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Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants.

Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI.

Nature. 2019 Feb 14. doi: 10.1038/s41586-019-0938-4. [Epub ahead of print]


Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.

Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK.

Nat Biotechnol. 2019 Feb 11. doi: 10.1038/s41587-018-0011-0. [Epub ahead of print]


Timing of Abatacept Before Elective Arthroplasty and Risk of Post-operative Outcomes.

George MD, Baker JF, Winthrop K, Alemao E, Chen L, Connolly S, Hsu JY, Simon TA, Wu Q, Xie F, Yang S, Curtis JR.

Arthritis Care Res (Hoboken). 2019 Feb 11. doi: 10.1002/acr.23843. [Epub ahead of print]


Complications of Corrective Osteotomies for Extra-Articular Distal Radius Malunion.

Haghverdian JC, Hsu JY, Harness NG.

J Hand Surg Am. 2019 Feb 4. pii: S0363-5023(17)31618-0. doi: 10.1016/j.jhsa.2018.12.013. [Epub ahead of print]


Crystal structure of the programmed cell death 5 protein from Sulfolobus solfataricus.

Lin KF, Hsu JY, Hsieh DL, Tsai MJ, Yeh CH, Chen CY.

Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):73-79. doi: 10.1107/S2053230X18017673. Epub 2019 Jan 23.


Profiling and comparison of toxicant metabolites in hair and urine using a mass spectrometry-based metabolomic data processing method.

Shih CL, Wu HY, Liao PM, Hsu JY, Tsao CY, Zgoda VG, Liao PC.

Anal Chim Acta. 2019 Apr 4;1052:84-95. doi: 10.1016/j.aca.2018.11.009. Epub 2018 Nov 13.


Health Behaviors in Younger and Older Adults With CKD: Results From the CRIC Study.

Schrauben SJ, Hsu JY, Wright Nunes J, Fischer MJ, Srivastava A, Chen J, Charleston J, Steigerwalt S, Tan TC, Fink JC, Ricardo AC, Lash JP, Wolf M, Feldman HI, Anderson AH; CRIC Study Investigators.

Kidney Int Rep. 2018 Sep 17;4(1):80-93. doi: 10.1016/j.ekir.2018.09.003. eCollection 2019 Jan.


CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.

Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L.

Nat Methods. 2018 Dec;15(12):992-993. doi: 10.1038/s41592-018-0225-6. No abstract available.


Safety and cardiovascular efficacy of spironolactone in dialysis-dependent ESRD (SPin-D): a randomized, placebo-controlled, multiple dosage trial.

Charytan DM, Himmelfarb J, Ikizler TA, Raj DS, Hsu JY, Landis JR, Anderson AH, Hung AM, Mehrotra R, Sharma S, Weiner DE, Williams M, DiCarli M, Skali H, Kimmel PL, Kliger AS, Dember LM; Hemodialysis Novel Therapies Consortium.

Kidney Int. 2018 Nov 22. pii: S0085-2538(18)30641-0. doi: 10.1016/j.kint.2018.08.034. [Epub ahead of print]


Predictable and precise template-free CRISPR editing of pathogenic variants.

Shen MW, Arbab M, Hsu JY, Worstell D, Culbertson SJ, Krabbe O, Cassa CA, Liu DR, Gifford DK, Sherwood RI.

Nature. 2018 Nov;563(7733):646-651. doi: 10.1038/s41586-018-0686-x. Epub 2018 Nov 7. Erratum in: Nature. 2019 Feb 14;:.


Genetic loci determining total immunoglobulin E levels from birth through adulthood.

Yao TC, Chung RH, Lin CY, Tsai PC, Chang WC, Yeh KW, Tsai MH, Liao SL, Hua MC, Lai SH, Chen LC, Chang SW, Yu YW, Hsu JY, Chang SC, Cheng WC, Hu D, Hong X, Burchard EG, Wang X, Tzeng JY, Tsai HJ, Huang JL.

Allergy. 2018 Oct 31. doi: 10.1111/all.13654. [Epub ahead of print] No abstract available.


Rafting on floating fruit is effective for oceanic dispersal of flightless weevils.

Yeh HY, Tseng HY, Lin CP, Liao CP, Hsu JY, Huang WS.

J Exp Biol. 2018 Dec 13;221(Pt 24). pii: jeb190488. doi: 10.1242/jeb.190488.


Patient Experience with Primary Care Physician and Risk for Hospitalization in Hispanics with CKD.

Cedillo-Couvert EA, Hsu JY, Ricardo AC, Fischer MJ, Gerber BS, Horwitz EJ, Kusek JW, Lustigova E, Renteria A, Rosas SE, Saunders M, Sha D, Slaven A, Lash JP; CRIC Study Investigators.

Clin J Am Soc Nephrol. 2018 Nov 7;13(11):1659-1667. doi: 10.2215/CJN.03170318. Epub 2018 Oct 18.


The impact of 2011 and 2017 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines on allocation and pharmacological management of patients with COPD in Taiwan: Taiwan Obstructive Lung Disease (TOLD) study.

Hsieh MJ, Huang SY, Yang TM, Tao CW, Cheng SL, Lee CH, Kuo PH, Wu YK, Chen NH, Hsu WH, Hsu JY, Lin MS, Wang CC, Wei YF, Tsai YH.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 25;13:2949-2959. doi: 10.2147/COPD.S176065. eCollection 2018.


Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome.

Hsu JY, James KE, Bormann CL, Donahoe PK, Pépin D, Sabatini ME.

J Clin Endocrinol Metab. 2018 Nov 1;103(11):4187-4196. doi: 10.1210/jc.2018-01320.


Incident Type 2 Diabetes Among Individuals With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Jepson C, Hsu JY, Fischer MJ, Kusek JW, Lash JP, Ricardo AC, Schelling JR, Feldman HI; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

Am J Kidney Dis. 2019 Jan;73(1):72-81. doi: 10.1053/j.ajkd.2018.06.017. Epub 2018 Sep 1.


Comparison between COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scores for evaluation of clinical symptoms, comorbidities and medical resources utilization in COPD patients.

Cheng SL, Lin CH, Wang CC, Chan MC, Hsu JY, Hang LW, Perng DW, Yu CJ, Wang HC; Taiwan Clinical Trial Consortium for Respiratory Disease (TCORE).

J Formos Med Assoc. 2019 Jan;118(1 Pt 3):429-435. doi: 10.1016/j.jfma.2018.06.018. Epub 2018 Aug 25.


Trends in Lipid Screening Among Adults in an Integrated Health Care Delivery System, 2009-2015.

Grant DSL, Scott RD, Harrison TN, Cheetham TC, Chang SC, Hsu JY, Wei R, Boklage SH, Romo-LeTourneau V, Reynolds K.

J Manag Care Spec Pharm. 2018 Nov;24(11):1090-1101. doi: 10.18553/jmcp.2018.18100. Epub 2018 Jul 31.


Trends in Statin Use 2009-2015 in a Large Integrated Health System: Pre- and Post-2013 ACC/AHA Guideline on Treatment of Blood Cholesterol.

Harrison TN, Scott RD, Cheetham TC, Chang SC, Hsu JY, Wei R, Ling Grant DS, Boklage SH, Romo-LeTourneau V, Reynolds K.

Cardiovasc Drugs Ther. 2018 Aug;32(4):397-404. doi: 10.1007/s10557-018-6810-1.


Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease.

Hsu JY, Lin HH, Hsu CC, Chen BC, Chen JH.

Nutrients. 2018 Jul 20;10(7). pii: E931. doi: 10.3390/nu10070931.


BrainImageR: spatiotemporal gene set analysis referencing the human brain.

Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH.

Bioinformatics. 2019 Jan 15;35(2):343-345. doi: 10.1093/bioinformatics/bty618.


Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor-Positive Advanced Breast Cancer.

Dickler MN, Saura C, Richards DA, Krop IE, Cervantes A, Bedard PL, Patel MR, Pusztai L, Oliveira M, Cardenas AK, Cui N, Wilson TR, Stout TJ, Wei MC, Hsu JY, Baselga J.

Clin Cancer Res. 2018 Sep 15;24(18):4380-4387. doi: 10.1158/1078-0432.CCR-18-0613. Epub 2018 May 23.


Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells.

Mariscal AM, Kakizawa S, Hsu JY, Tanaka K, González-González L, Broto A, Querol E, Lluch-Senar M, Piñero-Lambea C, Sun L, Weyman PD, Wise KS, Merryman C, Tse G, Moore AJ, Hutchison CA 3rd, Smith HO, Tomita M, Venter JC, Glass JI, Piñol J, Suzuki Y.

ACS Synth Biol. 2018 Jun 15;7(6):1538-1552. doi: 10.1021/acssynbio.8b00028. Epub 2018 May 22.


Comparative Effectiveness of Retromuscular and Intraperitoneal Repair: What Is the Value of Posterior Sheath Reconstruction?

Carney MJ, Messa CA 4th, Weissler JM, Shakir S, Wes AM, Enriquez FA, Hsu JY, Roth JS, Kovach SJ, Fischer JP.

Plast Reconstr Surg. 2018 May;141(5):733e-741e. doi: 10.1097/PRS.0000000000004298.


Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration.

Williams JS, Hsu JY, Rossi CC, Artinger KB.

Dev Biol. 2018 Mar 29. pii: S0012-1606(17)30939-9. doi: 10.1016/j.ydbio.2018.03.022. [Epub ahead of print]


Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".

Lareau CA, Clement K, Hsu JY, Pattanayak V, Joung JK, Aryee MJ, Pinello L.

Nat Methods. 2018 Apr;15(4):238-239. doi: 10.1038/nmeth.4541. Epub 2018 Mar 30. No abstract available.


CKD Self-management: Phenotypes and Associations With Clinical Outcomes.

Schrauben SJ, Hsu JY, Rosas SE, Jaar BG, Zhang X, Deo R, Saab G, Chen J, Lederer S, Kanthety R, Hamm LL, Ricardo AC, Lash JP, Feldman HI, Anderson AH; CRIC Study Investigators.

Am J Kidney Dis. 2018 Sep;72(3):360-370. doi: 10.1053/j.ajkd.2018.01.047. Epub 2018 Mar 24.


Characteristics and risk factors for inconsistency between the risk of exacerbations and the severity of airflow limitation in COPD based on GOLD 2017: A retrospective, cross-sectional study.

Huang WC, Wu MF, Chen HC, Hsu JY; Taiwan Obstructive Lung Disease Consortium.

PLoS One. 2018 Mar 12;13(3):e0193880. doi: 10.1371/journal.pone.0193880. eCollection 2018.


Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease.

Rahman M, Hsu JY, Desai N, Hsu CY, Anderson AH, Appel LJ, Chen J, Cohen DL, Drawz PE, He J, Qiang P, Ricardo AC, Steigerwalt S, Weir MR, Wright JT Jr, Zhang X, Townsend RR; CRIC Study Investigators.

Clin J Am Soc Nephrol. 2018 Apr 6;13(4):585-595. doi: 10.2215/CJN.08620817. Epub 2018 Feb 23.


Exposure marker discovery of di(isononyl)cyclohexane-1,2-dicarboxylate using two mass spectrometry-based metabolite profiling data processing methods.

Shih CL, Liao PM, Hsu JY, Chung YN, Zgoda VG, Liao PC.

Environ Sci Pollut Res Int. 2018 Apr;25(12):11999-12011. doi: 10.1007/s11356-018-1484-6. Epub 2018 Feb 15.


Unmet Patient Need in Statin Intolerance: the Clinical Characteristics and Management.

Harrison TN, Hsu JY, Rosenson RS, Levitan EB, Muntner P, Cheetham TC, Wei R, Scott RD, Reynolds K.

Cardiovasc Drugs Ther. 2018 Feb;32(1):29-36. doi: 10.1007/s10557-018-6775-0.


Comparative efficacy and tolerability of beclomethasone/formoterol and fluticasone/salmeterol fixed combination in Taiwanese asthmatic patients.

Hsieh MJ, Lin YC, Lai RS, Wu CL, Lai CL, Wang CC, Perng DW, Kao SJ, Chang ET, Wang HC, Perng WC, Hsu JY, Lin CH, Tsai YH.

J Formos Med Assoc. 2018 Dec;117(12):1078-1085. doi: 10.1016/j.jfma.2017.12.005. Epub 2017 Dec 29.


Estimation of discrete survival function for error-prone diagnostic tests.

Adeniji AK, Hsu JY, Wahed AS.

Pharm Stat. 2018 Feb;17(1):74-89. doi: 10.1002/pst.1838. Epub 2017 Nov 26. Review.


Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB.

Nature. 2017 Nov 16;551(7680):398. doi: 10.1038/nature24481. Epub 2017 Nov 8.


Identification of urinary biomarkers of exposure to di-(2-propylheptyl) phthalate using high-resolution mass spectrometry and two data-screening approaches.

Shih CL, Liao PM, Hsu JY, Chung YN, Zgoda VG, Liao PC.

Chemosphere. 2018 Feb;193:170-177. doi: 10.1016/j.chemosphere.2017.10.162. Epub 2017 Oct 30.


Transcatheter Closure of Perimembranous Ventricular Septal Defects With Amplatzer Duct Occluders.

Lin MT, Chen CA, Hsu JY, Lin HC, Chiu SN, Lin SM, Chang YM, Lu CW, Wu MH, Wang JK.

JACC Cardiovasc Interv. 2017 Nov 13;10(21):2227-2228. doi: 10.1016/j.jcin.2017.08.021. No abstract available.


Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.

Tak YE, Kleinstiver BP, Nuñez JK, Hsu JY, Horng JE, Gong J, Weissman JS, Joung JK.

Nat Methods. 2017 Dec;14(12):1163-1166. doi: 10.1038/nmeth.4483. Epub 2017 Oct 30.


Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB.

Nature. 2017 Oct 12;550(7675):255-259. doi: 10.1038/nature24042. Epub 2017 Sep 27. Erratum in: Nature. 2017 Nov 16;551(7680):398.


Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH.

Cell Stem Cell. 2017 Nov 2;21(5):618-634.e7. doi: 10.1016/j.stem.2017.08.012. Epub 2017 Sep 14.


CRISPR Fish Reel in Novel Roles for Estrogen Receptors in Reproduction.

Hsu JY, Sikora MJ.

Endocrinology. 2017 Jul 1;158(7):2082-2083. doi: 10.1210/en.2017-00417. No abstract available.


Statistical Methods for Modeling Time-Updated Exposures in Cohort Studies of Chronic Kidney Disease.

Xie D, Yang W, Jepson C, Roy J, Hsu JY, Shou H, Anderson AH, Landis JR, Feldman HI; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

Clin J Am Soc Nephrol. 2017 Nov 7;12(11):1892-1899. doi: 10.2215/CJN.00650117. Epub 2017 Aug 17. Review.


Analytic Considerations for Repeated Measures of eGFR in Cohort Studies of CKD.

Shou H, Hsu JY, Xie D, Yang W, Roy J, Anderson AH, Landis JR, Feldman HI, Parsa A, Jepson C; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

Clin J Am Soc Nephrol. 2017 Jul 27;12(8). pii: CJN.11311116. doi: 10.2215/CJN.11311116. Print 2017 Aug 7.


Statistical Methods for Recurrent Event Analysis in Cohort Studies of CKD.

Yang W, Jepson C, Xie D, Roy JA, Shou H, Hsu JY, Anderson AH, Landis JR, He J, Feldman HI; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators.

Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2066-2073. doi: 10.2215/CJN.12841216. Epub 2017 Jul 17. Review.


The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models.

Hsu JY, Jhang YL, Cheng PH, Chang YF, Mao SH, Yang HI, Lin CW, Chen CM, Yang SH.

Front Mol Neurosci. 2017 Jun 20;10:196. doi: 10.3389/fnmol.2017.00196. eCollection 2017.


Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.

Hsu JY, Chang JY, Chang KY, Chang WC, Chen BK.

FASEB J. 2017 Oct;31(10):4265-4276. doi: 10.1096/fj.201700156R. Epub 2017 Jun 8.


Exposure Marker Discovery of Phthalates Using Mass Spectrometry.

Hsu JY, Shih CL, Liao PC.

Mass Spectrom (Tokyo). 2017;6(Spec Iss):S0062. doi: 10.5702/massspectrometry.S0062. Epub 2017 Mar 24.


Transthoracic Echocardiography: Pitfalls and Limitations as Delineated at Cardiac CT and MR Imaging-Erratum.

Malik SB, Chen N, Parker RA 3rd, Hsu JY.

Radiographics. 2017 May-Jun;37(3):1004. doi: 10.1148/rg.2017174006. No abstract available.


ACR Appropriateness Criteria® Chronic Chest Pain-High Probability of Coronary Artery Disease.

Expert Panel on Cardiac Imaging:, Akers SR, Panchal V, Ho VB, Beache GM, Brown RKJ, Ghoshhajra BB, Greenberg SB, Hsu JY, Kicska GA, Min JK, Stillman AE, Stojanovska J, Abbara S, Jacobs JE.

J Am Coll Radiol. 2017 May;14(5S):S71-S80. doi: 10.1016/j.jacr.2017.01.034. Review.


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