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From the Clinic to the Bench and Back Again in One Dog Year: How a Cross-Species Pipeline to Identify New Treatments for Sarcoma Illuminates the Path Forward in Precision Medicine.

Rao SR, Somarelli JA, Altunel E, Selmic LE, Byrum M, Sheth MU, Cheng S, Ware KE, Kim SY, Prinz JA, Devos N, Corcoran DL, Moseley A, Soderblom E, Hsu SD, Eward WC.

Front Oncol. 2020 Feb 11;10:117. doi: 10.3389/fonc.2020.00117. eCollection 2020.


A High-Throughput Interbacterial Competition Screen Identifies ClpAP in Enhancing Recipient Susceptibility to Type VI Secretion System-Mediated Attack by Agrobacterium tumefaciens.

Lin HH, Yu M, Sriramoju MK, Hsu SD, Liu CT, Lai EM.

Front Microbiol. 2020 Feb 5;10:3077. doi: 10.3389/fmicb.2019.03077. eCollection 2019.


Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans.

Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu SD.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1438-1446. doi: 10.1073/pnas.1908898117. Epub 2020 Jan 3.


Protein knots provide mechano-resilience to an AAA+ protease-mediated proteolysis with profound ATP energy expenses.

Sriramoju MK, Chen Y, Hsu SD.

Biochim Biophys Acta Proteins Proteom. 2020 Feb;1868(2):140330. doi: 10.1016/j.bbapap.2019.140330. Epub 2019 Nov 20.


Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism.

Wang YW, Liu CC, Cherng JH, Lin CS, Chang SJ, Hong ZJ, Liu CC, Chiu YK, Hsu SD, Chang AH.

Polymers (Basel). 2019 Nov 19;11(11). pii: E1906. doi: 10.3390/polym11111906.


Author Correction: Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer.

Lello L, Raben TG, Yong SY, Tellier LCAM, Hsu SDH.

Sci Rep. 2019 Nov 20;9(1):17515. doi: 10.1038/s41598-019-54426-1.


Improving Cancer Drug Discovery by Studying Cancer across the Tree of Life.

Somarelli JA, Boddy AM, Gardner HL, DeWitt SB, Tuohy J, Megquier K, Sheth MU, Hsu SD, Thorne JL, London CA, Eward WC.

Mol Biol Evol. 2020 Jan 1;37(1):11-17. doi: 10.1093/molbev/msz254.


A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer.

Strickler JH, Rushing CN, Niedzwiecki D, McLeod A, Altomare I, Uronis HE, Hsu SD, Zafar SY, Morse MA, Chang DZ, Wells JL, Blackwell KL, Marcom PK, Arrowood C, Bolch E, Haley S, Rangwala FA, Hatch AJ, Nixon AB, Hurwitz HI.

BMC Cancer. 2019 Nov 1;19(1):1032. doi: 10.1186/s12885-019-6234-8.


Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer.

Lello L, Raben TG, Yong SY, Tellier LCAM, Hsu SDH.

Sci Rep. 2019 Oct 25;9(1):15286. doi: 10.1038/s41598-019-51258-x. Erratum in: Sci Rep. 2019 Nov 20;9(1):17515.


Evaluation of Chitosan-based Dressings in a Swine Model of Artery-Injury-Related Shock.

Wang YH, Liu CC, Cherng JH, Fan GY, Wang YW, Chang SJ, Hong ZJ, Lin YC, Hsu SD.

Sci Rep. 2019 Oct 10;9(1):14608. doi: 10.1038/s41598-019-51208-7.


Risk of ocular complications following radiation therapy in patients with nasopharyngeal carcinoma.

Lin KT, Lee SY, Liu SC, Tsao CC, Hsu SD, Chien WC, Chung CH, Chang WK, Chen YW, Lin CS.

Laryngoscope. 2019 Aug 23. doi: 10.1002/lary.28254. [Epub ahead of print]


Targeting protein tyrosine phosphatase PTP-PEST (PTPN12) for therapeutic intervention in acute myocardial infarction.

Yang CF, Chen YY, Singh JP, Hsu SF, Liu YW, Yang CY, Chang CW, Chen SN, Shih RH, Hsu SD, Jou YS, Cheng CF, Meng TC.

Cardiovasc Res. 2020 Apr 1;116(5):1032-1046. doi: 10.1093/cvr/cvz165.


Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer.

Ko KT, Hu IC, Huang KF, Lyu PC, Hsu SD.

Structure. 2019 Aug 6;27(8):1224-1233.e4. doi: 10.1016/j.str.2019.04.004. Epub 2019 May 16.


Untying a Protein Knot by Circular Permutation.

Chuang YC, Hu IC, Lyu PC, Hsu SD.

J Mol Biol. 2019 Feb 15;431(4):857-863. doi: 10.1016/j.jmb.2019.01.005. Epub 2019 Jan 9.


Soluble Siglec-14 glycan-recognition protein is generated by alternative splicing and suppresses myeloid inflammatory responses.

Huang PJ, Low PY, Wang I, Hsu SD, Angata T.

J Biol Chem. 2018 Dec 21;293(51):19645-19658. doi: 10.1074/jbc.RA118.005676. Epub 2018 Oct 30.


Experienced trauma team leaders save the lives of multiple-trauma patients with severe head injuries.

Hong ZJ, Chen CJ, Chan DC, Chen TW, Yu JC, Hsu SD.

Surg Today. 2019 Mar;49(3):261-267. doi: 10.1007/s00595-018-1723-y. Epub 2018 Oct 9.


The Risk of Erectile Dysfunction Following Pelvic Angiographic Embolization in Pelvic Fracture Patients: A Nationwide Population-Based Cohort Study in Taiwan.

Hsu SD, Chen CJ, Wang ID, Lin KT, Wang CC, Chien WC, Chung CH, Chang WK.

World J Surg. 2019 Feb;43(2):476-485. doi: 10.1007/s00268-018-4803-7.


Accurate Genomic Prediction of Human Height.

Lello L, Avery SG, Tellier L, Vazquez AI, de Los Campos G, Hsu SDH.

Genetics. 2018 Oct;210(2):477-497. doi: 10.1534/genetics.118.301267. Epub 2018 Aug 27. Erratum in: Genetics. 2020 Jan;214(1):231.


Risk of gastric cancer following percutaneous endoscopic gastrostomy: A nationwide population-based cohort study.

Tsao CC, Lee SY, Chang WK, Lin KT, Hsu SD, Tsai CL, Lin CS.

Med Hypotheses. 2018 Sep;118:93-97. doi: 10.1016/j.mehy.2018.06.028. Epub 2018 Jun 28.


Comparative folding analyses of unknotted versus trefoil-knotted ornithine transcarbamylases suggest stabilizing effects of protein knots.

Sriramoju MK, Yang TJ, Hsu SD.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):822-829. doi: 10.1016/j.bbrc.2018.06.082. Epub 2018 Jun 21.


How Native and Non-Native Cations Bind and Modulate the Properties of GTP/ATP.

Dudev T, Grauffel C, Hsu SD, Lim C.

J Chem Theory Comput. 2018 Jun 12;14(6):3311-3320. doi: 10.1021/acs.jctc.8b00259. Epub 2018 May 30.


The aquatic animals' transcriptome resource for comparative functional analysis.

Chou CH, Huang HY, Huang WC, Hsu SD, Hsiao CD, Liu CY, Chen YH, Liu YC, Huang WY, Lee ML, Chen YC, Huang HD.

BMC Genomics. 2018 May 9;19(Suppl 2):103. doi: 10.1186/s12864-018-4463-x.


Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease.

Sriramoju MK, Chen Y, Lee YC, Hsu SD.

Sci Rep. 2018 May 4;8(1):7076. doi: 10.1038/s41598-018-25470-0.


A Natively Monomeric Deubiquitinase UCH-L1 Forms Highly Dynamic but Defined Metastable Oligomeric Folding Intermediates.

Lee YC, Hsu SD.

J Phys Chem Lett. 2018 May 3;9(9):2433-2437. doi: 10.1021/acs.jpclett.8b00815. Epub 2018 Apr 25.


Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions.

Chan YC, Lin HY, Tu Z, Kuo YH, Hsu SD, Lin CH.

Int J Mol Sci. 2018 Jan 29;19(2). pii: E392. doi: 10.3390/ijms19020392. Review.


Integrated MicroRNA-mRNA Analysis Reveals miR-204 Inhibits Cell Proliferation in Gastric Cancer by Targeting CKS1B, CXCL1 and GPRC5A.

Shrestha S, Yang CD, Hong HC, Chou CH, Tai CS, Chiew MY, Chen WL, Weng SL, Chen CC, Chang YA, Lee ML, Huang WY, Hsu SD, Chen YC, Huang HD.

Int J Mol Sci. 2017 Dec 28;19(1). pii: E87. doi: 10.3390/ijms19010087.


Inappropriate self-medication among adolescents and its association with lower medication literacy and substance use.

Lee CH, Chang FC, Hsu SD, Chi HY, Huang LJ, Yeh MK.

PLoS One. 2017 Dec 14;12(12):e0189199. doi: 10.1371/journal.pone.0189199. eCollection 2017.


Risk of infertility following pelvic angiographic embolization in female patients with pelvic fractures: A nationwide population-based cohort study in Taiwan.

Hsu SD, Lee SY, Lin KT, Lin CS, Chien WC, Chen CJ, Chung CH, Chang WK.

PLoS One. 2017 Dec 1;12(12):e0174733. doi: 10.1371/journal.pone.0174733. eCollection 2017.


Effect of Early Pelvic Binder Use in the Emergency Management of Suspected Pelvic Trauma: A Retrospective Cohort Study.

Hsu SD, Chen CJ, Chou YC, Wang SH, Chan DC.

Int J Environ Res Public Health. 2017 Oct 12;14(10). pii: E1217. doi: 10.3390/ijerph14101217.


Adjuvant Chemotherapy After Preoperative Chemoradiation Improves Survival in Patients With Locally Advanced Rectal Cancer.

Sun Z, Gilmore B, Adam MA, Kim J, Hsu SD, Migaly J, Mantyh CR.

Dis Colon Rectum. 2017 Oct;60(10):1050-1056. doi: 10.1097/DCR.0000000000000907.


Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen-Deuterium Exchange.

Chien CH, Ho MR, Lin CH, Hsu SD.

Molecules. 2017 Aug 16;22(8). pii: E1357. doi: 10.3390/molecules22081357.


Senior general surgery residents can be trained to perform focused assessment with sonography for trauma patients accurately.

Hsu SD, Chen CJ, Chan DC, Yu JC.

Surg Today. 2017 Dec;47(12):1443-1449. doi: 10.1007/s00595-017-1535-5. Epub 2017 Apr 22.


Honeysuckle aqueous extract and induced let-7a suppress dengue virus type 2 replication and pathogenesis.

Lee YR, Yeh SF, Ruan XM, Zhang H, Hsu SD, Huang HD, Hsieh CC, Lin YS, Yeh TM, Liu HS, Gan DD.

J Ethnopharmacol. 2017 Feb 23;198:109-121. doi: 10.1016/j.jep.2016.12.049. Epub 2017 Jan 2.


Protein knotting through concatenation significantly reduces folding stability.

Hsu SD.

Sci Rep. 2016 Dec 16;6:39357. doi: 10.1038/srep39357.


An Investigation of the Outcomes of PGY Students' Cognition of and Persistent Behavior in Learning through the Intervention of the Flipped Classroom in Taiwan.

Hsu SD, Chen CJ, Chang WK, Hu YJ.

PLoS One. 2016 Dec 2;11(12):e0167598. doi: 10.1371/journal.pone.0167598. eCollection 2016.


The evolution of computed tomography from organ-selective to whole-body scanning in managing unconscious patients with multiple trauma: A retrospective cohort study.

Hong ZJ, Chen CJ, Yu JC, Chan DC, Chou YC, Liang CM, Hsu SD.

Medicine (Baltimore). 2016 Sep;95(37):e4653. doi: 10.1097/MD.0000000000004653.


Successful management of adult lymphoma-associated intussusception by laparoscopic reduction and appendectomy.

Yang TW, Lin YY, Tsuei YW, Chen YL, Huang CY, Hsu SD.

World J Gastroenterol. 2016 May 21;22(19):4781-5. doi: 10.3748/wjg.v22.i19.4781.


The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates.

Lou SC, Wetzel S, Zhang H, Crone EW, Lee YT, Jackson SE, Hsu SD.

J Mol Biol. 2016 Jun 5;428(11):2507-2520. doi: 10.1016/j.jmb.2016.04.002. Epub 2016 Apr 8.


Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.

Lee YC, Hsu SD.

Curr Protein Pept Sci. 2017;18(7):733-745. doi: 10.2174/1389203717666160217143721. Review.


Transcriptome sequencing based annotation and homologous evidence based scaffolding of Anguilla japonica draft genome.

Liu YC, Hsu SD, Chou CH, Huang WY, Chen YH, Liu CY, Lyu GJ, Huang SZ, Aganezov S, Alekseyev MA, Hsiao CD, Huang HD.

BMC Genomics. 2016 Jan 11;17 Suppl 1:13. doi: 10.1186/s12864-015-2306-6.


miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database.

Chou CH, Chang NW, Shrestha S, Hsu SD, Lin YL, Lee WH, Yang CD, Hong HC, Wei TY, Tu SJ, Tsai TR, Ho SY, Jian TY, Wu HY, Chen PR, Lin NC, Huang HT, Yang TL, Pai CY, Tai CS, Chen WL, Huang CY, Liu CC, Weng SL, Liao KW, Hsu WL, Huang HD.

Nucleic Acids Res. 2016 Jan 4;44(D1):D239-47. doi: 10.1093/nar/gkv1258. Epub 2015 Nov 20.


CircNet: a database of circular RNAs derived from transcriptome sequencing data.

Liu YC, Li JR, Sun CH, Andrews E, Chao RF, Lin FM, Weng SL, Hsu SD, Huang CC, Cheng C, Liu CC, Huang HD.

Nucleic Acids Res. 2016 Jan 4;44(D1):D209-15. doi: 10.1093/nar/gkv940. Epub 2015 Oct 7.


Determination of nonlinear genetic architecture using compressed sensing.

Ho CM, Hsu SD.

Gigascience. 2015 Sep 14;4:44. doi: 10.1186/s13742-015-0081-6. eCollection 2015.


Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling.

Hsu SD, Huang HY, Chou CH, Sun YM, Hsu MT, Tsou AP.

BMC Genomics. 2015;16 Suppl 2:S12. doi: 10.1186/1471-2164-16-S2-S12. Epub 2015 Jan 21.


Unraveling regulatory mechanisms of atrial remodeling of mitral regurgitation pigs by gene expression profiling analysis: role of type I angiotensin II receptor antagonist.

Chen MC, Chang JP, Chang TH, Hsu SD, Huang HD, Ho WC, Wang FS, Hsiao CC, Liu WH.

Transl Res. 2015 May;165(5):599-620. doi: 10.1016/j.trsl.2014.11.005. Epub 2014 Nov 20.


MethHC: a database of DNA methylation and gene expression in human cancer.

Huang WY, Hsu SD, Huang HY, Sun YM, Chou CH, Weng SL, Huang HD.

Nucleic Acids Res. 2015 Jan;43(Database issue):D856-61. doi: 10.1093/nar/gku1151. Epub 2014 Nov 14.


Meckel's diverticulum incarcerated in a transmesocolic internal hernia.

Wu SY, Ho MH, Hsu SD.

World J Gastroenterol. 2014 Oct 7;20(37):13615-9. doi: 10.3748/wjg.v20.i37.13615.


Thyroid storm following trauma: a pitfall in the emergency department.

Liang CM, Ho MH, Wu XY, Hong ZJ, Hsu SD, Chen CJ.

Injury. 2015 Jan;46(1):169-71. doi: 10.1016/j.injury.2014.08.003. Epub 2014 Aug 11.


Applying compressed sensing to genome-wide association studies.

Vattikuti S, Lee JJ, Chang CC, Hsu SD, Chow CC.

Gigascience. 2014 Jun 16;3:10. doi: 10.1186/2047-217X-3-10. eCollection 2014.

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