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A high-dose rapamycin treatment alleviates hepatopulmonary syndrome in cirrhotic rats.

Chang CC, Chuang CL, Hsin IF, Hsu SJ, Huang HC, Lee FY, Lee SD.

J Chin Med Assoc. 2019 Sep 17. doi: 10.1097/JCMA.0000000000000194. [Epub ahead of print]


Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis.

Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaat9284. doi: 10.1126/scitranslmed.aat9284.


Effects of Caffeine Treatment on Hepatopulmonary Syndrome in Biliary Cirrhotic Rats.

Chang CC, Chuang CL, Tsai MH, Hsin IF, Hsu SJ, Huang HC, Lee FY, Lee SD.

Int J Mol Sci. 2019 Mar 28;20(7). pii: E1566. doi: 10.3390/ijms20071566.


Effect of ivabradine, a funny current inhibitor, on portal hypertensive rats.

Chang CC, Lee WS, Chuang CL, Hsin IF, Hsu SJ, Huang HC, Lee FY, Lee SD.

J Chin Med Assoc. 2019 Jan;82(1):19-24. doi: 10.1016/j.jcma.2018.06.008.


Addition of Carvedilol to Gastric Variceal Obturation Does Not Decrease Recurrence of Gastric Variceal Bleeding in Patients With Cirrhosis.

Chen WC, Hsin IF, Chen PH, Hsu PI, Wang YP, Cheng JS, Lin HS, Hou MC, Lee FY.

Clin Gastroenterol Hepatol. 2019 Oct;17(11):2356-2363.e2. doi: 10.1016/j.cgh.2019.02.021. Epub 2019 Feb 14.


Insulin reverses major portal hypertension-related derangements in rats with liver cirrhosis and diabetes.

Hsin IF, Huang HC, Chang CC, Hsu SJ, Lee FY, Huo TI, Chuang CL, Hou MC, Lee SD.

Clin Sci (Lond). 2018 Nov 19;132(22):2391-2405. doi: 10.1042/CS20180557. Print 2018 Nov 30.


Effect of ivabradine, a funny current inhibitor, on portal hypertensive rats.

Chang CC, Lee WS, Chuang CL, Hsin IF, Hsu SJ, Huang HC, Lee FY, Lee SD.

J Chin Med Assoc. 2018 Sep 6. pii: S1726-4901(18)30207-7. doi: 10.1016/j.jcma.2018.06.008. [Epub ahead of print]


GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells.

Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL.

Environ Toxicol. 2018 Sep;33(9):955-961. doi: 10.1002/tox.22582. Epub 2018 Jul 4.


The effects of proton pump inhibitor on hepatic vascular responsiveness and hemodynamics in cirrhotic rats.

Hsin IF, Hsu SJ, Chuang CL, Huo TI, Huang HC, Lee FY, Ho HL, Chang SY, Lee SD.

J Chin Med Assoc. 2018 Jul;81(7):585-592. doi: 10.1016/j.jcma.2018.01.011. Epub 2018 May 18.


The factors associated with negative colonoscopy in screening subjects with positive immunochemical stool occult blood test outcomes.

Ting PH, Lin XH, Jiang JK, Luo JC, Chen PH, Wang YP, Hsin IF, Perng CL, Hou MC, Lee FY.

J Chin Med Assoc. 2018 Sep;81(9):759-765. doi: 10.1016/j.jcma.2017.11.015. Epub 2018 May 31.


NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.

Lin YJ, Hsin IL, Sun HS, Lin S, Lai YL, Chen HY, Chen TY, Chen YP, Shen YT, Wu HM.

Mol Neurobiol. 2018 Nov;55(11):8403-8413. doi: 10.1007/s12035-018-0995-y. Epub 2018 Mar 16.


Effect of sirolimus on liver cirrhosis and hepatic encephalopathy of common bile duct-ligated rats.

Wu KC, Huang HC, Chang T, Lee WS, Chuang CL, Hsin IF, Hsu SJ, Lee FY, Chang CC, Lee SD.

Eur J Pharmacol. 2018 Apr 5;824:133-139. doi: 10.1016/j.ejphar.2018.02.016. Epub 2018 Feb 11.


Combination of albumin-bilirubin grade and platelets to predict a compensated patient with hepatocellular carcinoma who does not require endoscopic screening for esophageal varices.

Chen PH, Hsieh WY, Su CW, Hou MC, Wang YP, Hsin IF, Yang TC, Liao WC, Lin HC, Lee FY, Wu JC.

Gastrointest Endosc. 2018 Aug;88(2):230-239.e2. doi: 10.1016/j.gie.2017.12.023. Epub 2018 Jan 6.


Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells.

Kang YT, Hsu WC, Wu CH, Hsin IL, Wu PR, Yeh KT, Ko JL.

Oncotarget. 2017 Nov 6;8(62):105536-105552. doi: 10.18632/oncotarget.22317. eCollection 2017 Dec 1.


Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells.

Hsin MC, Hsieh YH, Wang PH, Ko JL, Hsin IL, Yang SF.

Cell Death Dis. 2017 Oct 5;8(10):e3089. doi: 10.1038/cddis.2017.459.


Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women.

Huang WY, Hsin IL, Chen DR, Chang CC, Kor CT, Chen TY, Wu HM.

PLoS One. 2017 Aug 28;12(8):e0184011. doi: 10.1371/journal.pone.0184011. eCollection 2017.


Ascorbate lacks significant influence in rats with bile duct ligation-induced liver injury.

Ho HL, Huo TI, Chang T, Lee WS, Hsin IF, Lee FY, Huang HC, Hou MC, Lee SD.

J Chin Med Assoc. 2017 Sep;80(9):539-550. doi: 10.1016/j.jcma.2017.03.010. Epub 2017 Jul 3.


Metformin reduces intrahepatic fibrosis and intrapulmonary shunts in biliary cirrhotic rats.

Ko MT, Huang HC, Lee WS, Chuang CL, Hsin IF, Hsu SJ, Lee FY, Chang CC, Lee SD.

J Chin Med Assoc. 2017 Aug;80(8):467-475. doi: 10.1016/j.jcma.2017.05.005. Epub 2017 Jul 1.


The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers.

Ko JL, Cheng YJ, Liu GC, Hsin IL, Chen HL.

Ind Health. 2017 Aug 8;55(4):345-353. doi: 10.2486/indhealth.2016-0148. Epub 2017 Apr 14.


Effects of raloxifene on portal hypertension and hepatic encephalopathy in cirrhotic rats.

Chang CC, Lee WS, Chuang CL, Hsin IF, Hsu SJ, Chang T, Huang HC, Lee FY, Lee SD.

Eur J Pharmacol. 2017 May 5;802:36-43. doi: 10.1016/j.ejphar.2017.02.039. Epub 2017 Feb 24.


Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells.

Hsin IL, Wang SC, Li JR, Ciou TC, Wu CH, Wu HM, Ko JL.

Phytomedicine. 2016 Dec 1;23(13):1566-1573. doi: 10.1016/j.phymed.2016.09.003. Epub 2016 Sep 10.


Homocysteine deteriorates intrahepatic derangement and portal-systemic collaterals in cirrhotic rats.

Tung HC, Hsu SJ, Tsai MH, Lin TY, Hsin IF, Huo TI, Lee FY, Huang HC, Ho HL, Lin HC, Lee SD.

Clin Sci (Lond). 2017 Jan 1;131(1):69-86. Epub 2016 Nov 1.


Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats.

Ho HL, Hsu SJ, Lee FY, Huang HC, Hsin IF, Hou MC, Lee SD.

J Chin Med Assoc. 2016 Nov;79(11):583-588. doi: 10.1016/j.jcma.2016.05.007. Epub 2016 Aug 28.


The ERK-ZEB1 pathway mediates epithelial-mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids.

Chiu LY, Hsin IL, Yang TY, Sung WW, Chi JY, Chang JT, Ko JL, Sheu GT.

Oncogene. 2017 Jan 12;36(2):242-253. doi: 10.1038/onc.2016.195. Epub 2016 Jun 6.


Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1.

Hsin IF, Montano E, Seki E.

Hepatology. 2016 Jul;64(1):295-7. doi: 10.1002/hep.28627. Epub 2016 May 31. Review. No abstract available.


Endothelin receptor blockers reduce shunting and angiogenesis in cirrhotic rats.

Hsu SJ, Lin TY, Wang SS, Chuang CL, Lee FY, Huang HC, Hsin IF, Lee JY, Lin HC, Lee SD.

Eur J Clin Invest. 2016 Jun;46(6):572-80. doi: 10.1111/eci.12636.


Clinical Outcomes and Complications of Endoscopic Submucosal Dissection for Superficial Gastric Neoplasms in the Elderly.

Yang TC, Hou MC, Chen PH, Hsin IF, Chen LK, Tsou MY, Lin HC, Lee FY.

Medicine (Baltimore). 2015 Nov;94(44):e1964. doi: 10.1097/MD.0000000000001964.


2'-Hydroxyflavanone ameliorates mesenteric angiogenesis and portal-systemic collaterals in rats with liver fibrosis.

Hsin IF, Lee JY, Huo TI, Lee FY, Huang HC, Hsu SJ, Wang SS, Ho HL, Lin HC, Lee SD.

J Gastroenterol Hepatol. 2016 May;31(5):1045-51. doi: 10.1111/jgh.13197.


The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats.

Hsu SJ, Wang SS, Huo TI, Lee FY, Huang HC, Chang CC, Hsin IF, Ho HL, Lin HC, Lee SD.

J Pharmacol Exp Ther. 2015 Oct;355(1):117-24. doi: 10.1124/jpet.115.225516. Epub 2015 Aug 10.


Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells.

Chiu LY, Hu ME, Yang TY, Hsin IL, Ko JL, Tsai KJ, Sheu GT.

PLoS One. 2015 May 6;10(5):e0125774. doi: 10.1371/journal.pone.0125774. eCollection 2015.


The ability of 17 β-estradiol to attenuate intrahepatic vasoconstriction to endothelin-1 in female rats is lost in cirrhosis.

Ho HL, Lee FY, Hsu SJ, Wang SS, Hsin IF, Huang HC, Lee JY, Lin HC, Lee SD.

Ann Hepatol. 2015 May-Jun;14(3):404-13.


GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells.

Hsin IL, Ou CC, Wu MF, Jan MS, Hsiao YM, Lin CH, Ko JL.

Mol Pharm. 2015 May 4;12(5):1534-43. doi: 10.1021/mp500840z. Epub 2015 Apr 3.


Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells.

Hsu CP, Lee LW, Tang SC, Hsin IL, Lin YW, Ko JL.

Tumour Biol. 2015 Jul;36(7):5389-98. doi: 10.1007/s13277-015-3204-x. Epub 2015 Feb 14.


Caffeine ameliorates hemodynamic derangements and portosystemic collaterals in cirrhotic rats.

Hsu SJ, Lee FY, Wang SS, Hsin IF, Lin TY, Huang HC, Chang CC, Chuang CL, Ho HL, Lin HC, Lee SD.

Hepatology. 2015 May;61(5):1672-84. doi: 10.1002/hep.27679. Epub 2015 Mar 23.


Subdural hematoma associated with skull and dural metastasis of gastric carcinoma: a case report.

Kuan-Yin T, Dueng-Yuan H, Hsin-I M.

Turk Neurosurg. 2013;23(6):796-9. doi: 10.5137/1019-5149.JTN.3696-10.3.


Improvement of plant growth and seed yield in Jatropha curcas by a novel nitrogen-fixing root associated Enterobacter species.

Madhaiyan M, Peng N, Te NS, Hsin I C, Lin C, Lin F, Reddy C, Yan H, Ji L.

Biotechnol Biofuels. 2013 Oct 1;6(1):140. doi: 10.1186/1754-6834-6-140.


Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis.

Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD.

Clin Sci (Lond). 2014 May;126(9):633-44. doi: 10.1042/CS20130215.


A patient with hemodialysis-related hyperammonemic encephalopathy: a delayed presentation of congenital arterioportal fistulas.

Yang SF, Tseng HS, Huang HC, Hsin IF, Yao YH, Chen JY.

Clin Nephrol. 2013 Jun;79(6):499-503.


Effects of simvastatin on the portal-systemic collateral vascular response to endothelin-1 and shunting degree in portal hypertensive rats.

Hsu SJ, Wang SS, Hsin IF, Huang HC, Lee FY, Lee JY, Lin HC, Chuang CL, Lee SD.

Scand J Gastroenterol. 2013 Jul;48(7):831-8. doi: 10.3109/00365521.2012.711851. Epub 2013 May 14.


The influence of sorafenib on hepatic encephalopathy and the mechanistic survey in cirrhotic rats.

Hsu SJ, Hsin IF, Lin YL, Chen YC, Huang HC, Lee FY, Lin HC, Chang CC, Lee SD.

Eur J Clin Invest. 2012 Dec;42(12):1309-16. doi: 10.1111/eci.12006. Epub 2012 Oct 18.


p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation.

Cai BH, Hsu PC, Hsin IL, Chao CF, Lu MH, Lin HC, Chiou SH, Tao PL, Chen JY.

PLoS One. 2012;7(7):e41742. doi: 10.1371/journal.pone.0041742. Epub 2012 Jul 24.


Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.

Hsin IL, Hsiao YC, Wu MF, Jan MS, Tang SC, Lin YW, Hsu CP, Ko JL.

Toxicol Appl Pharmacol. 2012 Sep 15;263(3):330-7. doi: 10.1016/j.taap.2012.07.005. Epub 2012 Jul 16.


Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum.

Hsin IL, Sheu GT, Jan MS, Sun HL, Wu TC, Chiu LY, Lue KH, Ko JL.

Br J Pharmacol. 2012 Nov;167(6):1287-300. doi: 10.1111/j.1476-5381.2012.02073.x.


IFN-γ induction on carbohydrate binding module of fungal immunomodulatory protein in human peripheral mononuclear cells.

Liu YF, Chang SH, Sun HL, Chang YC, Hsin IL, Lue KH, Ko JL.

J Agric Food Chem. 2012 May 16;60(19):4914-22. doi: 10.1021/jf300957k. Epub 2012 May 4.


Cannabinoid receptor 2 agonist ameliorates mesenteric angiogenesis and portosystemic collaterals in cirrhotic rats.

Huang HC, Wang SS, Hsin IF, Chang CC, Lee FY, Lin HC, Chuang CL, Lee JY, Hsieh HG, Lee SD.

Hepatology. 2012 Jul;56(1):248-58. doi: 10.1002/hep.25625. Epub 2012 Jun 6.


Portosystemic collaterals are not prerequisites for the development of hepatic encephalopathy in cirrhotic rats.

Hsin IF, Wang SS, Huang HC, Lee FY, Chan CY, Chang CC, Hsu CY, Lin HC, Lee SD.

J Chin Med Assoc. 2012 Jan;75(1):3-9. doi: 10.1016/j.jcma.2011.10.008. Epub 2011 Nov 23.


Pravastatin for thioacetamide-induced hepatic failure and encephalopathy.

Huang HC, Chang CC, Wang SS, Chan CY, Lee FY, Chuang CL, Hsin IF, Teng TH, Lin HC, Lee SD.

Eur J Clin Invest. 2012 Feb;42(2):139-45. doi: 10.1111/j.1365-2362.2011.02566.x. Epub 2011 Jul 12.


Liver failure after transarterial chemoembolization for patients with hepatocellular carcinoma and ascites: incidence, risk factors, and prognostic prediction.

Hsin IF, Hsu CY, Huang HC, Huang YH, Lin HC, Lee RC, Chiang JH, Lee FY, Huo TI, Lee SD.

J Clin Gastroenterol. 2011 Jul;45(6):556-62. doi: 10.1097/MCG.0b013e318210ff17.


GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells.

Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH, Ko JL.

Autophagy. 2011 Aug;7(8):873-82. Epub 2011 Aug 1.


N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells.

Hsin IL, Sheu GT, Chen HH, Chiu LY, Wang HD, Chan HW, Hsu CP, Ko JL.

Mutat Res. 2010 Jun 1;688(1-2):72-7. doi: 10.1016/j.mrfmmm.2010.03.011. Epub 2010 Apr 2.


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