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Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.

Hsu JL, Chou JW, Chen TF, Hsu JT, Su FY, Lan JL, Wu PC, Hu CM, Lee EY, Lee WH.

EMBO Mol Med. 2019 Nov 29:e9386. doi: 10.15252/emmm.201809386. [Epub ahead of print]


The Combination of MK-2206 and WZB117 Exerts a Synergistic Cytotoxic Effect Against Breast Cancer Cells.

Li YL, Weng HC, Hsu JL, Lin SW, Guh JH, Hsu LC.

Front Pharmacol. 2019 Nov 6;10:1311. doi: 10.3389/fphar.2019.01311. eCollection 2019.


Effect of vitamin D on cognitive function and white matter hyperintensity in patients with mild Alzheimer's disease.

Shih EJ, Lee WJ, Hsu JL, Wang SJ, Fuh JL.

Geriatr Gerontol Int. 2019 Nov 26. doi: 10.1111/ggi.13821. [Epub ahead of print]


Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics.

Fromm PD, Silveira PA, Hsu JL, Papadimitrious MS, Lo TH, Ju X, Kupresanin F, Romano A, Hsu WH, Bryant CE, Kong B, Abadir E, Mekkawy A, M McGuire H, Groth BFS, Cunningham I, Newman E, Gibson J, Hogarth PM, Hart DNJ, Clark GJ.

J Leukoc Biol. 2019 Nov 21. doi: 10.1002/JLB.5A1119-362RRR. [Epub ahead of print]


CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.

Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC.

Nat Commun. 2019 Nov 8;10(1):5114. doi: 10.1038/s41467-019-13105-5.


The mediating effects of leisure engagement on relationships between caregiving stress and subjective wellbeing among family caregivers of persons with cognitive impairment: A cross-sectional study.

Chiu YC, Liao HC, Li CL, Lin CH, Hsu JL, Lin CY, Hsu WC.

Geriatr Nurs. 2019 Nov 4. pii: S0197-4572(19)30527-0. doi: 10.1016/j.gerinurse.2019.08.017. [Epub ahead of print]


Mechanisms Controlling PD-L1 Expression in Cancer.

Cha JH, Chan LC, Li CW, Hsu JL, Hung MC.

Mol Cell. 2019 Nov 7;76(3):359-370. doi: 10.1016/j.molcel.2019.09.030. Epub 2019 Oct 24. Review.


Brain computerized tomography reading in suspected acute ischemic stroke patients: what are essentials for medical students?

Liu CH, Hsiao CT, Chang TY, Chang YJ, Kuo SH, Chang CW, Chen CJ, Chen CF, Cheng PL, Chin SC, Chiu TF, Hsu JL, Hsu PW, Lee TH, Liao CH, Lin CJ, Lin LH, Seak CJ, Sung PS, Yang TC, Wu YM.

BMC Med Educ. 2019 Sep 18;19(1):359. doi: 10.1186/s12909-019-1781-x.


Determination of Phenolic Compounds, Procyanidins, and Antioxidant Activity in Processed Coffea arabica L. Leaves.

Ngamsuk S, Huang TC, Hsu JL.

Foods. 2019 Sep 4;8(9). pii: E389. doi: 10.3390/foods8090389.


The etiologies and prognosis associated with spinal cord infarction.

Hsu JL, Cheng MY, Liao MF, Hsu HC, Weng YC, Chang KH, Chang HS, Kuo HC, Huang CC, Lyu RK, Lin KJ, Ro LS.

Ann Clin Transl Neurol. 2019 Aug;6(8):1456-1464. doi: 10.1002/acn3.50840. Epub 2019 Jul 15.


Marine Organisms as Potential Sources of Bioactive Peptides that Inhibit the Activity of Angiotensin I-Converting Enzyme: A Review.

Pujiastuti DY, Ghoyatul Amin MN, Alamsjah MA, Hsu JL.

Molecules. 2019 Jul 12;24(14). pii: E2541. doi: 10.3390/molecules24142541. Review.


Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy.

Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Wei Y, Chou CK, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, Hsu JL, Hortobagyi GN, Hung MC.

Cancer Cell. 2019 Aug 12;36(2):168-178.e4. doi: 10.1016/j.ccell.2019.06.008. Epub 2019 Jul 18.


IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC.

J Clin Invest. 2019 Jul 15;129(8):3324-3338. doi: 10.1172/JCI126022. eCollection 2019 Jul 15.


Discovery and Study of Novel Antihypertensive Peptides Derived from Cassia obtusifolia Seeds.

Shih YH, Chen FA, Wang LF, Hsu JL.

J Agric Food Chem. 2019 Jul 17;67(28):7810-7820. doi: 10.1021/acs.jafc.9b01922. Epub 2019 Jul 2.


Dementia-friendly community indicators from the perspectives of people living with dementia and dementia-family caregivers.

Wu SM, Huang HL, Chiu YC, Tang LY, Yang PS, Hsu JL, Liu CL, Wang WS, Shyu YL.

J Adv Nurs. 2019 Jun 25. doi: 10.1111/jan.14123. [Epub ahead of print]


Dietary Profiles, Nutritional Biochemistry Status, and Attention-Deficit/Hyperactivity Disorder: Path Analysis for a Case-Control Study.

Wang LJ, Yu YH, Fu ML, Yeh WT, Hsu JL, Yang YH, Yang HT, Huang SY, Wei IL, Chen WJ, Chiang BL, Pan WH.

J Clin Med. 2019 May 18;8(5). pii: E709. doi: 10.3390/jcm8050709.


Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer.

Han Y, Li CW, Hsu JM, Hsu JL, Chan LC, Tan X, He GJ.

Am J Cancer Res. 2019 Apr 1;9(4):800-815. eCollection 2019.


Author Correction: Plasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder.

Wu KY, Hsiao IT, Chen CH, Liu CY, Hsu JL, Huang SY, Yen TC, Lin KJ.

Sci Rep. 2019 May 17;9(1):7701. doi: 10.1038/s41598-019-43800-8.


A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies.

Hsu JL, Cheng MY, Liao MF, Hsu HC, Weng YC, Chang KH, Chang HS, Kuo HC, Huang CC, Lyu RK, Lin KJ, Ro LS.

Sci Rep. 2019 May 15;9(1):7435. doi: 10.1038/s41598-019-43606-8.


H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism.

Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J, Hung MC.

J Biol Chem. 2019 May 24;294(21):8516-8528. doi: 10.1074/jbc.RA118.005953. Epub 2019 Apr 8.


Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells.

Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX, Nie L, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD, Hung MC.

Am J Cancer Res. 2019 Mar 1;9(3):608-618. eCollection 2019.


Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.

Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, Jia HL, Hung MC, Dong QZ, Qin LX.

Gut. 2019 Sep;68(9):1653-1666. doi: 10.1136/gutjnl-2019-318419. Epub 2019 Mar 22.


Building an Antibiotic Stewardship Program: An Interactive Teaching Module for Medical Students.

Hsu JL.

MedEdPORTAL. 2018 Jun 26;14:10726. doi: 10.15766/mep_2374-8265.10726.


High risk of silent stroke in older bipolar patients with typical-onset age.

Lee HC, Hsu JL, Chen PH, Chung KH, Huang YJ, Tsai SY.

Psychogeriatrics. 2019 Jul;19(4):355-362. doi: 10.1111/psyg.12419. Epub 2019 Feb 7.


MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, Sun X, Koller PB, Ye Q, Hung MC.

Gastroenterology. 2019 May;156(6):1849-1861.e13. doi: 10.1053/j.gastro.2019.01.252. Epub 2019 Jan 31.


Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.

Chang JF, Hsu JL, Sheng YH, Leu WJ, Yu CC, Chan SH, Chan ML, Hsu LC, Liu SP, Guh JH.

Front Oncol. 2019 Jan 17;8:681. doi: 10.3389/fonc.2018.00681. eCollection 2018.


PePIF1, a P-lineage of PIF-like transposable element identified in protocorm-like bodies of Phalaenopsis orchids.

Hsu CC, Lai PH, Chen TC, Tsai WC, Hsu JL, Hsiao YY, Wu WL, Tsai CH, Chen WH, Chen HH.

BMC Genomics. 2019 Jan 9;20(1):25. doi: 10.1186/s12864-018-5420-4.


Anti-hypertensive effects of Radix Rehmanniae and its active ingredients.

Chao CH, Hsu JL, Chen MF, Shih YH, Lee CH, Wu ML, Chang CI.

Nat Prod Res. 2018 Dec 22:1-6. doi: 10.1080/14786419.2018.1516660. [Epub ahead of print]


Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents.

Hsu JL, Leu WJ, Hsu LC, Liu SP, Zhong NS, Guh JH.

Front Pharmacol. 2018 Nov 13;9:1223. doi: 10.3389/fphar.2018.01223. eCollection 2018.


Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer.

Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC.

Cancer Cell. 2018 Dec 10;34(6):954-969.e4. doi: 10.1016/j.ccell.2018.11.007.


Palmitoylation stabilizes PD-L1 to promote breast tumor growth.

Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y, Hung MC.

Cell Res. 2019 Jan;29(1):83-86. doi: 10.1038/s41422-018-0124-5. Epub 2018 Dec 4. No abstract available.


Different routes of heroin intake cause various heroin-induced leukoencephalopathies.

Cheng MY, Chin SC, Chang YC, Wu T, Lim SN, Hsieh HY, Hsu JL, Chang CW, Tseng WJ, Li HT, Chiang HI, Chang BL, Tsai MH, Ro LS.

J Neurol. 2019 Feb;266(2):316-329. doi: 10.1007/s00415-018-9131-1. Epub 2018 Nov 26.


Screening of Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from Caulerpa lentillifera.

Joel CH, Sutopo CCY, Prajitno A, Su JH, Hsu JL.

Molecules. 2018 Nov 16;23(11). pii: E3005. doi: 10.3390/molecules23113005.


Iron: an essential nutrient for Aspergillus fumigatus and a fulcrum for pathogenesis.

Matthaiou EI, Sass G, Stevens DA, Hsu JL.

Curr Opin Infect Dis. 2018 Dec;31(6):506-511. doi: 10.1097/QCO.0000000000000487. Review.


Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder.

Tsai SY, Gildengers AG, Hsu JL, Chung KH, Chen PH, Huang YJ.

J Affect Disord. 2019 Feb 1;244:60-66. doi: 10.1016/j.jad.2018.10.093. Epub 2018 Oct 6.


Antioxidant properties of porcine liver proteins hydrolyzed using Monascus purpureus.

Yu HC, Hsu JL, Chang CI, Tan FJ.

Food Sci Biotechnol. 2017 Oct 23;26(5):1217-1225. doi: 10.1007/s10068-017-0166-3. eCollection 2017.


Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer's disease.

Huang SY, Hsu JL, Lin KJ, Liu HL, Wey SP, Hsiao IT; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2018 Sep 14;8(1):13807. doi: 10.1038/s41598-018-31794-8.


Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC.

Mol Cell. 2018 Aug 16;71(4):606-620.e7. doi: 10.1016/j.molcel.2018.07.030.


Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing.

Sun LL, Yang RY, Li CW, Chen MK, Shao B, Hsu JM, Chan LC, Yang Y, Hsu JL, Lai YJ, Hung MC.

Am J Cancer Res. 2018 Jul 1;8(7):1307-1316. eCollection 2018.


Activation of phagocytosis by immune checkpoint blockade.

Li CW, Lai YJ, Hsu JL, Hung MC.

Front Med. 2018 Aug;12(4):473-480. doi: 10.1007/s11684-018-0657-5. Epub 2018 Jul 30. Review.


Pulmonary Infections in Immunocompromised Hosts: Clinical.

Vazquez Guillamet C, Hsu JL, Dhillon G, Vazquez Guillamet R.

J Thorac Imaging. 2018 Sep;33(5):295-305. doi: 10.1097/RTI.0000000000000351. Review.


Diffusion kurtosis imaging as a neuroimaging biomarker in patients with carbon monoxide intoxication.

Lee JJ, Chang WN, Hsu JL, Huang CW, Chang YT, Hsu SW, Huang SH, Lee CC, Lien CY, Chang CC.

Neurotoxicology. 2018 Sep;68:38-46. doi: 10.1016/j.neuro.2018.07.001. Epub 2018 Jul 11.


Visualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography.

Huang KL, Hsu JL, Lin KJ, Chang CH, Wu YM, Chang TY, Chang YJ, Liu CH, Ho MY, Wey SP, Yen TC, Okamura N, Hsiao IT, Lee TH.

EJNMMI Res. 2018 Jul 16;8(1):62. doi: 10.1186/s13550-018-0417-1.


Catch Me If You Can.

Omar M, Sunassee A, Hayes M, Hsu JL.

S D Med. 2018 Jul;71(7):304.


Collaborating to Enhance Faculty Development through Structured Funding.

Hsu JL, Ridgway T, Kemnitz J, Chatterjee A.

S D Med. 2018 Jun;71(6):264-266.


M. chimaera: A Multi-Headed Pathogen.

Hsu JL, Bhatnagar U, Stys M, Hoffman W.

S D Med. 2018 Jun;71(6):246-250. Review.


Attention deficit-hyperactivity disorder is associated with allergic symptoms and low levels of hemoglobin and serotonin.

Wang LJ, Yu YH, Fu ML, Yeh WT, Hsu JL, Yang YH, Chen WJ, Chiang BL, Pan WH.

Sci Rep. 2018 Jul 6;8(1):10229. doi: 10.1038/s41598-018-28702-5.


Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.

Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, Hung MC.

Cell Res. 2018 Aug;28(8):862-864. doi: 10.1038/s41422-018-0060-4. Epub 2018 Jun 29. No abstract available.


Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis.

Hsu HC, Liao MF, Hsu JL, Lee YL, Ro LS.

J Vis Exp. 2018 Jun 9;(136). doi: 10.3791/57743.


Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.

Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC.

Cancer Res. 2018 Jul 15;78(14):3761-3768. doi: 10.1158/0008-5472.CAN-18-0040. Epub 2018 May 22.

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