-0432.CCR-16-0955. Epub 2017 Jan 18. Review.


Does tracheal intubation really matter? Discrepant survival between laryngeal mask and endotracheal intubation during out-of-hospital cardiac arrest.

Fan YJ, Dai CY, Huang DC, Wang ML.

J Formos Med Assoc. 2017 Feb;116(2):134-135. doi: 10.1016/j.jfma.2016.11.001. Epub 2016 Dec 18. No abstract available.


The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O.

Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19.


Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

Rohrbeck L, Gong JN, Lee EF, Kueh AJ, Behren A, Tai L, Lessene G, Huang DC, Fairlie WD, Strasser A, Herold MJ.

Cell Death Differ. 2016 Dec;23(12):2054-2062. doi: 10.1038/cdd.2016.96. Epub 2016 Sep 30.


Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.

Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T.

Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34.


MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM.

Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237.


Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

Gong JN, Khong T, Segal D, Yao Y, Riffkin CD, Garnier JM, Khaw SL, Lessene G, Spencer A, Herold MJ, Roberts AW, Huang DCS.

Blood. 2016 Oct 6;128(14):1834-1844. doi: 10.1182/blood-2016-03-704908. Epub 2016 Jul 27.


Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.

Khaw SL, Suryani S, Evans K, Richmond J, Robbins A, Kurmasheva RT, Billups CA, Erickson SW, Guo Y, Houghton PJ, Smith MA, Carol H, Roberts AW, Huang DC, Lock RB.

Blood. 2016 Sep 8;128(10):1382-95. doi: 10.1182/blood-2016-03-707414. Epub 2016 Jun 24.


Towards Identifying and Reducing the Bias of Disease Information Extracted from Search Engine Data.

Huang DC, Wang JF, Huang JX, Sui DZ, Zhang HY, Hu MG, Xu CD.

PLoS Comput Biol. 2016 Jun 6;12(6):e1004876. doi: 10.1371/journal.pcbi.1004876. eCollection 2016 Jun.


Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.

Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM.

Nat Commun. 2016 May 24;7:11734. doi: 10.1038/ncomms11734.


The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

Anderson MA, Deng J, Seymour JF, Tam C, Kim SY, Fein J, Yu L, Brown JR, Westerman D, Si EG, Majewski IJ, Segal D, Heitner Enschede SL, Huang DC, Davids MS, Letai A, Roberts AW.

Blood. 2016 Jun 23;127(25):3215-24. doi: 10.1182/blood-2016-01-688796. Epub 2016 Apr 11.


BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Xu Z, Sharp PP, Yao Y, Segal D, Ang CH, Khaw SL, Aubrey BJ, Gong J, Kelly GL, Herold MJ, Strasser A, Roberts AW, Alexander WS, Burns CJ, Huang DC, Glaser SP.

Leukemia. 2016 Jul;30(7):1531-41. doi: 10.1038/leu.2016.52. Epub 2016 Mar 8.


Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Valente LJ, Aubrey BJ, Herold MJ, Kelly GL, Happo L, Scott CL, Newbold A, Johnstone RW, Huang DC, Vassilev LT, Strasser A.

Cell Rep. 2016 Mar 1;14(8):1858-66. doi: 10.1016/j.celrep.2016.01.059. Epub 2016 Feb 18.


Current challenges and novel treatment strategies in double hit lymphomas.

Anderson MA, Tsui A, Wall M, Huang DC, Roberts AW.

Ther Adv Hematol. 2016 Feb;7(1):52-64. doi: 10.1177/2040620715608091. Review.


HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

Jacobsen AV, Lowes KN, Tanzer MC, Lucet IS, Hildebrand JM, Petrie EJ, van Delft MF, Liu Z, Conos SA, Zhang JG, Huang DC, Silke J, Lessene G, Murphy JM.

Cell Death Dis. 2016 Jan 14;7:e2051. doi: 10.1038/cddis.2015.386.


A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

Wölwer CB, Pase LB, Pearson HB, Gödde NJ, Lackovic K, Huang DC, Russell SM, Humbert PO.

PLoS One. 2015 Nov 16;10(11):e0142655. doi: 10.1371/journal.pone.0142655. eCollection 2015.


The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.

Ko TK, Chin HS, Chuah CT, Huang JW, Ng KP, Khaw SL, Huang DC, Ong ST.

Oncotarget. 2016 Jan 19;7(3):2721-33. doi: 10.18632/oncotarget.5436.


[Preparation of curcumin-EC sustained-release composite particles by supercritical CO2 anti-solvent technology].

Bai WL, Yan TY, Wang ZX, Huang DC, Yan TX, Li P.

Zhongguo Zhong Yao Za Zhi. 2015 Jan;40(2):226-30. Chinese.


Spatio-temporal analysis of malaria vectors in national malaria surveillance sites in China.

Huang JX, Xia ZG, Zhou SS, Pu XJ, Hu MG, Huang DC, Ren ZP, Zhang SS, Yang MN, Wang DQ, Wang JF.

Parasit Vectors. 2015 Mar 7;8:146. doi: 10.1186/s13071-015-0741-5.


Organic transistor memory with a charge storage molecular double-floating-gate monolayer.

Tseng CW, Huang DC, Tao YT.

ACS Appl Mater Interfaces. 2015 May 13;7(18):9767-75. doi: 10.1021/acsami.5b01625. Epub 2015 Apr 28.


Supplemental Content

Loading ...
Support Center