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Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.

Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP.

J Exp Med. 2019 Nov 4;216(11):2619-2634. doi: 10.1084/jem.20181218. Epub 2019 Aug 12.


Cytokine regulation of lung Th17 response to airway immunization using LPS adjuvant.

Caucheteux SM, Hu-Li J, Mohammed RN, Ager A, Paul WE.

Mucosal Immunol. 2017 Mar;10(2):361-372. doi: 10.1038/mi.2016.54. Epub 2016 Jun 22.


IL-1β enhances inflammatory TH2 differentiation.

Caucheteux SM, Hu-Li J, Guo L, Bhattacharyya N, Crank M, Collins MT, Paul WE.

J Allergy Clin Immunol. 2016 Sep;138(3):898-901.e4. doi: 10.1016/j.jaci.2016.02.033. Epub 2016 Apr 19. No abstract available.


Innate immunological function of TH2 cells in vivo.

Guo L, Huang Y, Chen X, Hu-Li J, Urban JF Jr, Paul WE.

Nat Immunol. 2015 Oct;16(10):1051-9. doi: 10.1038/ni.3244. Epub 2015 Aug 31.


IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.

Huang Y, Guo L, Qiu J, Chen X, Hu-Li J, Siebenlist U, Williamson PR, Urban JF Jr, Paul WE.

Nat Immunol. 2015 Feb;16(2):161-9. doi: 10.1038/ni.3078. Epub 2014 Dec 22.


Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection.

Wüthrich M, LeBert V, Galles K, Hu-Li J, Ben-Sasson SZ, Paul WE, Klein BS.

J Infect Dis. 2013 Oct 1;208(7):1175-82. doi: 10.1093/infdis/jit283. Epub 2013 Jun 20.


Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3.

Junttila IS, Watson C, Kummola L, Chen X, Hu-Li J, Guo L, Yagi R, Paul WE.

J Allergy Clin Immunol. 2013 Sep;132(3):704-712.e10. doi: 10.1016/j.jaci.2013.03.033. Epub 2013 May 14.


IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells.

Ben-Sasson SZ, Hogg A, Hu-Li J, Wingfield P, Chen X, Crank M, Caucheteux S, Ratner-Hurevich M, Berzofsky JA, Nir-Paz R, Paul WE.

J Exp Med. 2013 Mar 11;210(3):491-502. doi: 10.1084/jem.20122006. Epub 2013 Mar 4.


IL-1 acts on T cells to enhance the magnitude of in vivo immune responses.

Ben-Sasson SZ, Caucheteux S, Crank M, Hu-Li J, Paul WE.

Cytokine. 2011 Oct;56(1):122-5. doi: 10.1016/j.cyto.2011.07.006. Epub 2011 Aug 16. Review.


KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.

Lai D, Zhu J, Wang T, Hu-Li J, Terabe M, Berzofsky JA, Clayberger C, Krensky AM.

J Exp Med. 2011 May 9;208(5):1093-103. doi: 10.1084/jem.20101527. Epub 2011 Apr 11.


Regulation of microRNA expression and abundance during lymphopoiesis.

Kuchen S, Resch W, Yamane A, Kuo N, Li Z, Chakraborty T, Wei L, Laurence A, Yasuda T, Peng S, Hu-Li J, Lu K, Dubois W, Kitamura Y, Charles N, Sun HW, Muljo S, Schwartzberg PL, Paul WE, O'Shea J, Rajewsky K, Casellas R.

Immunity. 2010 Jun 25;32(6):828-39. doi: 10.1016/j.immuni.2010.05.009. Epub 2010 Jun 3.


IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.

Ben-Sasson SZ, Hu-Li J, Quiel J, Cauchetaux S, Ratner M, Shapira I, Dinarello CA, Paul WE.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7119-24. doi: 10.1073/pnas.0902745106. Epub 2009 Apr 9.


Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

Wei G, Wei L, Zhu J, Zang C, Hu-Li J, Yao Z, Cui K, Kanno Y, Roh TY, Watford WT, Schones DE, Peng W, Sun HW, Paul WE, O'Shea JJ, Zhao K.

Immunity. 2009 Jan 16;30(1):155-67. doi: 10.1016/j.immuni.2008.12.009.


Blimp-1 induced by IL-4 plays a critical role in suppressing IL-2 production in activated CD4 T cells.

Wang L, van Panhuys N, Hu-Li J, Kim S, Le Gros G, Min B.

J Immunol. 2008 Oct 15;181(8):5249-56.


In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation.

van Panhuys N, Tang SC, Prout M, Camberis M, Scarlett D, Roberts J, Hu-Li J, Paul WE, Le Gros G.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12423-8. doi: 10.1073/pnas.0806372105. Epub 2008 Aug 21.


Production of TH1 and TH2 cell lines and clones.

Fitch FW, Gajewski TF, Hu-Li J.

Curr Protoc Immunol. 2006 May;Chapter 3:Unit 3.13. doi: 10.1002/0471142735.im0313s72.


Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis.

Min B, Thornton A, Caucheteux SM, Younes SA, Oh K, Hu-Li J, Paul WE.

Eur J Immunol. 2007 Jul;37(7):1916-23.


Probabilistic regulation of IL-4 production.

Guo L, Hu-Li J, Paul WE.

J Clin Immunol. 2005 Nov;25(6):573-81. Review.


A critical control element for interleukin-4 memory expression in T helper lymphocytes.

Tykocinski LO, Hajkova P, Chang HD, Stamm T, Sözeri O, Löhning M, Hu-Li J, Niesner U, Kreher S, Friedrich B, Pannetier C, Grütz G, Walter J, Paul WE, Radbruch A.

J Biol Chem. 2005 Aug 5;280(31):28177-85. Epub 2005 Jun 7.


Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms.

Min B, Yamane H, Hu-Li J, Paul WE.

J Immunol. 2005 May 15;174(10):6039-44.


Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses.

Zhu J, Min B, Hu-Li J, Watson CJ, Grinberg A, Wang Q, Killeen N, Urban JF Jr, Guo L, Paul WE.

Nat Immunol. 2004 Nov;5(11):1157-65. Epub 2004 Oct 10.


Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite.

Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, Urban JF Jr, Dvorak AM, Finkelman FD, LeGros G, Paul WE.

J Exp Med. 2004 Aug 16;200(4):507-17.


Interleukin 2 plays a central role in Th2 differentiation.

Cote-Sierra J, Foucras G, Guo L, Chiodetti L, Young HA, Hu-Li J, Zhu J, Paul WE.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3880-5. Epub 2004 Mar 5.


Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation.

Löhning M, Richter A, Stamm T, Hu-Li J, Assenmacher M, Paul WE, Radbruch A.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12307-12. Epub 2003 Sep 26.


In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production.

Guo L, Hu-Li J, Zhu J, Watson CJ, Difilippantonio MJ, Pannetier C, Paul WE.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10623-8. Epub 2002 Jul 29.


Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.

Zhu J, Guo L, Min B, Watson CJ, Hu-Li J, Young HA, Tsichlis PN, Paul WE.

Immunity. 2002 May;16(5):733-44.


Interferon gamma stabilizes the T helper cell type 1 phenotype.

Zhang Y, Apilado R, Coleman J, Ben-Sasson S, Tsang S, Hu-Li J, Paul WE, Huang H.

J Exp Med. 2001 Jul 16;194(2):165-72.


Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion.

Zhu J, Guo L, Watson CJ, Hu-Li J, Paul WE.

J Immunol. 2001 Jun 15;166(12):7276-81.


Disrupting Il13 impairs production of IL-4 specified by the linked allele.

Guo L, Hu-Li J, Zhu J, Pannetier C, Watson C, McKenzie GJ, McKenzie AN, Paul WE.

Nat Immunol. 2001 May;2(5):461-6.


Bias in the expression of IL-4 alleles: the use of T cells from a GFP knock-in mouse.

Pannetier C, Hu-Li J, Paul WE.

Cold Spring Harb Symp Quant Biol. 1999;64:599-602. No abstract available.


Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene.

Hu-Li J, Pannetier C, Guo L, Löhning M, Gu H, Watson C, Assenmacher M, Radbruch A, Paul WE.

Immunity. 2001 Jan;14(1):1-11.


Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4.

Ben-Sasson SZ, Gerstel R, Hu-Li J, Paul WE.

J Immunol. 2001 Jan 1;166(1):112-20.


A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes.

Radu DL, Noben-Trauth N, Hu-Li J, Paul WE, Bona CA.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12700-4.


Transient inhibition of interleukin 4 signaling by T cell receptor ligation.

Zhu J, Huang H, Guo L, Stonehouse T, Watson CJ, Hu-Li J, Paul WE.

J Exp Med. 2000 Oct 16;192(8):1125-34.


Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation.

Noben-Trauth N, Hu-Li J, Paul WE.

J Immunol. 2000 Oct 1;165(7):3620-5.


Survival and cytokine polarization of naive CD4(+) T cells in vitro is largely dependent on exogenous cytokines.

Ben-Sasson SZ, Makedonski K, Hu-Li J, Paul WE.

Eur J Immunol. 2000 May;30(5):1308-17.


T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

Dent AL, Hu-Li J, Paul WE, Staudt LM.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13823-8.


Transient transfection of primary T helper cells by particle-mediated gene transfer.

Huang H, Pannetier C, Hu-Li J, Paul WE.

J Immunol Methods. 1998 Jun 1;215(1-2):173-7.


IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent.

Huang H, Hu-Li J, Chen H, Ben-Sasson SZ, Paul WE.

J Immunol. 1997 Oct 15;159(8):3731-8.


Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells.

Ryan JJ, Huang H, McReynolds LJ, Shelburne C, Hu-Li J, Huff TF, Paul WE.

Exp Hematol. 1997 Apr;25(4):357-62.


Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation.

Nelson N, Kanno Y, Hong C, Contursi C, Fujita T, Fowlkes BJ, O'Connell E, Hu-Li J, Paul WE, Jankovic D, Sher AF, Coligan JE, Thornton A, Appella E, Yang Y, Ozato K.

J Immunol. 1996 May 15;156(10):3711-20.


Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production.

Yoshimoto T, Bendelac A, Watson C, Hu-Li J, Paul WE.

Science. 1995 Dec 15;270(5243):1845-7.


Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

Yoshimoto T, Bendelac A, Hu-Li J, Paul WE.

Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11931-4.


Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, Russell SM, Drago J, Noguchi M, Grinberg A, Bloom ET, et al.

Immunity. 1995 Mar;2(3):223-38.

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