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Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma.

Hsieh YY, Liu TP, Chou CJ, Chen HY, Lee KH, Yang PM.

Genes (Basel). 2019 Sep 28;10(10). pii: E766. doi: 10.3390/genes10100766.


In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells.

Chen JC, Hsieh YY, Lo HL, Li A, Chou CJ, Yang PM.

Biomolecules. 2019 Sep 9;9(9). pii: E467. doi: 10.3390/biom9090467.


Effects of Running Exercise Combined With Blood Flow Restriction on Strength and Sprint Performance.

Chen YT, Hsieh YY, Ho JY, Lin JC.

J Strength Cond Res. 2019 Aug 23. doi: 10.1519/JSC.0000000000003313. [Epub ahead of print]


Fuzzy inference system for modeling the environmental risk map of air pollutants in Taiwan.

Chung CJ, Hsieh YY, Lin HC.

J Environ Manage. 2019 Sep 15;246:808-820. doi: 10.1016/j.jenvman.2019.06.038. Epub 2019 Jun 20.


HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells.

Chen SH, Chow JM, Hsieh YY, Lin CY, Hsu KW, Hsieh WS, Chi WM, Shabangu BM, Lee CH.

Int J Mol Sci. 2019 May 8;20(9). pii: E2271. doi: 10.3390/ijms20092271.


High thermoelectric power-factor composites based on flexible three-dimensional graphene and polyaniline.

Hsieh YY, Zhang Y, Zhang L, Fang Y, Kanakaraaj SN, Bahk JH, Shanov V.

Nanoscale. 2019 Apr 4;11(14):6552-6560. doi: 10.1039/c8nr10537e.


In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma.

Hsieh YY, Liu TP, Yang PM.

Pathol Res Pract. 2019 Jun;215(6):152373. doi: 10.1016/j.prp.2019.03.002. Epub 2019 Mar 4.


Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining.

Liu TP, Hsieh YY, Chou CJ, Yang PM.

R Soc Open Sci. 2018 Nov 28;5(11):181321. doi: 10.1098/rsos.181321. eCollection 2018 Nov.


Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells.

Huang WS, Huang CY, Hsieh MC, Kuo YH, Tung SY, Shen CH, Hsieh YY, Teng CC, Lee KC, Lee KF, Kuo HC.

Cell Physiol Biochem. 2018;51(6):2616-2630. doi: 10.1159/000495934. Epub 2018 Dec 11.


Correction: Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.

Siu MK, Abou-Kheir W, Yin JJ, Chang YS, Barrett B, Suau F, Casey O, Chen WY, Fang L, Hynes P, Hsieh YY, Liu YN, Huang J, Kelly K.

Oncotarget. 2018 Aug 17;9(64):32403. doi: 10.18632/oncotarget.26020. eCollection 2018 Aug 17.


Correction: Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine.

Hsieh YY, Huang TC, Lo HL, Jhan JY, Chen ST, Yang PM.

Oncotarget. 2018 Aug 17;9(64):32402. doi: 10.18632/oncotarget.26019. eCollection 2018 Aug 17.


Carpal tunnel syndrome after an electrical injury: a case report and review of literature.

Wong YS, Ong CT, Hsieh YY, Hung TW, Guo HR.

J Occup Health. 2018 Jul 25;60(4):320-323. doi: 10.1539/joh.2017-0247-CS. Epub 2018 Jun 14. Review.


Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients.

Hsieh YY, Tung SY, Pan HY, Yen CW, Xu HW, Deng YF, Lin YJ, Hsu WT, Wu CS, Li C.

BMC Cancer. 2018 May 2;18(1):508. doi: 10.1186/s12885-018-4383-9.


Comparative Proteomic Identification of Protein Disulphide Isomerase A6 Associated with Tert-Butylhydroperoxide-Induced Liver Injury in Rat Hepatocytes.

Shen CH, Tung SY, Huang WS, Lee KF, Hsieh YY, Hsieh MC, Chen CN, Kuo HC.

Cell Physiol Biochem. 2018;45(5):1915-1926. doi: 10.1159/000487968. Epub 2018 Mar 2.


Increased Abundance of Clostridium and Fusobacterium in Gastric Microbiota of Patients with Gastric Cancer in Taiwan.

Hsieh YY, Tung SY, Pan HY, Yen CW, Xu HW, Lin YJ, Deng YF, Hsu WT, Wu CS, Li C.

Sci Rep. 2018 Jan 9;8(1):158. doi: 10.1038/s41598-017-18596-0.


A Phase I/II study of the combination of lapatinib and oral vinorelbine in HER2-positive metastatic breast cancer.

Chen TW, Yeh DC, Chao TY, Lin CH, Chow LW, Chang DY, Hsieh YY, Huang SM, Cheng AL, Lu YS, Consortium TBC.

Jpn J Clin Oncol. 2018 Mar 1;48(3):242-247. doi: 10.1093/jjco/hyx188.


Assessment of the suitability of biodegradable rods for use in posterior lumbar fusion: An in-vitro biomechanical evaluation and finite element analysis.

Tsuang FY, Hsieh YY, Kuo YJ, Chen CH, Lin FH, Chen CS, Chiang CJ.

PLoS One. 2017 Nov 16;12(11):e0188034. doi: 10.1371/journal.pone.0188034. eCollection 2017.


Subject-enabled analytics model on measurement statistics in health risk expert system for public health informatics.

Chung CJ, Kuo YC, Hsieh YY, Li TC, Lin CC, Liang WM, Liao LN, Li CI, Lin HC.

Int J Med Inform. 2017 Nov;107:18-29. doi: 10.1016/j.ijmedinf.2017.08.011. Epub 2017 Sep 2.


A Comparative Proteomic Analysis of Erinacine A's Inhibition of Gastric Cancer Cell Viability and Invasiveness.

Kuo HC, Kuo YR, Lee KF, Hsieh MC, Huang CY, Hsieh YY, Lee KC, Kuo HL, Lee LY, Chen WP, Chen CC, Tung SY.

Cell Physiol Biochem. 2017;43(1):195-208. doi: 10.1159/000480338. Epub 2017 Aug 30.


Add-on neurological benefits of antiviral therapy in HCV patients with chronic kidney disease - a nationwide cohort study.

Lin MS, Chen TH, Lin WY, Liu CH, Hsieh YY, Chiu WN, Chang CH, Chen MY, Chung CM, Lin YS.

BMC Gastroenterol. 2017 Aug 16;17(1):99. doi: 10.1186/s12876-017-0653-2.


Hot-Water Extracts from Roots of Vitis thunbergii var. taiwaniana and Identified ε-Viniferin Improve Obesity in High-Fat Diet-Induced Mice.

Lu YL, Lin SY, Fang SU, Hsieh YY, Chen CR, Wen CL, Chang CI, Hou WC.

J Agric Food Chem. 2017 Mar 29;65(12):2521-2529. doi: 10.1021/acs.jafc.7b00327. Epub 2017 Mar 21.


Removal of fixation construct could mitigate adjacent segment stress after lumbosacral fusion: A finite element analysis.

Hsieh YY, Chen CH, Tsuang FY, Wu LC, Lin SC, Chiang CJ.

Clin Biomech (Bristol, Avon). 2017 Mar;43:115-120. doi: 10.1016/j.clinbiomech.2017.02.011. Epub 2017 Feb 23.


Flexible Micro-Supercapacitor Based on Graphene with 3D Structure.

Zhang L, DeArmond D, Alvarez NT, Malik R, Oslin N, McConnell C, Adusei PK, Hsieh YY, Shanov V.

Small. 2017 Mar;13(10). doi: 10.1002/smll.201603114. Epub 2017 Jan 5.


Corrigendum: Alpha-Fetoprotein Measurement Benefits Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis.

Chang TS, Wu YC, Tung SY, Wei KL, Hsieh YY, Huang HC, Chen WM, Shen CH, Lu CH, Wu CS, Tsai YH, Huang YH.

Am J Gastroenterol. 2016 Nov;111(11):1668. doi: 10.1038/ajg.2016.426. No abstract available.


A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness.

Lee KC, Kuo HC, Shen CH, Lu CC, Huang WS, Hsieh MC, Huang CY, Kuo YH, Hsieh YY, Teng CC, Lee LY, Tung SY.

J Cell Mol Med. 2017 Mar;21(3):588-599. doi: 10.1111/jcmm.13004. Epub 2016 Oct 6.


The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells.

Huang WS, Hsieh MC, Huang CY, Kuo YH, Tung SY, Shen CH, Hsieh YY, Teng CC, Lee KF, Chen TC, Lee KC, Kuo HC.

PLoS One. 2016 Sep 26;11(9):e0159927. doi: 10.1371/journal.pone.0159927. eCollection 2016.


Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer.

Hsieh YY, Chou CJ, Lo HL, Yang PM.

Cell Death Discov. 2016 May 9;2:16027. doi: 10.1038/cddiscovery.2016.27. eCollection 2016.


Transpapillary biliary biopsy for malignant biliary strictures: comparison between cholangiocarcinoma and pancreatic cancer.

Chen WM, Wei KL, Chen YS, Chang PJ, Tung SY, Chang TS, Huang HC, Shen CH, Hsieh YY, Wu CS.

World J Surg Oncol. 2016 May 4;14:140. doi: 10.1186/s12957-016-0883-8.


Hepatoprotective effect of resveratrol against ethanol-induced oxidative stress through induction of superoxide dismutase in vivo and in vitro.

Chen WM, Shaw LH, Chang PJ, Tung SY, Chang TS, Shen CH, Hsieh YY, Wei KL.

Exp Ther Med. 2016 Apr;11(4):1231-1238. Epub 2016 Feb 16.


Vitis thunbergii var. taiwaniana Extracts and Purified Compounds Ameliorate Obesity in High-Fat Diet-Induced Obese Mice.

Lin SY, Huang GC, Hsieh YY, Lin YS, Han CH, Wen CL, Chang CI, Hou WC.

J Agric Food Chem. 2015 Oct 28;63(42):9286-94. doi: 10.1021/acs.jafc.5b04269. Epub 2015 Oct 15.


Enrichment desired quality chitosan fraction and advance yield by sequential static and static-dynamic supercritical CO2.

Hsieh YY, Chin HY, Tsai ML.

Carbohydr Polym. 2015 Nov 20;133:313-9. doi: 10.1016/j.carbpol.2015.06.092. Epub 2015 Jul 9.


Alpha-Fetoprotein Measurement Benefits Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis.

Chang TS, Wu YC, Tung SY, Wei KL, Hsieh YY, Huang HC, Chen WM, Shen CH, Lu CH, Wu CS, Tsai YH, Huang YH.

Am J Gastroenterol. 2015 Jun;110(6):836-44; quiz 845. doi: 10.1038/ajg.2015.100. Epub 2015 Apr 14. Erratum in: Am J Gastroenterol. 2016 Nov;111(11):1668.


Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance.

Siu MK, Abou-Kheir W, Yin JJ, Chang YS, Barrett B, Suau F, Casey O, Chen WY, Fang L, Hynes P, Hsieh YY, Liu YN, Huang J, Kelly K.

Oncotarget. 2014 Jun 15;5(11):3770-84. Erratum in: Oncotarget. 2018 Aug 17;9(64):32403.


Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NFκB signaling pathway in gastric cancer cells.

Hsieh YY, Shen CH, Huang WS, Chin CC, Kuo YH, Hsieh MC, Yu HR, Chang TS, Lin TH, Chiu YW, Chen CN, Kuo HC, Tung SY.

J Biomed Sci. 2014 Jun 14;21:59. doi: 10.1186/1423-0127-21-59.


Primary leptomeningeal melanoma mimicking meningitis: a case report and literature review.

Hsieh YY, Yang ST, Li WH, Hu CJ, Wang LS.

J Clin Oncol. 2015 Apr 20;33(12):e57-61. doi: 10.1200/JCO.2013.50.0264. Epub 2014 Mar 17. Review. No abstract available.


Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach.

Shen CH, Tung SY, Huang WS, Lu CC, Lee KC, Hsieh YY, Chang PJ, Liang HF, Chen JH, Lin TH, Hsieh MC, Kuo HC.

Toxicology. 2014 Feb 28;316:61-70. doi: 10.1016/j.tox.2013.12.007. Epub 2014 Jan 3.


Hsp90 regulates nongenetic variation in response to environmental stress.

Hsieh YY, Hung PH, Leu JY.

Mol Cell. 2013 Apr 11;50(1):82-92. doi: 10.1016/j.molcel.2013.01.026. Epub 2013 Feb 21.


Antihyperlipidemic and Antioxidant Effects of C-phycocyanin in Golden Syrian Hamsters Fed with a Hypercholesterolemic Diet.

Sheu MJ, Hsieh YY, Lai CH, Chang CC, Wu CH.

J Tradit Complement Med. 2013 Jan;3(1):41-7. doi: 10.4103/2225-4110.106545.


CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.

Tung SY, Chang SF, Chou MH, Huang WS, Hsieh YY, Shen CH, Kuo HC, Chen CN.

J Biomed Sci. 2012 Oct 25;19:91. doi: 10.1186/1423-0127-19-91. Erratum in: J Biomed Sci. 2013;20:21.


The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae.

McDonald MJ, Hsieh YY, Yu YH, Chang SL, Leu JY.

Curr Biol. 2012 Jul 10;22(13):1235-40. doi: 10.1016/j.cub.2012.04.056. Epub 2012 Jun 21.


Chromosome 15q21-22-related polymorphisms and haplotypes are associated with susceptibility to type-2 diabetic nonproliferative retinopathy.

Hsieh YY, Huang YC, Chang CC, Wang YK, Lin WH, Tsai FJ.

Genet Test Mol Biomarkers. 2012 May;16(5):442-8. doi: 10.1089/gtmb.2011.0092. Epub 2012 Mar 12.


Routine blood tests to predict liver fibrosis in chronic hepatitis C.

Hsieh YY, Tung SY, Lee K, Wu CS, Wei KL, Shen CH, Chang TS, Lin YH.

World J Gastroenterol. 2012 Feb 28;18(8):746-53. doi: 10.3748/wjg.v18.i8.746.


Epidermal growth factor receptor R521K polymorphism shows favorable outcomes in KRAS wild-type colorectal cancer patients treated with cetuximab-based chemotherapy.

Hsieh YY, Tzeng CH, Chen MH, Chen PM, Wang WS.

Cancer Sci. 2012 Apr;103(4):791-6. doi: 10.1111/j.1349-7006.2012.02225.x. Epub 2012 Feb 22.


Molecular packing and lateral interactions of distearoylphosphatidylcholine with dihexadecyldimethylammonium bromide in Langmuir monolayers and vesicles.

Chang CH, Liang CH, Hsieh YY, Chou TH.

J Phys Chem B. 2012 Mar 1;116(8):2455-63. doi: 10.1021/jp211264h. Epub 2012 Feb 22.


Pretreatment risk stratification for non-metastatic head and neck squamous cell carcinoma in a high-prevalence area.

Hsieh YY, Mu-Hsin Chang P, Chen MH, Chu PY, Tzeng CH, Chang SY, Chen PM, Yang MH.

J Chin Med Assoc. 2011 Nov;74(11):487-92. doi: 10.1016/j.jcma.2011.09.003. Epub 2011 Nov 4.


XRCC1 399 Arg-related genotype and allele, but not XRCC1 His107Arg, XRCC1 Trp194Arg, KCNQ2, AT1R, and hOGG1 polymorphisms, are associated with higher susceptibility of endometriosis.

Hsieh YY, Chang CC, Chen SY, Chen CP, Lin WH, Tsai FJ.

Gynecol Endocrinol. 2012 Apr;28(4):305-9. doi: 10.3109/09513590.2011.631624. Epub 2011 Nov 15.


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